A SYRINGE-PLUG AND A CARTRIDGE FOR ANALYTIC ASSAYS COMPRISING SUCH A SYRINGE-PLUG

    公开(公告)号:US20240253047A1

    公开(公告)日:2024-08-01

    申请号:US18561414

    申请日:2022-05-17

    IPC分类号: B01L3/00

    摘要: A syringe-plug (1, 1a, 1b, 1c, 1d) for placement in a sample chamber inlet of a cartridge for analytic assays, the syringe-plug comprising a tank (2) pre-filled with a liquid, the tank (2) having a proximal end (2a) and a distal end (2b), the proximal end (2a) of the tank (2) being closed by a piston (3) movable towards said distal end (2b), the distal end (2b) of the tank (2) being closed by a pierceable membrane (6) and the piston (3) being provided on its distal end (2b) side with a rod (4) having a piercing part (5) at its end enabling to pierce the membrane (6), wherein the proximal end (2a) of the tank (2) is provided with a plug part (7) surrounding the proximal end (2a) of the tank (2), the plug part (7) comprising external sealing means in the form of: at least one retaining rib (7b) surrounding a part of the plug part (7) circumference and comprising at least one gap (8b): at least one scaling rib (7c) surrounding the whole plug part (7) circumference: a thrust flange (7d) extending to the outside of the plug part (7) by a distance larger than the retaining rib(s) (7b) and the sealing rib(s) (7c), said sealing means being arranged sequentially as seen from the distal end (2b) side of the tank (2). A cartridge (11) for analytic assays comprising a sample chamber (10, 10a) integrated with a microfluidic system (9), the microfluidic system (9) being fed with a sample of analyte (S) and with a separating liquid (L), the sample chamber (10, 10a) having an inlet (13) adapted for insertion of the sample of analyte (S), and the cartridge further comprising a syringe-plug according to the invention.