公开(公告)号：US09816916B2

公开(公告)日：2017-11-14

申请号：US14425259

申请日：2013-09-03

Applicant: Johann Wolfgang Goethe-Universitaet

Inventor： Francesco Pampaloni ,  Ernst H. K. Stelzer ,  Christian Mattheyer

IPC: G01N1/00 ,  G01N21/03 ,  B01L3/00 ,  G01N21/11 ,  G01N21/64 ,  G01N21/13 ,  G02B21/16 ,  G02B21/00 ,  G02B21/26 ,  G02B21/33

CPC classification number: G01N21/03 ,  B01L3/5082 ,  B01L2300/042 ,  B01L2300/0858 ,  G01N21/0303 ,  G01N21/11 ,  G01N21/13 ,  G01N21/6458 ,  G01N21/6486 ,  G01N2021/0307 ,  G01N2021/0346 ,  G01N2021/0378 ,  G01N2021/0389 ,  G01N2201/025 ,  G01N2201/06113 ,  G02B21/0076 ,  G02B21/16 ,  G02B21/26 ,  G02B21/33

Abstract: A capillary cell is described along with an arrangement and a method for receiving, positioning and examining a microscopic specimen, in particular a cleared fluorescent specimen with the help of a single-plane fluorescence microscope. The capillary cell is suitable for being positioned in a chamber volume and contains a capillary section, which comprises a wall. The wall encloses a specimen volume and is planar and transparent in at least some sections. In addition, the capillary cell includes an upper and a lower closure section, which are connected to the capillary section and which seal the capillary section. The specimen volume is separated from the chamber volume by the capillary section, the upper closure section and the lower closure section.

公开(公告)号：US20170152576A1

公开(公告)日：2017-06-01

申请号：US15388750

申请日：2016-12-22

Applicant: GeneWeave Biosciences, Inc.

Inventor： Diego Ariel REY ,  Shaunak ROY ,  Leonardo Maestri TEIXEIRA ,  Ryan C. GRISWOLD ,  Kenneth G. OLSON ,  Bruce J. RICHARDSON ,  Victor H. YEE

IPC: C12Q1/68 ,  C12Q1/14 ,  G01N21/76 ,  C12Q1/06 ,  B01L3/00 ,  B01L7/00 ,  C12Q1/66 ,  C12Q1/10

CPC classification number: C12Q1/6897 ,  B01L3/502 ,  B01L3/50825 ,  B01L3/52 ,  B01L3/523 ,  B01L3/54 ,  B01L3/545 ,  B01L7/00 ,  B01L2200/028 ,  B01L2200/16 ,  B01L2300/021 ,  B01L2300/042 ,  B01L2300/047 ,  B01L2300/049 ,  B01L2300/0672 ,  B01L2400/0478 ,  B01L2400/06 ,  B01L2400/0683 ,  C12Q1/02 ,  C12Q1/04 ,  C12Q1/06 ,  C12Q1/10 ,  C12Q1/14 ,  C12Q1/66 ,  G01J1/00 ,  G01N21/01 ,  G01N21/03 ,  G01N21/13 ,  G01N21/76 ,  G01N21/763 ,  G01N2035/00346 ,  G01N2035/0405 ,  G01N2333/195

Abstract: Systems and methods for detecting and/or identifying target cells (e.g., bacteria) using engineered transduction particles are described herein. In some embodiments, a method includes mixing a quantity of transduction particles within a sample. The transduction particles are associated with a target cell. The transduction particles are non-replicative, and are engineered to include a nucleic acid molecule formulated to cause the target cell to produce a series of reporter molecules. The sample and the transduction particles are maintained to express the series of the reporter molecules when target cell is present in the sample. A signal associated with a quantity of the reporter molecules is received. In some embodiments, a magnitude of the signal is independent from a quantity of the transduction particle above a predetermined quantity.

