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    VALVES AND OTHER FLOW CONTROL IN FLUIDIC SYSTEMS INCLUDING MICROFLUIDIC SYSTEMS
    63.
    发明申请
    VALVES AND OTHER FLOW CONTROL IN FLUIDIC SYSTEMS INCLUDING MICROFLUIDIC SYSTEMS 审中-公开
    流体系统中的阀门和其他流量控制，包括微流体系统

    公开(公告)号：US20160250638A1

    公开(公告)日：2016-09-01

    申请号：US15148955

    申请日：2016-05-06

    Applicant: President and Fellows of Harvard College

    Inventor： Adam R. Abate ,  David A. Weitz

    IPC: B01L3/00 ,  F16K99/00

    CPC classification number: B01L3/502738 ,  B01L3/0268 ,  B01L3/502746 ,  B01L3/502784 ,  B01L2200/0605 ,  B01L2200/0636 ,  B01L2200/146 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2400/0487 ,  B01L2400/0655 ,  B01L2400/082 ,  F16K99/0017 ,  F16K99/0026 ,  F16K99/0055 ,  Y10T436/2575

    Abstract: Articles and methods for controlling flow in fluidic systems, especially in microfluidic systems, are provided. In one aspect, a microfluidic system described herein includes a configuration such that the actuation of a single valve can allow the switching of fluids from a first fluid path (e.g., a first channel section) to a second fluid path (e.g., a second channel section). This may be achieved, for example, by incorporating a valve with a first channel section, which may have a lower hydrodynamic resistance than a second channel section prior to actuation of the valve. Actuation of the valve can cause only the hydrodynamic resistance of the first channel section to increase, thereby redirecting fluid flow into the second channel section (which now has a relatively lower hydrodynamic resistance). In some embodiments, the valve comprises a control channel for introducing a positive or reduced pressure, and is adapted to modulate fluid flow in an adjacent channel section by constricting or expanding the channel section. For example, the valve and/or the channel section may be formed in a flexible material and actuation of the valve may be achieved by applying a positive or reduced pressure to the valve to cause deformation of both the valve and the channel section. Another aspect of the invention includes articles and methods associated with manipulation of multiphase materials (e.g., dispersions). For instance, one or more valves may be combined with a flow focusing system so as to form droplets of different volumes and/or frequencies without the need to vary flow rates of the fluids when they are introduced into the fluidic system.

    Abstract translation: 提供了用于控制流体系统流动的文章和方法，特别是在微流体系统中。 在一个方面，本文所述的微流体系统包括使得单个阀的致动可以允许流体从第一流体路径（例如，第一通道部分）切换到第二流体路径（例如，第二通道 部分）。 这可以通过例如通过结合具有第一通道部分的阀来实现，该阀在致动阀之前可具有比第二通道部分更低的流体动力阻力。 阀的致动只能使第一通道部分的流体动力阻力增加，从而将流体流转向第二通道部分（其现在具有相对较低的流体动力阻力）。 在一些实施例中，阀包括用于引入正压或减压的控制通道，并且适于通过收缩或扩大通道部分来调制相邻通道部分中的流体流动。 例如，阀和/或通道部分可以形成为柔性材料，并且可以通过向阀施加正压或减压以使阀和通道部分变形来实现阀的致动。 本发明的另一方面包括与多相材料（例如分散体）的操作有关的制品和方法。 例如，一个或多个阀可以与流动聚焦系统组合，以便形成不同体积和/或频率的液滴，而不需要在将流体引入流体系统时改变流体的流速。

    SCREENING DEVICE FOR ANALYSIS OF BODILY FLUIDS
    67.
    发明申请
    SCREENING DEVICE FOR ANALYSIS OF BODILY FLUIDS 审中-公开
    用于分析液体流体的筛选装置

    公开(公告)号：US20160151779A1

    公开(公告)日：2016-06-02

    申请号：US14834534

    申请日：2015-08-25

    Applicant: PREMIER BIOTECH, INC.

