公开(公告)号：US20160214109A1

公开(公告)日：2016-07-28

申请号：US15092389

申请日：2016-04-06

Applicant: SHIMADZU CORPORATION

Inventor： Masakazu Akechi ,  Masaki Kanai ,  Takahiro Nishimoto ,  Nobuhiro Hanafusa

IPC: B01L3/00

CPC classification number: B01L3/502715 ,  B01L3/5027 ,  B01L3/502723 ,  B01L3/502738 ,  B01L3/502746 ,  B01L2200/027 ,  B01L2200/0605 ,  B01L2200/0642 ,  B01L2300/04 ,  B01L2300/046 ,  B01L2300/0816 ,  B01L2300/0858 ,  B01L2300/0861 ,  B01L2300/0864 ,  B01L2300/0887 ,  B01L2400/0622 ,  B01L2400/0644 ,  B01L2400/084 ,  C12M23/12 ,  G01N2035/00158 ,  G01N2035/1034

Abstract: Micro droplets are accurately placed in a reaction well. The reaction well (5) is formed in one surface of a well base (3). A channel base (11) is placed on the well base (3). The channel base (11) has, in its surface joined to the well base (3), a liquid introduction channel (12a) and a reaction well air vent channel (18a). The channel base (11) also has a recess (27) formed opposite to the reaction well (5) and recessed upward from the upper surface of the liquid introduction channel (12a). When viewed from above, a shoulder part (26) of the recess (27) is placed near the connection part between the reaction well (5) and the liquid introduction channel (12a) and is closer to the center of the reaction well (5) than a shoulder part (16) of the reaction well (5).

Abstract translation: 微滴精确地放置在反应井中。 反应井（5）形成在井底（3）的一个表面中。 通道底座（11）放置在井底（3）上。 通道底座11在其表面上与井底（3）连接，具有液体引入通道（12a）和反应井排气通道（18a）。 通道底座（11）还具有与反应槽（5）相对形成并从液体导入通道（12a）的上表面向上凹陷的凹部（27）。 当从上方观察时，凹部（27）的肩部（26）放置在反应槽（5）和液体导入通道（12a）之间的连接部分附近，并且更靠近反应槽（5）的中心 ）比反应井（5）的肩部（16）。

公开(公告)号：US10391483B2

公开(公告)日：2019-08-27

申请号：US14088226

申请日：2013-11-22

Applicant: SHIMADZU CORPORATION

Inventor： Masaki Kanai ,  Takahiro Nishimoto ,  Masakazu Akechi ,  Nobuhiro Hanafusa

IPC: B01L99/00 ,  G01N35/10 ,  B01L3/02 ,  B01L3/00

Abstract: A dispensing device for reducing the dead volume of a liquid sample includes a main channel connected to a sample inlet and a sample outlet, and branch channels connected to the main channel. Each branch channel is connected to a different liquid reservoir. High inflow-withstanding pressure sections are provided in the main channel between the branch channels and between the branch channel and the sample outlet. Each high inflow-withstanding pressure section has a channel inner wall forming a contact angle of 90° or larger with a liquid sample. A liquid sample enters the main channel through the sample inlet, reaches a branch point between the first branch channel and the main channel, flows into the first branch channel and the liquid reservoir, and then passes through the high inflow-withstanding pressure section to a branch point between the next branch channel and the main channel.

公开(公告)号：US20140079603A1

公开(公告)日：2014-03-20

申请号：US14088226

申请日：2013-11-22

Applicant: Shimadzu Corporation

Inventor： Masaki Kanai ,  Takahiro Nishimoto ,  Masakazu Akechi ,  Nobuhiro Hanafusa

IPC: B01L3/02

CPC classification number: B01L3/0293 ,  B01L3/502723 ,  B01L3/502738 ,  B01L2200/0605 ,  B01L2200/0621 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2400/0406 ,  B01L2400/0487 ,  B01L2400/0622 ,  B01L2400/0644 ,  B01L2400/0688 ,  G01N35/1016 ,  G01N2035/1039 ,  G01N2035/1062

Abstract: A dispensing device for reducing the dead volume of a liquid sample includes a main channel connected to a sample inlet and a sample outlet, and branch channels connected to the main channel. Each branch channel is connected to a different liquid reservoir. High inflow-withstanding pressure sections are provided in the main channel between the branch channels and between the branch channel and the sample outlet. Each high inflow-withstanding pressure section has a channel inner wall forming a contact angle of 90° or larger with a liquid sample. A liquid sample enters the main channel through the sample inlet, reaches a branch point between the first branch channel and the main channel, flows into the first branch channel and the liquid reservoir, and then passes through the high inflow-withstanding pressure section to a branch point between the next branch channel and the main channel.

