公开(公告)号：US20240068956A1

公开(公告)日：2024-02-29

申请号：US18341339

申请日：2023-06-26

申请人： Unity Semiconductor

发明人： Mayeul Durand de Gevigney ,  Guillaume Vienne ,  Kaiss Benhadjsalem

IPC分类号： G01N21/95 ,  G01N21/88

CPC分类号： G01N21/9501 ,  G01N21/8806 ,  G01N2021/8845 ,  G01N2201/0846

摘要： A system for optical inspection of a substrate. The system comprises an illumination device defining an inspection area on the substrate, a support to receive the substrate, and a detection device defining a detection area on the substrate. The inspection area is positioned ahead, with respect to the scanning direction, of at least a portion of the detection area.

公开(公告)号：US20180195938A1

公开(公告)日：2018-07-12

申请号：US15737414

申请日：2016-06-16

申请人： TASCOM CO., LTD.

发明人： Sung Dong LEE

IPC分类号： G01N1/40 ,  G01N21/07 ,  G01N21/31 ,  G01N21/64 ,  G01N21/76

CPC分类号： G01N1/4077 ,  B04B5/0407 ,  G01N21/07 ,  G01N21/31 ,  G01N21/64 ,  G01N21/6428 ,  G01N21/76 ,  G01N33/491 ,  G01N2001/4083 ,  G01N2021/0325 ,  G01N2021/0378 ,  G01N2035/00504 ,  G01N2201/0423 ,  G01N2201/08 ,  G01N2201/0846

摘要： A biological material measuring instrument is described. The biological material measuring instrument includes a rotating body and a main body. The rotating body includes one or more cartridge holders having cuvettes in which a reagent and an analyte in a sample react. The main body includes a pair of light-emitting parts and light-receiving parts to optically measure the analyte in the sample. The rotating body further includes a light-emitting optical waveguide for guiding the light of the light-emitting parts to the cuvette and a light-receiving optical waveguide for guiding.

公开(公告)号：US20180053298A1

公开(公告)日：2018-02-22

申请号：US15730996

申请日：2017-10-12

申请人： VANDERBILT UNIVERSITY

发明人： Anita Mahadevan-Jansen ,  The-Quyen Nguyen ,  Xiaohong Bi ,  Zain Gowani ,  Ginger Holt ,  Isaac Pence

IPC分类号： G06T7/00 ,  G01N21/65 ,  A61B5/00 ,  G01N21/64

CPC分类号： G06T7/0012 ,  A61B5/0071 ,  A61B5/0075 ,  A61B2505/05 ,  G01N21/6486 ,  G01N21/65 ,  G01N2201/0846 ,  G06T2207/30096

摘要： A method of evaluating a surgical margin of tumor tissues of a living subject includes acquiring images of a specimen of the tumor tissues; calculating a three-dimensional (3D) morphological surface of the specimen from the acquired images and displaying the 3D morphological surface; obtaining, from the 3D morphological surface, a plurality of specimen locations to cover a surface of the specimen; acquiring optical data at each specimen location; evaluating a margin status of the specimen at each specimen location to either positive or negative based on the acquired optical data; and displaying the margin status of the specimen on the 3D morphological surface of the specimen with morphological orientations.

公开(公告)号：US20170108641A1

公开(公告)日：2017-04-20

申请号：US15393163

申请日：2016-12-28

申请人： Shanghai Institute of Optics And Fine Mechanics, Chinese Academy of Sciences

发明人： Haiwen CAI ,  Zeheng CHEN ,  Fei YANG ,  Jianxin GENG ,  Dijun CHEN ,  Weibiao CHEN

IPC分类号： G02B6/02 ,  G02B6/255 ,  G01N21/03

CPC分类号： G02B6/02323 ,  G01N21/03 ,  G01N21/39 ,  G01N2021/399 ,  G01N2201/0846 ,  G02B6/02328 ,  G02B6/255 ,  G02B6/4207

摘要： A hollow-core photonic crystal fiber gas cell and method for preparing the same. The hollow-core photonic crystal fiber gas cell comprises a single-mode fiber, a fiber splicing protection sleeve, a hollow-core photonic crystal fiber, and a photoelectric detector. One end of the single-mode fiber is fusion spliced with one end of the hollow-core photonic crystal fiber to form a fusion splice and seal one end of the hollow-core photonic crystal fiber gas cell. The fiber splicing protection sleeve covers and protects the fusion splice. The other end of the hollow-core photonic crystal fiber is processed into an output end by fusion sealing, and the surface of the output end faces, but is not parallel to, a detection surface of the photoelectric detector.

