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公开(公告)号：US08029988B2
公开(公告)日：2011-10-04
申请号：US11987555
申请日：2007-11-30
Applicant: Andreas Crameri , Willem P. C. Stemmer , Jeremy Minshull , Steven H. Bass , Mark Welch , Jon E. Ness , Claes Gustafsson , Phillip A. Patten
Inventor： Andreas Crameri , Willem P. C. Stemmer , Jeremy Minshull , Steven H. Bass , Mark Welch , Jon E. Ness , Claes Gustafsson , Phillip A. Patten
CPC classification number: C12P21/06
Abstract: Methods of recombining nucleic acids, including homologous nucleic acids, are provided. Families of gene shuffling oligonucleotides and their use in recombination procedures, as well as polymerase and ligase mediated recombination methods are also provided.
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公开(公告)号：US07853410B2
公开(公告)日：2010-12-14
申请号：US11975638
申请日：2007-10-18
Applicant: Sergey A. Selifonov , Willem P. C. Stemmer , Claes Gustafsson , Matthew Tobin , Stephen del Cardayre , Phillip A. Patten , Jeremy Minshull , Lorraine J. Giver
Inventor： Sergey A. Selifonov , Willem P. C. Stemmer , Claes Gustafsson , Matthew Tobin , Stephen del Cardayre , Phillip A. Patten , Jeremy Minshull , Lorraine J. Giver
CPC classification number: G06F19/16 , B01J2219/007 , C40B50/02 , G06F19/14 , G06F19/18 , G06F19/22 , G06F19/24
Abstract: In silico nucleic acid recombination methods, related integrated systems utilizing genetic operators and libraries made by in silico shuffling methods are provided.
Abstract translation: 在硅胶核酸重组方法中，提供了利用遗传算子和通过计算机改组方法制备的文库的相关综合系统。
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公开(公告)号：US07803907B2
公开(公告)日：2010-09-28
申请号：US11155989
申请日：2005-06-17
Applicant: Willem P. C. Stemmer , D. Victor Perlroth , Sanjeev Satyal , Benjamin M. Alba , Alice Bakker , Amy N. Duguay , Qiang Liu , Joshua Silverman , Richard Smith , Candace Swimmer
Inventor： Willem P. C. Stemmer , D. Victor Perlroth , Sanjeev Satyal , Benjamin M. Alba , Alice Bakker , Amy N. Duguay , Qiang Liu , Joshua Silverman , Richard Smith , Candace Swimmer
CPC classification number: C07K14/47 , A61K38/00 , C07K14/705 , G01N33/566 , G01N33/574 , G01N2333/4753 , G01N2333/82 , G01N2500/00
Abstract: Polypeptides comprising monomer domains that bind to c-MET, or portions thereof, are provided.
Abstract translation: 提供了包含与c-MET结合的单体结构域的多肽或其部分。
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公开(公告)号：US07776598B2
公开(公告)日：2010-08-17
申请号：US12069011
申请日：2008-02-05
Applicant: Phillip A. Patten , Willem P. C. Stemmer
Inventor： Phillip A. Patten , Willem P. C. Stemmer
CPC classification number: C12N15/1031 , A61K38/45 , A61K48/00 , C07K14/43595 , C07K14/545 , C07K14/56 , C07K16/00 , C07K2317/565 , C07K2317/622 , C12N7/00 , C12N9/0069 , C12N9/1007 , C12N9/16 , C12N9/86 , C12N15/10 , C12N15/1027 , C12N15/1034 , C12N15/1037 , C12N15/1058 , C12N15/52 , C12N15/64 , C12N15/67 , C12N2795/14043 , C12N2795/14143 , C12Q1/6811 , C12Q1/6853 , C12Q1/686 , C40B40/02 , C40B40/08 , C40B50/06 , G01N33/68 , G01N33/6845
Abstract: Methods are provided for the evolution of proteins of industrial and pharmaceutical interest, including methods for effecting recombination and selection. Compositions produced by these methods are also disclosed.
