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    Scanner-type fluorescence detection apparatus using small sized excitation light source
    3.
    发明授权
    Scanner-type fluorescence detection apparatus using small sized excitation light source 失效
    使用小型激发光源的扫描仪型荧光检测仪

    公开(公告)号：US06515743B1

    公开(公告)日：2003-02-04

    申请号：US09667722

    申请日：2000-09-22

    申请人： Toshinori Hayashi ,  Yoshifumi Kurihara ,  Takahiko Ishiguro

    发明人： Toshinori Hayashi ,  Yoshifumi Kurihara ,  Takahiko Ishiguro

    IPC分类号： G01N2164

    CPC分类号： G01N21/6452 ,  G01N2021/6484 ,  G01N2201/0423

    摘要： A fluorescence detection apparatus comprising: a sample holder for fixing and holding sample vessels on a circular arc; a partition plate being joined to drive means for rotation on the center of the circular arc; an excitation light source; excitation light optical means; and fluorescence optical means containing a light guide being fixed on the partition plate for rotation integrally and a photosensor. The photosensor is mechanically discontinued from the drive means and fixedly placed. The fluorescence signal emission end of the light guide is placed facing the photosensor on the rotation center axis and the partition plate and the parts fixed thereto are rotated integrally, whereby fluorescence detection of the samples arranged on the circular arc is repeated in order.

    摘要翻译： 一种荧光检测装置，包括：用于将样品容器固定并保持在圆弧上的样品保持器; 一个隔板连接到驱动装置上，用于在圆弧的中心旋转; 激发光源; 激发光光学装置; 以及含有固定在隔板上的导光体的荧光光学装置一体地旋转，光传感器。 光传感器从驱动装置机械地停止并固定放置。 将导光体的荧光信号发射端面朝向旋转中心轴的光电传感器放置，分隔板和固定于其上的部件一体旋转，由此依次重复排列在圆弧上的样品的荧光检测。

    Device for automatically analyzing samples by means of colorimetric procedure especially applied to blood analysis
    4.
    发明授权
    Device for automatically analyzing samples by means of colorimetric procedure especially applied to blood analysis 失效
    用于自动分析样品的设备，特别适用于血液分析

    公开(公告)号：US5178833A

    公开(公告)日：1993-01-12

    申请号：US416261

    申请日：1989-10-03

    申请人： Serge A. Covain

    发明人： Serge A. Covain

    IPC分类号： G01N35/02 ,  G01N21/25 ,  G01N21/27

    CPC分类号： G01N21/253 ,  G01N2201/0415 ,  G01N2201/0423 ,  G01N2201/0853

    摘要： A device for automatically analyzing samples by a colorimetric procedure may be particularly used for blood analysis. A reaction ring bearing at its periphery an array of transparent reaction cups is stationary. An optical fiber is mounted on a rotating disk, concentric with the reaction ring and downwardly oriented with respect to the top of a cup, the optical fiber having one end at a central location where it receives light from a stationary light source and its other end opposite a bottom of a reaction cup in alignment with a measuring photomultiplier.

    摘要翻译： 用于通过比色程序自动分析样品的装置可以特别用于血液分析。 在其周边具有透明反应杯阵列的反应环是静止的。 光纤安装在与反应环同心并且相对于杯的顶部向下定向的旋转盘上，该光纤在其中心位置处具有一端，其中它接收来自固定光源的光并且其另一端 与测量光电倍增器对准的反应杯的底部。

    Scanner type fluorescence detection apparatus for treating numerous samples
    6.
    发明授权
    Scanner type fluorescence detection apparatus for treating numerous samples 失效
    用于处理多种样品的扫描仪型荧光检测装置

    公开(公告)号：US06396581B1

    公开(公告)日：2002-05-28

    申请号：US09492302

    申请日：2000-01-27

    申请人： Toshinori Hayashi ,  Takahiko Ishiguro

    发明人： Toshinori Hayashi ,  Takahiko Ishiguro

    IPC分类号： G01N2164

    CPC分类号： G01N21/645 ,  G01N21/253 ,  G01N35/025 ,  G01N2201/0231 ,  G01N2201/0423 ,  G01N2201/043 ,  G01N2201/0806 ,  G01N2201/0853

