公开(公告)号：US09960238B2

公开(公告)日：2018-05-01

申请号：US14720429

申请日：2015-05-22

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY ,  SANOFI

Inventor： Aditya Rajagopal ,  Chieh-feng Chang ,  Oliver Plettenburg ,  Stefan Petry ,  Axel Scherer ,  Charles L. Tschirhart

IPC: H01L29/00 ,  H01L29/41 ,  H01L29/73 ,  H01L29/78 ,  B82Y15/00 ,  H01L29/732 ,  H01L29/06 ,  G01N27/414 ,  H01L29/45 ,  H01L29/49 ,  H01L29/735

CPC classification number: H01L29/413 ,  B82Y15/00 ,  G01N27/4145 ,  G01N27/4146 ,  H01L29/0676 ,  H01L29/45 ,  H01L29/49 ,  H01L29/73 ,  H01L29/732 ,  H01L29/735 ,  H01L29/78

Abstract: Systems and methods for molecular sensing are described. Molecular sensors are described which are based on field-effect or bipolar junction transistors. These transistors have a nanopillar with a functionalized layer contacted to either the base or the gate electrode. The functional layer can bind molecules, which causes an electrical signal in the sensor.

公开(公告)号：US09037209B2

公开(公告)日：2015-05-19

申请号：US13706668

申请日：2012-12-06

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY ,  SANOFI

Inventor： Axel Scherer ,  Remi Brouard, III ,  Emil P. Kartalov ,  Jingqing Huang

IPC: A61B5/1455 ,  A61B5/1459 ,  A61B3/10 ,  A61B5/145 ,  A61B5/00 ,  A61B5/20 ,  A61B5/1491 ,  A61B5/01

CPC classification number: A61B5/1459 ,  A61B3/10 ,  A61B5/0002 ,  A61B5/01 ,  A61B5/14507 ,  A61B5/1451 ,  A61B5/14546 ,  A61B5/1491 ,  A61B5/20 ,  A61B5/418 ,  A61B5/42 ,  A61B5/4337 ,  A61B5/6848 ,  A61B5/6852 ,  A61B5/6866 ,  A61B5/7278 ,  A61B2560/0219 ,  A61B2560/0233

Abstract: An implantable diagnostic device in accordance with the present disclosure includes a probe assembly that can be implemented in a variety of ways. A few example implementations include: a needle inside which is located a bio-sensor chip (the needle being insertable into a human being); a compact package containing the bio-sensor chip (the compact package configured for placement inside a catheter); or a silicon-based bio-sensor package configured for insertion into a vein.

Abstract translation: 根据本公开的可植入诊断装置包括可以以各种方式实现的探针组件。 一些示例性实现包括：位于其内的针，其位于生物传感器芯片（针可插入人体中）; 包含生物传感器芯片的紧凑型封装（被配置用于放置在导管内的紧凑封装）; 或被配置为插入静脉中的硅基生物传感器封装。

公开(公告)号：US09070733B2

公开(公告)日：2015-06-30

申请号：US13941295

申请日：2013-07-12

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY ,  SANOFI

Inventor： Aditya Rajagopal ,  Chieh-feng Chang ,  Oliver Plettenburg ,  Stefan Petry ,  Axel Scherer ,  Charles L. Tschirhart

IPC: H01L29/73 ,  H01L29/78 ,  B82Y15/00 ,  H01L29/732 ,  H01L29/06 ,  H01L29/41 ,  G01N27/414

CPC classification number: H01L29/413 ,  B82Y15/00 ,  G01N27/4145 ,  G01N27/4146 ,  H01L29/0676 ,  H01L29/45 ,  H01L29/49 ,  H01L29/73 ,  H01L29/732 ,  H01L29/735 ,  H01L29/78

Abstract: Systems and methods for molecular sensing are described. Molecular sensors are described which are based on field-effect or bipolar junction transistors. These transistors have a nanopillar with a functionalized layer contacted to either the base or the gate electrode. The functional layer can bind molecules, which causes an electrical signal in the sensor.

