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公开(公告)号：US11510573B2
公开(公告)日：2022-11-29
申请号：US16457642
申请日：2019-06-28
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Muhammad Mujeeb-U-Rahman , Axel Scherer
IPC: A61B5/00 , A61B5/1473 , A61B5/145 , A61B5/1486
Abstract: An implantable device having a communication system, a sensor, and a monolithic substrate is described. The monolithic substrate has an integrated sensor circuit configured to process input from the sensor into a form conveyable by the communication system.
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公开(公告)号：US20170055835A1
公开(公告)日：2017-03-02
申请号：US15222866
申请日：2016-07-28
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
IPC: A61B5/00 , A61B5/1459 , A61M37/00 , A61B5/145 , A61B5/1473
CPC classification number: A61B5/0022 , A61B5/14521 , A61B5/14532 , A61B5/14539 , A61B5/1459 , A61B5/1473 , A61B5/6832 , A61B5/685 , A61B2560/0214 , A61B2562/12 , G06F19/00 , G16H40/67
Abstract: A sensing device allows detection of biological quantities in ways that are minimally invasive. Micrometer or nanometer sized needles allow sensing of bodily fluids in a minimally invasive method. The device comprises electronics and power harvesting. Antennas or coils allow communication and power harvesting from an external device, which can be attached to smartphones to allow operation of a camera and camera light for biosensing.
Abstract translation: 感测装置允许以微创方式检测生物量。 千分尺或纳米尺寸的针允许以微创方法感测体液。 该设备包括电子和电力收集。 天线或线圈允许从外部设备进行通信和电力采集，该外部设备可以连接到智能手机，以允许相机和相机灯的操作进行生物感测。
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公开(公告)号：US10959617B2
公开(公告)日：2021-03-30
申请号：US16204942
申请日：2018-11-29
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
IPC: A61B5/00 , A61B5/145 , G16H40/67 , A61B5/1473 , A61B5/1459 , G06F19/00
Abstract: A sensing device allows detection of biological quantities in ways that are minimally invasive. Micrometer or nanometer sized needles allow sensing of bodily fluids in a minimally invasive method. The device comprises electronics and power harvesting. Antennas or coils allow communication and power harvesting from an external device, which can be attached to smartphones to allow operation of a camera and camera light for biosensing.
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公开(公告)号：US10172520B2
公开(公告)日：2019-01-08
申请号：US15222866
申请日：2016-07-28
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
IPC: A61B5/00 , A61B5/145 , G06F19/00 , G16H40/67 , A61B5/1473 , A61B5/1459
Abstract: A sensing device allows detection of biological quantities in ways that are minimally invasive. Micrometer or nanometer sized needles allow sensing of bodily fluids in a minimally invasive method. The device comprises electronics and power harvesting. Antennas or coils allow communication and power harvesting from an external device, which can be attached to smartphones to allow operation of a camera and camera light for biosensing.
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公开(公告)号：US09173605B2
公开(公告)日：2015-11-03
申请号：US14340498
申请日：2014-07-24
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Muhammad Mujeeb-U-Rahman , Meisam Honarvar Nazari , Mehmet Sencan , Axel Scherer
IPC: H01L27/14 , A61B5/1473 , A61B5/145 , B82Y15/00 , G01N27/48 , H01L21/77 , H01L25/16 , H01L27/04 , H01L49/02 , B82Y10/00 , H01L29/06 , H01L29/41
CPC classification number: A61B5/1473 , A61B5/14532 , B82Y10/00 , B82Y15/00 , G01N27/48 , H01L21/77 , H01L25/16 , H01L27/04 , H01L28/10 , H01L29/0676 , H01L29/413 , H01L2924/0002 , Y10T29/49018 , H01L2924/00
Abstract: A fully integrated small size implantable sensing device is described, which can include a sensor and an electronic circuit to interface with the sensor and communicate with an external device. Various fabrication methods for the sensing device are described, including provision of wells, created using same fabrication technology as the electronic circuit, to contain electrodes of the sensor and corresponding functionalization chemicals. Such implantable sensing device can be used for a variety of electrochemical measuring applications within a living body as well as actuation by injecting a current into the living body.
Abstract translation: 描述了完全集成的小尺寸植入式感测装置，其可以包括传感器和电子电路以与传感器接口并与外部设备通信。 描述了用于感测装置的各种制造方法，包括提供使用与电子电路相同的制造技术产生的孔，以容纳传感器的电极和相应的功能化学品。 这种植入式感测装置可以用于生物体内的各种电化学测量应用，以及通过将电流注入生物体来启动。
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Patent Agency Ranking
公开(公告)号：US20190117071A1
公开(公告)日：2019-04-25
申请号：US16204942
申请日：2018-11-29
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Abstract: A sensing device allows detection of biological quantities in ways that are minimally invasive. Micrometer or nanometer sized needles allow sensing of bodily fluids in a minimally invasive method. The device comprises electronics and power harvesting. Antennas or coils allow communication and power harvesting from an external device, which can be attached to smartphones to allow operation of a camera and camera light for biosensing.
