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公开(公告)号：US07169277B2
公开(公告)日：2007-01-30
申请号：US09919505
申请日：2001-07-31
申请人： Walter Ausserer , Luc J. Bousse , Robert S. Dubrow , Steven A. Sundberg , Andrea W. Chow , Benjamin N. Wang
发明人： Walter Ausserer , Luc J. Bousse , Robert S. Dubrow , Steven A. Sundberg , Andrea W. Chow , Benjamin N. Wang
IPC分类号： G01N27/26
CPC分类号： G01N27/44791 , G01N27/44743
摘要： Devices, systems and methods for use in separating sample materials into different fractions that employ bulk fluid flow for loading of samples followed by electrophoretic separation of the sample material. Devices employ configurations that optionally allow bulk sample loading with some or no displacement of a separation matrix within a separation conduit. Methods of using these devices, and systems that incorporate these devices are also envisioned.
摘要翻译： 用于将样品材料分离成不同级分的装置，系统和方法，其使用大量流体流来装载样品，然后电泳分离样品材料。 设备采用可选地允许在分离管道内部分或不排出分离基质的大量样品加载的构造。 也可以设想使用这些装置的方法以及包含这些装置的系统。
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公开(公告)号：US06990851B2
公开(公告)日：2006-01-31
申请号：US10728528
申请日：2003-12-05
申请人： Michael Spaid , Andrea W. Chow , Benjamin N. Wang , Ring-Ling Chien , J. Wallace Parce , Anne R. Kopf-Sill
发明人： Michael Spaid , Andrea W. Chow , Benjamin N. Wang , Ring-Ling Chien , J. Wallace Parce , Anne R. Kopf-Sill
CPC分类号： G05D7/0694 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L3/502746 , B01L9/527 , B01L2200/027 , B01L2300/0663 , B01L2300/0816 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2400/0406 , B01L2400/0415 , B01L2400/0487 , B01L2400/084 , G01N11/08 , G01N27/44791 , G01N2035/1044 , Y10T137/8158
摘要： Microfluidic devices, systems, and methods measure viscosity, flow times, and/or other flow characteristics within the channels, and the measured flow characteristics can be used to generate a desired flow. Multi-reservoir pressure modulator and pressure controller systems, electrokinetic systems and/or other fluid transport mechanisms can generate the flow, controllably mix fluids, and the like.
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公开(公告)号：US06506609B1
公开(公告)日：2003-01-14
申请号：US09569747
申请日：2000-05-11
申请人： H. Garrett Wada , Anne R. Kopf-Sill , Marja Liisa Alajoki , J. Wallace Parce , Benjamin N. Wang , Andrea W. Chow , Robert S. Dubrow
发明人： H. Garrett Wada , Anne R. Kopf-Sill , Marja Liisa Alajoki , J. Wallace Parce , Benjamin N. Wang , Andrea W. Chow , Robert S. Dubrow
IPC分类号： G01N700
CPC分类号： B01F13/0062 , B01J19/0093 , B01J2219/00889 , B01J2219/00891 , B01L3/502761 , B01L3/502776 , B01L2200/0636 , B01L2200/0652 , B01L2400/0406 , B01L2400/0487 , G01N15/1404 , G01N27/44704 , G01N27/44791 , G01N2015/1409 , G01N2015/149 , G01N2333/4718 , Y10T436/117497 , Y10T436/2575
摘要： Methods and systems for particle focusing to increase assay throughput in microscale systems are provided. The invention includes methods for providing substantially uniform flow velocity to flowing particles in microfluidic devices. Methods of sorting members of particle populations, such as cells and various subcellular components are also provided. Integrated systems in which particles are focused and/or sorted are additionally included.
