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1.发明授权Methods for identifying sets of oligonucleotides for use in an in vitro recombination procedure 有权用于鉴定用于体外重组程序的寡核苷酸组的方法公开(公告)号：US07620502B2
公开(公告)日：2009-11-17
申请号：US11339090
申请日：2006-01-24
Applicant: Sergey A. Selifonov , Willem P. C. Stemmer , Claes Gustafsson , Matthew Tobin , Stephen del Cardayre , Phillip A. Patten , Jeremy Minshull , Lorraine J. Giver
Inventor： Sergey A. Selifonov , Willem P. C. Stemmer , Claes Gustafsson , Matthew Tobin , Stephen del Cardayre , Phillip A. Patten , Jeremy Minshull , Lorraine J. Giver
CPC classification number: G06F19/16 , B01J2219/007 , C40B50/02 , G06F19/14 , G06F19/18 , G06F19/22 , G06F19/24
Abstract: In silico nucleic acid recombination methods, related integrated systems utilizing genetic operators are used to identify sets of oligonucleotides for in vitro recombination.
Abstract translation: 在计算机核酸重组方法中，利用遗传算子的相关综合系统用于鉴定用于体外重组的寡核苷酸组。
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公开(公告)号：US07957912B2
公开(公告)日：2011-06-07
申请号：US12557463
申请日：2009-09-10
Applicant: Sergey A. Selifonov , Willem P. C. Stemmer , Claes Gustafsson , Matthew Tobin , Stephen del Cardayre , Phillip A. Patten , Jeremy Minshull , Lorraine J. Giver
Inventor： Sergey A. Selifonov , Willem P. C. Stemmer , Claes Gustafsson , Matthew Tobin , Stephen del Cardayre , Phillip A. Patten , Jeremy Minshull , Lorraine J. Giver
CPC classification number: G06F19/16 , B01J2219/007 , C40B50/02 , G06F19/14 , G06F19/18 , G06F19/22 , G06F19/24
Abstract: In silico nucleic acid recombination methods, related integrated systems utilizing genetic operators and libraries made by in silico shuffling methods are provided. One disclosed method involves identifying and producing a polypeptide. The method may involve (a) receiving data identifying sequences of two or more parental polypeptides or parental nucleic acids that encode the polypeptides; (b) selecting one or more cross-over sites on the sequences thereby defining one or more recombinant polypeptides or recombinant nucleic acids; (c) selecting at least one of the recombinant polypeptides or recombinant nucleic acids; (d) recombining one or more oligonucleotides, at least one of which has a sequence matching some or all of that of the recombinant polypeptides or recombinant nucleic acids selected in (c); (e) selecting at least some of the recombined oligonucleotides produced in (d); and (f) producing a polypeptide encoded by the selected nucleic acid.
Abstract translation: 在硅胶核酸重组方法中，提供了利用遗传算子和通过计算机改组方法制备的文库的相关综合系统。 一种公开的方法涉及鉴定和产生多肽。 该方法可以包括（a）接收识别编码多肽的两个或多个亲本多肽或亲本核酸的序列的数据; （b）在序列上选择一个或多个交叉位点，从而限定一个或多个重组多肽或重组核酸; （c）选择至少一种重组多肽或重组核酸; （d）重组一种或多种寡核苷酸，其中至少一种具有与（c）中选择的重组多肽或重组核酸的部分或全部相匹配的序列; （e）选择（d）中产生的至少一些重组寡核苷酸; 和（f）产生由所选择的核酸编码的多肽。
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3.发明申请METHODS FOR IDENTIFYING SETS OF OLIGONUCLEOTIDES FOR USE IN AN IN VITRO RECOMBINATION PROCEDURE 有权用于鉴定体外重组程序中使用寡核苷酸的方法公开(公告)号：US20100056385A1
公开(公告)日：2010-03-04
申请号：US12557463
申请日：2009-09-10
Applicant: Sergey A. Selifonov , Willem P.C. Stemmer , Claes Gustafsson , Matthew Tobin , Stephen del Cardayre , Phillip A. Patten , Jeremy Minshull , Lorraine J. Giver
Inventor： Sergey A. Selifonov , Willem P.C. Stemmer , Claes Gustafsson , Matthew Tobin , Stephen del Cardayre , Phillip A. Patten , Jeremy Minshull , Lorraine J. Giver
IPC: C40B30/02
CPC classification number: G06F19/16 , B01J2219/007 , C40B50/02 , G06F19/14 , G06F19/18 , G06F19/22 , G06F19/24
Abstract: In silico nucleic acid recombination methods, related integrated systems utilizing genetic operators and libraries made by in silico shuffling methods are provided.
