公开(公告)号：US20160041168A1

公开(公告)日：2016-02-11

申请号：US14921746

申请日：2015-10-23

Applicant: University of Rochester

Inventor： Benjamin L. Miller ,  Tim R. Mosmann ,  David Topham ,  Charles R. Mace

IPC: G01N33/569 ,  G01N21/552

CPC classification number: G01N33/56983 ,  C12N2760/16011 ,  G01N21/05 ,  G01N21/211 ,  G01N21/553 ,  G01N33/54373 ,  G01N2021/1725 ,  G01N2021/558 ,  G01N2021/5957 ,  G01N2333/11 ,  G01N2800/52

Abstract: A sensor chip for detecting an immune response against an influenza virus, the sensor chip including a substrate having a surface and a plurality of hemagglutinin polypeptides bound to discrete locations on the surface of the substrate, each hemagglutinin polypeptide having a hemagglutinin epitope. Detection devices containing the sensor chip and methods of detecting influenza immune responses are also described herein.

公开(公告)号：US20160009652A1

公开(公告)日：2016-01-14

申请号：US14861812

申请日：2015-09-22

Applicant: University of Rochester

Inventor： Benjamin L. Miller ,  Brian R. McNaughton ,  Peter Gareiss ,  Glynis Scott

IPC: C07D215/54 ,  A61Q17/04 ,  A61K8/49

CPC classification number: C07D215/54 ,  A61K8/4926 ,  A61K8/4953 ,  A61K8/4973 ,  A61K8/69 ,  A61Q17/04 ,  A61Q19/04 ,  C07D211/14 ,  C07D261/18 ,  C07D307/68 ,  C07D405/06

Abstract: The present invention relates to small molecule modulators of melanin expression and methods of making the small molecules. Also disclosed are methods of increasing pigmentation in a cell which involve providing compounds of the present invention and contacting a cell with the compounds under conditions effective to induce melanin expression in the cell, thereby increasing pigmentation. The present invention also relates to compositions containing compounds of the present invention and a carrier.

Abstract translation: 本发明涉及黑色素表达的小分子调节剂和制备小分子的方法。 还公开了增加细胞色素沉着的方法，其涉及提供本发明的化合物，并且在有效诱导细胞黑色素表达的条件下使细胞与化合物接触，从而增加色素沉着。 本发明还涉及含有本发明化合物和载体的组合物。

公开(公告)号：US20240409985A1

公开(公告)日：2024-12-12

申请号：US18698128

申请日：2022-09-15

Applicant: University of Rochester

Inventor： Benjamin L. Miller ,  Jeffrey W. Beard

IPC: C12Q1/6834 ,  C12Q1/70

Abstract: The present disclosure relates to novel methods for detection of nucleic acid sequences.

公开(公告)号：US20240287495A1

公开(公告)日：2024-08-29

申请号：US18572555

申请日：2022-06-23

Applicant: University of Rochester

Inventor： Benjamin L. Miller ,  Jeffrey W. Beard

IPC: C12N15/10 ,  B01L3/00 ,  C12Q1/6806

CPC classification number: C12N15/1003 ,  B01L3/502715 ,  B01L3/502761 ,  C12Q1/6806 ,  B01L2200/0621 ,  B01L2200/10 ,  B01L2300/0681 ,  B01L2300/0819 ,  B01L2300/087 ,  B01L2300/0874 ,  B01L2300/0877 ,  B01L2300/0887 ,  B01L2300/12

Abstract: The present invention relates to novel devices and methods for viral lysis and isolation as well as a simple, disposable, and nonenzymatic viral load assay based on a hairpin cascade reaction (HCR).

公开(公告)号：US20210268103A1

公开(公告)日：2021-09-02

申请号：US17236099

申请日：2021-04-21

Applicant: University of Rochester

Inventor： Matthew G. Brewer ,  Lisa A. Beck ,  Brian M. Ward ,  Benjamin L. Miller

IPC: A61K39/285 ,  A61K39/39 ,  C07K16/28 ,  C07K16/24 ,  A61K31/519 ,  A61K45/06

Abstract: This invention relates to dermatology and to treatments of infectious skin disease.

