公开(公告)号：US20240317676A1

公开(公告)日：2024-09-26

申请号：US18433950

申请日：2024-02-06

申请人： REATA PHARMACEUTICALS HOLDINGS, LLC

发明人： Eric ANDERSON ,  Xin JIANG ,  Melean VISNICK

IPC分类号： C07C255/47 ,  C07C271/24 ,  C07C275/26 ,  C07C275/34 ,  C07C311/07 ,  C07C311/09 ,  C07C311/10 ,  C07D209/56 ,  C07D211/44 ,  C07D231/12 ,  C07D261/08 ,  C07D261/20 ,  C07D295/195 ,  C07D295/215 ,  C07D307/20 ,  C07D333/34 ,  C07D487/08 ,  C07J63/00

CPC分类号： C07C255/47 ,  C07C271/24 ,  C07C275/26 ,  C07C275/34 ,  C07C311/07 ,  C07C311/09 ,  C07C311/10 ,  C07D209/56 ,  C07D211/44 ,  C07D231/12 ,  C07D261/08 ,  C07D261/20 ,  C07D295/195 ,  C07D295/215 ,  C07D307/20 ,  C07D333/34 ,  C07D487/08 ,  C07J63/008 ,  C07C2603/52

摘要： This invention provides, but is not limited to, novel oleanolic acid derivatives having the formula:




wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds, methods and intermediates useful for making the compounds, and methods of using the compounds and compositions.

公开(公告)号：US12065402B2

公开(公告)日：2024-08-20

申请号：US18200431

申请日：2023-05-22

申请人： Emory University

发明人： Eric Ortlund ,  Suzanne Mays ,  Nathan Jui ,  Autumn Flynn ,  Michael Dugan

IPC分类号： C07C59/54 ,  C07C35/50 ,  C07C39/23 ,  C07C43/23 ,  C07C49/683 ,  C07C49/83 ,  C07C215/70 ,  C07C255/47 ,  C07C271/34 ,  C07C307/02 ,  C07C309/66 ,  C07D249/04 ,  C07F9/09 ,  C07F9/572

CPC分类号： C07C59/54 ,  C07C35/50 ,  C07C39/23 ,  C07C43/23 ,  C07C49/683 ,  C07C49/83 ,  C07C215/70 ,  C07C255/47 ,  C07C271/34 ,  C07C307/02 ,  C07C309/66 ,  C07D249/04 ,  C07F9/091 ,  C07F9/572 ,  C07C2602/22

摘要： This disclosure relates to modulators of liver receptor homologue 1 (LRH-1) and methods of managing disease and conditions related thereto. In certain embodiments, modulators are derivatives of hexahydropentalene. In certain embodiments, this disclosure relates to methods of treating or preventing cancer, diabetes, or cardiovascular disease by administering an effective amount of a hexahydropentalene derivative disclosed herein.

公开(公告)号：US20220281807A1

公开(公告)日：2022-09-08

申请号：US17457808

申请日：2021-12-06

申请人： REATA PHARMACEUTICALS, INC.

发明人： Eric ANDERSON ,  Gary L. BOLTON ,  Bradley CAPRATHE ,  Xin JIANG ,  Chitase LEE ,  William H. ROARK ,  Melean VISNICK

IPC分类号： C07C255/47 ,  C07D239/70 ,  C07D401/04 ,  C07D403/04 ,  C07D413/04 ,  C07D417/04 ,  C07D487/04 ,  C07D231/54

摘要： Disclosed herein are novel antioxidant inflammation modulators, including those of the formula: wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds. Methods and intermediates useful for making the compounds, and methods of using the compounds and compositions thereof are also provided.

公开(公告)号：US11427533B2

公开(公告)日：2022-08-30

申请号：US16625111

申请日：2018-07-12

申请人： PLIVA HRVATSKA d.o.o.

发明人： Ivana Landeka ,  Helena Ceric

IPC分类号： C07C253/30 ,  C07C255/47

摘要： Disclosed are crystalline polymorphs of Bardoxolone methyl, and pharmaceutical compositions thereof.

公开(公告)号：US20220123217A1

公开(公告)日：2022-04-21

申请号：US17566602

申请日：2021-12-30

申请人： LG Display Co., Ltd. ,  LG Chem, Ltd.

