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公开(公告)号：US4234539A
公开(公告)日：1980-11-18
申请号：US69111
申请日：1979-08-23
CPC分类号： G01N21/253
摘要： Apparatus for measuring progressively the absorbance changes of a large number of aliquots from a plurality of different samples. The sample introduction, testing instructions, aliquot preparation, reagent dispensing, absorbance measuring and data recording all can be accomplished in a continuous mode of processing. Stat and batch operation also can be accomplished. The aliquots are in an array of cuvettes which is advanced slowly along a circular path. Photometer means, preferably having several photometric detectors, are mounted in fixed orientation on a common support that advances rapidly along a similar circular path, such that radiation passing through each of the cuvettes is monitored many times by a specific photometric detector by the time that that cuvette completes one circuit of its path. The photometric detectors can operate at several different wavelengths. Many different chemical reactions can be monitored at the same time. The radiant energy passing through each cuvette is received by the continuously moving photometer means, is converted electrically into a digitized value proportional to absorbance and is transmitted digitally from the moving assemblage of photometric detectors, cuvettes and electrical components to a stationary receiver. In one embodiment, the digital transmission is in the form of a pulsed train of light signals. In another embodiment, one or more slip rings transmit electric signals from the moving assemblage to the stationary portion. Suitable drive elements, sample and reagent storage and transfer mechanisms as well as cuvette laundry means may be provided as part of the complete apparatus.
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公开(公告)号：USRE31149E
公开(公告)日：1983-02-15
申请号：US296778
申请日：1981-08-27
CPC分类号： G01N21/253
摘要： Apparatus for measuring progressively the absorbance changes of a large number of aliquots from a plurality of different samples. The sample introduction, testing instructions, aliquot preparation, reagent dispensing, absorbance measuring and data recording all can be accomplished in a continuous mode of processing. Stat and batch operation also can be accomplished. The aliquots are in an array of cuvettes which is advanced slowly along a circular path. Photometer means, preferably having several photometric detectors, are mounted in fixed orientation on a common support that advances rapidly along a similar circular path, such that radiation passing through each of the cuvettes is monitored many times by a specific photometric detector by the time that that cuvette completes one circuit of its path. The photometric detectors can operate at several different wavelengths. Many different chemical reactions can be monitored at the same time. The radiant energy passing through each cuvette is received by the continuously moving photometer means, is converted electrically into a digitized value proportional to absorbance and is transmitted digitally from the moving assemblage of photometric detectors, cuvettes and electrical components to a stationary receiver. In one embodiment, the digital transmission is in the form of a pulsed train of light signals. In another embodiment, one or more slip rings transmit electric signals from the moving assemblage to the stationary portion. Suitable drive elements, sample and reagent storage and transfer mechanisms as well as cuvette laundry means may be provided as part of the complete apparatus.
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公开(公告)号：USRE31150E
公开(公告)日：1983-02-15
申请号：US296780
申请日：1981-08-27
IPC分类号： G01N21/25
CPC分类号： G01N21/253 , G01N2201/0423
摘要： Apparatus for measuring progressively the absorbance changes of a large number of aliquots from a plurality of different samples. The sample introduction, testing instructions, aliquot preparation, reagent dispensing, absorbance measuring and data recording all can be accomplished in a continuous mode of processing. Stat and batch operation also can be accomplished. The aliquots are in an array of cuvettes which is advanced slowly along a circular path. Photometer means, preferably having several photometric detectors, are mounted in fixed orientation on a common support that advances rapidly along a similar circular path, such that radiation passing through each of the cuvettes is monitored many times by a specific photometric detector by the time that cuvette completes one circuit of its path. The photometric detectors can operate at several different wavelengths. Many different chemical reactions can be monitored at the same time. The radiant energy passing through each cuvette is received by the continuously moving photometer means, is converted electrically into a digitized value proportional to absorbance and is transmitted digitally from the moving assemblage of photometric detectors, cuvettes and electrical components to a stationary receiver. In one embodiment, the digital transmission is in the form of a pulsed train of light signals. In another embodiment, one or more slip rings transmit electric signals from the moving assemblage to the stationary portion. Suitable drive elements, sample and reagent storage and transfer mechanisms as well as cuvette laundry means may be provided as part of the complete apparatus.
