公开(公告)号：US08048992B2

公开(公告)日：2011-11-01

申请号：US11885245

申请日：2006-02-22

申请人： Yoshikazu Kurosawa ,  Yasushi Akahori ,  Nobuhiro Takahashi ,  Atsushi Sugioka ,  Nobuhiro Hayashi ,  Akihiko Takasaki ,  Kazuhiro Suzuki ,  Miwa Morita ,  Gene Kurosawa ,  Sari Fujiyama ,  Susumu Tsustumi ,  Keiko Ogawa ,  Kazuki Matsuda ,  Chiho Muramatsu ,  Yoshitaka Iba ,  Mariko Sumitomo ,  Masachika Azuma ,  Yoshinori Ukai ,  Kazuhiro Morishita

发明人： Yoshikazu Kurosawa ,  Yasushi Akahori ,  Nobuhiro Takahashi ,  Atsushi Sugioka ,  Nobuhiro Hayashi ,  Akihiko Takasaki ,  Kazuhiro Suzuki ,  Miwa Morita ,  Gene Kurosawa ,  Sari Fujiyama ,  Susumu Tsustumi ,  Keiko Ogawa ,  Kazuki Matsuda ,  Chiho Muramatsu ,  Yoshitaka Iba ,  Mariko Sumitomo ,  Masachika Azuma ,  Yoshinori Ukai ,  Kazuhiro Morishita

IPC分类号： C07K16/00

CPC分类号： C07K16/303 ,  A61K2039/505 ,  C07K16/2803 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/732 ,  C07K2319/00 ,  G01N33/57426 ,  G01N33/57438

摘要： It is intended to clarify a molecule which is available as a target in treating or diagnosing cancer and utilize the molecule in the medical field or the research field. By treating IgSF4, which has been identified as a molecule specifically expressed in lung cancer cells, with an antibody, and ADCC activity is exerted. Based on this finding, an anti-IgSF4 antibody is provided as a means efficacious in treating cancer, etc.

摘要翻译： 旨在澄清可用作治疗或诊断癌症并在医学领域或研究领域中利用分子的靶标的分子。 通过用抗体处理被鉴定为特异性表达于肺癌细胞中的分子的IgSF4，并施加ADCC活性。 基于该发现，提供了抗IgSF4抗体作为治疗癌症等的手段。

公开(公告)号：US20090053243A1

公开(公告)日：2009-02-26

申请号：US11885245

申请日：2006-02-22

申请人： Yoshikazu Kurosawa ,  Yasushi Akahori ,  Nobuhiro Takahashi ,  Atsushi Sugioka ,  Nobuhiro Hayashi ,  Akihiko Takasaki ,  Kazuhiro Suzuki ,  Miwa Morita ,  Gene Kurosawa ,  Sari Fujiyama ,  Susumu Tsustumi ,  Keiko Ogawa ,  Kazuki Matsuda ,  Chiho Muramatsu ,  Yoshitaka Iba ,  Mariko Sumitomo ,  Masachika Azuma ,  Yoshinori Ukai ,  Kazuhiro Morishita

发明人： Yoshikazu Kurosawa ,  Yasushi Akahori ,  Nobuhiro Takahashi ,  Atsushi Sugioka ,  Nobuhiro Hayashi ,  Akihiko Takasaki ,  Kazuhiro Suzuki ,  Miwa Morita ,  Gene Kurosawa ,  Sari Fujiyama ,  Susumu Tsustumi ,  Keiko Ogawa ,  Kazuki Matsuda ,  Chiho Muramatsu ,  Yoshitaka Iba ,  Mariko Sumitomo ,  Masachika Azuma ,  Yoshinori Ukai ,  Kazuhiro Morishita

IPC分类号： A61K39/395 ,  C07K16/18 ,  C12N15/11 ,  C12N15/00 ,  A61P31/00 ,  C12N5/06 ,  G01N33/574

CPC分类号： C07K16/303 ,  A61K2039/505 ,  C07K16/2803 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/732 ,  C07K2319/00 ,  G01N33/57426 ,  G01N33/57438

摘要： It is intended to clarify a molecule which is available as a target in treating or diagnosing cancer and utilize the molecule in the medical field or the research field. By treating IgSF4, which has been identified as a molecule specifically expressed in lung cancer cells, with an antibody, and ADCC activity is exerted. Based on this finding, an anti-IgSF4 antibody is provided as a means efficacious in treating cancer, etc.

摘要翻译： 旨在澄清可用作治疗或诊断癌症并在医学领域或研究领域中利用分子的靶标的分子。 通过用抗体处理被鉴定为特异性表达于肺癌细胞中的分子的IgSF4，并施加ADCC活性。 基于该发现，提供了抗IgSF4抗体作为治疗癌症等的手段。