公开(公告)号：US20070142253A1

公开(公告)日：2007-06-21

申请号：US11674523

申请日：2007-02-13

申请人： Anubhav Narula ,  Edward Arruda ,  Franc Schiet

发明人： Anubhav Narula ,  Edward Arruda ,  Franc Schiet

IPC分类号： A61K8/49 ,  C07D313/02 ,  C11D3/50

CPC分类号： C07D313/00 ,  C07C45/69 ,  C07C49/427 ,  C07D337/00 ,  C11B9/0038 ,  C11B9/0049 ,  C11B9/0084 ,  C11B9/0092

摘要： The present invention is directed to novel cyclopropanated macrocyclic ketone and lactone compounds of the general formula wherein X is an atom or a functional group selected from the group consisting of O, N, S, R—CH, CH2 and wherein R is a C1-C3 alkyl group; a wherein Y and W independently represent is a linear or branched alkyl or alkenyl group, possibly substituted, consisting of less than 10 and preferably less than 7 carbon atoms; and wherein O is an oxygen atom; and the use of these novel compounds in creating fragrances, and scents in items such as perfumes, colognes and personal care products.

摘要翻译： 本发明涉及新的环丙烷化大环酮和通式的内酯化合物，其中X是选自O，N，S，R-CH，CH 2的原子或官能团，其中R是C1- C3烷基; 其中Y和W独立地表示可以被取代的直链或支链烷基或烯基，由少于10个，优选小于7个碳原子组成; 并且其中O是氧原子; 以及这些新型化合物在制造香料中的用途，以及香水，古龙水和个人护理产品中的香料。

公开(公告)号：US20030078300A1

公开(公告)日：2003-04-24

申请号：US10124210

申请日：2002-04-16

申请人： Pfizer Inc.

发明人： David Clive Blakemore ,  Justin Stephen Bryans ,  Sophie Caroline Williams

IPC分类号： A61K031/195 ,  C07C229/28 ,  C07C229/34

CPC分类号： C07C45/292 ,  C07C45/30 ,  C07C45/67 ,  C07C45/676 ,  C07C45/68 ,  C07C45/69 ,  C07C49/427 ,  C07C49/433 ,  C07C229/28 ,  C07C2602/18 ,  C07C2602/20 ,  C07C2602/22 ,  C07C2602/24

摘要： The compounds of the instant invention are bicyclic or tricyclic amino acids useful in the treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, pain, arthritis, neuropathological disorders, sleep disorders, visceral pain disorders, and gastrointestinal disorders. Processes for the preparation of the final products and intermediates useful in the process are included. Pharmaceutical compositions containing one or more of the compounds are also included.

公开(公告)号：US3709943A

公开(公告)日：1973-01-09

申请号：US3709943D

申请日：1970-08-17

申请人： MAC MILLAN BLOEDEL LTD

发明人： CARTLIDGE D ,  HACH V ,  LOCKHART R

IPC分类号： C07C45/67 ,  C07C45/85 ,  C07C49/26

CPC分类号： C07C45/67 ,  C07C45/85 ,  C07C49/427

摘要： AN IMPROVED PROCESS IS DESCRIBED FOR RECOVERING D-ISOTHUJONE FROM A MIXTURE CONTAINING 2-THUJONE AND D-ISOTHUJONE WHICH COMPRISES CONTACTING SUCH MIXTURE CONTAINING AT LEAST 35% BY WEIGHT OF D-ISOTHUJONE WITH AN AQUEOUS BISULFITE SOLUTION SO AS TO FORM AN ADDUCT OF DISOTHUJONE AND BISULFITE AND DECOMPOSING THE ADDUCT TO OBTAIN PURE D-ISOTHUJONE. THE THUJONE MIXTURE PREFERABLY CONTAINS AT LEAST 70% BY WEIGHT OF THE TWO THUJONES AND THE RATIO OF THE THUJONES CAN BE ADJUSTED BY ISOMERIZATION.

公开(公告)号：US20140024635A1

公开(公告)日：2014-01-23

申请号：US14036813

申请日：2013-09-25

申请人： The Trustees of The University Of Pennsylvania

发明人： WILLIAM F. DeGRADO ,  JUN WANG

IPC分类号： C07C255/47 ,  C07C61/13 ,  C07C211/38 ,  C07D223/32 ,  C07C49/447 ,  C07C49/427

CPC分类号： C07D223/32 ,  A61K31/045 ,  A61K31/122 ,  A61K31/13 ,  A61K31/19 ,  A61K31/277 ,  A61K31/55 ,  C07C35/23 ,  C07C49/323 ,  C07C49/427 ,  C07C49/447 ,  C07C49/623 ,  C07C61/13 ,  C07C211/19 ,  C07C211/38 ,  C07C255/47 ,  C07C2602/50

摘要： Provided are compounds that are capable of modulating the activity of the influenza A virus via interaction with the M2 transmembrane protein. Also provided are methods for treating an influenza A-affected disease state or infection comprising administering a composition comprising one or more compounds that have been identified as being capable of interaction with the M2 protein.

