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公开(公告)号：US20160016980A1
公开(公告)日：2016-01-21
申请号：US14746430
申请日：2015-06-22
IPC分类号： C07F9/24
CPC分类号： C07H1/00 , A61K31/7042 , A61K31/7052 , C07F9/2458 , C07F9/65586 , C07F9/6561 , C07F9/65616 , C07H19/02 , C07H19/10 , C07H19/20
摘要： Provided are methods and intermediates for preparing diastereomerically pure phosphoramidate prodrugs of nucleosides of Formulas Ia and Ib: The compounds of Formula Ia and Ib are useful for the treatment Hepatitis C infections.
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公开(公告)号：US12122765B2
公开(公告)日：2024-10-22
申请号：US18205877
申请日：2023-06-05
IPC分类号： C07F5/02 , C07C45/67 , C07C59/50 , C07D213/61 , C07D231/54 , C07D231/56 , C07D339/06 , C07D401/12 , C07D401/14 , C07D495/10
CPC分类号： C07D401/14 , C07C45/673 , C07C59/50 , C07D213/61 , C07D231/54 , C07D231/56 , C07D339/06 , C07D401/12 , C07D495/10 , C07C2602/18
摘要： The present disclosure relates to methods and intermediates useful for preparing a compound of formula I:
or a co-crystal, solvate, salt or combination thereof.-
公开(公告)号：US20220009904A1
公开(公告)日：2022-01-13
申请号：US17349288
申请日：2021-06-16
发明人： Kevin McCormack Allan , Amanda Lynn Vandehey , Gediminas Brizgys , Sachin Dhar , Ian James Doxsee , Alex Goldberg , Lars V. Heumann , Zilin Huang , Nathaniel Thomas Kadunce , Shahrokh Kazerani , Willard Lew , Vinh Xuan Ngo , Brian Michael O'Keefe , Trevor James Rainey , Benjamin James Roberts , Bing Shi , Dietrich P. Steinhuebel , Winston C. Tse , Anna Michelle Wagner , Xianghong Wang , Scott Alan Wolckenhauer , Chloe Yuyi Wong , Jennifer R. Zhang
IPC分类号： C07D401/14 , C07D401/12 , C07D495/10 , C07D339/06 , C07C59/50 , C07D231/56 , C07C45/67 , C07D213/61 , C07D231/54
摘要： The present disclosure relates to methods and intermediates useful for preparing a compound of formula I. or a co-crystal, solvate, salt or combination thereof.
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公开(公告)号：US20240101533A1
公开(公告)日：2024-03-28
申请号：US18205877
申请日：2023-06-05
发明人： Kevin McCormack Allan , Amanda Lynn Vandehey , Gediminas Brizgys , Sachin Dhar , Ian James Doxsee , Alex Goldberg , Lars V. Heumann , Zilin Huang , Nathaniel Thomas Kadunce , Shahrokh Kazerani , Willard Lew , Vinh Xuan Ngo , Brian Michael O`Keefe , Trevor James Rainey , Benjamin James Roberts , Bing Shi , Dietrich P. Steinhuebel , Winston C. Tse , Anna Michelle Wagner , Xianghong Wang , Scott Alan Wolckenhauer , Chloe Yuyi Wong , Jennifer R. Zhang
IPC分类号： C07D401/14 , C07D401/12 , C07D495/10 , C07D339/06 , C07C59/50 , C07D231/56 , C07C45/67 , C07D213/61 , C07D231/54
CPC分类号： C07D401/14 , C07D401/12 , C07D495/10 , C07D339/06 , C07C59/50 , C07D231/56 , C07C45/673 , C07D213/61 , C07D231/54 , C07C2602/18
摘要： The present disclosure relates to methods and intermediates useful for preparing a compound of formula I:
or a co-crystal, solvate, salt or combination thereof.-
公开(公告)号：US20200369647A1
公开(公告)日：2020-11-26
申请号：US16869653
申请日：2020-05-08
发明人： Kevin McCormack Allan , Amanda Lynn Vandehey , Gediminas Brizgys , Sachin Dhar , Ian James Doxsee , Alex Goldberg , Lars V. Heumann , Zilin Huang , Nathaniel Thomas Kadunce , Shahrokh Kazerani , Willard Lew , Vinh Xuan Ngo , Brian Michael O`Keefe , Trevor James Rainey , Benjamin James Roberts , Bing Shi , Dietrich P. Steinhuebel , Winston C. Tse , Anna Michelle Wagner , Xianghong Wang , Scott Alan Wolckenhauer , Chloe Yuyi Wong , Jennifer R. Zhang
IPC分类号： C07D401/14 , C07D401/12 , C07D495/10 , C07D339/06 , C07C59/50 , C07D231/56 , C07C45/67 , C07D213/61 , C07D231/54
摘要： The present disclosure relates to methods and intermediates useful for preparing a compound of formula I: or a co-crystal, solvate, salt or combination thereof.
