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公开(公告)号：US11959856B2
公开(公告)日：2024-04-16
申请号：US15701014
申请日：2017-09-11
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Imran R. Malik , Xiomara Linnette Madero , Erika F. Garcia , Sheel Mukesh Shah , Axel Scherer
IPC: G01N21/64 , C12Q1/6851
CPC classification number: G01N21/6486 , C12Q1/6851 , C12Q1/6851 , C12Q2537/143 , C12Q2537/165 , C12Q2565/629
Abstract: Methods and algorithms for a multiplexed single detection channel amplification process and quantification of generated amplicons is presented. Various mathematical approaches for quantifying and verifying the amplicons in a reaction are presented. Usage of such methods and approaches allow upgrading of existing single and multiple channel instruments for further multiplexing capabilities.
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公开(公告)号：US09284520B2
公开(公告)日：2016-03-15
申请号：US14070454
申请日：2013-11-01
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Imran R. Malik , Erika F. Garcia , Xiomara Linnette Madero , Axel Scherer
CPC classification number: C12M21/18 , B01L3/0275 , B01L3/502707 , B01L3/502715 , B01L7/52 , B01L9/527 , B01L2200/04 , B01L2200/10 , B01L2200/147 , B01L2200/16 , B01L2300/022 , B01L2300/023 , B01L2300/0681 , B01L2300/0816 , B01L2300/0861 , B01L2300/087 , B01L2300/1827 , B01L2400/0478
Abstract: Methods and devices for biological sample preparation and analysis are disclosed. A device may have a linear or circular arrangement of containers, with a connecting structure such as a bar or disk. Fluidics channels between containers allow the performance of different techniques for sample preparation, such as lysing, washing and elution. Different functional elements, such as grinders or mixers, may be attached to the containers.
Abstract translation: 公开了用于生物样品制备和分析的方法和装置。 装置可以具有容器的线性或圆形布置，其具有连接结构，例如杆或盘。 容器之间的流体通道允许执行不同的样品制备技术，如裂解，洗涤和洗脱。 可以将不同的功能元件，例如研磨机或混合器附接到容器。
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公开(公告)号：US08873055B2
公开(公告)日：2014-10-28
申请号：US13947469
申请日：2013-07-22
Applicant: California Institute of Technology
Inventor： Imran R. Malik , Xiomara L. Madero , Erika F. Garcia , Axel Scherer
CPC classification number: G01N21/64 , G01N21/0303 , G01N21/645
Abstract: Structures and methods are described for optical detection of physical, chemical and/or biological samples. An optical detection structure may include a LED source, multiple filters and single or multiple sample areas. A detector may be used to record a fluorescence signal. The sample area may allow the introduction of removable cartridges.
Abstract translation: 描述了物理，化学和/或生物样品的光学检测的结构和方法。 光学检测结构可以包括LED源，多个滤光器和单个或多个样品区域。 检测器可用于记录荧光信号。 样品区域可能允许引入可移除的墨盒。
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Patent Agency Ranking
公开(公告)号：US09518291B2
公开(公告)日：2016-12-13
申请号：US14070466
申请日：2013-11-01
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Imran R. Malik , Erika F. Garcia , Xiomara Linnette Madero , Axel Scherer
CPC classification number: C12Q1/686 , B01L3/502715 , B01L3/502723 , B01L3/50273 , B01L7/52 , B01L2200/027 , B01L2200/0689 , B01L2200/10 , B01L2300/0816 , B01L2400/0478 , F17D3/00 , G01N1/286 , G01N21/03 , G01N21/552 , G01N21/648 , G01N35/04 , G01N2001/2866 , G01N2001/4061 , G01N2021/0325 , G01N2035/00326 , G01N2035/00465 , G01N2035/0446 , G01N2035/1048 , G01N2035/1058 , G01N2201/0221 , Y02A50/58
Abstract: Methods and devices for biological sample preparation and analysis are disclosed. A device may have a linear or circular arrangement of containers, with a connecting structure such as a bar or disk. Fluidics channels between containers allow the performance of different techniques for sample preparation, such as lysing, washing and elution. Different functional elements, such as grinders or mixers, may be attached to the containers. The device may have a reaction cartridge with a reaction chamber to perform techniques such as polymerase chain reaction.