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7.发明授权Implantable vascular system biosensor with grown capillary beds and uses thereof 有权具有生长毛细管床的植入式血管系统生物传感器及其用途公开(公告)号：US09011330B2
公开(公告)日：2015-04-21
申请号：US13938156
申请日：2013-07-09
Applicant: California Institute of Technology
Inventor： Akram Sarwat Sadek , Axel Scherer , Muhammad Mujeeb-U-Rahman
IPC: A61B5/00 , A61B5/1455 , A61B5/1486 , A61B5/145 , A61B5/1459 , A61B5/1473
CPC classification number: A61B5/6846 , A61B5/14503 , A61B5/1459 , A61B5/1473 , A61B5/14865 , A61B5/686 , A61B5/6876 , A61B2562/028 , A61B2562/14 , A61B2562/164
Abstract: An implantable biocompatible biosensor is described herein. The biosensor includes a chip layer including a plurality of holes fabricated vertically there through, a power source, one or more sensors on the chip layer and coupled to the power source and a hydrogel matrix including one or more angiogenesis stimulating factors in contact with the chip layer. The stimulating factors stimulate growth of organic material through the plurality of holes when the biosensor is implanted in a subject.
Abstract translation: 本文描述了可植入的生物相容性生物传感器。 生物传感器包括芯片层，其包括垂直于其上形成的多个孔，电源，芯片层上的一个或多个传感器并耦合到电源，以及水凝胶基质，其包括与芯片接触的一个或多个血管生成刺激因子 层。 当将生物传感器植入受试者时，刺激因素刺激有机材料通过多个孔的生长。
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公开(公告)号：US09006014B2
公开(公告)日：2015-04-14
申请号：US14106701
申请日：2013-12-13
Applicant: California Institute of Technology
Inventor： Muhammad Mujeeb-U-Rahman , Axel Scherer
IPC: H01L21/283 , H01L21/285 , H01L29/41 , H01L33/38 , H01L31/00
CPC classification number: H01L21/285 , A61B2562/125 , B81C1/00111 , B81C1/0038 , H01L21/02425 , H01L21/28556 , H01L24/14 , H01L29/41 , H01L31/00 , H01L33/387 , H01L2224/1401 , H01L2924/11
Abstract: A method for fabricating three dimensional high surface electrodes is described. The methods including the steps: designing the pillars; selecting a material for the formation of the pillars; patterning the material; transferring the pattern to form the pillars; insulating the pillars and providing a metal layer for increased conductivity. Alternative methods for fabrication of the electrodes and fabrication of the electrodes using CMOS are also described.
Abstract translation: 描述了制造三维高表面电极的方法。 方法包括步骤：设计支柱; 选择用于形成支柱的材料; 图案化材料; 转移模式形成支柱; 绝缘柱并提供用于增加导电性的金属层。 还描述了用于制造电极和使用CMOS制造电极的替代方法。
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9.发明申请IMPLANTABLE VASCULAR SYSTEM BIOSENSOR WITH GROWN CAPILLARY BEDS AND USES THEREOF 有权可植入血管系统生物传感器，具有毛细管床及其用途公开(公告)号：US20140012122A1
公开(公告)日：2014-01-09
申请号：US13938156
申请日：2013-07-09
Applicant: California Institute of Technology
Inventor： Akram Sarwat Sadek , Axel Scherer , Muhammad Mujeeb-U-Rahman
IPC: A61B5/00
CPC classification number: A61B5/6846 , A61B5/14503 , A61B5/1459 , A61B5/1473 , A61B5/14865 , A61B5/686 , A61B5/6876 , A61B2562/028 , A61B2562/14 , A61B2562/164
Abstract: An implantable biocompatible biosensor is described herein. The biosensor includes a chip layer including a plurality of holes fabricated vertically there through, a power source, one or more sensors on the chip layer and coupled to the power source and a hydrogel matrix including one or more angiogenesis stimulating factors in contact with the chip layer. The stimulating factors stimulate growth of organic material through the plurality of holes when the biosensor is implanted in a subject.
Abstract translation: 本文描述了可植入的生物相容性生物传感器。 生物传感器包括芯片层，其包括垂直于其上形成的多个孔，电源，芯片层上的一个或多个传感器并耦合到电源，以及水凝胶基质，其包括与芯片接触的一个或多个血管生成刺激因子 层。 当将生物传感器植入受试者时，刺激因素刺激有机材料通过多个孔的生长。
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公开(公告)号：US11160476B2
公开(公告)日：2021-11-02
申请号：US16437890
申请日：2019-06-11
Inventor： Axel Scherer , Meisam Honarvar Nazari , Muhammad Mujeeb-U-Rahman , Mehmet Sencan , Arti Gaur
IPC: A61B5/1473 , A61B5/07 , A61B5/1459 , A61M5/172 , A61B17/34 , A61B5/1486 , A61B5/145 , A61M5/142 , A61B5/00
Abstract: A fully integrated small size implantable sensing device is described, which can include a sensor and an electronic circuit to interface with the sensor and communicate with an external device. Various fabrication methods for the sensing device are described, including provision of wells, created using same fabrication technology as the electronic circuit, to contain electrodes of the sensor and corresponding functionalization chemicals. Such implantable sensing device can be used for a variety of electrochemical measuring applications within a living body as well as actuation by injecting a current into the living body.
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