Abstract translation: 描述了用于分子感测的系统和方法。 描述了基于场效应或双极结型晶体管的分子传感器。 这些晶体管具有纳米柱，其具有与基极或栅电极接触的官能化层。 功能层可以结合分子，导致传感器中的电信号。

公开(公告)号：US09966443B2

公开(公告)日：2018-05-08

申请号：US14720473

申请日：2015-05-22

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY ,  SANOFI

Inventor： Aditya Rajagopal ,  Chieh-feng Chang ,  Oliver Plettenburg ,  Stefan Petry ,  Axel Scherer ,  Charles L. Tschirhart

IPC: H01L29/00 ,  H01L29/41 ,  H01L29/73 ,  H01L29/78 ,  B82Y15/00 ,  H01L29/732 ,  H01L29/06 ,  G01N27/414 ,  H01L29/45 ,  H01L29/49 ,  H01L29/735

CPC classification number: H01L29/413 ,  B82Y15/00 ,  G01N27/4145 ,  G01N27/4146 ,  H01L29/0676 ,  H01L29/45 ,  H01L29/49 ,  H01L29/73 ,  H01L29/732 ,  H01L29/735 ,  H01L29/78

Abstract: Systems and methods for molecular sensing are described. Molecular sensors are described which are based on field-effect or bipolar junction transistors. These transistors have a nanopillar with a functionalized layer contacted to either the base or the gate electrode. The functional layer can bind molecules, which causes an electrical signal in the sensor.

公开(公告)号：US11959856B2

公开(公告)日：2024-04-16

申请号：US15701014

申请日：2017-09-11

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Imran R. Malik ,  Xiomara Linnette Madero ,  Erika F. Garcia ,  Sheel Mukesh Shah ,  Axel Scherer

IPC: G01N21/64 ,  C12Q1/6851

CPC classification number: G01N21/6486 ,  C12Q1/6851 ,  C12Q1/6851 ,  C12Q2537/143 ,  C12Q2537/165 ,  C12Q2565/629

Abstract: Methods and algorithms for a multiplexed single detection channel amplification process and quantification of generated amplicons is presented. Various mathematical approaches for quantifying and verifying the amplicons in a reaction are presented. Usage of such methods and approaches allow upgrading of existing single and multiple channel instruments for further multiplexing capabilities.

公开(公告)号：US11690544B2

公开(公告)日：2023-07-04

申请号：US17314930

申请日：2021-05-07

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Samson Chen ,  Axel Scherer ,  Dvin Adalian ,  Peter Petillo ,  Muhammad Musab Jilani ,  Xiomara L. Madero ,  Deepan Kishore Kumar

IPC: A61B5/145 ,  C12N11/02 ,  A61B5/1486 ,  C12N9/02 ,  A61B5/1459 ,  G01N27/327 ,  C12N11/14

CPC classification number: A61B5/14865 ,  A61B5/1459 ,  A61B5/14532 ,  C12N9/0004 ,  C12N11/02 ,  C12N11/14 ,  G01N27/3272 ,  C12Y101/01001 ,  C12Y101/0301 ,  C12Y101/0302 ,  C12Y101/03003 ,  C12Y101/0303 ,  C12Y101/0304 ,  C12Y101/03005 ,  C12Y101/03007 ,  C12Y101/03008 ,  C12Y101/03011 ,  C12Y101/03012 ,  C12Y101/03015 ,  C12Y101/03016 ,  C12Y101/03018 ,  C12Y101/03019 ,  C12Y101/03023 ,  C12Y101/03027 ,  C12Y101/03029 ,  C12Y101/03037 ,  C12Y101/03038 ,  C12Y101/03041

Abstract: A sensor implanted in tissues and including a sensing layer is fabricated by mixing the signal transduction enzyme with non-reactive components including buffer salts and fillers, and spin coating the enzyme onto a substrate. The signal transduction enzyme is crosslinked by introducing the coated substrate in a vacuum chamber. In the chamber, a crosslinker evaporates and is deposited onto the enzyme, therefore crosslinking the enzyme.

