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    Method for manufacturing aromatic nitrile compound
    1.
    发明授权
    Method for manufacturing aromatic nitrile compound 有权

    公开(公告)号：US12054448B2

    公开(公告)日：2024-08-06

    申请号：US17050255

    申请日：2019-04-26

    申请人： API CORPORATION

    发明人： Masaki Nagahama ,  Hideki Oomiya ,  Daiki Okado ,  Hirotsugu Taniike

    IPC分类号： C07C253/10 ,  C07C51/06 ,  C07C253/20 ,  C07C57/38 ,  C07C255/33

    CPC分类号： C07C253/20 ,  C07C51/06 ,  C07C57/38 ,  C07C255/33 ,  C07C2602/10

    摘要： The present invention provides a method for industrially producing a highly pure aromatic nitrile compound and a highly pure aromatic carboxylic acid compound safely and highly efficiently at low costs. Compound (2) is subjected to Willgerodt reaction in the presence of an additive as necessary, and the obtained amide compound (3) is hydrolyzed and neutralized to give carboxylic acid compound (4). Carboxylic acid compound (4) is reacted with a halogenating agent in the presence of a catalyst as necessary in an organic solvent, and further reacted with an amidating agent, and the obtained amide compound (5) or (6) is reacted with a dehydrating agent to give nitrile compound (1). Alternatively, carboxylic acid compound (4) is reacted with a halogenating agent and a compound represented by the formula R6SO2R7 in the presence of a catalyst as necessary in an organic solvent to give nitrile compound (1). Np is a naphthyl group optionally having substituent(s), R5 is an alkylene group having 1-3 carbon atoms, and other symbols are as described in the DESCRIPTION.

    Cytostatic platinum organic complexes
    9.
    发明授权
    Cytostatic platinum organic complexes 失效
    细胞活性铂有机配合物

    公开(公告)号：US4710577A

    公开(公告)日：1987-12-01

    申请号：US637463

    申请日：1984-08-03

    申请人： Yoshinori Kidani ,  Masahide Noji

    发明人： Yoshinori Kidani ,  Masahide Noji

    IPC分类号： C07C55/12 ,  C07C57/38 ,  C07C59/245 ,  C07C59/347 ,  C07C63/331 ,  C07F15/00

    CPC分类号： C07F15/0093 ,  C07C55/12 ,  C07C57/38 ,  C07C59/245 ,  C07C59/347 ,  C07C63/331

    摘要： 1,2-Diaminocyclohexane platinum (II) complexes of the general formula: ##STR1## wherein R.sub.1 and R.sub.2, are selected from nitrate and various organic carboxylate groups, with the proviso that R.sub.1 and R.sub.2 are not both nitrate, and the configuration of the 1,2-diaminocyclohexane being selected from cis, trans-d and trans-1, have been found to exhibit potent cytostatic activity.They may be made by reacting a starting material, in which R.sub.1 and R.sub.2 are nitrate, with the appropriate carboxylic acid or salt thereof.

    摘要翻译： 具有以下通式的1,2-二氨基环己烷铂（II）络合物：其中R1和R2选自硝酸盐和各种有机羧酸盐基团，条件是R 1和R 2不是硝酸盐，并且 已经发现，选自顺式，反式和反式-1的1,2-二氨基环己烷的构型表现出有效的细胞生长抑制活性。 它们可以通过使其中R1和R2是硝酸根的原料与合适的羧酸或其盐反应来制备。

    4-Heterocyclic-substituted-2-indanyl alcohols and insecticidal ester derivatives
    10.
    发明授权
    4-Heterocyclic-substituted-2-indanyl alcohols and insecticidal ester derivatives 失效
    4-杂环取代-2-二氢化茚醇和杀虫酯衍生物

    公开(公告)号：US4368205A

    公开(公告)日：1983-01-11

    申请号：US303292

    申请日：1981-09-17

    申请人： John F. Engel

    发明人： John F. Engel

    IPC分类号： A01N37/10 ,  A01N53/00 ,  C07C57/38 ,  C07C61/40 ,  C07D277/24 ,  C07D333/16 ,  C07F9/54 ,  A01N43/36 ,  A01N43/02 ,  C07D207/12 ,  C07D333/24

    CPC分类号： C07D333/16 ,  A01N37/10 ,  A01N53/00 ,  C07C57/38 ,  C07C61/40 ,  C07F9/5442

    摘要： Disclosed are novel compounds of the formula ##STR1## wherein R.sup.1 is a heterocyclic radical selected from furanyl, thienyl, pyridyl, pyrimidyl, oxazolyl, pyrrolyl, isoxazolyl, thiazolyl, and isothiazolyl, and R.sup.2 is hydrogen, a tetramethylcylopropanecarbonyl group, a 1-(substituted-phenyl)-2-methylpropyl-1-carbonyl group, a 1-(4-ethoxyphenyl)-2-dichlorocyclopropanecarbonyl group, or a substituted-vinyl-cyclopropanecarbonyl group. The compounds wherein R.sup.2 is other than hydrogen are insecticides.

    摘要翻译： 公开了式IMA的新化合物，其中R 1是选自呋喃基，噻吩基，吡啶基，嘧啶基，恶唑基，吡咯基，异恶唑基，噻唑基和异噻唑基的杂环基，R2是氢，四甲基环丙烷羰基，1-（ 取代的苯基）-2-甲基丙基-1-羰基，1-（4-乙氧基苯基）-2-二氯环丙烷羰基或取代的乙烯基环丙烷羰基。 其中R2不是氢的化合物是杀虫剂。