公开(公告)号：US12195443B2

公开(公告)日：2025-01-14

申请号：US17577456

申请日：2022-01-18

Applicant: REATA PHARMACEUTICALS, INC.

Inventor： Xin Jiang ,  Christopher F. Bender ,  Melean Visnick ,  Martha R. Hotema ,  Zachary S. Sheldon ,  Chitase Lee ,  Bradley William Caprathe ,  Gary Bolton ,  Brian Kornberg

IPC: C07D401/04 ,  A61K31/517 ,  A61P29/00 ,  A61P35/00 ,  A61P37/00 ,  C07D221/04 ,  C07D239/70 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D405/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04

Abstract: Disclosed herein are compounds of the formulas: as well as analogs thereof, wherein the variables are defined herein. Also provided are pharmaceutical compositions thereof. In some aspects, the compounds and compositions provided herein may be used to inhibit RORγ and/or reduce the expression of IL-17. Also provided are methods of administering compounds and composition provided herein to a patient in need thereof, for example, for the treatment or prevention of diseases or disorders associated with inflammation or autoimmune disorders.

公开(公告)号：US11993574B2

公开(公告)日：2024-05-28

申请号：US17251295

申请日：2019-06-17

Applicant: REATA PHARMACEUTICALS, INC.

Inventor： Xin Jiang ,  Melean Visnick ,  Christopher F. Bender ,  Gary Bolton ,  Bradley Caprathe ,  Chitase Lee ,  Brian Kornberg ,  Patrick O'Brien ,  Martha R. Hotema

IPC: C07D231/54 ,  C07D235/02 ,  C07D401/04 ,  C07D401/06 ,  C07D401/10 ,  C07D401/14 ,  C07D403/04 ,  C07D403/10 ,  C07D403/14 ,  C07D405/04 ,  C07D409/04 ,  C07D413/10 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14

CPC classification number: C07D231/54 ,  C07D235/02 ,  C07D401/04 ,  C07D401/06 ,  C07D401/10 ,  C07D401/14 ,  C07D403/04 ,  C07D403/10 ,  C07D403/14 ,  C07D405/04 ,  C07D409/04 ,  C07D413/10 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14

Abstract: Disclosed herein are compounds of the formula: as well as analogs thereof, wherein the variables are defined herein. Also provided are pharmaceutical compositions thereof. In some aspects, the compounds and compositions provided herein may be used to modulate the activity of IL-17 and RORγ. Also provided are methods of administering compounds and composition provided herein to a patient in need thereof, for example, for the treatment or prevention of diseases or disorders associated with inflammation or for autoimmune disorders.

公开(公告)号：US11406648B2

公开(公告)日：2022-08-09

申请号：US17135128

申请日：2020-12-28

Applicant: REATA PHARMACEUTICALS, INC.

Inventor： Xin Jiang ,  Christopher F. Bender ,  Melean Visnick

IPC: C07D271/06 ,  C07D271/10 ,  A61K31/58 ,  C07J63/00

Abstract: Disclosed herein are novel C17-heteroaryl derivatives of oleanolic acid, including those of the formula: wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds. Methods and intermediates useful for making the compounds, and methods of using the compounds, for example, as antioxidant inflammation modulators, and compositions thereof are also provided.

公开(公告)号：US20220135534A1

公开(公告)日：2022-05-05

申请号：US17577456

申请日：2022-01-18

Applicant: REATA PHARMACEUTICALS, INC.

Inventor： Xin JIANG ,  Christopher F. BENDER ,  Melean VISNICK ,  Martha R. HOTEMA ,  Zachary S. SHELDON ,  Chitase LEE ,  Bradley William CAPRATHE ,  Gary BOLTON ,  Brian KORNBERG

IPC: C07D401/04 ,  C07D239/70 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D413/04 ,  C07D413/14 ,  C07D417/14

Abstract: Disclosed herein are compounds of the formulas: as well as analogs thereof, wherein the variables are defined herein. Also provided are pharmaceutical compositions thereof. In some aspects, the compounds and compositions provided herein may be used to inhibit RORγ and/or reduce the expression of IL-17. Also provided are methods of administering compounds and composition provided herein to a patient in need thereof, for example, for the treatment or prevention of diseases or disorders associated with inflammation or autoimmune disorders.

公开(公告)号：US11292781B2

公开(公告)日：2022-04-05

申请号：US16468054

申请日：2017-12-16

Applicant: REATA PHARMACEUTICALS, INC.

Inventor： Xin Jiang ,  Christopher F. Bender ,  Melean Visnick ,  Martha R. Hotema ,  Zachary S. Sheldon ,  Chitase Lee ,  Bradley William Caprathe ,  Gary Bolton ,  Brian Kornberg

IPC: A61P37/00 ,  C07D401/14 ,  C07D401/04 ,  C07D401/12 ,  C07D413/14 ,  C07D413/04 ,  C07D239/70 ,  C07D221/04 ,  C07D403/04 ,  C07D417/14 ,  A61P35/00 ,  A61P29/00

Abstract: Disclosed herein are compounds of the formulas: as well as analogs thereof, wherein the variables are defined herein. Also provided are pharmaceutical compositions thereof. In some aspects, the compounds and compositions provided herein may be used to inhibit RORγ and/or reduce the expression of IL-17. Also provided are methods of administering compounds and composition provided herein to a patient in need thereof, for example, for the treatment or prevention of diseases or disorders associated with inflammation or autoimmune disorders.

