公开(公告)号：US20240293811A1

公开(公告)日：2024-09-05

申请号：US18576517

申请日：2022-05-18

申请人： ams International AG

发明人： Erik Jan LOUS ,  Boon Chong CHEAH

IPC分类号： B01L3/00

CPC分类号： B01L3/502715 ,  B01L2200/027 ,  B01L2200/04 ,  B01L2300/023 ,  B01L2300/0636 ,  B01L2300/0816 ,  B01L2300/168

摘要： A flex foil for sealing a micro-fluidic cartridge includes a flexible carrier film and an integrated photodetector circuit including at least one photodetector. The carrier film includes at least one optically transparent window. The integrated photodetector circuit is arranged on the carrier film, such that the photodetector is aligned with the optically transparent window. The integrated photodetector circuit is electrically and operatively connected to the flexible carrier film.

公开(公告)号：US20240287495A1

公开(公告)日：2024-08-29

申请号：US18572555

申请日：2022-06-23

申请人： University of Rochester

发明人： Benjamin L. Miller ,  Jeffrey W. Beard

IPC分类号： C12N15/10 ,  B01L3/00 ,  C12Q1/6806

CPC分类号： C12N15/1003 ,  B01L3/502715 ,  B01L3/502761 ,  C12Q1/6806 ,  B01L2200/0621 ,  B01L2200/10 ,  B01L2300/0681 ,  B01L2300/0819 ,  B01L2300/087 ,  B01L2300/0874 ,  B01L2300/0877 ,  B01L2300/0887 ,  B01L2300/12

摘要： The present invention relates to novel devices and methods for viral lysis and isolation as well as a simple, disposable, and nonenzymatic viral load assay based on a hairpin cascade reaction (HCR).

公开(公告)号：US12071664B2

公开(公告)日：2024-08-27

申请号：US17939760

申请日：2022-09-07

申请人： Pacific Biosciences of California, Inc.

发明人： Adrian Fehr ,  Nathaniel Joseph McCaffrey ,  Stephen Turner

IPC分类号： C12Q1/6874 ,  B01L3/00 ,  B82Y20/00 ,  C12Q1/6825 ,  C12Q1/6869 ,  G01N21/03 ,  G01N21/05 ,  G01N21/64 ,  G01N21/75 ,  G01N21/77 ,  G01N33/543 ,  G02B6/122

CPC分类号： C12Q1/6874 ,  B01L3/502707 ,  B01L3/502715 ,  B82Y20/00 ,  C12Q1/6825 ,  C12Q1/6869 ,  G01N21/03 ,  G01N21/0303 ,  G01N21/05 ,  G01N21/64 ,  G01N21/6428 ,  G01N21/645 ,  G01N21/6452 ,  G01N21/6454 ,  G01N21/6456 ,  G01N21/648 ,  G01N21/75 ,  G01N21/77 ,  G01N33/54373 ,  G02B6/1226 ,  B01L2300/0654 ,  B01L2300/0663 ,  B01L2300/0816 ,  B01L2300/168 ,  G01N2021/0346 ,  G01N2021/6434 ,  G01N2021/6439 ,  G01N2021/6441 ,  G01N2021/6463 ,  G01N2021/757 ,  G01N2021/7786 ,  G01N2201/067 ,  G01N2201/068 ,  G01N2201/08 ,  Y10T436/143333

摘要： Optics collection and detection systems are provided for measuring optical signals from an array of optical sources over time. Methods of using the optics collection and detection systems are also described.

公开(公告)号：US20240278245A1

公开(公告)日：2024-08-22

申请号：US18649768

申请日：2024-04-29

申请人： Illumina, Inc. ,  Illumina Cambridge Limited

发明人： Bradley Kent DREWS ,  Gudrun STENGEL ,  James Christopher BLAKE ,  Mohammed Kafeel AHAMED ,  Michael Steven BECKER ,  Michael Dangelo ,  Mark J. NIBBE ,  Daniel L. FULLER ,  Oliver Jon MILLER

IPC分类号： B01L3/00 ,  B01L9/00

CPC分类号： B01L3/50853 ,  B01L3/502715 ,  B01L9/523 ,  B01L9/527 ,  B01L2200/025 ,  B01L2200/027 ,  B01L2200/0684 ,  B01L2200/0689 ,  B01L2300/041 ,  B01L2300/047 ,  B01L2300/048 ,  B01L2300/0681 ,  B01L2300/0819 ,  B01L2300/0829

摘要： The assembly includes a docking console and a manifold. The docking console includes a cartridge support surface having a first end and a second end. The manifold has one or more wells defined therein. The docking console further includes a manifold retention bracket to releasably hold the manifold against a fluid cartridge supported on the cartridge support surface at an interface position such that the one or more wells are in fluid communication with the fluid cartridge and a biased seal bar to press the fluid cartridge against the manifold held by the manifold retention bracket. A hydrophilic porous frit disposed within at least one of the wells and is to permit liquid to flow through the outlet aperture but prevent gas from passing through the outlet aperture.