    摘要： A fluorescence detection apparatus is provided which comprises a sample holder for holding stationarily sample vessels deployed along a circle line or concentric circle lines having different radiuses, a partition plate connected to a driving means to be rotatable around the center of the circle line or concentric circle lines, an optical means for excitation light and an optical means for fluorescence light fixed respectively to the partition plate to be rotatable in integration therewith, a first light guide constituted of numerous optical fibers, a photosensor, and a light source for generating the excitation light, wherein the partition plate, the optical means for excitation light, and the optical means for fluorescence are integrally rotated, and thereby the fluorescence of the sample arranged along the circle line is successively detected and the detected fluorescence is transmitted to the photosensor. This fluorescence detection apparatus is useful in real-time monitoring of fluorescence signals, and satisfies the requirements of precise temperature control, quick treatment of many samples, high sensitivity, high reliability, low cost, and small size of the apparatus.

    摘要翻译： 提供了一种荧光检测装置，其包括用于保持沿着圆线展开的固定样品容器的样本保持器或具有不同半径的同心圆线，连接到驱动装置的分隔板，以可围绕圆线或同心圆的中心旋转 线路，用于激发光的光学装置和用于荧光的光学装置分别固定在分隔板上以使其一体旋转;由多个光纤构成的第一导光体，光电传感器和用于产生激发光的光源 其中分隔板，用于激发光的光学装置和用于荧光的光学装置一体地旋转，从而连续检测沿着圆线排列的样品的荧光，并将检测到的荧光传输到光电传感器。 该荧光检测装置可用于实时监测荧光信号，满足精密温度控制，快速处理多种样品，高灵敏度，高可靠性，低成本，体积小的要求。

    Scanner type fluorescence detection apparatus
    7.
    发明授权
    Scanner type fluorescence detection apparatus 失效
    扫描仪型荧光检测仪

    公开(公告)号：US06359284B1

    公开(公告)日：2002-03-19

    申请号：US09391161

    申请日：1999-09-08

    申请人： Toshinori Hayashi ,  Takahiko Ishiguro

    发明人： Toshinori Hayashi ,  Takahiko Ishiguro

    IPC分类号： G01N3504

    CPC分类号： G01N21/645 ,  G01N2021/6482 ,  G01N2021/6484 ,  G01N2201/0423

    摘要： An apparatus including a sample holder which fixedly holds sample vessels arranged on a same arc, a partition plate, a light guide which is configured by optical fibers and which transmits fluorescent signals emitted from respective test samples, to an optical sensor, the single optical sensor, and a light source which generates excitation light. Fluorescent signal emission ends of the light guide are opposed to the optical sensor, and fluorescent signal incidence ends of the light guide are respectively opposed to the sample vessels via the partition plate therebetween. The partition plate includes an excitation light optical unit for selectively guiding the excitation light from the light source to only one of the sample vessels arranged on the arc, and a fluorescence optical unit for guiding only the fluorescent signal emitted from a selected one of the sample vessels to the light guide. The partition plate is coupled together with the excitation light optical unit and the fluorescence optical unit to a driving unit, to be rotatable about a center of the arc on which the sample vessels are arranged. Fluorescence is detected while the excitation light is guided sequentially to the sample vessels arranged on the arc, by rotation of the partition plate.

