公开(公告)号：US20190153022A1

公开(公告)日：2019-05-23

申请号：US15760662

申请日：2016-09-23

Applicant: REATA PHARMACEUTICALS, INC.

Inventor： Melean VISNICK ,  Xin JIANG ,  Martha R. HOTEMA ,  Chitase LEE ,  Bradley William CAPRATHE ,  William H. ROARK ,  Gary L. BOLTON

IPC: C07J63/00 ,  C07J71/00 ,  A61P29/00

Abstract: Disclosed herein are C4 modified oleanolic acid derivatives of the formula: Formula (X) or Formula (XII), as well as analogs thereof, wherein the variables are defined herein. In addition, disclosed herein are pharmaceutical compositions of these derivatives or analogs, methods for their manufacture, and methods for their use, including for the prevention and treatment of diseases or disorders associated with overproduction of IL-17.

公开(公告)号：US20230250130A1

公开(公告)日：2023-08-10

申请号：US18149696

申请日：2023-01-04

Applicant: REATA PHARMACEUTICALS, INC.

Inventor： Melean VISNICK ,  Xin JIANG ,  Martha R. HOTEMA ,  Chitase LEE ,  Bradley William CAPRATHE ,  William H. ROARK ,  Gary L. BOLTON

IPC: C07J63/00 ,  C07J71/00 ,  A61P29/00

CPC classification number: C07J63/008 ,  C07J71/0005 ,  A61P29/00

Abstract: Disclosed herein are C4 modified oleanolic acid derivatives of the formula:




as well as analogs thereof, wherein the variables are defined herein. In addition, disclosed herein are pharmaceutical compositions of these derivatives or analogs, methods for their manufacture, and methods for their use, including for the prevention and treatment of diseases or disorders associated with overproduction of IL-17.

公开(公告)号：US20220135534A1

公开(公告)日：2022-05-05

申请号：US17577456

申请日：2022-01-18

Applicant: REATA PHARMACEUTICALS, INC.

Inventor： Xin JIANG ,  Christopher F. BENDER ,  Melean VISNICK ,  Martha R. HOTEMA ,  Zachary S. SHELDON ,  Chitase LEE ,  Bradley William CAPRATHE ,  Gary BOLTON ,  Brian KORNBERG

IPC: C07D401/04 ,  C07D239/70 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D413/04 ,  C07D413/14 ,  C07D417/14

Abstract: Disclosed herein are compounds of the formulas: as well as analogs thereof, wherein the variables are defined herein. Also provided are pharmaceutical compositions thereof. In some aspects, the compounds and compositions provided herein may be used to inhibit RORγ and/or reduce the expression of IL-17. Also provided are methods of administering compounds and composition provided herein to a patient in need thereof, for example, for the treatment or prevention of diseases or disorders associated with inflammation or autoimmune disorders.

公开(公告)号：US20210292281A1

公开(公告)日：2021-09-23

申请号：US17251295

申请日：2019-06-17

Applicant: REATA PHARMACEUTICALS, INC.

Inventor： Xin JIANG ,  Melean VISNICK ,  Christopher F. BENDER ,  Gary BOLTON ,  Bradley CAPRATHE ,  Chitase LEE ,  Brian KORNBERG ,  Patrick O'BRIEN ,  Martha R. HOTEMA

IPC: C07D231/54 ,  C07D401/04 ,  C07D409/04 ,  C07D405/04 ,  C07D401/10 ,  C07D413/10 ,  C07D401/14 ,  C07D403/14 ,  C07D403/10 ,  C07D403/04 ,  C07D417/04 ,  C07D417/14 ,  C07D413/14 ,  C07D235/02

Abstract: Disclosed herein are compounds of the formula: as well as analogs thereof, wherein the variables are defined herein. Also provided are pharmaceutical compositions thereof. In some aspects, the compounds and compositions provided herein may be used to modulate the activity of IL-17 and RORγ. Also provided are methods of administering compounds and composition provided herein to a patient in need thereof, for example, for the treatment or prevention of diseases or disorders associated with inflammation or for autoimmune disorders.

公开(公告)号：US20240360084A1

公开(公告)日：2024-10-31

申请号：US18633495

申请日：2024-04-11

Applicant: REATA PHARMACEUTICALS, INC.

Inventor： Xin JIANG ,  Melean VISNICK ,  Christopher F. BENDER ,  Gary BOLTON ,  Bradley CAPRATHE ,  Chitase LEE ,  Brian KORNBERG ,  Patrick O'BRIEN ,  Martha R. HOTEMA

IPC: C07D231/54 ,  C07D235/02 ,  C07D401/04 ,  C07D401/06 ,  C07D401/10 ,  C07D401/14 ,  C07D403/04 ,  C07D403/10 ,  C07D403/14 ,  C07D405/04 ,  C07D409/04 ,  C07D413/10 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14

CPC classification number: C07D231/54 ,  C07D235/02 ,  C07D401/04 ,  C07D401/06 ,  C07D401/10 ,  C07D401/14 ,  C07D403/04 ,  C07D403/10 ,  C07D403/14 ,  C07D405/04 ,  C07D409/04 ,  C07D413/10 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14

Abstract: Disclosed herein are compounds of the formula:




as well as analogs thereof, wherein the variables are defined herein. Also provided are pharmaceutical compositions thereof. In some aspects, the compounds and compositions provided herein may be used to modulate the activity of IL-17 and RORγ. Also provided are methods of administering compounds and composition provided herein to a patient in need thereof, for example, for the treatment or prevention of diseases or disorders associated with inflammation or for autoimmune disorders.