公开(公告)号：US20100080733A1

公开(公告)日：2010-04-01

申请号：US12489159

申请日：2009-06-22

Applicant: Eric D. Carlson ,  Peijun Cong ,  William H. Chandler, JR. ,  Peter J. Desrosiers ,  J. Christopher Freitag ,  John F. Varni

Inventor： Eric D. Carlson ,  Peijun Cong ,  William H. Chandler, JR. ,  Peter J. Desrosiers ,  J. Christopher Freitag ,  John F. Varni

IPC: G01N1/02 ,  B01L3/02

CPC classification number: B01L3/50255 ,  B01J19/0046 ,  B01J2219/00283 ,  B01J2219/00308 ,  B01J2219/00315 ,  B01J2219/00335 ,  B01J2219/00364 ,  B01J2219/00373 ,  B01J2219/00423 ,  B01J2219/00481 ,  B01J2219/00484 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/00689 ,  B01J2219/00695 ,  B01J2219/00698 ,  B01J2219/00702 ,  B01J2219/00704 ,  B01J2219/00725 ,  B01J2219/00756 ,  B01L3/06 ,  B01L7/00 ,  B01L2300/0829 ,  B01L2300/185 ,  C40B40/04 ,  C40B40/10 ,  C40B60/10 ,  C40B60/14 ,  G01N5/045 ,  G01N21/23 ,  G01N21/65 ,  G01N25/04 ,  G01N33/15 ,  G01N33/54366 ,  G01N35/028 ,  G01N2013/006 ,  G01N2021/651 ,  G01N2500/00 ,  G16C20/20 ,  G16C20/90 ,  Y10T117/10

Abstract: A needle assembly has at least one guide member supported by a first body for sliding movement between an extended position and a retracted position. A second body is attached to the guide member. A biasing member biases the guide member to the extended position. A liquid handling needle is coupled to the first body so sliding movement of the guide member toward the retracted position retracts the second body relative to the liquid handling needle. The second body is adapted to contact a sealed receptacle. The biasing member urges the guide member toward said extended position during insertion and during said removal of the needle from the receptacle whereby the second body remains in contact with the sealed receptacle as the guide member moves from its extended position to its retracted position during said insertion and from its retracted position to its extended position during said removal.

Abstract translation: 针组件具有由第一主体支撑的至少一个引导构件，用于在延伸位置和缩回位置之间滑动。 第二主体附接到引导构件。 偏置构件将引导构件偏压到延伸位置。 液体处理针联接到第一主体，使得引导构件朝向缩回位置的滑动运动使第二主体相对于液体处理针退回。 第二主体适于接触密封的容器。 偏置构件在插入期间以及在从插座中取出针时将引导构件推向所述延伸位置，由此当引导构件在插入期间从其延伸位置移动到其缩回位置时，第二主体与密封容器保持接触 并且在所述移除期间从其缩回位置到其延伸位置。

公开(公告)号：US20050211622A1

公开(公告)日：2005-09-29

申请号：US11131277

申请日：2005-05-16

Applicant: Eric Carlson ,  Peijun Cong ,  William Chandler ,  Peter Desrosiers ,  J. Freitag ,  John Varni

Inventor： Eric Carlson ,  Peijun Cong ,  William Chandler ,  Peter Desrosiers ,  J. Freitag ,  John Varni

IPC: G01N21/64 ,  B01J19/00 ,  B01L3/00 ,  B01L3/06 ,  B01L7/00 ,  C07B61/00 ,  C07D209/20 ,  C07D293/00 ,  C40B40/10 ,  C40B60/08 ,  C40B60/14 ,  G01N5/04 ,  G01N13/00 ,  G01N21/23 ,  G01N21/27 ,  G01N21/33 ,  G01N21/35 ,  G01N21/47 ,  G01N21/65 ,  G01N21/78 ,  G01N24/08 ,  G01N25/04 ,  G01N30/88 ,  G01N33/15 ,  G01N33/483 ,  G01N33/50 ,  G01N33/53 ,  G01N33/543 ,  G01N35/02 ,  G01N37/00 ,  B01D29/88

