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公开(公告)号：US09023343B2
公开(公告)日：2015-05-05
申请号：US13263876
申请日：2010-03-26
IPC分类号： A61K38/46 , C12N15/00 , G01N33/53 , C12Q1/48 , A61K31/223 , A61K31/7088 , C07K16/40 , C07K16/44 , C12N9/12 , C12N9/18 , A61K48/00
CPC分类号： C12Q1/485 , A61K31/223 , A61K31/7088 , A61K48/005 , C07K16/40 , C07K16/44 , C07K2317/34 , C12N9/12 , C12N9/18 , G01N2500/00 , A61K2300/00
摘要： Provided is a preventive, progression inhibitor or remedy for a disease one of the causes of which is the activation of the P13K/AKT signaling pathway or vice versa. A phosphorylation-inhibiting and/or dephosphorylating agent, which has an effect of inhibiting the phosphorylation at least at one of the phosphorylation sites of PTEN protein selected from the group consisting of T382, T383 and S380 and/or an effect of dephosphorylating the same, is prepared. Alternatively, a phosphorylation-inhibiting or dephosphorylating agent for PTEN is screened by a method comprising a step for confirming an ability of a test substance to inhibit the phosphorylation at least at one of the phosphorylation sites of PTEN protein selected from the group consisting of T382, T383 and S380 or a dephosphorylation ability thereof. Then, a substance having an effect opposite to the inhibition of PTEN phosphorylation or dephosphorylation thereof, e.g., an antibody against the phosphorylation-inhibiting or dephosphorylating agent for PTEN obtained above, is also obtained.
摘要翻译： 提供预防性，进展抑制剂或疾病的补救方法，其原因之一是激活P13K / AKT信号传导途径，反之亦然。 一种磷酸化抑制剂和/或去磷酸化剂，其至少在选自T382，T383和S380的PTEN蛋白的磷酸化位点之一处抑制磷酸化和/或使其去磷酸化的作用， 准备好了 或者，通过包括以下方法筛选用于PTEN的磷酸化抑制剂或去磷酸化剂，所述方法包括用于确认测试物质至少在PTEN蛋白的一个磷酸化位点抑制磷酸化的能力的步骤，所述磷酸化位点选自T382， T383和S380或其去磷酸化能力。 然后，也可获得具有与抑制PTEN磷酸化或其去磷酸化作用相反的作用的物质，例如针对上述获得的PTEN的磷酸化抑制或去磷酸化剂的抗体。
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公开(公告)号：US20120107299A1
公开(公告)日：2012-05-03
申请号：US13263876
申请日：2010-03-26
IPC分类号： A61K38/46 , C12N15/55 , C07K16/40 , A61P3/10 , A61K48/00 , C12N5/02 , C12Q1/42 , A61P35/00 , C12N9/18 , C12N15/63
CPC分类号： C12Q1/485 , A61K31/223 , A61K31/7088 , A61K48/005 , C07K16/40 , C07K16/44 , C07K2317/34 , C12N9/12 , C12N9/18 , G01N2500/00 , A61K2300/00
摘要： Provided is a preventive, progression inhibitor or remedy for a disease one of the causes of which is the activation of the P13K/AKT signaling pathway or vice versa. A phosphorylation-inhibiting and/or dephosphorylating agent, which has an effect of inhibiting the phosphorylation at least at one of the phosphorylation sites of PTEN protein selected from the group consisting of T382, T383 and S380 and/or an effect of dephosphorylating the same, is prepared. Alternatively, a phosphorylation-inhibiting or dephosphorylating agent for PTEN is screened by a method comprising a step for confirming an ability of a test substance to inhibit the phosphorylation at least at one of the phosphorylation sites of PTEN protein selected from the group consisting of T382, T383 and S380 or a dephosphorylation ability thereof. Then, a substance having an effect opposite to the inhibition of PTEN phosphorylation or dephosphorylation thereof, e.g., an antibody against the phosphorylation-inhibiting or dephosphorylating agent for PTEN obtained above, is also obtained.
摘要翻译： 提供预防性，进展抑制剂或疾病的补救方法，其原因之一是激活P13K / AKT信号传导途径，反之亦然。 一种磷酸化抑制剂和/或去磷酸化剂，其至少在选自T382，T383和S380的PTEN蛋白的磷酸化位点之一处抑制磷酸化和/或使其去磷酸化的作用， 准备好了 或者，通过包括以下方法筛选用于PTEN的磷酸化抑制剂或去磷酸化剂，所述方法包括用于确认测试物质至少在PTEN蛋白的一个磷酸化位点抑制磷酸化的能力的步骤，所述磷酸化位点选自T382， T383和S380或其去磷酸化能力。 然后，也可获得具有与抑制PTEN磷酸化或其去磷酸化作用相反的作用的物质，例如针对上述获得的PTEN的磷酸化抑制或去磷酸化剂的抗体。
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