Abstract translation: 提供了用于工业和药物兴趣的蛋白质进化的方法，包括用于进行重组和选择的方法。 还公开了通过这些方法制备的组合物。
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公开(公告)号：US07629170B2
公开(公告)日：2009-12-08
申请号：US11506215
申请日：2006-08-17
Applicant: Stephen delCardayre , Matthew B. Tobin , Willem P. C. Stemmer , Jon E. Ness , Jeremy S. Minshull , Phillip A. Patten , Venkiteswatan Mani Subramanian , Linda A. Castle , Claus M. Krebber , Steven H. Bass , Ying-Xin Zhang , Anthony R. Cox , Gjalt W. Huisman , Ling Yuan , Joseph A. Affholter
Inventor： Stephen delCardayre , Matthew B. Tobin , Willem P. C. Stemmer , Jon E. Ness , Jeremy S. Minshull , Phillip A. Patten , Venkiteswatan Mani Subramanian , Linda A. Castle , Claus M. Krebber , Steven H. Bass , Ying-Xin Zhang , Anthony R. Cox , Gjalt W. Huisman , Ling Yuan , Joseph A. Affholter
CPC classification number: C12R1/465 , A01K2267/02 , C07K14/245 , C12N15/1027 , C12N15/8271 , C12N15/8273 , C12N15/8279 , C12N15/90 , C12P17/162 , C12Q1/6811 , C12Q1/6827
Abstract: The invention provides methods employing iterative cycles of recombination and selection/screening for evolution of whole cells and organisms toward acquisition of desired properties. Examples of such properties include enhanced recombinogenicity, genome copy number, and capacity for expression and/or secretion of proteins and secondary metabolites.
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Patent Agency Ranking
公开(公告)号：US07534564B2
公开(公告)日：2009-05-19
申请号：US10646221
申请日：2003-08-22
Applicant: Phillip A. Patten , Willem P. C. Stemmer
Inventor： Phillip A. Patten , Willem P. C. Stemmer
CPC classification number: C12N15/1031 , A61K38/45 , A61K48/00 , C07K14/43595 , C07K14/545 , C07K14/56 , C07K16/00 , C07K2317/565 , C07K2317/622 , C12N7/00 , C12N9/0069 , C12N9/1007 , C12N9/16 , C12N9/86 , C12N15/10 , C12N15/1027 , C12N15/1034 , C12N15/1037 , C12N15/1058 , C12N15/52 , C12N15/64 , C12N15/67 , C12N2795/14043 , C12N2795/14143 , C12Q1/6811 , C12Q1/6853 , C12Q1/686 , C40B40/02 , C40B40/08 , C40B50/06 , G01N33/68 , G01N33/6845
Abstract: Methods are provided for the evolution of proteins of industrial and pharmaceutical interest, including methods for effecting recombination and selection. Compositions produced by these methods are also disclosed.
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公开(公告)号：US06946296B2
公开(公告)日：2005-09-20
申请号：US09954692
申请日：2001-09-12
Applicant: Phillip A. Patten , Willem P. C. Stemmer
Inventor： Phillip A. Patten , Willem P. C. Stemmer
IPC: C12N15/09 , A61K38/45 , A61K48/00 , C07K14/435 , C07K14/47 , C07K14/545 , C07K14/56 , C07K16/00 , C12N7/00 , C12N9/02 , C12N9/10 , C12N9/12 , C12N9/38 , C12N9/86 , C12N15/10 , C12N15/52 , C12N15/64 , C12P21/02 , C12Q1/68 , C40B40/02 , G01N33/68 , C12N15/00 , C07H21/02 , C07H21/04
CPC classification number: C12N15/1031 , A61K38/45 , A61K48/00 , C07K14/43595 , C07K14/545 , C07K14/56 , C07K16/00 , C07K2317/565 , C07K2317/622 , C12N7/00 , C12N9/0069 , C12N9/1007 , C12N9/16 , C12N9/86 , C12N15/10 , C12N15/1027 , C12N15/1034 , C12N15/1037 , C12N15/1058 , C12N15/52 , C12N15/64 , C12N15/67 , C12N2795/14043 , C12N2795/14143 , C12Q1/6811 , C12Q1/6853 , C12Q1/686 , C40B40/02 , C40B40/08 , C40B50/06 , G01N33/68 , G01N33/6845
Abstract: Methods are provided for the evolution of proteins of industrial and pharmaceutical interest, including methods for effecting recombination and selection. Compositions produced by these methods are also disclosed.
