知搜-全球专利检索

  1. 登录
  2. 注册

搜索结果

28 条记录 (耗时 0.025 秒)

    Phosphorylation-inhibiting agent or dephosphorylating agent for PTEN
    1.
    发明授权
    Phosphorylation-inhibiting agent or dephosphorylating agent for PTEN 有权
    PTEN的磷酸化抑制剂或去磷酸化剂

    公开(公告)号：US09023343B2

    公开(公告)日：2015-05-05

    申请号：US13263876

    申请日：2010-03-26

    申请人： Kazuhiro Morishita ,  Shingo Nakahata ,  Makoto Hamasaki

    发明人： Kazuhiro Morishita ,  Shingo Nakahata ,  Makoto Hamasaki

    IPC分类号： A61K38/46 ,  C12N15/00 ,  G01N33/53 ,  C12Q1/48 ,  A61K31/223 ,  A61K31/7088 ,  C07K16/40 ,  C07K16/44 ,  C12N9/12 ,  C12N9/18 ,  A61K48/00

    CPC分类号： C12Q1/485 ,  A61K31/223 ,  A61K31/7088 ,  A61K48/005 ,  C07K16/40 ,  C07K16/44 ,  C07K2317/34 ,  C12N9/12 ,  C12N9/18 ,  G01N2500/00 ,  A61K2300/00

    摘要： Provided is a preventive, progression inhibitor or remedy for a disease one of the causes of which is the activation of the P13K/AKT signaling pathway or vice versa. A phosphorylation-inhibiting and/or dephosphorylating agent, which has an effect of inhibiting the phosphorylation at least at one of the phosphorylation sites of PTEN protein selected from the group consisting of T382, T383 and S380 and/or an effect of dephosphorylating the same, is prepared. Alternatively, a phosphorylation-inhibiting or dephosphorylating agent for PTEN is screened by a method comprising a step for confirming an ability of a test substance to inhibit the phosphorylation at least at one of the phosphorylation sites of PTEN protein selected from the group consisting of T382, T383 and S380 or a dephosphorylation ability thereof. Then, a substance having an effect opposite to the inhibition of PTEN phosphorylation or dephosphorylation thereof, e.g., an antibody against the phosphorylation-inhibiting or dephosphorylating agent for PTEN obtained above, is also obtained.

    摘要翻译： 提供预防性，进展抑制剂或疾病的补救方法，其原因之一是激活P13K / AKT信号传导途径，反之亦然。 一种磷酸化抑制剂和/或去磷酸化剂，其至少在选自T382，T383和S380的PTEN蛋白的磷酸化位点之一处抑制磷酸化和/或使其去磷酸化的作用， 准备好了 或者，通过包括以下方法筛选用于PTEN的磷酸化抑制剂或去磷酸化剂，所述方法包括用于确认测试物质至少在PTEN蛋白的一个磷酸化位点抑制磷酸化的能力的步骤，所述磷酸化位点选自T382， T383和S380或其去磷酸化能力。 然后，也可获得具有与抑制PTEN磷酸化或其去磷酸化作用相反的作用的物质，例如针对上述获得的PTEN的磷酸化抑制或去磷酸化剂的抗体。

    Protective cover
    8.
    发明授权
    Protective cover 有权

    公开(公告)号：US06568967B2

    公开(公告)日：2003-05-27

    申请号：US09899081

    申请日：2001-07-06

    申请人： Shigemitsu Inaba ,  Kazuhiro Morishita ,  Tsuyoshi Hamai

    发明人： Shigemitsu Inaba ,  Kazuhiro Morishita ,  Tsuyoshi Hamai

    IPC分类号： H01R1344

    CPC分类号： H01R13/501 ,  H01R13/516 ,  H01R13/5213 ,  H01R13/562 ,  Y10S439/906

    摘要： In the present invention, a protective cover is provided with, a base bottom portion and a cover portion which is disposed in the base bottom portion through a hinge. The protective cover can be attached to a connector so as to be fitted with a through-lock portion of the connector and the cover portion is then closed. The base bottom portion is formed in a gutter-shape and the rear end side of the base bottom portion is partially closed by a closing portion. In the present invention, a protective cover is also provided with, a cylindrical cover main body to be fitted with a connector, and a pair of opening-and-closing members disposed on the cover main body through hinges. The protective cover further includes securing holes for securing the opening-and-closing members to securing projections disposed on the cover main body, and securing pawls and securing frames for engaging the opening-and-closing members with each other.