Abstract translation: 公开了用于生物样品制备和分析的方法和装置。 装置可以具有线性或圆形的容器布置，其具有连接结构，例如杆或盘。 容器之间的流体通道允许执行不同的样品制备技术，如裂解，洗涤和洗脱。 可以将不同的功能元件，例如研磨机或混合器附接到容器。 该装置可以具有带有反应室的反应筒，以进行诸如聚合酶链式反应的技术。
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公开(公告)号：US09416343B2
公开(公告)日：2016-08-16
申请号：US14070440
申请日：2013-11-01
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Imran R. Malik , Axel Scherer , Erika F. Garcia , Xiomara L. Madero
IPC: G01N21/75 , G01N21/00 , G01N21/01 , C12M1/40 , B01L9/00 , G01N21/17 , B01L3/00 , B01L3/02 , B01L7/00
CPC classification number: C12M21/18 , B01L3/0275 , B01L3/502707 , B01L3/502715 , B01L7/52 , B01L9/527 , B01L2200/04 , B01L2200/10 , B01L2200/147 , B01L2200/16 , B01L2300/022 , B01L2300/023 , B01L2300/0681 , B01L2300/0816 , B01L2300/0861 , B01L2300/087 , B01L2300/1827 , B01L2400/0478
Abstract: Methods and devices for biological sample preparation and analysis are disclosed. A device may have a linear or circular arrangement of containers, with a connecting structure such as a bar or disk. Fluidics channels between containers allow the performance of different techniques for sample preparation, such as lysing, washing and elution. Different functional elements, such as grinders or mixers, may be attached to the containers.
Abstract translation: 公开了用于生物样品制备和分析的方法和装置。 装置可以具有容器的线性或圆形布置，其具有连接结构，例如杆或盘。 容器之间的流体通道允许执行不同的样品制备技术，如裂解，洗涤和洗脱。 可以将不同的功能元件，例如研磨机或混合器附接到容器。
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公开(公告)号：US08968585B2
公开(公告)日：2015-03-03
申请号：US14070469
申请日：2013-11-01
Applicant: California Institute of Technology
Inventor： Imran R. Malik , Axel Scherer , Erika F. Garcia , Xiomara L. Madero
CPC classification number: B01L3/52 , B01L3/502707 , B01L7/52 , B01L2200/027 , B01L2200/04 , B01L2200/0689 , B01L2300/0654 , B01L2300/0867 , B01L2300/0877 , B01L2400/0478 , B33Y80/00 , Y10T156/10
Abstract: Methods to fabricate reaction cartridges for biological sample preparation and analysis are disclosed. A cartridge may have a reaction chamber and openings to allow fluids to enter the chamber. The cartridge may also have handles to facilitate its use. Such cartridges may be used for polymerase chain reaction.
Abstract translation: 公开了制备用于生物样品制备和分析的反应柱的方法。 墨盒可以具有反应室和开口以允许流体进入腔室。 墨盒也可以具有便于使用的手柄。 这种药盒可用于聚合酶链反应。
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公开(公告)号：US09791372B2
公开(公告)日：2017-10-17
申请号：US13958479
申请日：2013-08-02
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Imran R. Malik , Xiomara Linnette Madero , Erika F. Garcia , Sheel Mukesh Shah , Axel Scherer
CPC classification number: G01N21/6486 , C12Q1/6851 , C12Q2537/143 , C12Q2537/165 , C12Q2565/629
Abstract: Methods and algorithms for a multiplexed single detection channel amplification process and quantification of generated amplicons is presented. Various mathematical approaches for quantifying and verifying the amplicons in a reaction are presented. Usage of such methods and approaches allow upgrading of existing single and multiple channel instruments for further multiplexing capabilities.
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公开(公告)号：US09561505B2
公开(公告)日：2017-02-07
申请号：US14483605
申请日：2014-09-11
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Imran R. Malik , Axel Scherer
CPC classification number: B01L3/502784 , B01L3/502 , B01L3/502715 , B01L3/502753 , B01L3/502776 , B01L7/52 , B01L2200/0621 , B01L2200/10 , B01L2300/0681 , B01L2300/0867 , B01L2300/087 , B01L2300/165 , B01L2400/0478 , B01L2400/0481 , B01L2400/0487 , B01L2400/0644 , C12Q1/68 , F17D3/00 , G01N35/1097 , G01N2001/4088 , Y10T137/0318 , Y10T137/8593 , Y10T137/85978
Abstract: Devices and system for preparing samples are described. Such devices can comprise fluidic chambers, reservoirs, and movable structures for controlling the movement of samples. The device can also comprise functional elements for performing specific operations.
Abstract translation: 描述用于制备样品的装置和系统。 这种装置可以包括用于控制样品运动的流体室，储存器和可移动结构。 该装置还可以包括用于执行特定操作的功能元件。
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