公开(公告)号：US20170138864A1

公开(公告)日：2017-05-18

申请号：US15322476

申请日：2015-06-30

Applicant: Chauvin Arnoux

Inventor： Eric Lopez ,  Vincent Huret

IPC: G01N21/85 ,  G01N21/359 ,  G01J3/02 ,  G01N21/13 ,  G01N21/11 ,  G01N33/10 ,  G01N21/3563 ,  G01N21/03

CPC classification number: G01N21/85 ,  A01D41/1277 ,  B07C5/3425 ,  G01J3/0202 ,  G01J3/0237 ,  G01J3/0289 ,  G01J3/10 ,  G01N21/0303 ,  G01N21/11 ,  G01N21/13 ,  G01N21/3563 ,  G01N21/359 ,  G01N33/10 ,  G01N2021/0339 ,  G01N2021/8466 ,  G01N2021/8592 ,  G01N2201/0633

Abstract: An arrangement for the spectrometric measurement of products, such as cereals, oleaginous products, or derived products, includes a mechanism for selective adjustment of the position of a light beam in vertical and horizontal planes, and a selective adjustment device for ensuring that rays of the light beam are parallel.

公开(公告)号：US09578220B2

公开(公告)日：2017-02-21

申请号：US14713755

申请日：2015-05-15

Applicant: PANASONIC HEALTHCARE HOLDINGS CO., LTD.

Inventor： Mikio Houjou ,  Atsushi Oda

IPC: G01N21/01 ,  G02B21/00 ,  G02B21/36 ,  C12M1/34 ,  H04N5/225 ,  G01N21/13 ,  A61B5/00

CPC classification number: H04N5/2254 ,  A61B5/0033 ,  C12M41/36 ,  G01N21/01 ,  G01N21/13 ,  G01N2201/022 ,  G01N2201/062 ,  G01N2201/0638 ,  G02B21/0088 ,  G02B21/361 ,  G02B21/365 ,  H04N5/2256

Abstract: An observation device (1) is provided with: a general observation unit (10) for observing sample cells by observing an entire container (C) containing the cells and a culture solution; and a magnification observation unit (20) for magnifying a region within the container (C) and observing the cells, the general observation unit (10) and the magnification observation unit (20) each individually having lighting for illuminating the cells with light, and an optical system for observing the cells. The general observation unit (10) and the magnification observation unit (20) are thereby each provided with an individual optical system and lighting, making it possible to configure an appropriate observation unit for use both when the cells are observed by observing the entire container (C) and when a part within the container (C) is magnified and the cells are observed.

Abstract translation: 观察装置（1）具备：通过观察包含细胞的整个容器（C）和培养液观察样品池的一般观察单元（10） 以及用于放大容器（C）内的区域并观察细胞的放大观察单元（20），一般观察单元（10）和放大观察单元（20）各自具有用光照亮细胞的照明，以及 用于观察细胞的光学系统。 一般观察单元（10）和放大率观察单元（20）各自设置有单独的光学系统和照明，使得可以配置在通过观察整个容器观察细胞时使用的适当的观察单元（ C），并且当容器（C）中的一部分被放大并观察细胞时。

公开(公告)号：US20170003203A1

公开(公告)日：2017-01-05

申请号：US15112792

申请日：2015-06-30

Applicant: Dale Lee HEINTZELMAN, JR. ,  Beacon Technologies, LLC

Inventor： Dale Lee Heintzelman, JR.

IPC: G01N1/14 ,  B01L3/02 ,  G01N21/01 ,  G01N35/10

CPC classification number: B01L3/0275 ,  B01L3/021 ,  B01L9/543 ,  B01L2200/025 ,  B01L2200/026 ,  B01L2300/0654 ,  B01L2300/0858 ,  B01L2300/123 ,  B01L2300/168 ,  G01N1/14 ,  G01N21/01 ,  G01N21/0303 ,  G01N21/13 ,  G01N21/59 ,  G01N35/10 ,  G01N2021/0367 ,  G01N2035/1062 ,  G01N2201/0662

Abstract: This disclosure is directed to exemplary embodiments of systems, methods, techniques, processes, products and product components that can facilitate users making improved absorbance or fluorescence measurements in the field of spectroscopy with reduced (minimal) sample waste, and increased throughput, particularly in the study of biological sciences. A measuring system is provided having: a base unit with a means for locating a pipette tip; a pipette tip designed to interact with the base unit for purposes of accurate pipette tip positioning; at least one light supplying unit positioned to supply light to a liquid sample in the pipette tip and at least one light collecting unit positioned to collect light from a liquid sample in the pipette tip.