CPC classification number: B01L3/50255 ,  B01J19/0046 ,  B01J2219/00283 ,  B01J2219/00308 ,  B01J2219/00315 ,  B01J2219/00335 ,  B01J2219/00364 ,  B01J2219/00373 ,  B01J2219/00423 ,  B01J2219/00481 ,  B01J2219/00484 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/00689 ,  B01J2219/00695 ,  B01J2219/00698 ,  B01J2219/00702 ,  B01J2219/00704 ,  B01J2219/00725 ,  B01J2219/00756 ,  B01L3/06 ,  B01L7/00 ,  B01L2300/0829 ,  B01L2300/185 ,  C40B40/04 ,  C40B40/10 ,  C40B60/10 ,  C40B60/14 ,  G01N5/045 ,  G01N21/23 ,  G01N21/65 ,  G01N25/04 ,  G01N33/15 ,  G01N33/54366 ,  G01N35/028 ,  G01N2013/006 ,  G01N2021/651 ,  G01N2500/00 ,  G06F19/703 ,  G06F19/709 ,  Y10T117/10

Abstract: The invention provides methods, apparatus, and systems for performing high-throughput preparation and screening of salts and polymorphs of drug candidates. The invention is directed towards enhancing the pre-formulation discovery process used for drug development. In particular, processes that determine suitable salts and processes that discover substantially every polymorph that can form from a particular drug candidate are provided. The processes are performed using several apparatuses that are specifically configured to carry-out various steps in a high-throughput characterization process. One such apparatus is configured for synthesizing a plurality of library members based on, for example, a library model generated by a computer system. Another apparatus may filter the synthesized solution to provide a substantially pure mixture that can be subjected to salt or polymorph testing. Yet another apparatus may be used to crystallize mixtures on a substrate such that the crystallized mixture can be screened by one or more screening devices.

公开(公告)号：US06939515B2

公开(公告)日：2005-09-06

申请号：US10156245

申请日：2002-05-24

Applicant: Eric D. Carlson ,  Peijun Cong ,  William H. Chandler, Jr. ,  Peter J. Desrosiers ,  J. Christopher Freitag ,  John F. Varni

Inventor： Eric D. Carlson ,  Peijun Cong ,  William H. Chandler, Jr. ,  Peter J. Desrosiers ,  J. Christopher Freitag ,  John F. Varni

IPC: G01N21/64 ,  B01J19/00 ,  B01L3/00 ,  B01L3/06 ,  B01L7/00 ,  C07B61/00 ,  C07D209/20 ,  C07D293/00 ,  C40B40/10 ,  C40B60/08 ,  C40B60/14 ,  G01N5/04 ,  G01N13/00 ,  G01N21/23 ,  G01N21/27 ,  G01N21/33 ,  G01N21/35 ,  G01N21/47 ,  G01N21/65 ,  G01N21/78 ,  G01N24/08 ,  G01N25/04 ,  G01N30/88 ,  G01N33/15 ,  G01N33/483 ,  G01N33/50 ,  G01N33/53 ,  G01N33/543 ,  G01N35/02 ,  G01N37/00 ,  B01L11/00

CPC classification number: B01L3/50255 ,  B01J19/0046 ,  B01J2219/00283 ,  B01J2219/00308 ,  B01J2219/00315 ,  B01J2219/00335 ,  B01J2219/00364 ,  B01J2219/00373 ,  B01J2219/00423 ,  B01J2219/00481 ,  B01J2219/00484 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/00689 ,  B01J2219/00695 ,  B01J2219/00698 ,  B01J2219/00702 ,  B01J2219/00704 ,  B01J2219/00725 ,  B01J2219/00756 ,  B01L3/06 ,  B01L7/00 ,  B01L2300/0829 ,  B01L2300/185 ,  C40B40/04 ,  C40B40/10 ,  C40B60/10 ,  C40B60/14 ,  G01N5/045 ,  G01N21/23 ,  G01N21/65 ,  G01N25/04 ,  G01N33/15 ,  G01N33/54366 ,  G01N35/028 ,  G01N2013/006 ,  G01N2021/651 ,  G01N2500/00 ,  G06F19/703 ,  G06F19/709 ,  Y10T117/10

Abstract: The invention provides methods, apparatus, and systems for performing high-throughput preparation and screening of salts and polymorphs of drug candidates. The invention is directed towards enhancing the pre-formulation discovery process used for drug development. In particular, processes that determine suitable salts and processes that discover substantially every polymorph that can form from a particular drug candidate are provided. The processes are performed using several apparatuses that are specifically configured to carry-out various steps in a high-throughput characterization process. One such apparatus is configured for synthesizing a plurality of library members based on, for example, a library model generated by a computer system. Another apparatus may filter the synthesized solution to provide a substantially pure mixture that can be subjected to salt or polymorph testing. Yet another apparatus may be used to crystallize mixtures on a substrate such that the crystallized mixture can be screened by one or more screening devices.

