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    Methyl substituted oxobicyclo-4,4,0-decane derivatives, process for preparing same and organoleptic uses thereof
    1.
    发明授权
    Methyl substituted oxobicyclo-4,4,0-decane derivatives, process for preparing same and organoleptic uses thereof 失效
    甲基取代的氧代二环-4,4,0癸烷衍生物，其制备方法和感官用途

    公开(公告)号：US4377714A

    公开(公告)日：1983-03-22

    申请号：US313931

    申请日：1981-10-22

    申请人： Takao Yoshida

    发明人： Takao Yoshida

    IPC分类号： A24B15/34 ,  C07C29/17 ,  C07C29/68 ,  C07C35/36 ,  C07C45/62 ,  C07C45/69 ,  C07C49/447 ,  C07C49/637 ,  C07F3/00 ,  C11B9/00 ,  C07C29/136

    CPC分类号： C11B9/0053 ,  A24B15/34 ,  C07C29/172 ,  C07C29/68 ,  C07C35/36 ,  C07C45/62 ,  C07C45/69 ,  C07C49/447 ,  C07C49/637 ,  C07F3/003 ,  C07B2200/09 ,  C07C2102/28

    摘要： Described are compounds having the generic structure: ##STR1## wherein the dashed line represents a carbon-carbon single bond or a carbon-carbon double bond; wherein X represents the moieties: ##STR2## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 represent hydrogen or methyl with the proviso that (i) at least three of R.sub.1, R.sub.2, R.sub.3 and R.sub.4 represent hydrogen and (ii) when the dashed line is a carbon-carbon single bond and X is: ##STR3## then one of R.sub.1, R.sub.2, R.sub.3 or R.sub.4 is methyl and the other represents hydrogen; wherein R.sub.5 represents hydrogen, MgX, MgR.sub.7, CdR.sub.7, ZnR.sub.7, Na, K or Li; wherein X represents Chloro, Bromo or Iodo; wherein R.sub.6 represents hydrogren or methyl; and wherein R.sub.7 represents lower alkyl; and uses thereof for their organoleptic properties in augmenting or enhancing or enhancing the aromas or tastes of perfumes, perfumed articles, foodstuffs, chewing gums, smoking tobaccos, toothpastes, medicinal products, chewing tobacco and smoking tobacco articles, as well as processes for preparing same.

    摘要翻译： 描述的是具有通用结构的化合物：其中虚线表示碳 - 碳单键或碳 - 碳双键; 其中X表示部分：其中R 1，R 2，R 3和R 4表示氢或甲基，条件是（i）R 1，R 2，R 3和R 4中的至少3个表示氢，和（ii） 虚线是碳 - 碳单键，X是：其中R1，R2，R3或R4之一是甲基，另一个代表氢; 其中R5表示氢，MgX，MgR7，CdR7，ZnR7，Na，K或Li; 其中X表示氯，溴或碘; 其中R6代表氢原子或甲基; 并且其中R 7表示低级烷基; 以及其用于增强或增强香料，香料，食品，口香糖，吸烟烟草，牙膏，药用产品，咀嚼烟草和烟草制品的香气或口味的感官特性，以及其制备方法 。

    1,9-Dihydroxyoctahydrophenanthrenes
    2.
    发明授权
    1,9-Dihydroxyoctahydrophenanthrenes 失效
    1,9-二羟基焦氢氯苯

    公开(公告)号：US4341906A

    公开(公告)日：1982-07-27

    申请号：US219320

    申请日：1980-12-22

    申请人： Thomas H. Althuis ,  Charles A. Harbert ,  Michael R. Johnson ,  Lawrence S. Melvin, Jr.

    发明人： Thomas H. Althuis ,  Charles A. Harbert ,  Michael R. Johnson ,  Lawrence S. Melvin, Jr.