公开(公告)号：US20240272150A1

公开(公告)日：2024-08-15

申请号：US18560724

申请日：2022-04-22

申请人： SENSACTIVE TECNOLOGY S.L

发明人： Enrique SANCHEZ TAVIRA ,  Iván IGLESIAS BAENA ,  Gabriel Edgardo PROCUPETZ SCHEIN

IPC分类号： G01N33/543 ,  B01L3/00

CPC分类号： G01N33/54386 ,  B01L3/502715 ,  G01N33/54346 ,  B01L2200/027 ,  B01L2200/16 ,  B01L2300/0663

摘要： A system for the continuous detection of microbes of interest in waters, including: at least one biosensor tank having an inlet and an outlet for the waters to be monitored and containing nanoparticles functionalised with at least one antibody specific for the antigenic capture of a particular type of microbe present in the water, and the creation of networks that give rise to an agglutination reaction that creates turbidity in the water, captured by a spectrophotometric sensor or sensor for the measurement of the turbidity in the water; and a control unit for monitoring, logging, and processing the information provided by the spectrophotometric sensor or sensor for the measurement of turbidity; and for monitoring the operation of the system.

公开(公告)号：US20240271070A1

公开(公告)日：2024-08-15

申请号：US17261023

申请日：2019-07-16

申请人： TECHNISCHE UNIVERSITAET WIEN

发明人： Peter Ertl ,  Mario Rothbauer

IPC分类号： C12M3/06 ,  B01L3/00 ,  C12M1/00 ,  C12M1/12 ,  C12M1/26 ,  C12M1/34

CPC分类号： C12M23/16 ,  B01L3/502715 ,  C12M23/40 ,  C12M25/04 ,  C12M33/12 ,  C12M41/46 ,  B01L2200/0647 ,  B01L2300/0636 ,  B01L2300/0848 ,  B01L2300/087 ,  B01L2300/123

摘要： Microfluidic device (1) for applying pressure to a cell assembly (16), comprising at least one cell chamber (2), wherein the at least one cell chamber (2) comprises:



an inlet (5) for introducing a cell assembly (16) into the cell chamber (2),
at least one mechanical pressing means (13) for applying pressure to the cell assembly (16) and being operable between a releasing position and a pressing position via an actuation line (7),


wherein the at least one pressing means (13) has a cell assembly contact surface (4) facing the interior of the cell chamber (2), wherein the cell assembly contact surface (4) has at least one structured portion (14), preferably a micro-structured portion.

公开(公告)号：US12053780B2

公开(公告)日：2024-08-06

申请号：US17470615

申请日：2021-09-09

申请人： CUE HEALTH INC.

发明人： Ayub Khattak ,  Clinton Sever ,  Paul Nelson ,  Ryan Cooper ,  Thomas Congdon ,  Justin Demartino ,  Raphael Shapiro ,  Mark Duncan

IPC分类号： B01L3/00 ,  A61B10/00 ,  A61B10/02 ,  B65D83/00 ,  B65D83/04 ,  B65D83/08 ,  G01N27/327 ,  G01N33/543 ,  G01N35/00 ,  G01N35/10 ,  A61B5/157 ,  C12Q1/6825

CPC分类号： B01L3/508 ,  A61B10/0045 ,  A61B10/02 ,  B01L3/5023 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/502738 ,  B01L3/5029 ,  B01L3/523 ,  B65D83/005 ,  B65D83/04 ,  B65D83/0817 ,  B65D83/0858 ,  G01N27/3273 ,  G01N33/54366 ,  G01N35/0098 ,  G01N35/10 ,  A61B5/157 ,  B01L2200/025 ,  B01L2200/027 ,  B01L2200/0668 ,  B01L2200/0684 ,  B01L2200/0689 ,  B01L2200/10 ,  B01L2200/14 ,  B01L2200/16 ,  B01L2300/023 ,  B01L2300/047 ,  B01L2300/0627 ,  B01L2300/0645 ,  B01L2300/0663 ,  B01L2300/0672 ,  B01L2300/069 ,  B01L2300/0809 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2300/1805 ,  B01L2300/1827 ,  B01L2400/0406 ,  B01L2400/0481 ,  B01L2400/0677 ,  C12Q1/6825

摘要： Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component. The reader component may communicate with a remote computing device for the digital transmission of test protocols and test results. In various disclosed embodiments, the systems, components, and methods are configured to identify the presence, absence, and/or quantity of particular nucleic acids, proteins, or other analytes of interest, for example, in order to test for the presence of one or more pathogens or contaminants in a sample.