Abstract translation: 在硅胶核酸重组方法中，提供了利用遗传算子和通过计算机改组方法制备的文库的相关综合系统。
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4.发明申请公开(公告)号：US20070026446A1
公开(公告)日：2007-02-01
申请号：US11506215
申请日：2006-08-17
Applicant: Stephen del Cardayre , Matthew Tobin , Willem Stemmer , Jon Ness , Jeremy Minshull , Phillip Patten , Venkiteswaran Subramanian , Linda Castle , Claus Krebber , Steven Bass , Ying-Xin Zhang , Tony Cox , Gjalt Huisman , Ling Yuan , Joseph Affholter
Inventor： Stephen del Cardayre , Matthew Tobin , Willem Stemmer , Jon Ness , Jeremy Minshull , Phillip Patten , Venkiteswaran Subramanian , Linda Castle , Claus Krebber , Steven Bass , Ying-Xin Zhang , Tony Cox , Gjalt Huisman , Ling Yuan , Joseph Affholter
CPC classification number: C12R1/465 , A01K2267/02 , C07K14/245 , C12N15/1027 , C12N15/8271 , C12N15/8273 , C12N15/8279 , C12N15/90 , C12P17/162 , C12Q1/6811 , C12Q1/6827
Abstract: The invention provides methods employing iterative cycles of recombination and selection/screening for evolution of whole cells and organisms toward acquisition of desired properties. Examples of such properties include enhanced recombinogenicity, genome copy number, and capacity for expression and/or secretion of proteins and secondary metabolites.
Abstract translation: 本发明提供了采用迭代循环重组和选择/筛选全细胞和生物体以获得所需性质的方法的方法。 这些性质的实例包括增加的重组原性，基因组拷贝数以及蛋白质和次级代谢物的表达和/或分泌能力。
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5.发明申请METHODS FOR IDENTIFYING SETS OF OLIGONUCLEOTIDES FOR USE IN AN IN VITRO RECOMBINATION PROCEDURE 审中-公开用于鉴定体外重组程序中使用寡核苷酸的方法公开(公告)号：US20110257892A1
公开(公告)日：2011-10-20
申请号：US13095797
申请日：2011-04-27
Applicant: Sergey A. Selifonov , Willem P.C. Stemmer , Claes Gustafsson , Matthew Tobin , Stephen del Cardayre , Phillip A. Patten , Jeremy Minshull , Lorraine J. Giver
Inventor： Sergey A. Selifonov , Willem P.C. Stemmer , Claes Gustafsson , Matthew Tobin , Stephen del Cardayre , Phillip A. Patten , Jeremy Minshull , Lorraine J. Giver
IPC: G06F19/00
CPC classification number: G16B20/00 , B01J2219/007 , G16B10/00 , G16B15/00 , G16B30/00 , G16B35/00 , G16B40/00 , G16C20/60
Abstract: In silico nucleic acid recombination methods, related integrated systems utilizing genetic operators and libraries made by in silico shuffling methods are provided.
Abstract translation: 在硅胶核酸重组方法中，提供了利用遗传算子和通过计算机改组方法制备的文库的相关综合系统。
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Patent Agency Ranking
公开(公告)号：US20100199548A1
公开(公告)日：2010-08-12
申请号：US12278964
申请日：2008-07-02
Applicant: Stephen del Cardayre , Michael Charles Milner Cockrem
Inventor： Stephen del Cardayre , Michael Charles Milner Cockrem
Abstract: Disclosed herein are various embodiments regarding the use of impure and/or unrefined alcohol in the production of fatty esters. Various production hosts that are capable of producing a fatty ester from an impure or unrefined alcohol are also disclosed.