    IPC分类号： C07C41/22 ,  C07C41/26 ,  C07C43/225 ,  C07C43/23 ,  C07C45/45 ,  C07C45/54 ,  C07C45/61 ,  C07C45/67 ,  C07C45/68 ,  C07C45/71 ,  C07C45/73 ,  C07C49/747 ,  C07C49/755 ,  C07D211/32 ,  C07D213/30 ,  C07D213/50 ,  C07D317/22 ,  C07D317/72 ,  C07C49/637 ,  C07C49/447

    CPC分类号： C07D213/30 ,  C07C41/01 ,  C07C41/22 ,  C07C41/26 ,  C07C45/45 ,  C07C45/54 ,  C07C45/61 ,  C07C45/67 ,  C07C45/68 ,  C07C45/71 ,  C07C45/73 ,  C07C49/747 ,  C07C49/755 ,  C07D211/32 ,  C07D213/50 ,  C07D317/22 ,  C07D317/72 ,  C07C2101/14

    摘要： Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, benzyl, benzoyl, alkanoyl of 1 to 5 carbon atoms or --CO--(CH.sub.2).sub.p --NR'R" wherein p is 0 or an integer from 1 to 4; each of R' and R" when taken individually is hydrogen or alkyl of 1 to 4 carbon atoms; R' and R" when taken together with the nitrogen to which they are attached form a 5- or 6-membered heterocyclic ring selected from piperidino, pyrollo, pyrrolidino, morpholino and N-alkylpiperazino having from 1 to 4 carbon atoms in the alkyl group;R.sub.2 is selected from hydrogen, alkanoyl of 1 to 6 carbon atoms and benzoyl;R.sub.3 is selected from hydrogen, methyl and ethyl;R.sub.4 is selected from hydrogen, alkyl of 1 to 6 carbon atoms and benzyl;Z is selected from:(a) alkylene having from one to nine carbon atoms;(b) -(alk.sub.1).sub.m -X-(alk.sub.2).sub.n - wherein each of (alk.sub.1) and (alk.sub.2) is alkylene having from 1 to 9 carbon atoms, with the proviso that the summation of carbon atoms in (alk.sub.1) plus (alk.sub.2) is not greater than 9;m and n are each 0 or 1;X is selected from O, S, SO and SO.sub.2 ; andW is selected from hydrogen, methyl, pyridyl, piperidyl, phenyl, monochlorophenyl, monofluorophenyl and ##STR2## wherein W.sub.1 is selected from hydrogen, phenyl, monochlorophenyl and monofluorophenyl; a is an integer from 1 to 5 and b is 0 or an integer from 1 to 4, with the proviso that the sum of a and b is not greater than 5.Compounds I and II are useful as analgesics. Compound III is useful as an intermediate for the preparation of Compounds I and II. Intermediates for the preparation of I, II and III are disclosed. A process for the use of compounds I and II to produce analgesia is also described.

    摘要翻译： 其中R 1是氢，苄基，苯甲酰基，1至5个碳原子的烷酰基或-CO-（CH 2）p -NR'R“的化合物，其中p是 0或1至4的整数; 当单独使用时，R'和R“各自为氢或1至4个碳原子的烷基; 当与它们所连接的氮一起取代时，R'和R“与烷基中具有1至4个碳原子的5-或6-元杂环选自哌啶子基，吡咯烷基，吡咯烷子基，吗啉代和N-烷基哌嗪基 组; R 2选自氢，1至6个碳原子的烷酰基和苯甲酰基; R 3选自氢，甲基和乙基; R4选自氢，1至6个碳原子的烷基和苄基; Z选自：（a）具有1至9个碳原子的亚烷基; （b） - （alk1）mX-（alk2）n-其中（alk1）和（alk2）各自为具有1至9个碳原子的亚烷基，条件是（alk1）加（alk2） ）不大于9; m和n分别为0或1; X选自O，S，SO和SO2; W选自氢，甲基，吡啶基，哌啶基，苯基，一氯苯基，一氟苯基和其中W1选自氢，苯基，一氯苯基和单氟苯基; a为1至5的整数，b为0或1至4的整数，条件是a和b之和不大于5.化合物I和II可用作止痛剂。 化合物III可用作制备化合物I和II的中间体。 公开了制备I，II和III的中间体。 还描述了使用化合物I和II产生止痛的方法。