    Inventor： Kevin S. FULLER ,  Wayde J. ALTENDORF

    IPC: B01L3/00

    CPC classification number: B01L3/508 ,  A61B10/0051 ,  B01L3/5029 ,  B01L2200/026 ,  B01L2200/0605 ,  B01L2300/042 ,  B01L2300/0618 ,  B01L2300/0663 ,  B01L2300/0672 ,  B01L2300/0832 ,  B01L2300/0864 ,  G01N1/18

    Abstract: A screening device for testing bodily fluids for the presence of certain constituents. The device can include a planar front face through which all of the test strips are viewed. The device also includes an inclined surface that directs the fluid under test to test strips with more efficiency, and partitions the fluid that is directed to a given test strip to better assure that the test strip receives an adequate amount of bodily fluid for a valid analysis. In one embodiment, the device includes a three-dimensional gasket that creates a pressurized environment upon insertion of the sampling stem for improved diffusion of the bodily fluid into the test strips.

    Abstract translation: 用于测试某些成分存在的体液的筛选装置。 该装置可包括平面前表面，通过该平面前表面可以看到所有测试条。 该装置还包括倾斜表面，其以更有效的方式将待测流体引导到测试条上，并且将导向到给定测试条的流体分隔，以更好地确保测试条接收足够量的体液用于有效分析 。 在一个实施例中，该装置包括三维垫圈，其在插入采样杆时产生加压环境，以改善体液扩散到测试条中。

    Rapid test device
    70.
    发明授权
    Rapid test device 有权
    快速测试装置

    公开(公告)号：US09291515B2

    公开(公告)日：2016-03-22

    申请号：US13978794

    申请日：2011-04-22

    Applicant: Shisheng Ling ,  Xuehao Ji ,  Keyuan Yao

    Inventor： Shisheng Ling ,  Xuehao Ji ,  Keyuan Yao

    IPC: G01N1/10 ,  G01L7/18 ,  B01L3/00 ,  G01N35/00

    CPC classification number: G01L7/18 ,  B01L3/502 ,  B01L2200/0605 ,  B01L2200/0689 ,  B01L2300/042 ,  B01L2300/046 ,  B01L2300/0663 ,  B01L2400/0457 ,  B01L2400/0644 ,  G01N2035/00108

    Abstract: The invention discloses a rapid test device, includes a cup vessel (4), which comprises a first chamber (41) and a dosing piston assembling hole (44) communicating with the first chamber (41); a base (8) fastened at the bottom of the cup vessel (4); a second chamber (81), formed between the base (8) and the cup vessel (4) and communicating with the dosing piston assembling hole (44); a partition (7), arranged in the second chamber (81) and provided with test paper; a dosing piston (6), provided with a dosing slot (61) thereon and provided with a key hole at one end, inserted in the dosing piston assembling hole (44); and a key (1) matching the key hole. In present invention the sample in the dosing slot can be transmitted into the second chamber by rotating the dosing piston. The sample is absorbed by the test paper after flowing by the test paper, and test result appears on the test paper. Since the dosing slot is machined on the dosing piston, the volume of the liquid sample obtained each time is equal and the accuracy of test result is improved. The dosing piston used to obtain the liquid sample is changed from being pushed linearly to being moved rotationally, which makes leak-proof effect better.

    Abstract translation: 本发明公开了一种快速测试装置，包括杯容器（4），其包括与第一腔室（41）连通的第一腔室（41）和计量活塞组装孔（44）; 固定在杯容器（4）的底部的底座（8）; 第二室（81），形成在所述基座（8）和所述杯容器（4）之间并与所述计量活塞组装孔（44）连通; 分隔件（7），布置在第二腔室（81）中并设有试纸; 配量活塞（6），在其上设置有定量槽（61），并在其一端设置有插入到计量活塞组装孔（44）中的键孔; 以及与键孔匹配的键（1）。 在本发明中，定量给料槽中的样品可以通过旋转定量活塞而传递到第二腔室中。 样品在试纸流动后被试纸吸收，测试结果出现在试纸上。 由于计量槽在配量活塞上加工，所以每次获得的液体样品的体积相等，并且提高了测试结果的准确性。 用于获得液体样品的计量活塞从被线性推动到旋转移动，这使得防漏效果更好。

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