摘要翻译： 提供了用于增加微尺度系统中测定通过量的粒子聚焦的方法和系统。 本发明包括为微流体装置中的流动颗粒提供基本均匀的流速的方法。 还提供了分选颗粒群体成员的方法，例如细胞和各种亚细胞组分。 另外包括其中聚焦和/或分选颗粒的集成系统。
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公开(公告)号：US07040144B2
公开(公告)日：2006-05-09
申请号：US10207735
申请日：2002-07-26
申请人： Michael Spaid , Andrea W. Chow , Benjamin N. Wang , Ring-Ling Chien , J. Wallace Parce , Anne R. Kopf-Sill , Josh Molho , Anubhav Tripathi , Matthew B. Kerby
发明人： Michael Spaid , Andrea W. Chow , Benjamin N. Wang , Ring-Ling Chien , J. Wallace Parce , Anne R. Kopf-Sill , Josh Molho , Anubhav Tripathi , Matthew B. Kerby
CPC分类号： G01N27/44791 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L3/502746 , B01L9/527 , B01L2200/027 , B01L2300/0663 , B01L2300/0816 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2400/0406 , B01L2400/0415 , B01L2400/0487 , B01L2400/084 , G01N11/08 , G01N2035/1044 , G05D7/0694
摘要： Microfluidic devices, systems, and methods measure viscosity, flow times, and/or pressures, other flow characteristics within the channels, and the measured flow characteristics can be used to generate a desired flow. Multi-reservoir pressure modulator and pressure controller systems, electrokinetic systems and/or other fluid transport mechanisms can generate the flow, controllably mix fluids, and the like.
摘要翻译： 微流体装置，系统和方法测量通道内的粘度，流动时间和/或压力，其它流动特性，并且所测量的流动特性可用于产生所需的流量。 多储层压力调节器和压力控制器系统，电动系统和/或其它流体输送机构可以产生流动，可控地混合流体等。
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公开(公告)号：US07001716B2
公开(公告)日：2006-02-21
申请号：US10442006
申请日：2003-05-20
IPC分类号： C12Q1/00
CPC分类号： G01N21/64 , B01J19/0093 , B01L3/5027 , B01L2300/0816 , B01L2300/0867 , B01L2400/0415 , B01L2400/0487 , B01L2400/084 , G01N21/6428 , G01N21/75 , G01N30/02 , G01N2021/6482 , B01D15/3857
摘要： Methods for monitoring time dependent reactions that comprise providing a flow channel, typically microscale in dimension, flowing at least two reagents into the flow channel and varying the flow rate of the mixture through the flow channel. By increasing and/or decreasing the flow rate of the reagent mixture from the point of mixing to the point of detection, one alters the amount of reaction time, allowing monitoring reaction kinetics over time.
摘要翻译： 用于监测时间依赖性反应的方法，其包括提供流动通道，尺寸通常为微尺寸，将至少两种试剂流入流动通道并改变混合物通过流动通道的流速。 通过增加和/或降低试剂混合物从混合点到检测点的流速，可以改变反应时间的量，从而监测反应动力学随时间的变化。
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6.发明授权公开(公告)号：US06695009B2
公开(公告)日：2004-02-24
申请号：US10013847
申请日：2001-10-30
申请人： Ring-Ling Chien , Benjamin N. Wang
发明人： Ring-Ling Chien , Benjamin N. Wang
IPC分类号： G05D706
CPC分类号： G01N27/44791 , B01L3/502753 , B01L2200/0631 , B01L2200/0673 , B01L2300/0816 , B01L2400/0415 , B01L2400/0487 , G01N1/40 , G01N27/44704 , G01N27/44773 , Y10T137/0391 , Y10T137/2076 , Y10T137/2142 , Y10T137/2191
摘要： Methods of concentrating materials within microfluidic channel networks by moving materials into regions in which overall velocities of the material are reduced, resulting in stacking of the material within those reduced velocity regions. These methods, devices and systems employ static fluid interfaces to generate the differential velocities, as well as counter-current flow methods, to concentrate materials within microscale channels.
