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    Peptidomimetics for the treatment of HIV infection
    2.
    发明授权
    Peptidomimetics for the treatment of HIV infection 失效
    用于治疗艾滋病毒感染的肽模拟物

    公开(公告)号：US5990172A

    公开(公告)日：1999-11-23

    申请号：US807473

    申请日：1997-02-27

    申请人： Matthew R. Pincus ,  Andrew S. Kende ,  Joseph J. Hlavka ,  Henry B. Abajian

    发明人： Matthew R. Pincus ,  Andrew S. Kende ,  Joseph J. Hlavka ,  Henry B. Abajian

    IPC分类号： A61K31/12 ,  A61K31/165 ,  C07C69/738 ,  C07C235/78 ,  C07C233/05

    CPC分类号： C07C69/738 ,  A61K31/12 ,  A61K31/165 ,  C07C235/78 ,  C07C2102/28

    摘要： This invention provides peptidomimetics which bind to T4 or CD4 cell receptors and are useful in inhibiting viral infectivity by viruses which bind to T4 cell receptors. More specifically, peptidomimetics of this invention can alleviate symptoms of AIDS by inhibiting binding of HIV, the virus associated with AIDS, to receptor sites in human cells susceptible to HIV infection. These peptidomimetics, in particular, inhibit binding of HIV to cells of brain membrane and the immune system. They also display substantially longer half-lives in vivo than peptide T. The compounds of this invention which bind to T4 or CD4 receptors and thereby inhibit binding of HIV, alone or in combination with one another, can be used to alleviate AIDS symptoms and ameliorate symptoms of HIV infection, especially neuronal dementias and Kaposi's sarcoma. The compounds of this invention, alone or in combination, can further be used to prevent development of AIDS in persons who might become exposed to HIV.

    摘要翻译： 本发明提供结合T4或CD4细胞受体的肽模拟物，并且可用于通过结合T4细胞受体的病毒抑制病毒感染性。 更具体地说，本发明的肽模拟物可以通过抑制与艾滋病相关的HIV的HIV结合到易感染于HIV感染的人类细胞中的受体位点来减轻AIDS的症状。 特别是这些肽模拟物抑制HIV与脑膜和免疫系统细胞的结合。 它们的体内半衰期比肽T还要长得更长。本发明的结合T4或CD4受体从而抑制HIV单独或彼此组合的结合的本发明化合物可用于缓解AIDS症状和改善 HIV感染的症状，特别是神经元性痴呆和卡波西氏肉瘤。 单独或组合的本发明化合物可进一步用于预防可能变得暴露于HIV的人中的AIDS的发展。