摘要翻译： 提供能够通过与M2跨膜蛋白相互作用来调节甲型流感病毒的活性的化合物。 还提供了用于治疗受甲型流感感染的疾病状态或感染的方法，其包括施用包含已被鉴定为能够与M2蛋白相互作用的一种或多种化合物的组合物。

公开(公告)号：US20090081150A1

公开(公告)日：2009-03-26

申请号：US12329091

申请日：2008-12-05

申请人： Anubhav P.S. Narula ,  Edward Mark Arruda ,  Franc T. Schiet

发明人： Anubhav P.S. Narula ,  Edward Mark Arruda ,  Franc T. Schiet

IPC分类号： A61K8/49 ,  A61K47/22 ,  A61K47/00 ,  A61Q13/00 ,  A61L9/01 ,  C11D3/50

CPC分类号： C07D313/00 ,  C07C45/69 ,  C07C49/427 ,  C07D337/00 ,  C11B9/0038 ,  C11B9/0049 ,  C11B9/0084 ,  C11B9/0092

摘要： The present invention is directed to novel cyclopropanated macrocyclic ketone and lactone compounds of the general formula: wherein X is an atom or a functional group selected from the group consisting of O, N, S, R—CH, and CH2; wherein R is a C1-C3 alkyl group; wherein Y and W independently represent is a linear or branched alkyl or alkenyl group, optionally substituted, consisting of less than 10 and preferably less than 7 carbon atoms; and wherein O is an oxygen atom, and the use of these novel compounds in creating fragrances and scents in items such as perfumes, colognes, and personal care products.

摘要翻译： 本发明涉及新的环丙烷化大环酮和具有以下通式的内酯化合物：其中X是选自O，N，S，R-CH和CH 2的原子或官能团; 其中R是C1-C3烷基; 其中Y和W独立地表示直链或支链的烷基或烯基，任选被取代，由少于10个，优选小于7个碳原子组成; 并且其中O是氧原子，以及这些新化合物在诸如香水，古龙水和个人护理产品之类的产品中产生香料和香料的用途。

公开(公告)号：US07256170B2

公开(公告)日：2007-08-14

申请号：US10680138

申请日：2003-10-08

申请人： Christian Vial ,  Robert Moretti ,  Alain Charpilloz ,  Peter Fankhauser ,  Piero Fantini

发明人： Christian Vial ,  Robert Moretti ,  Alain Charpilloz ,  Peter Fankhauser ,  Piero Fantini

IPC分类号： A61Q19/00 ,  A61Q19/10 ,  A61Q13/00 ,  C07D493/00 ,  C07D311/96

CPC分类号： C07C35/23 ,  C07C43/18 ,  C07C43/188 ,  C07C45/62 ,  C07C45/68 ,  C07C45/69 ,  C07C49/427 ,  C07C49/447 ,  C07C49/623 ,  C07C49/637 ,  C07C69/013 ,  C07C2602/50 ,  C11B9/0057

摘要： The present invention relates to the perfumery industry. It concerns more particularly an alcohol, ester, ether or ketone derivative having a spiro-type skeleton, the latter being substituted by short alkyl groups. The invention also relates to the use of the invention compounds as perfuming ingredients, able to impart a woody and/or aromatic, as well as to the perfumed articles or perfuming compositions comprising as active ingredient a compound of formula (I).

摘要翻译： 本发明涉及香料工业。 更特别地涉及具有螺型骨架的醇，酯，醚或酮衍生物，后者被短烷基取代。 本发明还涉及本发明化合物作为能够赋予木质和/或芳族化合物的加香成分以及包含作为活性成分的式（I）化合物的加香制品或加香组合物的用途。

公开(公告)号：US07189881B2

公开(公告)日：2007-03-13

申请号：US11105626

申请日：2005-04-14

申请人： Anubhav P. S. Narula ,  Edward Mark Arruda ,  Franc T. Schiet

发明人： Anubhav P. S. Narula ,  Edward Mark Arruda ,  Franc T. Schiet

IPC分类号： C07D49/00

CPC分类号： C11D3/50 ,  C07C45/69 ,  C07C49/427 ,  C07D225/04 ,  C07D313/00 ,  C07D337/00

摘要： The present invention is directed to novel cyclopropanated macrocyclic ketone and lactone compounds of the general formula wherein X is an atom or a functional group selected from the group consisting of O, N, S, CH, or CH2; wherein Y is a straight or branched hydrocarbon moiety consisting of 1 to 20 carbon atoms; wherein W is a straight or branched hydrocarbon moiety of consisting of 1 to 20 carbon atoms; and wherein O is an oxygen atom; and the use of these novel compounds in creating fragrances, and scents in items such as perfumes, colognes and personal care products.