公开(公告)号：US09341515B2

公开(公告)日：2016-05-17

申请号：US13370969

申请日：2012-02-10

申请人： Alfons Schulte ,  Silki Arora

发明人： Alfons Schulte ,  Silki Arora

IPC分类号： G01J3/42 ,  G02B21/00 ,  G01J3/02 ,  G01J3/427 ,  G01N21/03 ,  G01N21/31 ,  G02B21/26 ,  G02B21/36 ,  G01N21/05 ,  G01N21/65

CPC分类号： G01J3/42 ,  G01J3/0208 ,  G01J3/0229 ,  G01J3/0289 ,  G01J3/427 ,  G01N21/03 ,  G01N21/31 ,  G01N21/314 ,  G01N21/3151 ,  G01N2021/0346 ,  G01N2021/058 ,  G01N2021/651 ,  G01N2021/656 ,  G01N2201/0627 ,  G01N2201/0846 ,  G02B21/0028 ,  G02B21/0032 ,  G02B21/26 ,  G02B21/367

摘要： Apparatus and method to measure optical absorption spectra with spatial resolution on the micron scale. An exemplary setup combines a continuous white light excitation beam in transmission geometry with a confocal microscope. Spatial resolution better than 1.4 μm in the lateral and 3.6 μm in the axial, directions was obtained. The detection and measurement of the absorption spectrum of hemoglobin in a single red blood cell under physiological conditions on the timescale of seconds was realized. The apparatus and method enables the investigation of spatial variations in the optical density of small samples on the micron scale and the study of biological assemblies at the single cell level, leading to applications in optical diagnostics, microfluidics, and other areas.

摘要翻译： 用微米尺度测量空间分辨率的光吸收光谱的装置和方法。 示例性设置将透射几何中的连续白光激发光束与共聚焦显微镜组合。 获得横向分辨率优于1.4μm，轴向方向为3.6μm。 实现了在生理条件下单次红细胞血红蛋白吸收光谱在秒的时间刻度上的检测和测量。 该装置和方法能够调查微尺度上小样品的光密度的空间变化以及在单细胞水平上对生物组装的研究，导致在光学诊断，微流体等领域的应用。

公开(公告)号：US09212999B2

公开(公告)日：2015-12-15

申请号：US14396388

申请日：2013-03-12

申请人： AVL EMISSION TEST SYSTEMS GMBH

发明人： Norbert Kreft

IPC分类号： G01N21/76 ,  G01N33/00

CPC分类号： G01N21/766 ,  G01N33/0037 ,  G01N2201/0636 ,  G01N2201/0806 ,  G01N2201/084 ,  G01N2201/0846 ,  Y02A50/245

摘要： A device for determining a concentration of at least one gas in a sample gas stream includes an analysis chamber, a detector, and a connecting channel. The analysis chamber is configured to have the sample gas stream and a reaction gas stream be introduced therein. The sample gas stream and the reaction gas stream are mixed to a gas mixture which reacts so as to emit an optical radiation. The detector is configured to measure the optical radiation. The connecting channel is configured to connect the analysis chamber to the detector. The connecting channel is configured as a light conductor extending from the analysis chamber to the detector.

摘要翻译： 用于确定样品气流中的至少一种气体的浓度的装置包括分析室，检测器和连接通道。 分析室被构造成具有样品气流并且反应气流被引入其中。 将样品气流和反应气流混合到反应以发射光辐射的气体混合物中。 检测器被配置成测量光辐射。 连接通道被配置为将分析室连接到检测器。 连接通道被配置为从分析室延伸到检测器的光导体。

公开(公告)号：US20150182151A1

公开(公告)日：2015-07-02

申请号：US14638834

申请日：2015-03-04

申请人： Trent Ridder ,  Ben Ver Steeg ,  Mike Mills

发明人： Trent Ridder ,  Ben Ver Steeg ,  Mike Mills

IPC分类号： A61B5/1455 ,  A61B5/145

CPC分类号： A61B5/1455 ,  A61B5/14532 ,  A61B5/14546 ,  A61B2562/0233 ,  A61B2562/0238 ,  A61B2562/046 ,  A61B2562/12 ,  G01N21/474 ,  G01N21/4795 ,  G01N21/49 ,  G01N2021/4745 ,  G01N2201/0846 ,  Y10T29/49764

摘要： An optical probe for non-invasively measuring an analyte property in a biological sample of a subject, comprises a plurality of illumination fibers that deliver source light from an optical probe input to a sample interface, a plurality of collection fibers that deliver light returned from the sample interface to an optical probe output, and wherein the illumination and collection fibers are oriented substantially perpendicular to the sample interface and the illumination and collection fibers are stacked in a plurality of linear rows to provide a stack of fibers arranged in a rectangular pattern. The optical probe is amenable to manufacturing on a scale consistent with a commercial product.