Abstract translation: 本发明提供了用于进行候选药物的盐和多晶型物的高通量制备和筛选的方法，装置和系统。 本发明旨在增强用于药物开发的预配制发现过程。 特别地，提供了确定基本上发现可从特定药物候选物形成的每个多晶型物的合适的盐和方法的方法。 使用特定配置为在高吞吐量表征过程中执行各种步骤的几个装置来执行处理。 一种这样的装置被配置为基于例如由计算机系统生成的库模型来合成多个库成员。 另一种装置可以过滤合成的溶液以提供可以进行盐或多晶型测试的基本上纯的混合物。 可以使用另一种装置将混合物在基底上结晶，使得结晶的混合物可以被一个或多个筛选装置筛选。

公开(公告)号：US06799629B1

公开(公告)日：2004-10-05

申请号：US09852159

申请日：2001-05-09

Applicant: Peijun Cong ,  Robert D. Doolen ,  Tony N. Wheeler

Inventor： Peijun Cong ,  Robert D. Doolen ,  Tony N. Wheeler

IPC: F28F500

CPC classification number: G01N27/44782 ,  G01N27/44708 ,  G01N27/44721

Abstract: Apparatus for cooling a bundle of capillary tubes to prevent overheating of the tubes during a parallel capillary electrophoresis procedure. The apparatus includes a jacket of thermally conductive solid material comprising mating jacket members movable between an open position in which the jacket members are separated to allow placement of the bundle in the jacket and a closed position in which the jacket members are mated together and the bundle is disposed inside the jacket in thermally conductive relation with the jacket. Window openings in the mating jacket members define a window to permit the passage of light through the window and the capillary tubes of the bundle at the location of the window.

Abstract translation: 用于冷却一束毛细管以在平行毛细管电泳过程中防止管过热的装置。 该装置包括导热固体材料夹套，其包括配合护套构件，其可在打开位置之间移动，在打开位置中，夹套构件被分离，以允许将束放置在护套中，并且封闭位置，夹套构件配合在一起， 与护套以导热关系设置在护套内。 配合护套构件中的窗口开口限定窗口，以允许光通过窗口的位置处的窗口和毛细管的通道。

公开(公告)号：US06544396B1

公开(公告)日：2003-04-08

申请号：US09621890

申请日：2000-07-20

Applicant: Peijun Cong ,  Robert D. Doolen

Inventor： Peijun Cong ,  Robert D. Doolen

IPC: C02F140

CPC classification number: G01N27/44782 ,  G01N27/44708 ,  G01N27/44721

Abstract: A multiplexed capillary electrophoresis system with cooling sufficient to prevent overheating during chiral separation. The system includes a thermally insulated enclosure enclosing a bundle of capillary tubes, a light source and photodetector. A heat transfer system is provided for cooling closely spaced portions and spread apart portions of the capillary tubes to an extent sufficient to prevent overheating of the tubes and contents thereof due to the heat generated during chiral separation.

Abstract translation: 多重毛细管电泳系统，其冷却足以防止在手性分离过程中过热。 该系统包括封闭一束毛细管的隔热外壳，光源和光电检测器。 提供了一种传热系统，用于冷却紧密间隔的部分，并将毛细管的一部分扩展到足以防止由于在手性分离期间产生的热而使管及其内容物过热的程度。

公开(公告)号：US06462816B1

公开(公告)日：2002-10-08

申请号：US09621423

申请日：2000-07-21

Applicant: Robert D. Doolen ,  Peijun Cong

Inventor： Robert D. Doolen ,  Peijun Cong

IPC: G01N2100

CPC classification number: G01N27/44721

Abstract: A multiplexed capillary electrophoresis system and process including a bundle of capillary tubes, a power source, a light source, a processor and an array of photodetector elements. Each element of the array generates a pixel signal corresponding to the light passing through the bundle of capillary tubes during the multiplexed capillary electrophoresis process. An A/D converter converts each of the pixel elements signals into a digital value corresponding to the light received by one of the photodetector elements. For each peak digital value, the processor selects five digital values corresponding to the light received by five contiguous photodetector elements and generates output signals. Each output signal corresponds to the light passing through the bundle of capillary tubes and is a function of the selected digital values. As a result, noise and drifts of the pixel signals are minimized.