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8.发明授权Methods for making character strings, polynucleotides and polypeptides having desired characteristics 有权制备具有所需特征的字符串，多核苷酸和多肽的方法公开(公告)号：US06917882B2
公开(公告)日：2005-07-12
申请号：US09494282
申请日：2000-01-18
Applicant: Sergey A. Selifonov , Willem P. C. Stemmer , Claes Gustafsson , Matthew Tobin , Stephen del Cardayre , Phillip A. Patten , Jeremy Minshull
Inventor： Sergey A. Selifonov , Willem P. C. Stemmer , Claes Gustafsson , Matthew Tobin , Stephen del Cardayre , Phillip A. Patten , Jeremy Minshull
IPC: A61K39/00 , C07K14/16 , C07K14/505 , C07K14/535 , C12N9/16 , C12N15/10 , C12N15/11 , G06F19/00 , G01N33/48 , C07H21/02 , C07H21/04 , C12Q1/00 , C12Q1/48 , C12Q1/68
CPC classification number: C12N15/1031 , A61K39/00 , C07K14/005 , C07K14/505 , C07K14/535 , C12N9/16 , C12N15/1027 , C12N15/11 , C12N2740/16122
Abstract: “In silico” nucleic acid recombination methods, related integrated systems utilizing genetic operators and libraries made by in silico shuffling methods are provided.
Abstract translation: 提供了“计算机”核酸重组方法，利用遗传算子和利用计算机混洗方法制作的图书馆的相关综合系统。
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公开(公告)号：US06413774B1
公开(公告)日：2002-07-02
申请号：US09240734
申请日：1999-01-29
Applicant: Willem P. C. Stemmer , Andreas M. Cramieri
Inventor： Willem P. C. Stemmer , Andreas M. Cramieri
IPC: C12N1500
CPC classification number: C40B40/02 , C07K14/43595 , C07K14/545 , C07K16/00 , C07K2317/565 , C07K2317/622 , C12N9/2471 , C12N9/86 , C12N15/1027 , C12N15/1034 , C12N15/1037 , C12N15/1058 , C12N15/52 , C12N15/64 , C12Q1/68 , C12Q1/6811 , C12Y302/01023 , C12Y305/02006 , H01L39/228 , C12Q2525/179
Abstract: A method for DNA reassembly after random fragmentation, and its application to mutagenesis of nucleic acid sequences by in vitro or in vivo recombination is described. In particular, a method for the production of nucleic acid fragments or polynucleotides encoding mutant proteins is described. The present invention also relates to a method of repeated cycles of mutagenesis, shuffling and selection which allow for the directed molecular evolution in vitro or in vivo of proteins.
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公开(公告)号：US06413745B1
公开(公告)日：2002-07-02
申请号：US09723520
申请日：2000-11-27
Applicant: Phillip A. Patten , Volker Heinrichs , Willem P. C. Stemmer
Inventor： Phillip A. Patten , Volker Heinrichs , Willem P. C. Stemmer
IPC: C12P2106
CPC classification number: C12N15/8274 , C12N15/10 , C12N15/1027 , C12N15/8216 , C12N15/8289 , Y10T436/143333
Abstract: Methods of modulating, tuning and improving hybridization properties and recombination properties of molecules for use in nucleic acid shuffling procedures, relates recombination mixtures and methods of modulating, tuning, improving and evolving splicing of RNAs and proteins are provided.
Abstract translation: 调节，调节和改进用于核酸洗牌过程的分子的杂交性质和重组性质的方法涉及重组混合物，并且提供调节，调节，改进和进化的RNA和蛋白质剪接的方法。
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