公开(公告)号：US09864835B2

公开(公告)日：2018-01-09

申请号：US12288026

申请日：2008-10-15

Applicant: Linda Avey ,  Oleksiy Khomenko ,  Brian Thomas Naughton ,  Serge Saxonov ,  Anne Wojcicki ,  Alexander Wong

Inventor： Linda Avey ,  Oleksiy Khomenko ,  Brian Thomas Naughton ,  Serge Saxonov ,  Anne Wojcicki ,  Alexander Wong

IPC: G06F19/20 ,  G06F19/26 ,  G06F19/14 ,  G06F19/18 ,  G06F19/22

CPC classification number: G06F19/26 ,  G06F19/14 ,  G06F19/18 ,  G06F19/22

Abstract: Displaying a comparison of genotypic information between relatives is disclosed, including receiving an indication that a first individual is a grandparent, receiving an indication that a second individual is a grandchild of the first individual, comparing the genotypic information of the first individual and the second individual and calculating a similarity score, and displaying an indication of the similarity score graphically using colors.

公开(公告)号：US20170329866A1

公开(公告)日：2017-11-16

申请号：US13910890

申请日：2013-06-05

Applicant: 23andMe, Inc.

Inventor： John Michael Macpherson

IPC: G06F17/30

CPC classification number: G06F17/30958 ,  G06F19/00 ,  G06F19/14 ,  G16H10/60

Abstract: Determining relative connections between individuals includes: obtaining identification information of a first individual and identification information of a second individual; determining, based at least in part on a relative connections graph, a relative connections path connecting the first individual, the second individual, and at least one additional individual; and outputting information pertaining to the relative connections path.

公开(公告)号：US09008974B2

公开(公告)日：2015-04-14

申请号：US13337382

申请日：2011-12-27

Applicant: Sharmila Shekhar Mande ,  Maheedhar Reddy Rachamalla ,  Monzoorul Haque Mohammed

Inventor： Sharmila Shekhar Mande ,  Maheedhar Reddy Rachamalla ,  Monzoorul Haque Mohammed

IPC: G06F19/14 ,  G06K9/62 ,  G06F19/24

CPC classification number: G06F19/14 ,  G06F19/24 ,  G06K9/6276

Abstract: In an implementation, a query signature corresponding to a query sequence based on a set of closest cluster centroids is generated. Based on the query signature, one or more target reference signatures from a plurality of reference signatures are identified. Further based on the one or more target reference signatures, a probable taxonomic group is identified and assigned to the query sequence.

Abstract translation: 在实现中，生成与基于一组最近的聚类质心的查询序列相对应的查询签名。 基于查询签名，识别来自多个参考签名的一个或多个目标参考签名。 进一步基于一个或多个目标参考签名，识别可能的分类群并将其分配给查询序列。

公开(公告)号：US08849576B2

公开(公告)日：2014-09-30

申请号：US11740994

申请日：2007-04-27

Applicant: Hakima Amri ,  Mones Abu-asab ,  Mohamed Chaouchi

Inventor： Hakima Amri ,  Mones Abu-asab ,  Mohamed Chaouchi

IPC: G01N33/48 ,  G01N31/00 ,  G06F19/24 ,  G06F19/00 ,  G06F19/14 ,  G06F19/20

CPC classification number: G01N33/4833 ,  G06F19/14 ,  G06F19/20 ,  G06F19/24 ,  G16H50/30 ,  G16H50/50 ,  G16H50/70 ,  Y02A90/26

Abstract: A universal data-mining platform is provided capable of analyzing mass spectrometry (MS) serum proteomic profiles and/or gene array data to produce biologically meaningful classification; i.e., group together biologically related specimens into clades. This platform utilizes the principles of phylogenetics, such as parsimony, to reveal susceptibility to cancer development (or other physiological or pathophysiological conditions), diagnosis and typing of cancer, identifying stages of cancer, as well as post-treatment evaluation. By outgroup comparison, the parsing algorithm identifies under and/or overexpressed gene values or in the case of sera, (i) novel or (ii) vanished MS peaks, and peaks signifying (iii) up or (iv) down regulated proteins, and scores the variations as either derived (do not exist in the outgroup set) or ancestral (exist in the outgroup set); the derived is given a score of “1”, and the ancestral a score of “0”—these are called the polarized values.