Abstract translation: 一种复用的毛细管电泳系统和方法，包括一束毛细管，电源，光源，处理器和光电检测器元件阵列。 在复用毛细管电泳过程中，阵列的每个元件产生对应于通过毛细管束的光的像素信号。 A / D转换器将每个像素元件的信号转换成与由光检测器元件之一接收的光对应的数字值。 对于每个峰值数字值，处理器选择与由五个相邻光电检测器元件接收的光对应的五个数字值，并产生输出信号。 每个输出信号对应于通过毛细管束的光，并且是所选数字值的函数。 结果，像素信号的噪声和漂移被最小化。

公开(公告)号：US20080159064A1

公开(公告)日：2008-07-03

申请号：US11793193

申请日：2005-12-13

Applicant: Youqi Wang ,  Peijun Cong ,  Guilin Wang ,  Wenhui Wang ,  Lichen Diao ,  Youshu Kang ,  Yubin Zhong ,  Bohejin Tang ,  Fuxin Huang

Inventor： Youqi Wang ,  Peijun Cong ,  Guilin Wang ,  Wenhui Wang ,  Lichen Diao ,  Youshu Kang ,  Yubin Zhong ,  Bohejin Tang ,  Fuxin Huang

IPC: B01F15/02 ,  B01F15/06

CPC classification number: B01F7/008 ,  B01F3/0807 ,  B01F7/00816 ,  B29B7/407

Abstract: The present invention discloses an apparatus for processing materials, which is used to process the materials introduced thereinto, comprising a working part and a driving part, wherein the working part comprises, in cylindrical form, a first element and a second element arranged within the first element, and a containing chamber for storing materials to be processed being formed by the gap between the first element and the second element, and the second element is driven by the driving part to rotate relatively to the first element, and on the surface of the second element toward the containing chamber, provided is a disturbing part capable of producing axial forces in a direction parallel to the axis of the first element. Thanks to the disturbing part of the second element, the apparatus of the present invention can process materials thoroughly, control retention time of materials within the containing chamber, prevent materials from entering into the mixing blind area and thus make all materials processed thoroughly.

Abstract translation: 本发明公开了一种用于处理材料的装置，其用于处理引入其中的材料，包括工作部分和驱动部分，其中工作部件包括圆柱形形式的第一元件和布置在第一 元件和用于存储待处理材料的容纳室由第一元件和第二元件之间的间隙形成，并且第二元件由驱动部分驱动以相对于第一元件旋转，并且在第二元件的表面上 第二元件朝向容纳室设置有能够在平行于第一元件的轴线的方向上产生轴向力的扰动部。 由于第二元件的干扰部分，本发明的装置可以充分地处理材料，控制容纳室内材料的保留时间，防止材料进入混合遮光区域，从而使所有材料被彻底处理。

公开(公告)号：US07255474B2

公开(公告)日：2007-08-14

申请号：US10900612

申请日：2004-07-28

Applicant: Peijun Cong ,  Shenheng Guan ,  Stephen Cypes ,  Jason Wells ,  H. Sam Bergh

Inventor： Peijun Cong ,  Shenheng Guan ,  Stephen Cypes ,  Jason Wells ,  H. Sam Bergh

IPC: G01J3/10 ,  G01K11/00 ,  G01K13/02 ,  G01K25/00 ,  G01N31/00

CPC classification number: G01N21/253 ,  B01J2219/00286 ,  B01J2219/00306 ,  B01J2219/00704 ,  B01J2219/00745 ,  B01J2219/00747 ,  B01L3/5027 ,  C40B30/08 ,  C40B40/18 ,  G01N21/0303 ,  G01N21/05 ,  G01N21/3577 ,  G01N35/028 ,  G01N2021/0346 ,  G01N2035/00237

Abstract: A library of material samples is provided in a condition suitable for imaging using infrared (IR) spectroscopy. The samples are provided to one or more detection cells, each of the cells including or containing a reflective surface. Preferably, for imaging, an energy source (e.g. a source of infrared radiation) provides energy to the detection cells to interact with the samples. Thereafter, images (e.g., spectra) related to the samples are created based upon the interaction.