    摘要翻译： 一种装置，包括固定地保持设置在同一弧上的样本容器的样本保持器，隔板，由光纤构成并将从各测试样本发射的荧光信号传输到光学传感器的光导，单个光学传感器 ，以及产生激发光的光源。 光导体的荧光信号发射端与光学传感器相对，并且光导的荧光信号入射端分别通过其间的隔板与样品容器相对。 分隔板包括用于选择性地将来自光源的激发光引导到仅布置在电弧上的一个样品容器的激发光光学单元，以及用于仅引导从所选样品中发射的荧光信号的荧光光学单元 船只到光导。 分隔板与激发光光学单元和荧光光学单元耦合到驱动单元，以围绕放置样品容器的弧的中心旋转。 通过分隔板的旋转，激发光被顺序地引导到布置在电弧上的样品容器中，检测荧光。

    Multiplexer for use with a device for optically analyzing a sample
    8.
    发明授权
    Multiplexer for use with a device for optically analyzing a sample 失效
    用于光学分析样品的设备的多路复用器

    公开(公告)号：US4989932A

    公开(公告)日：1991-02-05

    申请号：US318246

    申请日：1989-03-03

    申请人： Isaac Landa ,  Michael M. Anthony ,  George E. Toth

    发明人： Isaac Landa ,  Michael M. Anthony ,  George E. Toth

    IPC分类号： G01N21/25 ,  G02B6/28 ,  G02B6/36

    CPC分类号： G02B6/2808 ,  G01N21/253 ,  G02B6/3504 ,  G02B6/3624 ,  G01N2201/0423 ,  G01N2201/08 ,  G02B6/032 ,  G02B6/3644 ,  G02B6/40 ,  G02B6/403

    摘要： The invention is a multiplexer which enables light to be sent to and received from samples for simultaneous analysis. A multiplexer is described which uses a transverse probe to reflect light at an angle into an optical rod. The transverse probe is selectively rotated to transmit light to a second optical rod. Various numbers of optical rods may be used in the linear mutliplexer. A multiplexer is also described in which a conjugate optical barrel is utilized to selectively reflect light to various probes.

    摘要翻译： 本发明是一种多路复用器，其使得能够将光发送到和从样本接收以用于同时分析。 描述了一种多路复用器，其使用横向探针将光以一定角度反射到光学棒中。 选择性地旋转横向探针以将光透射到第二光学棒。 线性多路复用器中可以使用各种数量的光棒。 还描述了多路复用器，其中使用共轭光学镜筒来选择性地将光反射到各种探针。

    Apparatus for monitoring chemical reactions and employing moving photometer means
    9.
    发明授权
    Apparatus for monitoring chemical reactions and employing moving photometer means 失效

    公开(公告)号：US4234540A

    公开(公告)日：1980-11-18

    申请号：US69256

    申请日：1979-08-24

    申请人： Guenter Ginsberg ,  Thomas Horne ,  Robert L. Kreiselman

    发明人： Guenter Ginsberg ,  Thomas Horne ,  Robert L. Kreiselman

    IPC分类号： G01N21/25 ,  G01N21/24 ,  G01N1/14

    CPC分类号： G01N21/253 ,  G01N2201/0423

    摘要： Apparatus for measuring progressively the absorbance changes of a large number of aliquots from a plurality of different samples. The sample introduction, testing instructions, aliquot preparation, reagent dispensing, absorbance measuring and data recording all can be accomplished in a continuous mode of processing. Stat and batch operation also can be accomplished. The aliquots are in an array of cuvettes which is advanced slowly along a circular path. Photometer means, preferably having several photometric detectors, are mounted in fixed orientation on a common support that advances rapidly along a similar circular path, such that radiation passing through each of the cuvettes is monitored many times by a specific photometric detector by the time that that cuvette completes one circuit of its path. The photometric detectors can operate at several different wavelengths. Many different chemical reactions can be monitored at the same time. The radiant energy passing through each cuvette is received by the continuously moving photometer means, is converted electrically into a digitized value proportional to absorbance and is transmitted digitally from the moving assemblage of photometric detectors, cuvettes and electrical components to a stationary receiver. In one embodiment, the digital transmission is in the form of a pulsed train of light signals. In another embodiment, one or more slip rings transmit electric signals from the moving assemblage to the stationary portion. Suitable drive elements, sample and reagent storage and transfer mechanisms as well as cuvette laundry means may be provided as part of the complete apparatus.