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    Cell-chip and automatic controlled system capable of detecting conditions for optimizing differentiation of stem cell using mechanical stimulus
    2.
    发明授权
    Cell-chip and automatic controlled system capable of detecting conditions for optimizing differentiation of stem cell using mechanical stimulus 有权
    细胞芯片和自动控制系统能够检测使用机械刺激优化干细胞分化的条件

    公开(公告)号：US08187863B2

    公开(公告)日：2012-05-29

    申请号：US12438103

    申请日：2008-09-24

    申请人： Woo Young Sim ,  Sang Sik Yang

    发明人： Woo Young Sim ,  Sang Sik Yang

    IPC分类号： C12M1/36

    CPC分类号： G01N35/1074 ,  B01L3/502715 ,  B01L2200/0647 ,  B01L2200/146 ,  B01L2300/0645 ,  B01L2300/0803 ,  B01L2300/0816 ,  B01L2300/0874 ,  B01L2300/0887 ,  B01L2300/14 ,  B01L2400/0487 ,  B01L2400/0655 ,  C12M23/12 ,  C12M23/16 ,  C12M35/04 ,  G01N35/1095 ,  G01N2035/00158 ,  G01N2035/1044

    摘要： Provided are a cell chip and a system thereof that are capable of detecting optimal conditions for stem cell differentiation by mechanical stimuli. The cell chip for cell differentiation experimentation includes a plurality of cell chambers for storing cells and culture media, cell and culture medium injection ports for transferring the cells and culture media to corresponding cell chambers, fine passages for moving the cells and the culture media injected into the cell and culture medium injection ports to the cell chambers, pneumatic injection ports for injecting pneumatic pressures applied to the cell chambers, and apertures having circular films for transferring the pneumatic pressures injected through the pneumatic injection ports to corresponding cell chambers. Here, at least two of the apertures may have different areas to vary the magnitude of pneumatic pressure applied to corresponding cell chambers.

    摘要翻译： 提供了能够通过机械刺激来检测干细胞分化的最佳条件的细胞芯片及其系统。 用于细胞分化实验的细胞芯片包括用于储存细胞和培养基的多个细胞室，用于将细胞和培养基转移到相应的细胞室的细胞和培养基注射端口，用于移动细胞的细小通道和注入的培养基 向细胞室注入细胞培养基和培养基注入口，用于注入施加到细胞室的气压的气动注射口，以及具有圆形膜的孔，用于将通过气动注射口注入的气压传递到相应的细胞室。 这里，至少两个孔可以具有不同的面积以改变施加到相应的细胞室的气压的大小。

    Liquid handling means for excision apparatus
    6.
    发明申请
    Liquid handling means for excision apparatus 审中-公开
    用于切除装置的液体处理装置

    公开(公告)号：US20060189890A1

    公开(公告)日：2006-08-24

    申请号：US10723990

    申请日：2003-11-25

    申请人： Andrew Gooley ,  Robert Ramsden ,  Kurt Weber

    发明人： Andrew Gooley ,  Robert Ramsden ,  Kurt Weber

    IPC分类号： A61B10/00

    CPC分类号： G01N35/1016 ,  B01J2219/00691 ,  G01N35/0099 ,  G01N35/1065 ,  G01N2001/2873 ,  G01N2035/1044

    摘要： A device for dispensing liquids includes one or more liquid outlet means carried on a movable head. The device forms part of an automated excision apparatus for cutting biomolecule spots from an array of such spots carried in a gel. The head is mounted on an automated motion control system to allow for movement of the head in X, Y, Z directions under the control of a control means. A displacement means for causing the dispensing of liquid from the one or more liquid outlet means of the device is also carried by the moveable head carrying the liquid delivery outlets allowing the length of the tubing between the outlet and the aspiration device, typically a syringe, to be much shorter. This means that swelling and contraction of the tube is minimized during liquid handling operations which means more accurate delivery of specified volumes through the outlet. The syringes and the outlets are mounted on opposite sides of an axis of movement of the apparatus, keeping the machine compact. Typically the axis will be a horizontal X or vertical Y axis defined by a beam or the like which supports the movable head.

    摘要翻译： 用于分配液体的装置包括承载在可移动头上的一个或多个液体出口装置。 该装置构成用于从凝胶中携带的这种斑点的阵列切割生物分子斑点的自动切除装置的一部分。 头部安装在自动运动控制系统上，以允许头部在X，Y，Z方向上在控制装置的控制下移动。 用于引起来自装置的一个或多个液体出口装置的液体分配的位移装置也由携带液体输送出口的可移动头承载，允许出口和抽吸装置（通常为注射器）之间的管道的长度， 要短得多 这意味着在液体处理操作期间管的膨胀和收缩最小化，这意味着通过出口更精确地输送指定的体积。 注射器和出口安装在装置的运动轴线的相对侧上，保持机器紧凑。 通常，轴将是由支撑可移动头的梁等限定的水平X或垂直Y轴。

    Article comprising a multi-channel dispensing head
    10.
    发明授权
    Article comprising a multi-channel dispensing head 失效

    公开(公告)号：US06786253B2

    公开(公告)日：2004-09-07

    申请号：US10660251

    申请日：2003-09-11

    申请人： Ilya Feygin

    发明人： Ilya Feygin

    IPC分类号： B65B104

    CPC分类号： B01L3/0265 ,  B01J3/002 ,  B01J3/03 ,  B01J4/02 ,  B01J2219/00274 ,  B01J2219/00315 ,  B01J2219/00317 ,  B01J2219/0036 ,  B01J2219/00369 ,  B01J2219/00585 ,  B01L2200/025 ,  B01L2200/146 ,  B01L2400/0633 ,  B01L2400/082 ,  C40B60/14 ,  G01N35/1065 ,  G01N2035/1041 ,  G01N2035/1044

    摘要： A multi-channel fluid dispenser includes a reservoir with multiple internal chambers, a multi-channel liquid dispensing head, a plurality of fluid-delivery conduits, and support and positioning elements. The fluid-delivery conduits receive liquid from the chambers in the reservoir and deliver it to the dispensing head. The support and positioning elements are operable to support and position the dispensing head so that it can deliver the liquid from the reservoir to an underlying receiver. The fluid-delivery conduits include one or more optional flow control features that improve the accuracy of the dispensing operation. The multi-channel liquid dispensing head, which includes a valve-support member, a plurality of valves and a plurality of nozzles, is advantageously movable in three directions to facilitate alignment with an underlying receiver. Movement of the dispensing head along two axes is provided by the simple expedient of elongate holes having their long axes aligned in mutually orthogonal directions. In some embodiments, the valves are tiltable away from the vertical so that liquid dispensed from such tilted valves is directed at a non-normal angle into a receiver.