公开(公告)号：US11993574B2

公开(公告)日：2024-05-28

申请号：US17251295

申请日：2019-06-17

申请人： REATA PHARMACEUTICALS, INC.

发明人： Xin Jiang ,  Melean Visnick ,  Christopher F. Bender ,  Gary Bolton ,  Bradley Caprathe ,  Chitase Lee ,  Brian Kornberg ,  Patrick O'Brien ,  Martha R. Hotema

IPC分类号： C07D231/54 ,  C07D235/02 ,  C07D401/04 ,  C07D401/06 ,  C07D401/10 ,  C07D401/14 ,  C07D403/04 ,  C07D403/10 ,  C07D403/14 ,  C07D405/04 ,  C07D409/04 ,  C07D413/10 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14

CPC分类号： C07D231/54 ,  C07D235/02 ,  C07D401/04 ,  C07D401/06 ,  C07D401/10 ,  C07D401/14 ,  C07D403/04 ,  C07D403/10 ,  C07D403/14 ,  C07D405/04 ,  C07D409/04 ,  C07D413/10 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14

摘要： Disclosed herein are compounds of the formula: as well as analogs thereof, wherein the variables are defined herein. Also provided are pharmaceutical compositions thereof. In some aspects, the compounds and compositions provided herein may be used to modulate the activity of IL-17 and RORγ. Also provided are methods of administering compounds and composition provided herein to a patient in need thereof, for example, for the treatment or prevention of diseases or disorders associated with inflammation or for autoimmune disorders.

公开(公告)号：US11406648B2

公开(公告)日：2022-08-09

申请号：US17135128

申请日：2020-12-28

申请人： REATA PHARMACEUTICALS, INC.

发明人： Xin Jiang ,  Christopher F. Bender ,  Melean Visnick

IPC分类号： C07D271/06 ,  C07D271/10 ,  A61K31/58 ,  C07J63/00

摘要： Disclosed herein are novel C17-heteroaryl derivatives of oleanolic acid, including those of the formula: wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds. Methods and intermediates useful for making the compounds, and methods of using the compounds, for example, as antioxidant inflammation modulators, and compositions thereof are also provided.

公开(公告)号：US11292781B2

公开(公告)日：2022-04-05

申请号：US16468054

申请日：2017-12-16

申请人： REATA PHARMACEUTICALS, INC.

发明人： Xin Jiang ,  Christopher F. Bender ,  Melean Visnick ,  Martha R. Hotema ,  Zachary S. Sheldon ,  Chitase Lee ,  Bradley William Caprathe ,  Gary Bolton ,  Brian Kornberg

IPC分类号： A61P37/00 ,  C07D401/14 ,  C07D401/04 ,  C07D401/12 ,  C07D413/14 ,  C07D413/04 ,  C07D239/70 ,  C07D221/04 ,  C07D403/04 ,  C07D417/14 ,  A61P35/00 ,  A61P29/00

摘要： Disclosed herein are compounds of the formulas: as well as analogs thereof, wherein the variables are defined herein. Also provided are pharmaceutical compositions thereof. In some aspects, the compounds and compositions provided herein may be used to inhibit RORγ and/or reduce the expression of IL-17. Also provided are methods of administering compounds and composition provided herein to a patient in need thereof, for example, for the treatment or prevention of diseases or disorders associated with inflammation or autoimmune disorders.

公开(公告)号：US10898499B2

公开(公告)日：2021-01-26

申请号：US16527171

申请日：2019-07-31

申请人： REATA PHARMACEUTICALS, INC.

发明人： Xin Jiang ,  Christopher F. Bender ,  Melean Visnick

IPC分类号： C07J63/00 ,  C07D271/06 ,  A61K31/58 ,  C07D271/10

摘要： Disclosed herein are novel C17-heteroaryl derivatives of oleanolic acid, including those of the formula: wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds. Methods and intermediates useful for making the compounds, and methods of using the compounds, for example, as antioxidant inflammation modulators, and compositions thereof are also provided.

公开(公告)号：US09512094B2

公开(公告)日：2016-12-06

申请号：US14566827

申请日：2014-12-11

申请人： REATA PHARMACEUTICALS, INC.

发明人： Xin Jiang ,  Christopher F. Bender ,  Melean Visnick

IPC分类号： C07D271/10 ,  C07D271/06 ,  C07J63/00

CPC分类号： A61K31/58 ,  C07D271/06 ,  C07D271/10 ,  C07J63/008

摘要： Disclosed herein are novel C17-heteroaryl derivatives of oleanolic acid, including those of the formula: wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds. Methods and intermediates useful for making the compounds, and methods of using the compounds, for example, as antioxidant inflammation modulators, and compositions thereof are also provided.

公开(公告)号：US09593074B2

公开(公告)日：2017-03-14

申请号：US14022986

申请日：2013-09-10

申请人： REATA PHARMACEUTICALS, INC.

发明人： Christopher F. Bender ,  Xin Jiang ,  Eric Anderson ,  Melean Visnick

IPC分类号： C07C255/47 ,  C07J63/00 ,  C07D207/08 ,  C07D207/12 ,  C07D211/46 ,  C07D213/75 ,  C07D233/90 ,  C07D295/205 ,  C07D305/08

CPC分类号： C07J63/008 ,  C07C255/47 ,  C07D207/08 ,  C07D207/12 ,  C07D211/46 ,  C07D213/75 ,  C07D233/90 ,  C07D295/205 ,  C07D305/08

摘要： Disclosed herein are novel C17-alkanediyl and alkenediyl derivatives of oleanolic acid, including those of the formula: wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds. Methods and intermediates useful for making the compounds, and methods of using the compounds, for example, as antioxidant inflammation modulators, and compositions thereof are also provided.