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4.再颁专利Apparatus for monitoring chemical reactions and employing moving photometer means 失效用于监测化学反应并使用移动光度计装置的装置
公开(公告)号：USRE31108E
公开(公告)日：1982-12-21
申请号：US296779
申请日：1981-08-27
CPC分类号： G01N21/253
摘要： Apparatus for measuring progressively the absorbance changes of a large number of aliquots from a plurality of different samples. The sample introduction, testing instructions, aliquot preparation, reagent dispensing, absorbance measuring and data recording all can be accomplished in a continuous mode of processing. Stat and batch operation also can be accomplished. The aliquots are in an array of cuvettes which is advanced slowly along a circular path. Photometer means, preferably having several photometric detectors, are mounted in fixed orientation on a common support that advances rapidly along a similar circular path, such that radiation passing through each of the cuvettes is monitored many times by a specific photometric detector by the time that that cuvette completes one circuit of its path. The photometric detectors can operate at several different wavelengths. Many different chemical reactions can be monitored at the same time. The radiant energy passing through each cuvette is received by the continuously moving photometer means, is converted electrically into a digitized value proportional to absorbance and is transmitted digitally from the moving assemblage of photometric detectors, cuvettes and electrical components to a stationary receiver. In one embodiment, the digital transmission is in the form of a pulsed train of light signals. In another embodiment, one or more slip rings transmit electric signals from the moving assemblage to the stationary portion. Suitable drive elements, sample and reagent storage and transfer mechanisms as well as cuvette laundry means may be provided as part of the complete apparatus.
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公开(公告)号：US4308231A
公开(公告)日：1981-12-29
申请号：US177092
申请日：1980-08-11
CPC分类号： G01N21/253
摘要： An optical timing and A/D conversion method and apparatus for converting analog signals obtained by movement of a plurality of reaction vessels relative to one or more beams of light from analog to digital signals. The sample signals are obtained each time a reaction vessel passes through a beam of light. The converted digital signals indicate the absorbance of the respective vessels and their contents. Each of the reaction vessels or cuvettes has translucent wall portions providing a radiation path therethrough for the light beams which may be monitored by photometer means in a chemical reaction analyzer. The vessels are repeatedly passed through the light beams of the photometer means as chemical reactions take place therein, the purpose being to monitor the changes in the reaction of the fluids therein by measuring the changes in the absorbance of the vessel and fluids. The sample interval of the analog signal is repeatable for each vessel for each light beam and may be shifted to select the best portion of the analog signal generated as the vessel passes through the particular light beam. The A/D conversion also may eliminate the dark sample or noise error between the light beams and the reaction vessels and may eliminate the variations in the sample signals caused by changes in the rate of relative movement between the beams and vessels and changes in the velocity of the rotating beam.