Abstract translation: 提供了一个通用的数据挖掘平台，能够分析质谱（MS）血清蛋白质组图谱和/或基因阵列数据以产生生物意义上的分类; 即将生物相关标本组合在一起进行分支。 该平台利用诸如简约等系统发育学原理揭示对癌症发展（或其他生理或病理生理条件）的敏感性，癌症的诊断和分型，确定癌症的阶段以及后治疗评估。 通过外组比较，解析算法识别下和/或过表达的基因值或在血清的情况下，（i）新的或（ii）消失的MS峰，以及表示（iii）上调或（iv）下调的蛋白质的峰，以及 将差异作为派生（不存在于外组中）或祖先（存在于外组中）得分。 得到的得分为“1”，祖先得分为“0” - 这些被称为极化值。

公开(公告)号：US20140278138A1

公开(公告)日：2014-09-18

申请号：US14214856

申请日：2014-03-15

Applicant: Ancestry.com DNA, LLC

Inventor： Mathew J. Barber ,  Ross E. Curtis ,  Catherine Ann Ball ,  Kenneth Gregory Chahine

IPC: G06F19/14

CPC classification number: G06F19/14 ,  G06F17/30327 ,  G06F17/30528 ,  G06F17/30554 ,  G06F17/3056 ,  G09B19/0046

Abstract: Described embodiments enable identification of family networks using combinations of DNA analysis and genealogical information. Genealogical data is provided by users of a genealogical research service or collected from other sources and used to create family trees for each user. DNA samples are also received from the users. By analyzing the DNA samples, potential genetic relationships can be identified between some users. Once these DNA-suggested relationships have been identified, common ancestors can be sought in the respective trees of the potentially related users. Where these common ancestors exist, an inference is drawn that the DNA-suggested relationship accurately represents a familial overlap between the individuals in question. People descended from the same common ancestor are each members of a family network. Members of a family network not in a user's tree may be identified for the user, enabling the user to discover additional ancestors that might otherwise have remained unknown.

Abstract translation: 描述的实施方案使得能够使用DNA分析和家谱信息的组合来鉴定家族网络。 家谱数据由家谱研究服务的用户提供或从其他来源收集，并用于为每个用户创建家庭树。 也从用户那里收到DNA样本。 通过分析DNA样本，可以在一些用户之间识别潜在的遗传关系。 一旦确定了这些DNA建议的关系，可以在潜在相关用户的相应树中寻找共同的祖先。 在这些共同祖先存在的地方，推断出DNA建议关系准确地表示了所讨论的个体之间的家族重叠。 来自同一共同祖先的人是家庭网络的每个成员。 可以为用户识别不在用户树中的家庭网络的成员，使得用户能够发现否则将保持未知的其他祖先。

公开(公告)号：US08463554B2

公开(公告)日：2013-06-11

申请号：US12644791

申请日：2009-12-22

Applicant: Lawrence Hon ,  Serge Saxonov ,  Brian Thomas Naughton ,  Joanna Louise Mountain ,  Anne Wojcicki ,  Linda Avey

Inventor： Lawrence Hon ,  Serge Saxonov ,  Brian Thomas Naughton ,  Joanna Louise Mountain ,  Anne Wojcicki ,  Linda Avey

IPC: G06F7/00

CPC classification number: G06F19/14 ,  G06F17/30522 ,  G06F17/30867 ,  G06F19/22 ,  G06F19/28 ,  G06N5/048

Abstract: Determining relative relationship includes receiving recombinable deoxyribonucleic acid (DNA) information of a first user and recombinable DNA information of a second user, determining, based at least in part on the recombinable DNA information of the first user and recombinable DNA information of the second user, a predicted degree of relationship between the first user and the second user, and in the event that the expected degree of relationship between the first user and the second user at least meets the threshold, notifying at least the first user about a relative relationship with the second user.

Abstract translation: 确定相对关系包括接收第一用户的可重复脱氧核糖核酸（DNA）信息和第二用户的可重复DNA信息，至少部分基于第一用户的可重复DNA信息和第二用户的可重复DNA信息， 第一用户和第二用户之间的预测关系程度，并且在第一用户和第二用户之间的预期关系程度至少满足阈值的情况下，至少通知第一用户关于与第 第二个用户

公开(公告)号：US08275555B2

公开(公告)日：2012-09-25

申请号：US12986865

申请日：2011-01-07

Applicant: Gad M. Landau ,  Laxmi Priya Parida ,  Oren Weimann

Inventor： Gad M. Landau ,  Laxmi Priya Parida ,  Oren Weimann

IPC: G06F19/00

CPC classification number: G06F19/22 ,  G06F19/14 ,  G06F19/18 ,  G06F19/24

Abstract: A method and system for representing a similarity between at least two genomes that includes detecting gene clusters which are common to the at least two genomes and representing the common gene clusters in a PQ tree. The PQ tree includes a first internal node (P node), that allows permutation of the children thereof, and a second internal node (Q node), that maintains unidirectional order of the children thereof.