摘要翻译： 本文公开了齐墩果酸的新C17-烷二基和亚烯基二基衍生物，包括下式的那些：其中变量在本文中定义。 还提供了包含这些化合物的药物组合物，试剂盒和制品。 还提供了可用于制备化合物的方法和中间体，以及使用该化合物的方法，例如抗氧化剂炎症调节剂及其组合物。

公开(公告)号：US09556222B2

公开(公告)日：2017-01-31

申请号：US14406854

申请日：2013-06-14

申请人： REATA PHARMACEUTICALS, INC.

发明人： Eric Anderson ,  Christopher F. Bender ,  Xin Jiang ,  Xiaofeng Liu ,  Haizhou Sun ,  Melean Visnick

IPC分类号： C07J71/00 ,  C07J75/00 ,  C07D493/22 ,  A61K31/336 ,  C07J63/00

CPC分类号： C07J71/001 ,  A61K31/336 ,  C07D493/22 ,  C07J63/008 ,  C07J75/00

摘要： Disclosed herein are novel A-ring epoxidized triterpenoid compounds and derivatives thereof, including those of the formula (I), wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits, and articles of manufacture comprising such compounds. Methods and intermediates useful for making the compounds, and methods of using the compounds, for example as antioxidant inflammation modulators, and compositions thereof are also provided.

摘要翻译： 本文公开了新型的A环环氧化三萜化合物及其衍生物，包括式（I）的那些，其中变量在本文中定义。 还提供了包含这些化合物的药物组合物，试剂盒和制品。 还提供了可用于制备化合物的方法和中间体，以及使用化合物的方法，例如抗氧化剂炎症调节剂及其组合物。

公开(公告)号：US09278912B2

公开(公告)日：2016-03-08

申请号：US14023180

申请日：2013-09-10

申请人： REATA PHARMACEUTICALS, INC.

发明人： Xin Jiang ,  Christopher F. Bender ,  Melean Visnick

IPC分类号： A61K31/343 ,  A61K31/16 ,  A61K31/122 ,  C07C69/74 ,  C07C233/58 ,  C07C35/44 ,  C07D307/00 ,  C07C255/47 ,  C07J63/00

CPC分类号： C07C255/47 ,  C07D307/00 ,  C07J63/008

摘要： Disclosed herein are novel C13-hydroxy derivatives of oleanolic acid, including those of the formula: wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds. Methods and intermediates useful for making the compounds, and methods of using the compounds, for example, as antioxidant inflammation modulators, and compositions thereof are also provided.

摘要翻译： 本文公开了齐墩果酸的新C13-羟基衍生物，包括下式的那些：其中变量在本文中定义。 还提供了包含这些化合物的药物组合物，试剂盒和制品。 还提供了可用于制备化合物的方法和中间体，以及使用该化合物的方法，例如抗氧化剂炎症调节剂及其组合物。

公开(公告)号：US11059792B2

公开(公告)日：2021-07-13

申请号：US15548909

申请日：2016-02-12

申请人： REATA PHARMACEUTICALS, INC.

发明人： Xin Jiang ,  Bradley William Caprathe ,  Chitase Lee ,  Gary Bolton ,  Christopher F. Bender ,  Melean Visnick

IPC分类号： C07D235/08 ,  A61P29/00 ,  C07D235/02 ,  C07D235/10 ,  C07D235/12 ,  C07D401/04 ,  C07D403/04 ,  C07D403/10 ,  C07D403/14 ,  C07C235/02

摘要： Disclosed herein are compounds of the formula: (I), wherein the variables are defined herein. Also provided are pharmaceutical compositions thereof. In some aspects, the compounds and compositions provided herein may be used as antioxidant inflammation modulators. In some aspects, the present disclosure provides methods wherein the compounds and composition described herein are used for the treatment of diseases and disorders associated with inflammation and cancer.

公开(公告)号：US20150148384A1

公开(公告)日：2015-05-28

申请号：US14406854

申请日：2013-06-14

申请人： REATA PHARMACEUTICALS, INC.

发明人： Eric Anderson ,  Christopher F. Bender ,  Xin Jiang ,  Xiaofeng Liu ,  Haizhou Sun ,  Melean Visnick

IPC分类号： C07J71/00

CPC分类号： C07J71/001 ,  A61K31/336 ,  C07D493/22 ,  C07J63/008 ,  C07J75/00

摘要： Disclosed herein are novel A-ring epoxidized triterpenoid compounds and derivatives thereof, including those of the formula (I), wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits, and articles of manufacture comprising such compounds. Methods and intermediates useful for making the compounds, and methods of using the compounds, for example as antioxidant inflammation modulators, and compositions thereof are also provided.

摘要翻译： 本文公开了新型的A环环氧化三萜化合物及其衍生物，包括式（I）的那些，其中变量在本文中定义。 还提供了包含这些化合物的药物组合物，试剂盒和制品。 还提供了可用于制备化合物的方法和中间体，以及使用化合物的方法，例如抗氧化剂炎症调节剂及其组合物。