公开(公告)号：US20230151440A1

公开(公告)日：2023-05-18

申请号：US17810696

申请日：2022-07-05

Applicant: California Institute of Technology

Inventor： Aditya Rajagopal ,  Mark D. Goldberg ,  Erika F. Garcia ,  Xiomara L. Madero ,  Thomas A. Tombrello ,  Axel Scherer

IPC: C12Q1/70 ,  C12Q1/68 ,  C12Q1/6851

CPC classification number: C12Q1/701 ,  C12Q1/703 ,  C12Q1/68 ,  C12Q1/6851 ,  Y10T436/143333

Abstract: A non-transitory computer-readable storage medium storing executable instructions to cause a system to detect a genetic variation in a polynucleotide analyte in a sample. A fluorophore is attached to a first primer, a quencher is attached to a second primer, and the first primer and the second primer are specific for the polynucleotide analyte. The primers are configured to amplify the polynucleotide analyte having the genetic variation and a corresponding polynucleotide analyte lacking the generic variation. There is a detectable difference between a measured change in signal generated by the fluorophore and quencher, when using the first and second primers to amplify the polynucleotide analyte with the genetic variation, and a change in signal generated by the fluorophore and quencher, when using the first and second primers to amplify the corresponding polynucleotide analyte lacking the genetic variation.

公开(公告)号：US11635064B1

公开(公告)日：2023-04-25

申请号：US17338393

申请日：2021-06-03

Applicant: California Institute of Technology ,  The Government of the United States of America, as represented by the Secretary of the Navy

Inventor： Emil P. Kartalov ,  Axel Scherer

IPC: A61F2/08 ,  H02N1/00 ,  B33Y80/00 ,  A61H1/02 ,  F15B21/06 ,  F03G7/06 ,  A61F2/70 ,  A61H3/00 ,  B25J9/10 ,  F15B15/10 ,  F15B13/044 ,  A61F2/48

Abstract: Artificial muscles comprising a body of dielectric elastomer, wherein the body contains a pair of microfluidic networks are presented. Each microfluidic network includes a plurality of channels fluidically coupled via a manifold. The channels of the microfluidic networks are interdigitated and filled with conductive fluid such that each set of adjacent channels functions as the electrodes of an electroactive polymer (EAP) actuator. By using the manifolds as compliant wiring to energize the electrodes, artificial muscles in accordance with the present disclosure mitigate some or all of the reliability problems associated with prior-art artificial muscles.

公开(公告)号：US11510573B2

公开(公告)日：2022-11-29

申请号：US16457642

申请日：2019-06-28

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Muhammad Mujeeb-U-Rahman ,  Axel Scherer

IPC: A61B5/00 ,  A61B5/1473 ,  A61B5/145 ,  A61B5/1486

Abstract: An implantable device having a communication system, a sensor, and a monolithic substrate is described. The monolithic substrate has an integrated sensor circuit configured to process input from the sensor into a form conveyable by the communication system.

公开(公告)号：US11422084B2

公开(公告)日：2022-08-23

申请号：US16212499

申请日：2018-12-06

Applicant: California Institute of Technology

Inventor： Axel Scherer ,  Amirhossein Nateghi ,  Taeyoon Jeon

IPC: G01N21/03 ,  G01N1/42 ,  G01N1/44 ,  G01N21/17 ,  G01N21/25 ,  G01N21/35 ,  G01N21/3504 ,  G01N21/3577

Abstract: The present disclosure is directed toward a measurement system capable of rapid spectroscopic and calorimetric analysis of the chemical makeup of a test sample. Systems in accordance with the present disclosure include a low-thermal-mass sample holder having a substrate whose surface has been engineered to create a large-area sample-collection surface. The sample holder includes an integrated temperature controller that can rapidly heat or cool the test sample. As a result, the sample holder enables differential scanning calorimetry Fourier-Transform Infrared Spectroscopy (DSC-FTIR) that can be performed in minutes rather than hours, as required in the prior art.