摘要翻译： 一种用于非侵入性测量受试者的生物样品中的分析物质的光学探针包括将源光从光学探针输入传送到样品界面的多个照明纤维，多个收集纤维，其将从 样品接口连接到光学探针输出，并且其中照明和收集光纤基本上垂直于样品界面定向，并且照明和收集光纤以多个线性行堆叠以提供以矩形图案布置的纤维堆叠。 光学探针适合于与商业产品一致的尺寸制造。

公开(公告)号：US08691591B2

公开(公告)日：2014-04-08

申请号：US13850154

申请日：2013-03-25

申请人： Trustees of Tufts College, Tufts University

发明人： David R. Walt ,  Todd A. Dickinson

IPC分类号： G01N21/00 ,  G01N33/543 ,  G01N21/75

CPC分类号： C12Q1/682 ,  B01J2219/00317 ,  B01J2219/0045 ,  B01J2219/00466 ,  B01J2219/005 ,  B01J2219/00524 ,  B01J2219/00585 ,  B01J2219/00648 ,  B01J2219/00659 ,  C12Q1/6834 ,  C40B60/14 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/7703 ,  G01N33/0031 ,  G01N33/54313 ,  G01N2201/0846 ,  Y10T436/101666 ,  Y10T436/109163

摘要： Disclosed herein are compositions and methods for combining the output obtained from redundant sensor elements in a sensor array.

摘要翻译： 这里公开了用于组合从传感器阵列中的冗余传感器元件获得的输出的组合物和方法。

公开(公告)号：US08644663B2

公开(公告)日：2014-02-04

申请号：US12987736

申请日：2011-01-10

申请人： Bertrand Viellerobe ,  Francois Lacombe ,  Nicolas Boularot ,  Francois Doussoux ,  Nicolas Lavillonniere

发明人： Bertrand Viellerobe ,  Francois Lacombe ,  Nicolas Boularot ,  Francois Doussoux ,  Nicolas Lavillonniere

IPC分类号： G02B6/06

CPC分类号： G01N21/6458 ,  A61B1/00117 ,  A61B1/00165 ,  A61B1/00172 ,  A61B1/043 ,  A61B1/0638 ,  A61B1/0646 ,  A61B1/07 ,  A61B5/0068 ,  A61B5/0071 ,  A61B5/0084 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2201/024 ,  G01N2201/0846 ,  G01N2201/086 ,  G02B6/29362 ,  G02B21/16

摘要： An imaging device including an illumination module including at least one emitter for emitting at least one excitation beam, a scanning and injection module including an image guide, a proximal end and a distal end of which are linked by a plurality of optical fibers, and a scanning and injection optical system configured to alternately inject the at least one excitation beam into an optical fiber of the image guide from the proximal end of the image guide, and a detection module including at least one detector for detecting at least one luminous flux collected at the distal end of the image guide. At least one of the illumination module and the detection module is optically conjugated with the scanning and injection module by a conjugating optical fiber.

摘要翻译： 一种成像装置，包括包括至少一个用于发射至少一个激发光束的发射器的照明模块，包括图像引导件的扫描和注射模块，其近端和远端由多根光纤连接， 扫描和注射光学系统，被配置为将至少一个激发光束从图像引导件的近端交替地注入到图像引导件的光纤中，以及检测模块，包括至少一个检测器，用于检测在 图像引导件的远端。 照明模块和检测模块中的至少一个通过共轭光纤与扫描和注入模块光学共轭。

公开(公告)号：US08098373B2

公开(公告)日：2012-01-17

申请号：US12759082

申请日：2010-04-13

申请人： Matthew Nelson ,  Patrick Treado ,  Ryan Priore

发明人： Matthew Nelson ,  Patrick Treado ,  Ryan Priore

IPC分类号： G01J3/28

CPC分类号： G01J3/36 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/027 ,  G01J3/0289 ,  G01J3/0291 ,  G01J3/2823 ,  G01N21/31 ,  G01N2201/0833 ,  G01N2201/0846

摘要： System and method for spatially and spectrally parallelized FAST. A sample is illuminated to thereby produce interacted photons. The photons are passed through a filter and received at a two-dimensional end of a FAST device wherein said FAST device comprises a two-dimensional array of optical fibers drawn into a one-dimensional fiber stack so as to effectively convert a two-dimensional array of optical fibers into a curvilinear field of view, and wherein said two-dimensional array of optical fibers is configured to receive said photons and transfer said photons out of said fiber array spectral translator device and to a spectrograph through said one-dimensional fiber stack wherein said one-dimensional fiber stack comprises at least two columns of fibers spatially offset in parallel at the entrance slit of said spectrograph. The photons are then detected at a detector to thereby obtain a spectroscopic data set representative of the sample.

摘要翻译： 用于空间和光谱平行化FAST的系统和方法。 照射样品从而产生相互作用的光子。 光子通过过滤器并在FAST装置的二维端接收，其中所述FAST装置包括被拉入一维纤维堆叠的二维光纤阵列，以有效地将二维阵列 的光纤变成曲线视场，并且其中所述二维光纤阵列被配置为接收所述光子并将所述光子从所述光纤阵列光谱转换器装置传送到通过所述一维光纤堆的光谱仪，其中 所述一维纤维堆叠包括在所述光谱仪的入口狭缝处空间上平行偏移的至少两列纤维。 然后在检测器处检测光子，从而获得代表样品的光谱数据集。