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公开(公告)号：US11903708B2
公开(公告)日：2024-02-20
申请号：US16144174
申请日：2018-09-27
IPC分类号： A61B5/1486 , A61B5/1459 , G01N27/419 , G01N27/30 , A61B5/145
CPC分类号： A61B5/14865 , A61B5/1459 , A61B5/14532 , G01N27/30 , G01N27/419
摘要： A sensor implanted in tissues and including a sensing enzyme takes an electrical measurement and compares it to reference curves for the voltage current relationship. The sensor determines whether molecular compounds are present which interfere with the detection of the molecule of interest. If interfering species are found, the measurement voltage is set in a low range to reduce errors, while if the interfering species are not found, the measurement voltage is set in a high range to increase the detected signal.
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公开(公告)号：US11969246B2
公开(公告)日：2024-04-30
申请号：US18319085
申请日：2023-05-17
发明人： Samson Chen , Axel Scherer , Dvin I. Adalian , Peter Petillo , Muhammad Musab Jilani , Xiomara L. Madero , Deepan Kishore Kumar
IPC分类号： C12N11/14 , A61B5/145 , A61B5/1459 , A61B5/1486 , C12N9/02 , C12N11/02 , G01N27/327
CPC分类号： A61B5/14865 , A61B5/14532 , A61B5/1459 , C12N9/0004 , C12N11/02 , C12N11/14 , G01N27/3272 , C12Y101/01001 , C12Y101/03003 , C12Y101/03005 , C12Y101/03007 , C12Y101/03008 , C12Y101/0301 , C12Y101/03011 , C12Y101/03012 , C12Y101/03015 , C12Y101/03016 , C12Y101/03018 , C12Y101/03019 , C12Y101/0302 , C12Y101/03023 , C12Y101/03027 , C12Y101/03029 , C12Y101/0303 , C12Y101/03037 , C12Y101/03038 , C12Y101/0304 , C12Y101/03041
摘要： A sensor implanted in tissues and including a sensing layer is fabricated by mixing the signal transduction enzyme with non-reactive components including buffer salts and fillers, and spin coating the enzyme onto a substrate. The signal transduction enzyme is crosslinked by introducing the coated substrate in a vacuum chamber. In the chamber, a crosslinker evaporates and is deposited onto the enzyme, therefore crosslinking the enzyme.
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公开(公告)号：US20190117071A1
公开(公告)日：2019-04-25
申请号：US16204942
申请日：2018-11-29
摘要： A sensing device allows detection of biological quantities in ways that are minimally invasive. Micrometer or nanometer sized needles allow sensing of bodily fluids in a minimally invasive method. The device comprises electronics and power harvesting. Antennas or coils allow communication and power harvesting from an external device, which can be attached to smartphones to allow operation of a camera and camera light for biosensing.
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公开(公告)号：US10959617B2
公开(公告)日：2021-03-30
申请号：US16204942
申请日：2018-11-29
IPC分类号： A61B5/00 , A61B5/145 , G16H40/67 , A61B5/1473 , A61B5/1459 , G06F19/00
摘要： A sensing device allows detection of biological quantities in ways that are minimally invasive. Micrometer or nanometer sized needles allow sensing of bodily fluids in a minimally invasive method. The device comprises electronics and power harvesting. Antennas or coils allow communication and power harvesting from an external device, which can be attached to smartphones to allow operation of a camera and camera light for biosensing.
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公开(公告)号：US10172520B2
公开(公告)日：2019-01-08
申请号：US15222866
申请日：2016-07-28
IPC分类号： A61B5/00 , A61B5/145 , G06F19/00 , G16H40/67 , A61B5/1473 , A61B5/1459
摘要： A sensing device allows detection of biological quantities in ways that are minimally invasive. Micrometer or nanometer sized needles allow sensing of bodily fluids in a minimally invasive method. The device comprises electronics and power harvesting. Antennas or coils allow communication and power harvesting from an external device, which can be attached to smartphones to allow operation of a camera and camera light for biosensing.
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公开(公告)号：US11690544B2
公开(公告)日：2023-07-04
申请号：US17314930
申请日：2021-05-07
发明人： Samson Chen , Axel Scherer , Dvin Adalian , Peter Petillo , Muhammad Musab Jilani , Xiomara L. Madero , Deepan Kishore Kumar
IPC分类号： A61B5/145 , C12N11/02 , A61B5/1486 , C12N9/02 , A61B5/1459 , G01N27/327 , C12N11/14
CPC分类号： A61B5/14865 , A61B5/1459 , A61B5/14532 , C12N9/0004 , C12N11/02 , C12N11/14 , G01N27/3272 , C12Y101/01001 , C12Y101/0301 , C12Y101/0302 , C12Y101/03003 , C12Y101/0303 , C12Y101/0304 , C12Y101/03005 , C12Y101/03007 , C12Y101/03008 , C12Y101/03011 , C12Y101/03012 , C12Y101/03015 , C12Y101/03016 , C12Y101/03018 , C12Y101/03019 , C12Y101/03023 , C12Y101/03027 , C12Y101/03029 , C12Y101/03037 , C12Y101/03038 , C12Y101/03041
摘要： A sensor implanted in tissues and including a sensing layer is fabricated by mixing the signal transduction enzyme with non-reactive components including buffer salts and fillers, and spin coating the enzyme onto a substrate. The signal transduction enzyme is crosslinked by introducing the coated substrate in a vacuum chamber. In the chamber, a crosslinker evaporates and is deposited onto the enzyme, therefore crosslinking the enzyme.
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公开(公告)号：US11026610B2
公开(公告)日：2021-06-08
申请号：US16144079
申请日：2018-09-27
发明人： Samson Chen , Axel Scherer , Dvin Adalian , Peter Petillo , Muhammad Musab Jilani , Xiomara L. Madero , Deepan Kishore Kumar
IPC分类号： C12N9/02 , C12N9/04 , C12N11/14 , A61B5/1486 , C12N11/02 , A61B5/145 , A61B5/1459 , G01N27/327
摘要： A sensor implanted in tissues and including a sensing layer is fabricated by mixing the signal transduction enzyme with non-reactive components including buffer salts and fillers, and spin coating the enzyme onto a substrate. The signal transduction enzyme is crosslinked by introducing the coated substrate in a vacuum chamber. In the chamber, a crosslinker evaporates and is deposited onto the enzyme, therefore crosslinking the enzyme.
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公开(公告)号：US20170055835A1
公开(公告)日：2017-03-02
申请号：US15222866
申请日：2016-07-28
IPC分类号： A61B5/00 , A61B5/1459 , A61M37/00 , A61B5/145 , A61B5/1473
CPC分类号： A61B5/0022 , A61B5/14521 , A61B5/14532 , A61B5/14539 , A61B5/1459 , A61B5/1473 , A61B5/6832 , A61B5/685 , A61B2560/0214 , A61B2562/12 , G06F19/00 , G16H40/67
摘要： A sensing device allows detection of biological quantities in ways that are minimally invasive. Micrometer or nanometer sized needles allow sensing of bodily fluids in a minimally invasive method. The device comprises electronics and power harvesting. Antennas or coils allow communication and power harvesting from an external device, which can be attached to smartphones to allow operation of a camera and camera light for biosensing.
摘要翻译： 感测装置允许以微创方式检测生物量。 千分尺或纳米尺寸的针允许以微创方法感测体液。 该设备包括电子和电力收集。 天线或线圈允许从外部设备进行通信和电力采集，该外部设备可以连接到智能手机，以允许相机和相机灯的操作进行生物感测。
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