Abstract translation: 用于减少液体样品的死体积的分配装置包括连接到样品入口和样品出口的主通道以及连接到主通道的分支通道。 每个分支通道连接到不同的液体储存器。 在分支通道之间和分支通道与样品出口之间的主通道中设有高流入耐压部分。 每个高流入耐压部分具有与液体样品形成90°或更大接触角的通道内壁。 液体样品通过样品入口进入主通道，到达第一分支通道和主通道之间的分支点，流入第一分支通道和液体储存器，然后通过高流入耐压段进入 下一个分支通道和主通道之间的分支点。

公开(公告)号：US20140051160A1

公开(公告)日：2014-02-20

申请号：US14052299

申请日：2013-10-11

Applicant: SHIMADZU CORPORATION

Inventor： Masakazu Akechi ,  Masaki Kanai ,  Takahiro Nishimoto ,  Nobuhiro Hanafusa

IPC: C12M1/32

CPC classification number: B01L3/502715 ,  B01L3/5027 ,  B01L3/502723 ,  B01L3/502738 ,  B01L3/502746 ,  B01L2200/027 ,  B01L2200/0605 ,  B01L2200/0642 ,  B01L2300/04 ,  B01L2300/046 ,  B01L2300/0816 ,  B01L2300/0858 ,  B01L2300/0861 ,  B01L2300/0864 ,  B01L2300/0887 ,  B01L2400/0622 ,  B01L2400/0644 ,  B01L2400/084 ,  C12M23/12 ,  G01N2035/00158 ,  G01N2035/1034

Abstract: Micro droplets are accurately placed in a reaction well. The reaction well (5) is formed in one surface of a well base (3). A channel base (11) is placed on the well base (3). The channel base (11) has, in its surface joined to the well base (3), a liquid introduction channel (12a) and a reaction well air vent channel (18a). The channel base (11) also has a recess (27) formed opposite to the reaction well (5) and recessed upward from the upper surface of the liquid introduction channel (12a). When viewed from above, a shoulder part (26) of the recess (27) is placed near the connection part between the reaction well (5) and the liquid introduction channel (12a) and is closer to the center of the reaction well (5) than a shoulder part (16) of the reaction well (5).

Abstract translation: 微滴精确地放置在反应井中。 反应井（5）形成在井底（3）的一个表面中。 通道底座（11）放置在井底（3）上。 通道底座11在其表面上与井底（3）连接，具有液体引入通道（12a）和反应井排气通道（18a）。 通道底座（11）还具有与反应槽（5）相对形成并从液体导入通道（12a）的上表面向上凹陷的凹部（27）。 当从上方观察时，凹部（27）的肩部（26）放置在反应槽（5）和液体导入通道（12a）之间的连接部分附近，并且更靠近反应槽（5）的中心 ）比反应井（5）的肩部（16）。

公开(公告)号：US20190136171A1

公开(公告)日：2019-05-09

申请号：US16235432

申请日：2018-12-28

Applicant: SHIMADZU CORPORATION ,  KYOTO UNIVERSITY ,  WASEDA UNIVERSITY

Inventor： Tatsuya Munaka ,  Hirohisa Abe ,  Masaki Kanai ,  Masakazu Akechi ,  Taira Maekawa ,  Shinya Kimura ,  Eishi Ashihara ,  Shuichi Shoji ,  Kentaro Kawai

IPC: C12M1/04 ,  C12M1/12 ,  C12M1/00 ,  C12N5/074 ,  C12M1/32

Abstract: A well has a pair of side surfaces, and one of the side surfaces is in contact with a compartment of a first channel with a gas-permeable membrane being interposed therebetween and the other side surface is in contact with a compartment of a second channel with a gas-permeable membrane being interposed therebetween. The well is filled with a liquid cell culture medium, and in such a state, a high-concentration gas and a low-concentration gas, which are different in the concentration of a specific component from each other, are allowed to flow through the first and second channels, respectively, to form a concentration distribution of the specific component in the well.

