公开(公告)号：US20200347088A1

公开(公告)日：2020-11-05

申请号：US16894461

申请日：2020-06-05

申请人： Reata Pharmaceuticals, Inc.

发明人： Xin Jiang ,  John Allen Walling ,  Melanie J. Bevill ,  Christopher S. Seadeek ,  Jared P. Smit

IPC分类号： C07H15/207 ,  A61P3/10 ,  C07H1/06 ,  A61P25/02 ,  A61K31/7048

摘要： Disclosed are co-crystal forms of N-(2-(5-(((2R,3R,4S,5R)-3,4-dihydroxy-5-methoxy-6,6-dimethyltetra-hydro-2H-pyran-2-yl)oxy)-3′-fluoro-[1,1′-biphenyl]-2-yl)ethyl)-acetamide and L-proline or D-proline, their pharmaceutical compositions, processes of manufacture, and methods of use for treating neurodegenerative disorders such as diabetic peripheral neuropathy.

公开(公告)号：US10717755B2

公开(公告)日：2020-07-21

申请号：US16265256

申请日：2019-02-01

申请人： Reata Pharmaceuticals, Inc.

发明人： Xin Jiang ,  John Allen Walling ,  Melanie J. Bevill ,  Christopher S. Seadeek ,  Jared P. Smit

IPC分类号： A01N43/04 ,  A61K31/70 ,  C07H15/207 ,  A61P3/10 ,  C07H1/06 ,  A61P25/02 ,  A61K31/7048

摘要： Disclosed are co-crystal forms of N-(2-(5-(((2R,3R,4S,5R)-3,4-dihydroxy-5-methoxy-6,6-dimethyltetra-hydro-2H-pyran-2-yl)oxy)-3′-fluoro-[1,1′-biphenyl]-2-yl)ethyl)-acetamide and L-proline or D-proline, their pharmaceutical compositions, processes of manufacture, and methods of use for treating neurodegenerative disorders such as diabetic peripheral neuropathy.

公开(公告)号：US20190241599A1

公开(公告)日：2019-08-08

申请号：US16265256

申请日：2019-02-01

申请人： Reata Pharmaceuticals, Inc.

发明人： Xin Jiang ,  John Allen Walling ,  Melanie J. Bevill ,  Christopher S. Seadeek ,  Jared P. Smit

IPC分类号： C07H15/207 ,  A61P3/10 ,  A61P25/02 ,  C07H1/06

摘要： Disclosed are co-crystal forms of N-(2-(5-(((2R,3R,4S,5R)-3,4-dihydroxy-5-methoxy-6,6-dimethyltetra-hydro-2H-pyran-2-yl)oxy)-3′-fluoro-[1,1′-biphenyl]-2-yl)ethyl)-acetamide and L-proline or D-proline, their pharmaceutical compositions, processes of manufacture, and methods of use for treating neurodegenerative disorders such as diabetic peripheral neuropathy.

公开(公告)号：US20240043465A1

公开(公告)日：2024-02-08

申请号：US18168495

申请日：2023-02-13

申请人： Reata Pharmaceuticals, Inc.

发明人： Xin Jiang ,  John Allen Walling ,  Melanie J. Bevill ,  Christopher S. Seadeek ,  Jared P. Smit

IPC分类号： C07H15/207 ,  A61P3/10 ,  C07H1/06 ,  A61P25/02 ,  A61K31/7048

CPC分类号： C07H15/207 ,  A61P3/10 ,  C07H1/06 ,  A61P25/02 ,  A61K31/7048 ,  C07B2200/13

摘要： Disclosed are co-crystal forms of N-(2-(5-(((2R,3R,4S,5R)-3,4-dihydroxy-5-methoxy-6,6-dimethyltetra-hydro-2H-pyran-2-yl)oxy)-3′-fluoro-[1,1′-biphenyl]-2-yl)ethyl)-acetamide and L-proline or D-proline, their pharmaceutical compositions, processes of manufacture, and methods of use for treating neurodegenerative disorders such as diabetic peripheral neuropathy.