Abstract translation: 用于表示至少两个基因组之间的相似性的方法和系统，其包括检测至少两个基因组共有的基因簇，并且表示PQ树中的共同基因簇。 PQ树包括允许其子节点排列的第一内部节点（P节点）和维持其子节点的单向顺序的第二内部节点（Q节点）。

公开(公告)号：US07957912B2

公开(公告)日：2011-06-07

申请号：US12557463

申请日：2009-09-10

Applicant: Sergey A. Selifonov ,  Willem P. C. Stemmer ,  Claes Gustafsson ,  Matthew Tobin ,  Stephen del Cardayre ,  Phillip A. Patten ,  Jeremy Minshull ,  Lorraine J. Giver

Inventor： Sergey A. Selifonov ,  Willem P. C. Stemmer ,  Claes Gustafsson ,  Matthew Tobin ,  Stephen del Cardayre ,  Phillip A. Patten ,  Jeremy Minshull ,  Lorraine J. Giver

IPC: G01N33/48 ,  C12Q1/00 ,  C12Q1/48 ,  C07H21/02 ,  C07H21/04

CPC classification number: G06F19/16 ,  B01J2219/007 ,  C40B50/02 ,  G06F19/14 ,  G06F19/18 ,  G06F19/22 ,  G06F19/24

Abstract: In silico nucleic acid recombination methods, related integrated systems utilizing genetic operators and libraries made by in silico shuffling methods are provided. One disclosed method involves identifying and producing a polypeptide. The method may involve (a) receiving data identifying sequences of two or more parental polypeptides or parental nucleic acids that encode the polypeptides; (b) selecting one or more cross-over sites on the sequences thereby defining one or more recombinant polypeptides or recombinant nucleic acids; (c) selecting at least one of the recombinant polypeptides or recombinant nucleic acids; (d) recombining one or more oligonucleotides, at least one of which has a sequence matching some or all of that of the recombinant polypeptides or recombinant nucleic acids selected in (c); (e) selecting at least some of the recombined oligonucleotides produced in (d); and (f) producing a polypeptide encoded by the selected nucleic acid.

Abstract translation: 在硅胶核酸重组方法中，提供了利用遗传算子和通过计算机改组方法制备的文库的相关综合系统。 一种公开的方法涉及鉴定和产生多肽。 该方法可以包括（a）接收识别编码多肽的两个或多个亲本多肽或亲本核酸的序列的数据; （b）在序列上选择一个或多个交叉位点，从而限定一个或多个重组多肽或重组核酸; （c）选择至少一种重组多肽或重组核酸; （d）重组一种或多种寡核苷酸，其中至少一种具有与（c）中选择的重组多肽或重组核酸的部分或全部相匹配的序列; （e）选择（d）中产生的至少一些重组寡核苷酸; 和（f）产生由所选择的核酸编码的多肽。

公开(公告)号：US07957907B2

公开(公告)日：2011-06-07

申请号：US10113901

申请日：2002-03-29

Applicant: James L. Sorenson ,  Scott R. Woodward ,  Joel Myres ,  Natalie Myres, legal representative

Inventor： James L. Sorenson ,  Scott R. Woodward ,  Joel Myres

IPC: G01N33/48 ,  G06F19/00 ,  G01N31/00 ,  G06G7/48

CPC classification number: G06F19/22 ,  G06F19/14

Abstract: A genealogical research and record keeping system and method for identifying commonalities in haplotypes and other genetic characteristics of two or more individual members of a biological sample. Chromosomal fragments identical by descent identify family ties between siblings, parents and children and ancestors and progeny across many generations. It is particularly useful in corroborating and improving the accuracy of genealogical data, and identifying previously unknown genetic relationships.

Abstract translation: 用于确定生物样品中两个或更多个体成员的单元型和其他遗传特征的共同性的谱系研究和记录保存系统和方法。 染色体片段通过血统相同识别兄弟姐妹，父母和孩子之间的亲缘关系，祖先和子代多代人之间的亲缘关系。 它在确证和提高谱系数据的准确性以及识别以前未知的遗传关系方面特别有用。

公开(公告)号：US07917306B2

公开(公告)日：2011-03-29

申请号：US11887551

申请日：2006-03-27

Applicant: Dan Frumkin ,  Adam Wasserstrom ,  Shai Kaplan ,  Uriel Feige ,  Ehud Y. Shapiro

Inventor： Dan Frumkin ,  Adam Wasserstrom ,  Shai Kaplan ,  Uriel Feige ,  Ehud Y. Shapiro

IPC: C12P1/00

CPC classification number: G06F19/18 ,  G06F19/14 ,  G06F19/24

Abstract: A method of generating a cell lineage tree of a plurality of cells of an individual is provided. The method comprising: (a) determining at least one genotypic marker for each cell of the plurality of cells; and (b) computationally clustering data representing the at least one genotypic marker to thereby generate the cell lineage tree of the plurality of cells of the individual.

Abstract translation: 提供了生成个体的多个细胞的细胞谱系树的方法。 所述方法包括：（a）确定所述多个细胞中的每个细胞的至少一种基因型标记; 和（b）计算表示所述至少一个基因型标记的数据，从而生成所述个体的多个细胞的细胞谱系树。