公开(公告)号：US12053774B2

公开(公告)日：2024-08-06

申请号：US17185177

申请日：2021-02-25

申请人： The General Hospital Corporation

发明人： Robert Granier ,  Ramin Haghgooie ,  Ken Kotz ,  Anne C. Petrofsky ,  Ronald G. Tompkins

IPC分类号： G01N1/00 ,  B01L3/00 ,  G01N15/01 ,  G01N15/10 ,  G01N15/12 ,  G01N15/14 ,  G01N15/1434 ,  G01N21/01 ,  G01N21/359 ,  G01N21/53 ,  G01N21/64 ,  G01N21/78 ,  G01N35/00

CPC分类号： B01L3/502715 ,  B01L3/50273 ,  B01L3/502738 ,  G01N15/1434 ,  G01N21/01 ,  G01N21/359 ,  G01N21/532 ,  G01N21/6486 ,  G01N21/78 ,  G01N35/00029 ,  G01N35/00871 ,  B01L2200/027 ,  B01L2200/028 ,  B01L2200/0689 ,  B01L2300/0627 ,  B01L2300/0816 ,  B01L2300/0832 ,  B01L2300/0861 ,  B01L2400/0487 ,  G01N15/01 ,  G01N2015/1006 ,  G01N15/12 ,  G01N15/1459 ,  G01N2021/6493 ,  G01N2035/00158 ,  G01N2035/00326 ,  G01N2035/00356 ,  G01N2035/00881 ,  G01N2201/024 ,  G01N2201/06113 ,  G01N2201/062

摘要： A modular analytic system includes a base, at least one fluid sample processing module configured to be removably attached to the base, at least one fluid sample analysis module configured to be removably attached to the base, a fluid actuation module positioned on the base, a fluidic network comprising multiple fluidic channels, in which the fluid actuation module is arranged to control transport of a fluid sample between the at least one sample processing module and the at least one sample analysis module through the fluidic network, and an electronic processor, in which the electronic processor is configured to control operation of the fluid actuation module and receive measurement data from the at least one fluid sample analysis module.

公开(公告)号：US20240253047A1

公开(公告)日：2024-08-01

申请号：US18561414

申请日：2022-05-17

申请人： Bacteromic Sp. z o.o.

发明人： Radoslaw MILCZAREK ,  Maria ZUZGA ,  Pawel MICHALAK ,  Seweryn BAJER-BORSTYN

IPC分类号： B01L3/00

CPC分类号： B01L3/50825 ,  B01L3/502715 ,  B01L3/502723 ,  B01L3/523 ,  B01L2200/027 ,  B01L2200/0673 ,  B01L2200/0689 ,  B01L2300/042 ,  B01L2300/047 ,  B01L2300/049 ,  B01L2400/0478 ,  B01L2400/0683

摘要： A syringe-plug (1, 1a, 1b, 1c, 1d) for placement in a sample chamber inlet of a cartridge for analytic assays, the syringe-plug comprising a tank (2) pre-filled with a liquid, the tank (2) having a proximal end (2a) and a distal end (2b), the proximal end (2a) of the tank (2) being closed by a piston (3) movable towards said distal end (2b), the distal end (2b) of the tank (2) being closed by a pierceable membrane (6) and the piston (3) being provided on its distal end (2b) side with a rod (4) having a piercing part (5) at its end enabling to pierce the membrane (6), wherein the proximal end (2a) of the tank (2) is provided with a plug part (7) surrounding the proximal end (2a) of the tank (2), the plug part (7) comprising external sealing means in the form of: at least one retaining rib (7b) surrounding a part of the plug part (7) circumference and comprising at least one gap (8b): at least one scaling rib (7c) surrounding the whole plug part (7) circumference: a thrust flange (7d) extending to the outside of the plug part (7) by a distance larger than the retaining rib(s) (7b) and the sealing rib(s) (7c), said sealing means being arranged sequentially as seen from the distal end (2b) side of the tank (2). A cartridge (11) for analytic assays comprising a sample chamber (10, 10a) integrated with a microfluidic system (9), the microfluidic system (9) being fed with a sample of analyte (S) and with a separating liquid (L), the sample chamber (10, 10a) having an inlet (13) adapted for insertion of the sample of analyte (S), and the cartridge further comprising a syringe-plug according to the invention.

公开(公告)号：US12037634B2

公开(公告)日：2024-07-16

申请号：US17353202

申请日：2021-06-21

申请人： 10X Genomics, Inc.

发明人： Benjamin Hindson ,  Serge Saxonov ,  Michael Schnall-Levin

IPC分类号： C12Q1/6806 ,  B01J19/00 ,  B01L3/00 ,  C12N15/10

CPC分类号： C12Q1/6806 ,  B01J19/0046 ,  B01L3/502715 ,  B01L3/508 ,  B01L3/523 ,  C12N15/1065 ,  B01L2200/0647 ,  B01L2400/0677 ,  C12Q2535/122 ,  C12Q2563/159 ,  C12Q1/6806 ,  C12Q2535/122 ,  C12Q2563/159

摘要： This disclosure provides microwell capsule array devices. The microwell capsule array devices are generally capable of performing one or more sample preparation operations. Such sample preparation operations may be used as a prelude to one more or more analysis operations. For example, a device of this disclosure can achieve physical partitioning and discrete mixing of samples with unique molecular identifiers within a single unit in preparation for various analysis operations. The device may be useful in a variety of applications and most notably nucleic-acid-based sequencing, detection and quantification of gene expression and single-cell analysis.