摘要翻译： 本发明涉及新的环丙烷化大环酮和通式的内酯化合物，其中X是选自O，N，S，CH或CH 2的原子或官能团。 ; 其中Y是由1至20个碳原子组成的直链或支链烃部分; 其中W是由1至20个碳原子组成的直链或支链烃部分; 并且其中O是氧原子; 以及这些新型化合物在制造香料中的用途，以及香水，古龙水和个人护理产品中的香料。

公开(公告)号：US11760746B2

公开(公告)日：2023-09-19

申请号：US17349288

申请日：2021-06-16

申请人： Gilead Sciences, Inc.

发明人： Sachin Dhar ,  Alex Goldberg ,  Lars V. Heumann ,  Zilin Huang ,  Vinh Xuan Ngo ,  Trevor James Rainey ,  Dietrich P. Steinhuebel ,  Xianghong Wang ,  Scott Alan Wolckenhauer

IPC分类号： C07D213/24 ,  C07D401/14 ,  C07D401/12 ,  C07D495/10 ,  C07D339/06 ,  C07C59/50 ,  C07D231/56 ,  C07C45/67 ,  C07D213/61 ,  C07D231/54

CPC分类号： C07D401/14 ,  C07C45/673 ,  C07C59/50 ,  C07D213/61 ,  C07D231/54 ,  C07D231/56 ,  C07D339/06 ,  C07D401/12 ,  C07D495/10 ,  C07C2602/18 ,  C07C45/673 ,  C07C49/427

摘要： The present disclosure relates to methods and intermediates useful for preparing a compound of formula I.




or a co-crystal, solvate, salt or combination thereof.

公开(公告)号：US20120028957A1

公开(公告)日：2012-02-02

申请号：US12848197

申请日：2010-08-01

申请人： William F. DeGrado ,  Jun Wang

发明人： William F. DeGrado ,  Jun Wang

IPC分类号： A61K31/13 ,  A61K31/277 ,  A61K31/19 ,  A61K31/122 ,  A61K31/045 ,  C07D223/32 ,  C07C255/47 ,  C07C61/13 ,  C07C211/19 ,  C07C211/38 ,  C07C49/623 ,  C07C35/23 ,  C07C49/637 ,  A61P31/16 ,  A61K31/55

CPC分类号： C07D223/32 ,  A61K31/045 ,  A61K31/122 ,  A61K31/13 ,  A61K31/19 ,  A61K31/277 ,  A61K31/55 ,  C07C35/23 ,  C07C49/323 ,  C07C49/427 ,  C07C49/447 ,  C07C49/623 ,  C07C61/13 ,  C07C211/19 ,  C07C211/38 ,  C07C255/47 ,  C07C2602/50

摘要： Provided are compounds that are capable of modulating the activity of the influenza A virus via interaction with the M2 transmembrane protein. Also provided are methods for treating an influenza A-affected disease state or infection comprising administering a composition comprising one or more compounds that have been identified as being capable of interaction with the M2 protein.

摘要翻译： 提供能够通过与M2跨膜蛋白相互作用来调节甲型流感病毒的活性的化合物。 还提供了用于治疗受甲型流感感染的疾病状态或感染的方法，其包括施用包含已被鉴定为能够与M2蛋白相互作用的一种或多种化合物的组合物。

公开(公告)号：US20060234883A1

公开(公告)日：2006-10-19

申请号：US11105626

申请日：2005-04-14

申请人： Anubhav Narula ,  Edward Arruda ,  Franc Schiet

发明人： Anubhav Narula ,  Edward Arruda ,  Franc Schiet

IPC分类号： A61K8/49 ,  C11D3/50 ,  C07D335/06

CPC分类号： C11D3/50 ,  C07C45/69 ,  C07C49/427 ,  C07D225/04 ,  C07D313/00 ,  C07D337/00

摘要： The present invention is directed to novel cyclopropanated macrocyclic ketone and lactone compounds of the general formula wherein X is an atom or a functional group selected from the group consisting of 0, N, S, CH, or CH2; wherein Y is a straight or branched hydrocarbon moiety consisting of 1 to 20 carbon atoms; wherein W is a straight or branched hydrocarbon moiety of consisting of 1 to 20 carbon atoms; and wherein O is an oxygen atom; and the use of these novel compounds in creating fragrances, and scents in items such as perfumes, colognes and personal care products.

摘要翻译： 本发明涉及新的环丙烷化大环酮和通式的内酯化合物，其中X是选自0，N，S，CH或CH 2的原子或官能团。 ; 其中Y是由1至20个碳原子组成的直链或支链烃部分; 其中W是由1至20个碳原子组成的直链或支链烃部分; 并且其中O是氧原子; 以及这些新型化合物在制造香料中的用途，以及香水，古龙水和个人护理产品中的香料。