摘要翻译： 通过将材料移动到其中材料的总体速度减小的区域中将材料集中在微流体通道网络内的方法，导致材料在那些降低的速度区域内堆叠。 这些方法，设备和系统采用静态流体界面来产生差分速度，以及逆流流动方法，以将材料集中在微量通道内。
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公开(公告)号：US06592821B1
公开(公告)日：2003-07-15
申请号：US09853887
申请日：2001-05-10
申请人： H. Garrett Wada , Anne R. Kopf-Sill , Marja Liisa Alajoki , J. Wallace Parce , Benjamin N. Wang , Andrea W. Chow , Robert S. Dubrow , Yevgeny Yurkovetsky , Javier Anibal Farinas
发明人： H. Garrett Wada , Anne R. Kopf-Sill , Marja Liisa Alajoki , J. Wallace Parce , Benjamin N. Wang , Andrea W. Chow , Robert S. Dubrow , Yevgeny Yurkovetsky , Javier Anibal Farinas
IPC分类号： G01N3348
CPC分类号： B01F13/0062 , B01J19/0093 , B01L3/502776 , B01L2200/0636 , B01L2400/0406 , B01L2400/0487 , G01N15/1404 , G01N27/44704 , G01N27/44791 , G01N2015/1409 , G01N2015/149 , G01N2333/4718 , Y10T436/11
摘要： Methods and systems for particle focusing to increase assay throughput and sensitivity in microscale systems are provided. The invention includes methods for providing substantially uniform flow velocity to flowing particles in microfluidic devices. Methods of sorting members of particle populations, such as cells and various subcellular components are also provided. Integrated systems in which particles are focused and/or sorted are additionally included.
摘要翻译： 提供了粒子聚焦的方法和系统，以增加微量体系中的分析产量和灵敏度。 本发明包括为微流体装置中的流动颗粒提供基本均匀的流速的方法。 还提供了分选颗粒群体成员的方法，例如细胞和各种亚细胞组分。 另外包括其中聚焦和/或分选颗粒的集成系统。
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公开(公告)号：US06681616B2
公开(公告)日：2004-01-27
申请号：US10008604
申请日：2001-11-09
申请人： Michael Spaid , Andrea W. Chow , Benjamin N. Wang , Ring-Ling Chien , J. Wallace Parce , Anne R. Kopf-Sill
发明人： Michael Spaid , Andrea W. Chow , Benjamin N. Wang , Ring-Ling Chien , J. Wallace Parce , Anne R. Kopf-Sill
IPC分类号： G01N1106
CPC分类号： G05D7/0694 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L3/502746 , B01L9/527 , B01L2200/027 , B01L2300/0663 , B01L2300/0816 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2400/0406 , B01L2400/0415 , B01L2400/0487 , B01L2400/084 , G01N11/08 , G01N27/44791 , G01N2035/1044 , Y10T137/8158
摘要： Microfluidic devices, systems, and methods measure viscosity, flow times, and/or other flow characteristics within the channels, and the measured flow characteristics can be used to generate a desired flow. Multi-reservoir pressure modulator and pressure controller systems, electrokinetic systems and/or other fluid transport mechanisms can generate the flow, controllably mix fluids, and the like.
摘要翻译： 微流体装置，系统和方法测量通道内的粘度，流动时间和/或其他流动特性，并且可以使用测量的流动特性来产生期望的流量。 多储层压力调节器和压力控制器系统，电动系统和/或其它流体输送机构可以产生流动，可控地混合流体等。
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9.发明授权公开(公告)号：US06589729B2
公开(公告)日：2003-07-08
申请号：US09774531
申请日：2001-01-31
IPC分类号： C12Q100
CPC分类号： G01N21/64 , B01J19/0093 , B01L3/5027 , B01L2300/0816 , B01L2300/0867 , B01L2400/0415 , B01L2400/0487 , B01L2400/084 , G01N21/6428 , G01N21/75 , G01N30/02 , G01N2021/6482 , B01D15/3857
摘要： Methods for monitoring time dependent reactions that comprise providing a flow channel, typically microscale in dimension, flowing at least two reagents into the flow channel and varying the flow rate of the mixture through the flow channel. By increasing and/or decreasing the flow rate of the reagent mixture from the point of mixing to the point of detection, one alters the amount of reaction time, allowing monitoring reaction kinetics over time.
摘要翻译： 用于监测时间依赖性反应的方法，其包括提供流动通道，尺寸通常为微尺寸，将至少两种试剂流入流动通道并改变混合物通过流动通道的流速。 通过增加和/或降低试剂混合物从混合点到检测点的流速，可以改变反应时间的量，从而监测反应动力学随时间的变化。
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