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公开(公告)号：US11760746B2
公开(公告)日：2023-09-19
申请号：US17349288
申请日：2021-06-16
发明人： Sachin Dhar , Alex Goldberg , Lars V. Heumann , Zilin Huang , Vinh Xuan Ngo , Trevor James Rainey , Dietrich P. Steinhuebel , Xianghong Wang , Scott Alan Wolckenhauer
IPC分类号： C07D213/24 , C07D401/14 , C07D401/12 , C07D495/10 , C07D339/06 , C07C59/50 , C07D231/56 , C07C45/67 , C07D213/61 , C07D231/54
CPC分类号： C07D401/14 , C07C45/673 , C07C59/50 , C07D213/61 , C07D231/54 , C07D231/56 , C07D339/06 , C07D401/12 , C07D495/10 , C07C2602/18 , C07C45/673 , C07C49/427
摘要： The present disclosure relates to methods and intermediates useful for preparing a compound of formula I.
or a co-crystal, solvate, salt or combination thereof.-
公开(公告)号：US11117886B2
公开(公告)日：2021-09-14
申请号：US16869653
申请日：2020-05-08
发明人： Amanda Lynn Vandehey , Gediminas Brizgys , Vinh Xuan Ngo , Brian Michael O'Keefe , Trevor James Rainey , Bing Shi , Winston C. Tse , Anna Michelle Wagner , Xianghong Wang , Scott Alan Wolckenhauer , Jennifer R. Zhang
IPC分类号： C07D401/14 , C07D401/12 , C07D495/10 , C07D339/06 , C07C59/50 , C07D231/56 , C07C45/67 , C07D213/61 , C07D231/54
摘要： The present disclosure relates to methods and intermediates useful for preparing a compound of formula I: or a co-crystal, solvate, salt or combination thereof.
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公开(公告)号：US20190300505A1
公开(公告)日：2019-10-03
申请号：US16277552
申请日：2019-02-15
发明人： Kevin McCormack Allan , Amanda Lynn Batten , Gediminas Brizgys , Sachin Dhar , Ian James Doxsee , Alex Goldberg , Lars V. Heumann , Zilin Huang , Nathaniel Thomas Kadunce , Shahrokh Kazerani , Willard Lew , Vinh Xuan Ngo , Brian Michael O'Keefe , Trevor James Rainey , Benjamin James Roberts , Bing Shi , Dietrich P. Steinhuebel , Winston C. Tse , Anna Michelle Wagner , Xianghong Wang , Scott Alan Wolckenhauer , Chloe Yuyi Wong , Jennifer R. Zhang
IPC分类号： C07D401/14
摘要： The present disclosure relates to methods and intermediates useful for preparing a compound of formula I: or a co-crystal, solvate, salt or combination thereof.
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9.发明授权Methods for the preparation of diasteromerically pure phosphoramidate prodrugs 有权制备非特异性纯的氨基磷酸酯前体药物的方法公开(公告)号：US09487544B2
公开(公告)日：2016-11-08
申请号：US14746430
申请日：2015-06-22
IPC分类号： C07H21/00 , C07F9/24 , A61K31/7052 , A61K31/7042 , C07H1/00 , C07H19/02 , C07H19/10 , C07H19/20 , C07F9/6558 , C07F9/6561
CPC分类号： C07H1/00 , A61K31/7042 , A61K31/7052 , C07F9/2458 , C07F9/65586 , C07F9/6561 , C07F9/65616 , C07H19/02 , C07H19/10 , C07H19/20
摘要： Provided are methods and intermediates for preparing diastereomerically pure phosphoramidate prodrugs of nucleosides of Formulas Ia and Ib: The compounds of Formula Ia and Ib are useful for the treatment Hepatitis C infections.
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