    Carboxylic esters for the preparation of a bicyclic decalin ketone
    6.
    发明授权
    Carboxylic esters for the preparation of a bicyclic decalin ketone 失效
    用于制备双环十氢萘酮的羧酸酯

    公开(公告)号：US5453525A

    公开(公告)日：1995-09-26

    申请号：US280909

    申请日：1994-07-27

    申请人： Roger L. Snowden ,  Cyril Mahaim ,  Dana P. Simmons

    发明人： Roger L. Snowden ,  Cyril Mahaim ,  Dana P. Simmons

    IPC分类号： C07C45/45 ,  C07C45/65 ,  C07C45/67 ,  C07C49/447 ,  C07C69/602 ,  C07C69/732 ,  C07C69/78 ,  C07F9/117 ,  C07C45/00

    CPC分类号： C07F9/117 ,  C07C403/20 ,  C07C45/673 ,  C07C69/732 ,  C07C2101/14 ,  C07C2101/16

    摘要： Perhydro-5,5-8a-trimethyl-2-naphthalenone is prepared by acid cyclization of carboxylic esters of formula ##STR1## having a double bond in one of the positions indicated by the dotted lines and wherein symbol R designates a C.sub.1 -C.sub.6 alkyl radical, X stands for a monovalent radical of formula P(O)(OR.sup.1).sub.2 or C(O)R.sup.2, R.sup.1 represents a C.sub.1 -C.sub.6 alkyl group and R.sup.2 is either a linear or branched alkyl group or a substituted or unsubstituted phenyl radical, and wherein the wavy line represents a C--C bond of cis or trans configuration, or of formula ##STR2## wherein the wavy lines and symbol R are defined as above, and R.sup.0 represents a C.sub.3 -C.sub.6 alkyl radical, preferably branched, followed by basic decarboxylation of the obtained product.

    摘要翻译： 通过在由虚线表示的一个位置中具有双键的式（II）的羧酸酯进行酸环化制备全氢-5,5-甲基-2-萘酮，其中符号R表示C1 -C 6烷基，X表示式P（O）（OR 1）2或C（O）R 2的一价基团，R 1表示C 1 -C 6烷基，R 2为直链或支链烷基或取代或 未取代的苯基，并且其中波浪线表示顺式或反式构型的CC键，或式R的定义如上，R 0表示C 3 -C 6烷基，优选支链，然后进行所得产物的碱性脱羧。

    Process for the preparation of a bicyclic decalin ketone
    7.
    发明授权
    Process for the preparation of a bicyclic decalin ketone 失效
    制备双环十氢萘酮的方法

    公开(公告)号：US5386039A

    公开(公告)日：1995-01-31

    申请号：US94679

    申请日：1993-07-20

    申请人： Roger L. Snowden ,  Cyril Mahaim ,  Dana P. Simmons

    发明人： Roger L. Snowden ,  Cyril Mahaim ,  Dana P. Simmons

    IPC分类号： C07C45/45 ,  C07C45/65 ,  C07C45/67 ,  C07C49/447 ,  C07C69/602 ,  C07C69/732 ,  C07C69/78 ,  C07F9/117

    CPC分类号： C07F9/117 ,  C07C403/20 ,  C07C45/673 ,  C07C69/732 ,  C07C2101/14 ,  C07C2101/16

    摘要： Perhydro-5,5-8a-trimethyl-2-naphthalenone is prepared by acid cyclization of carboxylic esters of formula ##STR1## having a double bond in one of the positions indicated by the dotted lines and wherein symbol R designates a C.sub.1 -C.sub.6 alkyl radical, X stands for a monovalent radical of formula P(O)(OR.sup.1).sub.2 or C(O)R.sup.2, R.sup.1 represents a C.sub.1 -C.sub.6 alkyl group and R.sup.2 is either a linear or branched alkyl group or a substituted or unsubstituted phenyl radical, and wherein the wavy line represents a C--C bond of cis or trans configuration, or of formula ##STR2## wherein the wavy lines and symbol R are defined as above, and R.sup.0 represents a C.sub.3 -C.sub.6 alkyl radical, preferably branched, followed by basic decarboxylation of the obtained product.