公开(公告)号：US20210292281A1

公开(公告)日：2021-09-23

申请号：US17251295

申请日：2019-06-17

Applicant: REATA PHARMACEUTICALS, INC.

Inventor： Xin JIANG ,  Melean VISNICK ,  Christopher F. BENDER ,  Gary BOLTON ,  Bradley CAPRATHE ,  Chitase LEE ,  Brian KORNBERG ,  Patrick O'BRIEN ,  Martha R. HOTEMA

IPC: C07D231/54 ,  C07D401/04 ,  C07D409/04 ,  C07D405/04 ,  C07D401/10 ,  C07D413/10 ,  C07D401/14 ,  C07D403/14 ,  C07D403/10 ,  C07D403/04 ,  C07D417/04 ,  C07D417/14 ,  C07D413/14 ,  C07D235/02

Abstract: Disclosed herein are compounds of the formula: as well as analogs thereof, wherein the variables are defined herein. Also provided are pharmaceutical compositions thereof. In some aspects, the compounds and compositions provided herein may be used to modulate the activity of IL-17 and RORγ. Also provided are methods of administering compounds and composition provided herein to a patient in need thereof, for example, for the treatment or prevention of diseases or disorders associated with inflammation or for autoimmune disorders.

公开(公告)号：US11091430B2

公开(公告)日：2021-08-17

申请号：US16786429

申请日：2020-02-10

Applicant: REATA PHARMACEUTICALS, INC.

Inventor： Eric Anderson ,  Xin Jiang ,  Melean Visnick

IPC: C07C255/47 ,  C07J63/00 ,  C07C275/34 ,  C07C271/24 ,  C07C275/26 ,  C07C311/09 ,  C07D261/08 ,  C07D307/20 ,  C07D487/08 ,  C07C311/07 ,  C07D209/56 ,  C07D211/44 ,  C07D231/12 ,  C07D295/195

Abstract: This invention provides, but is not limited to, novel oleanolic acid derivatives having the formula: wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds, methods and intermediates useful for making the compounds, and methods of using the compounds and compositions.

公开(公告)号：US10898499B2

公开(公告)日：2021-01-26

申请号：US16527171

申请日：2019-07-31

Applicant: REATA PHARMACEUTICALS, INC.

Inventor： Xin Jiang ,  Christopher F. Bender ,  Melean Visnick

IPC: C07J63/00 ,  C07D271/06 ,  A61K31/58 ,  C07D271/10

Abstract: Disclosed herein are novel C17-heteroaryl derivatives of oleanolic acid, including those of the formula: wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds. Methods and intermediates useful for making the compounds, and methods of using the compounds, for example, as antioxidant inflammation modulators, and compositions thereof are also provided.

公开(公告)号：US20200347088A1

公开(公告)日：2020-11-05

申请号：US16894461

申请日：2020-06-05

Applicant: Reata Pharmaceuticals, Inc.

Inventor： Xin Jiang ,  John Allen Walling ,  Melanie J. Bevill ,  Christopher S. Seadeek ,  Jared P. Smit

IPC: C07H15/207 ,  A61P3/10 ,  C07H1/06 ,  A61P25/02 ,  A61K31/7048

Abstract: Disclosed are co-crystal forms of N-(2-(5-(((2R,3R,4S,5R)-3,4-dihydroxy-5-methoxy-6,6-dimethyltetra-hydro-2H-pyran-2-yl)oxy)-3′-fluoro-[1,1′-biphenyl]-2-yl)ethyl)-acetamide and L-proline or D-proline, their pharmaceutical compositions, processes of manufacture, and methods of use for treating neurodegenerative disorders such as diabetic peripheral neuropathy.

公开(公告)号：US20200239410A1

公开(公告)日：2020-07-30

申请号：US16786429

申请日：2020-02-10

Applicant: REATA PHARMACEUTICALS, INC.

Inventor： Eric ANDERSON ,  Xin JIANG ,  Melean VISNICK

IPC: C07C255/47 ,  C07C275/34 ,  C07J63/00 ,  C07C271/24 ,  C07D261/08 ,  C07C311/09 ,  C07D211/44 ,  C07D307/20 ,  C07C275/26 ,  C07C311/07 ,  C07D487/08 ,  C07D209/56 ,  C07D295/195 ,  C07D231/12

Abstract: This invention provides, but is not limited to, novel oleanolic acid derivatives having the formula: wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds, methods and intermediates useful for making the compounds, and methods of using the compounds and compositions.