Abstract translation: 本公开涉及系统，方法，技术，方法，产品和产品组件的示例性实施方案，其可以促进用户在减少（最小）样品废物和增加的产量的光谱学领域中进行改进的吸光度或荧光测量，特别是在 生物科学研究。 提供了一种测量系统，其具有：具有用于定位移液管尖端的装置的基座单元; 移液管尖端设计为与基座单元相互作用，用于精确移液管尖端定位; 至少一个供光单元，其被定位成向移液管尖端中的液体样品提供光，以及至少一个聚光单元，定位成收集来自移液管尖端中的液体样品的光。

公开(公告)号：US20160349175A1

公开(公告)日：2016-12-01

申请号：US15085782

申请日：2016-03-30

Applicant: MICROAETH CORPORATION

Inventor： Jeffrey R. Blair ,  Steven S. Blair ,  Zachary Radding ,  Kris Young

IPC: G01N21/3504 ,  G01N21/13

CPC classification number: G01N21/3504 ,  G01N21/13 ,  G01N21/59 ,  G01N21/8483 ,  G01N35/00009 ,  G01N2021/135 ,  G01N2201/0636

Abstract: An apparatus for receiving an analyte comprises two opposing housings that clamp onto a substrate. One of the housings includes passageways that deliver the analyte and optical signals to the substrate. Another one of the housings includes passageways that allow optical signals, which have passed through the substrate, to travel to photometric sensors which may be used to study the analyte or its effects. The apparatus may include a light guide that uniformly distributes light from a plurality of point emitters to multiple areas of the substrate. The apparatus may include an actuator assembly that opens and closes the two housing to allow for installation and removal of the substrate. The substrate may be carried in a cartridge that is removable from the two housings.

Abstract translation: 用于接收分析物的装置包括夹在基板上的两个相对的壳体。 其中一个外壳包括将分析物和光学信号传递到基底的通道。 另一个外壳包括允许已经通过基板的光信号行进到可用于研究分析物或其影响的光度传感器的通道。 该装置可以包括将来自多个点发射器的光均匀地分布到衬底的多个区域的光导。 该装置可以包括致动器组件，该致动器组件打开和关闭两个壳体以允许安装和移除基板。 衬底可以被携带在可从两个壳体移除的盒中。

公开(公告)号：US20160011117A1

公开(公告)日：2016-01-14

申请号：US14764185

申请日：2014-01-30

Applicant: COMMISSARIAT À L'ÉNERGIE ATOMIQUE ET AUX ÉNERGIES ALTERNATIVES

Inventor： Samy STROLA ,  Cedric ALLIER ,  Mathieu DUPOY ,  Emmanuelle SCHULTZ

IPC: G01N21/65 ,  G01N21/13

CPC classification number: G01N21/65 ,  G01N21/01 ,  G01N21/13 ,  G01N2021/135 ,  G03H1/0443 ,  G03H2001/0447 ,  G03H2001/045

Abstract: A method for regulating the relative position of an analyte of a sample (16) in relation to a light beam (F) includes the illumination of the analyte of the sample (16) with the light beam (F), capturing by an imaging device (38) a transmission image of the beams scattered by the analyte of the sample (16) in order to establish a diffraction pattern, and modifying the relative position of the analyte of the sample (16) in relation to the light beam (F) according to at least one property of the diffraction pattern.

Abstract translation: 用于调节样品（16）的分析物相对于光束（F）的相对位置的方法包括用光束（F）照射样品（16）的分析物，通过成像装置 （38）由样品（16）的分析物散射的光束的透射图像，以建立衍射图案，并且改变样品（16）的分析物相对于光束（F）的相对位置， 根据衍射图案的至少一个性质。

公开(公告)号：US09207249B2

公开(公告)日：2015-12-08

申请号：US13953572

申请日：2013-07-29

Applicant: CALIPER LIFE SCIENCES, INC.

Inventor： Michael Greenstein ,  Colin B Kennedy ,  James C Mikkelsen, Jr.