    Semiconductor device
    9.
    发明授权
    Semiconductor device 有权
    半导体器件

    公开(公告)号：US06472692B1

    公开(公告)日：2002-10-29

    申请号：US09566737

    申请日：2000-05-09

    申请人： Katsumi Satoh ,  Kazuhiro Morishita ,  Shinji Koga

    发明人： Katsumi Satoh ,  Kazuhiro Morishita ,  Shinji Koga

    IPC分类号： H01L2974

    CPC分类号： H01L29/744 ,  H01L29/1016

    摘要： To suppress spike voltage generated at turn-off operation, a semiconductor device according to the invention comprises a first region composed of a first conductor, a second region composed of a second conductor formed on top of the first region, a third region composed of the first conductor formed on top of the second region and a fourth region composed of the second conductor formed on top of the third region. The second region is comprised of a depletion-layer forming auxiliary layer having a short lifetime and formed in the vicinity of the third region, a tail-current suppression layer having a shorter lifetime than that of the depletion-layer forming auxiliary layer and formed in the vicinity of the first region and a depletion-layer forming suppression layer having a longer lifetime than that of the depletion-layer forming auxiliary layer and formed between the depletion-layer forming auxiliary layer and the tail-current suppression layer.

    摘要翻译： 为了抑制在关断操作时产生的尖峰电压，根据本发明的半导体器件包括由第一导体构成的第一区域，由形成在第一区域的顶部上的第二导体构成的第二区域，由 第一导体形成在第二区域的顶部上，第四区域由形成在第三区域的顶部上的第二导体构成。 第二区域由具有短寿命且在第三区域附近形成的耗尽层形成辅助层构成，具有比耗尽层形成辅助层的寿命短的尾电流抑制层，并形成在 形成在耗尽层形成辅助层和尾流抑制层之间的第一区域附近和耗尽层形成抑制层的寿命比耗尽层形成辅助层的寿命更长。

    Rear holder having a releasing hole which extends beyond a rear end of a connector housing
    10.
    发明授权
    Rear holder having a releasing hole which extends beyond a rear end of a connector housing 失效
    后保持器具有延伸超过连接器壳体的后端的释放孔

    公开(公告)号：US5603642A

    公开(公告)日：1997-02-18

    申请号：US396782

    申请日：1995-03-01

    申请人： Yasuhisa Shinji ,  Kazuhiro Morishita

    发明人： Yasuhisa Shinji ,  Kazuhiro Morishita

    IPC分类号： H01R13/42 ,  H01R13/436 ,  H01R13/506 ,  H01R13/514

    CPC分类号： H01R13/506 ,  H01R13/4367 ,  Y10S439/923 ,  Y10S439/94

    摘要： A flat rectangular rear holder having groovelike wire inserting parts and a thickness. On a side surface of the rear holder are retaining projections for retaining a housing and a releasing hole for inserting a releasing jig. The rear holder is engaged with the housing that has a plurality of terminal accommodating chambers on a rear end thereof and retaining holes corresponding to the retaining projections along the peripheral wall thereof. With the rear holder engaged with and retained by the housing, an upper end part of the rear holder is projected from the rear end of the housing, so that the upper part of the releasing hole is exposed. This exposed part has an opening area so large as to allow a rear holder releasing jig to be inserted thereinto.

    摘要翻译： 具有槽形线插入部分和厚度的扁平矩形后保持器。 在后保持器的侧表面上具有用于保持壳体的保持突起和用于插入释放夹具的释放孔。 后保持器与其后端具有多个端子容纳室的壳体接合，并且沿着其周壁保持与保持突起对应的孔。 随着后保持器与壳体接合并保持，后保持器的上端部从壳体的后端突出，使得释放孔的上部露出。 该暴露部分具有如此大的开口面积，以允许后保持器释放夹具插入其中。