发明人： Jungkeun KIM ,  Dohan KIM ,  Jeongdae SEO ,  Hyoseok KIM ,  Heungwoo CHOI ,  Wanpyo HONG

IPC分类号： H01L51/00 ,  H01L51/52 ,  H01L51/50 ,  C07C255/47 ,  C07D213/61 ,  C09K11/06

摘要： An organic light emitting display device is provided. The organic light emitting display device may include at least one light emitting part between an anode and a cathode, and the at least one light emitting part having at least one organic layer and a light emitting layer, wherein the at least one organic layer comprises a compound represented by Chemical Formula 1 or 2.

公开(公告)号：US20220102640A9

公开(公告)日：2022-03-31

申请号：US16892815

申请日：2020-06-04

申请人： LG Display Co., Ltd. ,  LG Chem, Ltd.

发明人： Jungkeun KIM ,  Dohan KIM ,  Jeongdae SEO ,  Hyoseok KIM ,  Heungwoo CHOI ,  Wanpyo HONG

IPC分类号： H01L51/00 ,  H01L51/52 ,  H01L51/50 ,  C07C255/47 ,  C07D213/61 ,  C09K11/06

摘要： An organic light emitting display device is provided. The organic light emitting display device may include at least one light emitting part between an anode and a cathode, and the at least one light emitting part having at least one organic layer and a light emitting layer, wherein the at least one organic layer comprises a compound represented by Chemical Formula 1 or 2.

公开(公告)号：US20210355156A1

公开(公告)日：2021-11-18

申请号：US17304778

申请日：2021-06-25

申请人： REATA PHARMACEUTICALS, INC.

发明人： Eric ANDERSON ,  Xiaofeng LIU ,  Andrea DECKER

IPC分类号： C07J63/00 ,  A61K31/277 ,  C07C255/47

摘要： The present invention relates generally to the compound: N-((4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,12a,14,14a,14b-octadecahydropicen-4a-yl)-2,2-difluoropropanamide, polymorphic forms thereof, methods for preparation and use thereof, pharmaceutical compositions thereof, and kits and articles of manufacture thereof.

公开(公告)号：US20200331828A1

公开(公告)日：2020-10-22

申请号：US16919466

申请日：2020-07-02

申请人： The Board of Trustees of the University of Illinois ,  Board of Regents of the University of Texas System

发明人： John A. Katzenellenbogen ,  Benita Katzenellenbogen ,  Sung Hoon Kim ,  Zeynep Madak-Erdogan ,  Philip Shaul

IPC分类号： C07C39/17 ,  C07C255/47 ,  C07C39/42 ,  C07C235/34 ,  C07C49/755 ,  C07C43/196 ,  C07C49/733 ,  C07C39/12 ,  C07C39/14 ,  C07C57/38 ,  C07C39/367 ,  C07C39/23 ,  A61P25/00 ,  A61P35/00 ,  C07C39/06

摘要： Provided are compounds of formulae provided herein. The compounds may include pathway-preferential estrogens (PaPEs) derivatives with tissue-selective activities. Also provided are pharmaceutical compositions comprising the compounds, as well as methods of treating a disease or condition including administering the compounds. The disease or condition may include postmenopausal symptoms, cardiovascular disease, stroke, vascular disease, bone disease, metabolic disease, arthritis, osteoporosis, obesity, vasomotor/hot flush, cognitive decline, cancer including breast cancer.

公开(公告)号：US20200299230A1

公开(公告)日：2020-09-24

申请号：US16765614

申请日：2018-11-21

申请人： BIOGEN MA INC.

发明人： Andrew George Capacci ,  Edward Yin Shiang Lin ,  Brian Stuart Lucas

IPC分类号： C07C255/47 ,  C07D317/72

摘要： Provided are compounds of Formula I, or pharmaceutically acceptable salts thereof, and methods for their use as Nrf2 activators and for their production.

公开(公告)号：US20200223791A1

公开(公告)日：2020-07-16

申请号：US16625111

申请日：2018-07-12

申请人： PLIVA HRVATSKA d.o.o.

发明人： Ivana LANDEKA ,  Helena CERIC

IPC分类号： C07C255/47 ,  C07C253/30

摘要： Disclosed are crystalline polymorphs of Bardoxolone methyl, and pharmaceutical compositions thereof.