IPC: G01N35/00 ,  B01L9/00 ,  G01N21/05 ,  G01N21/11 ,  G01N21/13 ,  G01N35/04 ,  G01N35/10 ,  B01L3/00 ,  G01N21/03

CPC classification number: G01N35/00584 ,  B01L3/5027 ,  B01L3/502715 ,  B01L9/527 ,  B01L2300/0819 ,  G01N21/05 ,  G01N21/11 ,  G01N21/13 ,  G01N35/04 ,  G01N35/1095 ,  G01N2021/0346 ,  G01N2021/058

Abstract: The present invention is an automated microfluidic chip processing apparatus that includes a deck for holding at least one microfluidic chip and capable of being accessed by a liquid handling system, a fluid control system, and a detection system, wherein a chip handling device transports the chip from the deck to the fluid control system and the detection system. The present invention also includes a chip for use with an automated microfluidic chip processing apparatus, and a method for processing a microfluidic chip using such an apparatus.

Abstract translation: 本发明是一种自动化微流体芯片处理装置，其包括用于保持至少一个微流体芯片并能够被液体处理系统，流体控制系统和检测系统访问的甲板，其中，芯片处理装置将芯片 从甲板到流体控制系统和检测系统。 本发明还包括用于自动微流控芯片处理装置的芯片，以及使用这种装置处理微流控芯片的方法。

公开(公告)号：US09110043B2

公开(公告)日：2015-08-18

申请号：US13337574

申请日：2011-12-27

Applicant: Shuhei Kaneko

Inventor： Shuhei Kaneko

IPC: G01N35/04 ,  B65G47/14 ,  B65G47/18 ,  G01N35/02 ,  G01N35/00

CPC classification number: G01N21/13 ,  B65G47/1471 ,  G01N35/021 ,  G01N35/025 ,  G01N35/026 ,  G01N35/04 ,  G01N2035/00306 ,  G01N2035/0446 ,  G01N2035/0465 ,  G01N2035/0491

Abstract: A cuvette supplying device is disclosed. The cuvette supplying device comprises: a cuvette storage for storing cuvettes; a carrier, provided inside the cuvette storage, for carrying the cuvettes in the cuvette storage outside the cuvette storage; a conveyor for conveying the cuvettes existing at the bottom of the cuvette storage towards the carrier; and an arranging section for arranging the cuvettes carried outside the cuvette storage by the carrier at a predetermined position. The specimen analyzer comprising the cuvette supplying device is also disclosed.

Abstract translation: 公开了一种试管供应装置。 试管供应装置包括：用于储存比色杯的比色皿储存器; 提供在比色皿存储器内部的载体，用于将比色杯携带在比色皿储存器外面的比色皿储存器中; 输送机，用于将存在于比色皿存储器底部的比色皿输送到载体; 以及布置部，用于将运送在比色杯存储体外部的比色皿布置在预定位置。 还公开了包括比色皿供应装置的样本分析仪。

公开(公告)号：US20150226662A1

公开(公告)日：2015-08-13

申请号：US14690902

申请日：2015-04-20

Applicant: Sony Corporation

Inventor： Yu HIRONO ,  Fumiyasu SUZUKI ,  Yuichi MACHIDA

IPC: G01N21/13 ,  G02B21/34 ,  G02B21/26

CPC classification number: G01N21/13 ,  G01N2021/135 ,  G02B21/26 ,  G02B21/34

Abstract: A microscope system including: a storage unit storing two or more sheets of slide glasses to be subjected to a predetermined treatment; a stage holding only one sheet of slide glass to be subjected to the treatment; a supply arm by which one sheet of slide glass to be subjected to the treatment is picked up from the storage unit and supplied onto the stage; a discharge arm by which the slide glass mounted on the stage is picked up and discharged in the storage unit; a moving unit operable to move the supply arm and the discharge arm in an integral manner so as to bring the supply arm or the discharge arm into proximity to each of the storage unit and the stage; and a control unit operable to control the supply arm, the discharge arm and the moving unit.

Abstract translation: 一种显微镜系统，其特征在于，包括：存储要进行预定处理的两片以上的滑动玻璃片的存储部; 仅容纳一张待处理的载玻片的台阶; 供给臂，通过该供给臂从所述存储单元拾取待处理的一张载玻片并供给到所述台上; 安装在台架上的载玻片通过该排出臂拾取并放出到存储单元中; 移动单元，其可操作以一体地移动所述供给臂和所述排出臂，以使所述供应臂或所述排出臂接近所述存储单元和所述台中的每一个; 以及控制单元，其可操作以控制供应臂，排出臂和移动单元。