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    Method and system of array imaging
    7.
    发明授权
    Method and system of array imaging 有权
    阵列成像的方法和系统

    公开(公告)号：US07595473B2

    公开(公告)日：2009-09-29

    申请号：US11209432

    申请日：2005-08-22

    Applicant: David R. Walt ,  Sandra Bencic-Nagale

    Inventor： David R. Walt ,  Sandra Bencic-Nagale

    IPC: G01N21/00

    CPC classification number: G01J3/2803 ,  G01J3/02 ,  G01J3/0213 ,  G01J3/0229 ,  G01J3/10 ,  G01J3/4406 ,  G01J2001/0276 ,  G01N21/6428 ,  G01N21/6458 ,  G01N2021/6441 ,  G01N2021/6484 ,  G01N2201/08 ,  G01N2201/088

    Abstract: The present invention relates to a method and system of array imaging that extends or maximizes the longevity of the sensor array by minimizing the effects of photobleaching. The imaging system has a light source, a variable exposure aperture, and a variable filter system. The system extends the longevity of sensors by (1) using the variable exposure aperture to selectively expose sections of the sensor array containing representative numbers of each type of sensor, and/or (2) using the variable filter system to control the intensity of the excitation light, providing only the intensity required to induce the appropriate excitation and increasing that intensity over time as necessary to counteract the effects of photobleaching.

    Abstract translation: 本发明涉及阵列成像的方法和系统，该方法和系统通过最小化光漂白的影响来延长或最大化传感器阵列的寿命。 成像系统具有光源，可变曝光孔径和可变过滤器系统。 该系统通过（1）使用可变曝光孔径来延长传感器的寿命，以选择性地暴露包含每种类型的传感器的代表数的传感器阵列的部分，和/或（2）使用可变过滤器系统来控制传感器的强度 激发光，仅提供诱导适当激发所需的强度，并根据需要随时间增加强度以抵消光漂白的影响。

    Spectroscopic Imaging Microscopy
    8.
    发明申请
    Spectroscopic Imaging Microscopy 有权
    光谱成像显微镜

    公开(公告)号：US20090201499A1

    公开(公告)日：2009-08-13

    申请号：US12239628

    申请日：2008-09-26

    Applicant: David J. Monk ,  David R. Walt

    Inventor： David J. Monk ,  David R. Walt

    IPC: G01J3/04

    CPC classification number: G01J3/18 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/0229 ,  G01J3/0237 ,  G01J3/0264 ,  G01J3/14 ,  G01J3/32 ,  G02B21/06 ,  G02B21/367

    Abstract: Disclosed herein are systems that include: (a) an objective lens system configured to collect light from a sample; (b) a first aperture positioned to allow a portion of the collected light received from the objective lens system to pass as input light; (c) a first lens positioned to transmit the input light received from the first aperture; (d) a dispersive element configured to spatially disperse the input light received from the first lens in a first plane; (e) a second lens positioned to transmit the spatially dispersed light; (f) a second aperture positioned to allow a portion of the spatially dispersed light received from the second lens to pass as detection light; and (g) a detector positioned to receive the detection light and configured to form at least one image of the sample.

    Abstract translation: 这里公开的系统包括：（a）被配置为收集来自样品的光的物镜系统; （b）第一孔，定位成允许从物镜系统接收的一部分收集的光作为输入光通过; （c）第一透镜，定位成透射从第一孔接收的输入光; （d）分散元件，被配置为在第一平面中将从第一透镜接收的输入光空间分散; （e）定位成透射空间分散的光的第二透镜; （f）第二孔，定位成允许从第二透镜接收的部分空间分散的光作为检测光通过; 和（g）定位成接收检测光并被配置成形成样品的至少一个图像的检测器。

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