Abstract translation: 以适于使用红外（IR）光谱法进行成像的条件提供材料样品库。 将样品提供给一个或多个检测细胞，每个细胞包括或包含反射表面。 优选地，对于成像，能量源（例如，红外辐射源）向检测单元提供能量以与样品相互作用。 此后，基于相互作用创建与样本相关的图像（例如，光谱）。

公开(公告)号：US07071000B2

公开(公告)日：2006-07-04

申请号：US10334099

申请日：2002-12-30

Applicant: Youqi Wang ,  Peijun Cong ,  Tony N. Wheeler ,  Lynn Thomas Van Erden ,  H. Sam Bergh

Inventor： Youqi Wang ,  Peijun Cong ,  Tony N. Wheeler ,  Lynn Thomas Van Erden ,  H. Sam Bergh

IPC: G01N31/10 ,  G01N1/22 ,  G01N35/10 ,  H01J49/00

CPC classification number: G01N35/109 ,  G01N1/14 ,  G01N2035/00277 ,  Y10T436/11 ,  Y10T436/24 ,  Y10T436/2575 ,  Y10T436/25875

Abstract: A method for sampling reaction products includes delivering a reactant through a sampling probe to contact a substance deposited on a substrate and reacting the reactant to form a reaction product. At least a portion of the reaction product is withdrawn through the sampling probe and analyzed. The sampling probe is contacted with the substrate during at least a portion of the delivering, reacting and withdrawing steps.

公开(公告)号：US07549978B2

公开(公告)日：2009-06-23

申请号：US11131277

申请日：2005-05-16

Applicant: Eric D. Carlson ,  Peijun Cong ,  William H. Chandler, Jr. ,  Peter J. Desrosiers ,  J. Christopher Freitag ,  John F. Varni

Inventor： Eric D. Carlson ,  Peijun Cong ,  William H. Chandler, Jr. ,  Peter J. Desrosiers ,  J. Christopher Freitag ,  John F. Varni

IPC: A61M5/31 ,  A61M5/00

CPC classification number: B01L3/50255 ,  B01J19/0046 ,  B01J2219/00283 ,  B01J2219/00308 ,  B01J2219/00315 ,  B01J2219/00335 ,  B01J2219/00364 ,  B01J2219/00373 ,  B01J2219/00423 ,  B01J2219/00481 ,  B01J2219/00484 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/00689 ,  B01J2219/00695 ,  B01J2219/00698 ,  B01J2219/00702 ,  B01J2219/00704 ,  B01J2219/00725 ,  B01J2219/00756 ,  B01L3/06 ,  B01L7/00 ,  B01L2300/0829 ,  B01L2300/185 ,  C40B40/04 ,  C40B40/10 ,  C40B60/10 ,  C40B60/14 ,  G01N5/045 ,  G01N21/23 ,  G01N21/65 ,  G01N25/04 ,  G01N33/15 ,  G01N33/54366 ,  G01N35/028 ,  G01N2013/006 ,  G01N2021/651 ,  G01N2500/00 ,  G06F19/703 ,  G06F19/709 ,  Y10T117/10

Abstract: A needle assembly has a first body and a guide rod supported for sliding movement between an extended position and a retracted position. A second body is attached to the guide rod. The second body is relatively farther from the first body when the guide rod is in the extended position and relatively closer to the first body when the guide rod is in the retracted position. The guide rod is biased to the extended position. The second body supports a venting needle that extends beyond the second body by a fixed length. A liquid handling needle is coupled to the first body. Sliding movement of the guide rod toward the retracted position retracts the second body and the venting needle relative to the liquid handling needle.

Abstract translation: 针组件具有第一主体和支撑件，用于在延伸位置和缩回位置之间滑动。 第二主体附接到导杆。 当导杆处于缩回位置时，当导杆处于伸出位置并相对靠近第一主体时，第二主体相对较远离第一主体。 引导杆偏置到伸出位置。 第二主体支撑一个排气针，其延伸超过第二主体一个固定的长度。 液体处理针联接到第一主体。 引导杆朝向缩回位置的滑动运动使第二主体和排气针相对于液体处理针退回。