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    Electro-optical stimulation/measurement
    1.
    发明授权
    Electro-optical stimulation/measurement 有权
    电光刺激/测量

    公开(公告)号：US07480433B2

    公开(公告)日：2009-01-20

    申请号：US10503995

    申请日：2003-02-14

    Applicant: David R. Walt ,  Sabine Szunerits

    Inventor： David R. Walt ,  Sabine Szunerits

    IPC: G02B6/06

    CPC classification number: G01D5/268 ,  A61B5/0071 ,  A61N1/08 ,  A61N1/205 ,  A61N5/0613 ,  A61N5/0622 ,  A61N2005/063 ,  B82Y15/00 ,  B82Y30/00 ,  G01N21/66

    Abstract: An electro-optical system includes an array including a plurality of optical fibers and a plurality of electrodes, and an insulator. The optical fibers are configured to transmit light, the optical fibers being mechanically coupled at distal ends in a distal arrangement and mechanically coupled at proximal ends in a proximal arrangement. The plurality of electrodes are substantially coaxially disposed with at least portions of corresponding optical fibers, the electrodes being electrically conductive, with the electrodes and optical fibers being disposed in pairs, thereby being pair components, with one of the pair components of each pair being disposed about a radial periphery of the other pair component. The insulator is disposed between the plurality of electrodes and configured to inhibit transfer of electrical energy between the plurality of electrodes.

    Abstract translation: 电光系统包括包括多个光纤和多个电极的阵列和绝缘体。 光纤被配置为透射光，光纤在远端机构耦合在远端装置中并且在近端装置中在近端机械联接。 多个电极与对应的光纤的至少部分基本上同轴地布置，电极是导电的，电极和光纤成对设置，从而成对成对，每对中的一个部件之一被设置 围绕另一对组件的径向周边。 绝缘体设置在多个电极之间并且被配置为抑制多个电极之间的电能传递。

    Method and system of array imaging
    4.
    发明授权
    Method and system of array imaging 有权
    阵列成像的方法和系统

    公开(公告)号：US07595473B2

    公开(公告)日：2009-09-29

    申请号：US11209432

    申请日：2005-08-22

    Applicant: David R. Walt ,  Sandra Bencic-Nagale

    Inventor： David R. Walt ,  Sandra Bencic-Nagale

    IPC: G01N21/00

    CPC classification number: G01J3/2803 ,  G01J3/02 ,  G01J3/0213 ,  G01J3/0229 ,  G01J3/10 ,  G01J3/4406 ,  G01J2001/0276 ,  G01N21/6428 ,  G01N21/6458 ,  G01N2021/6441 ,  G01N2021/6484 ,  G01N2201/08 ,  G01N2201/088

    Abstract: The present invention relates to a method and system of array imaging that extends or maximizes the longevity of the sensor array by minimizing the effects of photobleaching. The imaging system has a light source, a variable exposure aperture, and a variable filter system. The system extends the longevity of sensors by (1) using the variable exposure aperture to selectively expose sections of the sensor array containing representative numbers of each type of sensor, and/or (2) using the variable filter system to control the intensity of the excitation light, providing only the intensity required to induce the appropriate excitation and increasing that intensity over time as necessary to counteract the effects of photobleaching.

    Abstract translation: 本发明涉及阵列成像的方法和系统，该方法和系统通过最小化光漂白的影响来延长或最大化传感器阵列的寿命。 成像系统具有光源，可变曝光孔径和可变过滤器系统。 该系统通过（1）使用可变曝光孔径来延长传感器的寿命，以选择性地暴露包含每种类型的传感器的代表数的传感器阵列的部分，和/或（2）使用可变过滤器系统来控制传感器的强度 激发光，仅提供诱导适当激发所需的强度，并根据需要随时间增加强度以抵消光漂白的影响。

    Spectroscopic Imaging Microscopy
    5.
    发明申请
    Spectroscopic Imaging Microscopy 有权
    光谱成像显微镜