公开(公告)号：US10209254B2

公开(公告)日：2019-02-19

申请号：US15028370

申请日：2014-10-09

Applicant: UNIVERSITY OF ROCHESTER ,  THE UAB RESEARCH FOUNDATION

Inventor： Benjamin L. Miller ,  Moon H. Nahm

IPC: C40B30/04 ,  G01N33/569 ,  G01N33/543 ,  G01N21/21 ,  G01N21/55

Abstract: According to aspects illustrated herein, there are provided a sensor chip suitable for serological detection of Streptococcus pneumoniae, a method for detecting serotypes of Streptococcus pneumoniae using the sensor chip, a detection system that includes the sensor chip, and a method for detecting serotypes of Streptococcus pneumoniae using the detection system described herein.

公开(公告)号：US09217745B2

公开(公告)日：2015-12-22

申请号：US13940011

申请日：2013-07-11

Applicant: University of Rochester

Inventor： Benjamin L. Miller ,  Tim R. Mosmann ,  David Topham ,  Charles R. Mace

IPC: G01N33/569 ,  G01N21/05 ,  G01N21/21 ,  G01N21/552 ,  G01N33/543 ,  G01N21/59 ,  G01N21/17 ,  G01N21/55

CPC classification number: G01N33/56983 ,  C12N2760/16011 ,  G01N21/05 ,  G01N21/211 ,  G01N21/553 ,  G01N33/54373 ,  G01N2021/1725 ,  G01N2021/558 ,  G01N2021/5957 ,  G01N2333/11 ,  G01N2800/52

Abstract: A sensor chip for detecting an immune response against an influenza virus, the sensor chip including a substrate having a surface and a plurality of hemagglutinin polypeptides bound to discrete locations on the surface of the substrate, each hemagglutinin polypeptide having a hemagglutinin epitope. Detection devices containing the sensor chip and methods of detecting influenza immune responses are also described herein.

Abstract translation: 一种用于检测针对流感病毒的免疫应答的传感器芯片，所述传感器芯片包括具有表面的底物和与所述底物表面上的离散位置结合的多个血凝素多肽，每个血凝素多肽具有血凝素表位。 本文还描述了包含传感器芯片的检测装置和检测流感免疫应答的方法。

公开(公告)号：US20220249364A1

公开(公告)日：2022-08-11

申请号：US17596162

申请日：2020-06-02

Applicant: University of Rochester

Inventor： Benjamin L. Miller ,  Lisa A. Beck ,  Matthew G. Brewer

IPC: A61K9/00 ,  C07K14/00 ,  A61K39/145 ,  A61K39/00 ,  A61K39/35 ,  A61K9/70 ,  A61K47/42 ,  A61P37/04 ,  A61P31/16

Abstract: The present invention relates to isolated peptides suitable for disrupting an epithelial barrier, transepithelial dmg or vaccine formulations, drug delivery vehicles for delivering these formulations, and methods of using of these formulations for disrupting an epithelial barrier.

公开(公告)号：US11280782B2

公开(公告)日：2022-03-22

申请号：US15546737

申请日：2016-02-08

Applicant: UNIVERSITY OF ROCHESTER ,  ADARZA BIOSYSTEMS, INC.

Inventor： Benjamin L. Miller ,  Mark A. Lifson ,  Jared A. Carter

IPC: G01N33/543 ,  G01N33/545

Abstract: Disclosed is a sensor chip for detecting a target molecule in a sample. The sensor chip includes a substrate having a surface and a layer of hydrogel particles immobilized on the substrate surface at two or more locations on the surface, wherein the hydrogel particles at a first location comprise a plurality of first probe molecules bound to the particles and the hydrogel particles at a second location comprise a plurality of second probe molecules bound to the particles. Systems that include the sensor chip, as well as methods of preparing and using the sensor chip, are also disclosed.

公开(公告)号：US20130288922A1

公开(公告)日：2013-10-31

申请号：US13940011

申请日：2013-07-11

Applicant: University of Rochester

Inventor： Benjamin L. Miller ,  Tim R. Mosmann ,  David Topham ,  Charles R. Mace

IPC: G01N33/569

CPC classification number: G01N33/56983 ,  C12N2760/16011 ,  G01N21/05 ,  G01N21/211 ,  G01N21/553 ,  G01N33/54373 ,  G01N2021/1725 ,  G01N2021/558 ,  G01N2021/5957 ,  G01N2333/11 ,  G01N2800/52

Abstract: A sensor chip for detecting an immune response against an influenza virus, the sensor chip including a substrate having a surface and a plurality of hemagglutinin polypeptides bound to discrete locations on the surface of the substrate, each hemagglutinin polypeptide having a hemagglutinin epitope. Detection devices containing the sensor chip and methods of detecting influenza immune responses are also described herein.