公开(公告)号：US10029253B2

公开(公告)日：2018-07-24

申请号：US14052299

申请日：2013-10-11

Applicant: SHIMADZU CORPORATION

Inventor： Masakazu Akechi ,  Masaki Kanai ,  Takahiro Nishimoto ,  Nobuhiro Hanafusa

IPC: B01L3/00 ,  C12M1/32 ,  G01N35/00 ,  G01N35/10

Abstract: Micro droplets are accurately placed in a reaction well. The reaction well (5) is formed in one surface of a well base (3). A channel base (11) is placed on the well base (3). The channel base (11) has, in its surface joined to the well base (3), a liquid introduction channel (12a) and a reaction well air vent channel (18a). The channel base (11) also has a recess (27) formed opposite to the reaction well (5) and recessed upward from the upper surface of the liquid introduction channel (12a). When viewed from above, a shoulder part (26) of the recess (27) is placed near the connection part between the reaction well (5) and the liquid introduction channel (12a) and is closer to the center of the reaction well (5) than a shoulder part (16) of the reaction well (5).

公开(公告)号：US09726658B2

公开(公告)日：2017-08-08

申请号：US14262209

申请日：2014-04-25

Applicant: SHIMADZU CORPORATION

Inventor： Akira Oishi ,  Nobuya Hashizume ,  Tomoaki Tsuda ,  Masakazu Akechi

IPC: G01N33/49 ,  G06T3/20 ,  G01N23/20 ,  G01N35/00

CPC classification number: G01N33/491 ,  G01N23/20008 ,  G01N35/00 ,  G01N2035/0091 ,  G01N2201/06113 ,  G06T3/20

Abstract: A display device, a display method, and a display program used in a measurement system capable of facilitating positioning in a measurement information image by displaying an IP (imaging plate) image having measurement information for β+ rays contained in blood to be measured and appending a guide G based on design information of a disc housing the blood to an IP image and displaying the image. The guide G is appended to an IP image in which a guide is not originally reflected, which makes it possible to visually discern a reference position (for example, the central position of the disc) in the IP image based on design information. As a result, it is possible to facilitate positioning in the IP image based on the guide G indicating the reference position (central position of the disc).

公开(公告)号：US20170120259A1

公开(公告)日：2017-05-04

申请号：US15319960

申请日：2015-05-25

Applicant: SHIMADZU CORPORATION

Inventor： Ippei Takeuchi ,  Masakazu Akechi ,  Masaki Kanai ,  Shinobu Kudoh

IPC: B04B5/02 ,  G01N1/40 ,  B04B11/04

CPC classification number: B04B5/02 ,  B01L3/50273 ,  B01L2200/026 ,  B01L2200/04 ,  B01L2300/0803 ,  B01L2300/0864 ,  B01L2400/0406 ,  B01L2400/0409 ,  B01L2400/0683 ,  B04B5/0407 ,  B04B11/04 ,  G01N1/4077 ,  G01N21/07 ,  G01N33/491 ,  G01N2001/4083 ,  G01N2035/00504 ,  G01N2035/0441

Abstract: A centrifugal separation device including a supporter attached to a centrifuge and a divisional part removable from the supporter is provided. The divisional part has two flow channels and an extracting part. The flow channels extend substantially in parallel to the direction in which centrifugal force acts, and are connected to each other on the leading end side in the direction in which centrifugal force acts. One of the flow channels is a sample flow channel having a sample inlet on the base end side in the direction in which centrifugal force acts, and the other flow channel is an air-discharging flow channel having an outlet on the base end side. The extracting part includes part of the sample flow channel, and has a connecting part for the part to be cut off from the remainder of the sample flow channel.