摘要翻译： 一种光学定时和A / D转换方法和装置，用于转换通过多个反应容器相对于一个或多个光束从模拟信号到数字信号的移动获得的模拟信号。 每当反应容器通过光束时，获得样品信号。 转换的数字信号表示各个血管的吸光度及其含量。 每个反应容器或比色皿具有透光壁部分，为通过其中的光束提供通过其的光束，该光束可在化学反应分析仪中由光度计装置监测。 当化学反应发生时，容器被重复地通过光度计装置的光束，其目的是通过测量容器和流体的吸光度的变化来监测其中的流体的反应变化。 模拟信号的采样间隔对于每个光束的每个容器是可重复的，并且可以移位以选择当容器通过特定光束时产生的模拟信号的最佳部分。 A / D转换还可以消除光束和反应容器之间的暗样本或噪声误差，并且可以消除由光束和容器之间的相对运动速率的变化引起的样本信号的变化以及速度的变化 的旋转光束。
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公开(公告)号：US4234540A
公开(公告)日：1980-11-18
申请号：US69256
申请日：1979-08-24
CPC分类号： G01N21/253 , G01N2201/0423
摘要： Apparatus for measuring progressively the absorbance changes of a large number of aliquots from a plurality of different samples. The sample introduction, testing instructions, aliquot preparation, reagent dispensing, absorbance measuring and data recording all can be accomplished in a continuous mode of processing. Stat and batch operation also can be accomplished. The aliquots are in an array of cuvettes which is advanced slowly along a circular path. Photometer means, preferably having several photometric detectors, are mounted in fixed orientation on a common support that advances rapidly along a similar circular path, such that radiation passing through each of the cuvettes is monitored many times by a specific photometric detector by the time that that cuvette completes one circuit of its path. The photometric detectors can operate at several different wavelengths. Many different chemical reactions can be monitored at the same time. The radiant energy passing through each cuvette is received by the continuously moving photometer means, is converted electrically into a digitized value proportional to absorbance and is transmitted digitally from the moving assemblage of photometric detectors, cuvettes and electrical components to a stationary receiver. In one embodiment, the digital transmission is in the form of a pulsed train of light signals. In another embodiment, one or more slip rings transmit electric signals from the moving assemblage to the stationary portion. Suitable drive elements, sample and reagent storage and transfer mechanisms as well as cuvette laundry means may be provided as part of the complete apparatus.
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7.发明授权Apparatus for monitoring chemical reactions and employing moving photometer means 失效用于监测化学反应并使用移动光度计装置的装置
公开(公告)号：US4234538A
公开(公告)日：1980-11-18
申请号：US846337
申请日：1977-10-28
CPC分类号： G01N21/253
摘要： Apparatus for measuring progressively the absorbance changes of a large number of aliquots from a plurality of different samples. The sample introduction, testing instructions, aliquot preparation, reagent dispensing, absorbance measuring and data recording all can be accomplished in a continuous mode of processing. Stat and batch operation also can be accomplished. The aliquots are in an array of cuvettes which is advanced slowly along a circular path. Photometer means, preferably having several photometric detectors, are mounted in fixed orientation on a common support that advances rapidly along a similar circular path, such that radiation passing through each of the cuvettes is monitored many times by a specific photometric detector by the time that that cuvette completes one circuit of its path. The photometric detectors can operate at several different wavelengths. Many different chemical reactions can be monitored at the same time. The radiant energy passing through each cuvette is received by the continuously moving photometer means, is converted electrically into a digitized value proportional to absorbance and is transmitted digitally from the moving assemblage of photometric detectors, cuvettes and electrical components to a stationary receiver. In one embodiment, the digital transmission is in the form of a pulsed train of light signals. In another embodiment, one or more slip rings transmit electric signals from the moving assemblage to the stationary portion. Suitable drive elements, sample and reagent storage and transfer mechanisms as well as cuvette laundry means may be provided as part of the complete apparatus.
摘要翻译： 用于逐渐测量来自多个不同样品的大量等分试样的吸光度变化的装置。 样品介绍，测试说明，等分试样，试剂分配，吸光度测量和数据记录都可以在连续的加工方式下完成。 统计和批量操作也可以完成。 等分试样是沿圆形路径缓慢进展的比色皿阵列。 优选地具有几个光度检测器的光度计装置以固定取向安装在沿着类似的圆形路径快速前进的公共支撑上，使得通过特定的光度检测器多次监测通过每个比色杯的辐射，直到该时间 比色杯完成其路径的一个电路。 光度检测器可以在几种不同的波长下工作。 可以同时监测许多不同的化学反应。 通过连续运动的光度计装置接收通过每个比色杯的辐射能，被电转换成与吸光度成比例的数字化值，并从光度检测器，比色皿和电气部件的移动组合数字地传输到固定接收器。 在一个实施例中，数字传输是脉冲序列的光信号的形式。 在另一个实施例中，一个或多个滑环将电信号从移动组件传送到固定部分。 可以提供合适的驱动元件，样品和试剂储存和转移机构以及比色皿洗涤装置作为整个装置的一部分。
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