Abstract translation: 本文公开了关于在制备脂肪酯中使用不纯和/或未精制的醇的各种实施方案。 还公开了能够从不纯或未精制的醇生产脂肪酯的各种生产主体。
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公开(公告)号：US07421347B2
公开(公告)日：2008-09-02
申请号：US11075231
申请日：2005-03-07
Applicant: Sergey A. Selifonov , Willem P. C. Stemmer , Claes Gustafsson , Matthew Tobin , Stephen del Cardayre , Phillip A. Patten , Jeremy Minshull
Inventor： Sergey A. Selifonov , Willem P. C. Stemmer , Claes Gustafsson , Matthew Tobin , Stephen del Cardayre , Phillip A. Patten , Jeremy Minshull
CPC classification number: C12N15/1031 , A61K39/00 , C07K14/005 , C07K14/505 , C07K14/535 , C12N9/16 , C12N15/1027 , C12N15/11 , C12N2740/16122
Abstract: “In silico” nucleic acid recombination methods, related integrated systems utilizing genetic operators and libraries made by in silico shuffling methods are provided.
Abstract translation: 提供了“计算机”核酸重组方法，利用遗传算子和利用计算机混洗方法制作的图书馆的相关综合系统。
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公开(公告)号：US07058515B1
公开(公告)日：2006-06-06
申请号：US09539486
申请日：2000-03-30
Applicant: Sergey A. Selifonov , Willem P. C. Stemmer , Claes Gustafsson , Matthew Tobin , Stephen del Cardayre , Phillip A. Patten , Jeremy Minshull , Lorraine J. Giver
Inventor： Sergey A. Selifonov , Willem P. C. Stemmer , Claes Gustafsson , Matthew Tobin , Stephen del Cardayre , Phillip A. Patten , Jeremy Minshull , Lorraine J. Giver
CPC classification number: C12N15/11 , B01J2219/00689 , C12N15/1031
Abstract: “In silico” nucleic acid recombination methods, related integrated systems utilizing genetic operators and libraries made by in silico shuffling methods are provided.
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公开(公告)号：US20050191688A1
公开(公告)日：2005-09-01
申请号：US11075231
申请日：2005-03-07
Applicant: Sergey Selifonov , Willem Stemmer , Claes Gustafsson , Matthew Tobin , Stephen del Cardayre , Phillip Patten , Jeremy Minshull
Inventor： Sergey Selifonov , Willem Stemmer , Claes Gustafsson , Matthew Tobin , Stephen del Cardayre , Phillip Patten , Jeremy Minshull
IPC: A61K39/00 , C07K14/16 , C07K14/505 , C07K14/535 , C12N9/16 , C12N15/10 , C12N15/11 , G06F19/00 , C12Q1/68 , G01N33/48 , G01N33/50
CPC classification number: C12N15/1031 , A61K39/00 , C07K14/005 , C07K14/505 , C07K14/535 , C12N9/16 , C12N15/1027 , C12N15/11 , C12N2740/16122
Abstract: “In silico” nucleic acid recombination methods, related integrated systems utilizing genetic operators and libraries made by in silico shuffling methods are provided.
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公开(公告)号：US06379964B1
公开(公告)日：2002-04-30
申请号：US09354922
申请日：1999-07-15
Applicant: Stephen del Cardayre , Matthew Tobin , Willem P. C. Stemmer , Jeremy Minshull
Inventor： Stephen del Cardayre , Matthew Tobin , Willem P. C. Stemmer , Jeremy Minshull
IPC: C12N1500
CPC classification number: A01H1/00 , A01K2217/05 , C12N15/1027 , C12N15/8271 , C12N15/8273 , C12N15/8279 , C12Q1/6811
Abstract: The invention provides methods employing iterative cycles of recombination and selection/screening for evolution of whole cells and organisms toward acquisition of desired properties. Examples of such properties include enhanced recombinogenicity, genome copy number, and capacity for expression and/or secretion of proteins and secondary metabolites.
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