    摘要翻译： 通过在由虚线表示的一个位置中具有双键的式（II）的羧酸酯进行酸环化制备全氢-5,5-甲基-2-萘酮，其中符号R表示C1 -C 6烷基，X表示式P（O）（OR 1）2或C（O）R 2的一价基团，R 1表示C 1 -C 6烷基，R 2为直链或支链烷基或取代或 未取代的苯基，并且其中波浪线表示顺式或反式构型的CC键，或式R的定义如上，R 0表示C 3 -C 6烷基，优选支链，然后进行所得产物的碱性脱羧。

    Fungicidal spirocyclic amines
    10.
    发明授权
    Fungicidal spirocyclic amines 失效
    杀真菌的螺环胺

    公开(公告)号：US5849802A

    公开(公告)日：1998-12-15

    申请号：US722787

    申请日：1996-09-27

    申请人： Waldemar Franz Augustin Pfrengle

    发明人： Waldemar Franz Augustin Pfrengle

    IPC分类号： A01N31/04 ,  A01N33/06 ,  A01N43/40 ,  A01N43/84 ,  C07C45/29 ,  C07C45/62 ,  C07C45/66 ,  C07C49/185 ,  C07C49/447 ,  C07C49/637 ,  C07C211/16 ,  C07C211/34 ,  C07C217/08 ,  C07C217/40 ,  A61K31/13 ,  A61K31/445 ,  A61K31/535 ,  C07C211/00

    CPC分类号： C07C217/40 ,  A01N31/04 ,  A01N33/06 ,  A01N43/40 ,  A01N43/84 ,  C07C211/16 ,  C07C211/34 ,  C07C217/08 ,  C07C45/29 ,  C07C45/62 ,  C07C45/66 ,  C07C49/185 ,  C07C49/447 ,  C07C49/637 ,  C07C2103/94

    摘要： New antimicrobial spirocarbocyclic compounds are described, having the general formula I, ##STR1## or an acid-addition salt thereof, in which R.sub.1 represents an optionally substituted alkyl, cycloalkyl, cycloalkylalkyl, alkoxy, cycloalkoxy, alkoxyalkyl, aralkyl group R.sub.2 and R.sub.3 each independently represent hydrogen or an optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, bicycloalkyl, tricycloalkyl, alkoxyalkyl, aralkyl, aryl or haloaralkyl, a 4- to 6-membered heterocyclyl, tetrahydrofuryl or dioxolanyl group, or R.sub.2 and R.sub.3, together represents an optionally substituted, saturated or unsaturated chain which may optionally contain one or more oxygen atoms and which may optionally be aryl- or cycloalkyl-fused, and n represents zero or an integer from 1 to 3. The invention further relates to the preparation of the above spirocarbocyclic compounds, intermediates prepared during the synthesis of these compounds, compositions containing the compounds and their use as fungicides in the control of phytopathogenic fungi.

    摘要翻译： 描述了具有通式I，（I）或其酸加成盐的新型抗菌螺环碳环化合物，其中R 1表示任选取代的烷基，环烷基，环烷基烷基，烷氧基，环烷氧基，烷氧基烷基，芳烷基R2和 R 3各自独立地表示氢或任选取代的烷基，烯基，炔基，环烷基，环烷基烷基，二环烷基，三环烷基，烷氧基烷基，芳烷基，芳基或卤代烷基，4-至6-元杂环基，四氢呋喃基或二氧戊环基，或R 2和R 3， 一起表示任选取代的饱和或不饱和的链，其可任选地含有一个或多个氧原子，并且其可以任选地被芳基或环烷基稠合，并且n表示0或1至3的整数。本发明还涉及制备 的上述螺环化合物，在合成这些化合物期间制备的中间体，含有这些化合物的组合物及其用途 杀真菌剂控制植物病原真菌。