    公开(公告)号：US20090201499A1

    公开(公告)日：2009-08-13

    申请号：US12239628

    申请日：2008-09-26

    Applicant: David J. Monk ,  David R. Walt

    Inventor： David J. Monk ,  David R. Walt

    IPC: G01J3/04

    CPC classification number: G01J3/18 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/0229 ,  G01J3/0237 ,  G01J3/0264 ,  G01J3/14 ,  G01J3/32 ,  G02B21/06 ,  G02B21/367

    Abstract: Disclosed herein are systems that include: (a) an objective lens system configured to collect light from a sample; (b) a first aperture positioned to allow a portion of the collected light received from the objective lens system to pass as input light; (c) a first lens positioned to transmit the input light received from the first aperture; (d) a dispersive element configured to spatially disperse the input light received from the first lens in a first plane; (e) a second lens positioned to transmit the spatially dispersed light; (f) a second aperture positioned to allow a portion of the spatially dispersed light received from the second lens to pass as detection light; and (g) a detector positioned to receive the detection light and configured to form at least one image of the sample.

    Abstract translation: 这里公开的系统包括：（a）被配置为收集来自样品的光的物镜系统; （b）第一孔，定位成允许从物镜系统接收的一部分收集的光作为输入光通过; （c）第一透镜，定位成透射从第一孔接收的输入光; （d）分散元件，被配置为在第一平面中将从第一透镜接收的输入光空间分散; （e）定位成透射空间分散的光的第二透镜; （f）第二孔，定位成允许从第二透镜接收的部分空间分散的光作为检测光通过; 和（g）定位成接收检测光并被配置成形成样品的至少一个图像的检测器。

    Self-encoding fiber optic sensor
    8.
    发明授权
    Self-encoding fiber optic sensor 失效
    自编光纤传感器

    公开(公告)号：US07115884B1

    公开(公告)日：2006-10-03

    申请号：US08944850

    申请日：1997-10-06

    Applicant: David R. Walt ,  Todd A. Dickinson

    Inventor： David R. Walt ,  Todd A. Dickinson

    IPC: G01N21/64

    CPC classification number: G01N21/6452 ,  B01J2219/00317 ,  B01J2219/00524 ,  B01J2219/00648 ,  B01J2219/00659 ,  C40B60/14 ,  G01N21/6428 ,  G01N21/7703 ,  G01N33/0031 ,  G01N33/54313 ,  G01N33/54373 ,  G01N33/54393 ,  G01N2021/6484 ,  G01N2021/7786

    Abstract: Self-encoding microspheres having distinct characteristic optical response signatures to specific target analytes may be mixed together while the ability is retained to identify the sensor type and location of each sensor in a random dispersion of large numbers of such sensors in a sensor array using an optically interrogatable encoding scheme, resulting in a microsphere-based analytic chemistry system. Individual microsphere sensors are disposed in microwells at a distal end of a fiber bundle and are optically coupled to discrete fibers or groups of fibers within the bundle to form an optical fiber bundle sensor. The identities of the individual sensors in the array are self-encoded by exposing the array to a reference analyte while illuminating the array with excitation light energy. A single sensor array may carry thousands of discrete sensing elements whose combined signal provides for substantial improvements in sensor detection limits, response times and signal-to-noise ratios.

    Abstract translation: 具有针对特定目标分析物的特征性光学响应特征的自编码微球可以混合在一起，同时保留能力以在传感器阵列中使用光学方法识别大量这种传感器的随机色散中的每个传感器的传感器类型和位置 可询问的编码方案，导致基于微球的分析化学系统。 单个微球传感器设置在纤维束的远端处的微孔中，并且光学耦合到束内的离散纤维或纤维组，以形成光纤束传感器。 阵列中各个传感器的身份通过将阵列暴露于参考分析物而进行自编​​码，同时用激发光能照射阵列。 单个传感器阵列可以携带数千个离散感测元件，其组合信号提供传感器检测限，响应时间和信噪比方面的实质性改进。

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