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61.发明授权公开(公告)号：US09896708B2
公开(公告)日：2018-02-20
申请号：US14897667
申请日：2014-06-12
CPC分类号： C12P19/24 , C08B37/0075 , C12N9/90 , C12P19/04 , C12Y501/03
摘要： To provide a polypeptide having heparosan-glucuronate 5-epimerase activity, whereby means for producing a polysaccharide in which hexuronic acid residues has been epimerized is provided. Through screening of Achatina fulica cDNA library, a DNA encoding a polypeptide of heparosan-glucuronate 5-epimerase is obtained. The epimerase acts on glucuronic acid residues of N-acetyl heparosan and/or iduronic acid residues of completely desulfated N-acetylated heparin. The polypeptide encoded by the DNA is expressed by insect cells, to thereby yield the polypeptide having heparosan-glucuronate 5-epimerase activity. By bringing the polypeptide into contact with N-acetyl heparosan or completely desulfated N-acetylated heparin, a polysaccharide in which hexuronic acid residues has been epimerized is yielded.
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公开(公告)号：US09885030B2
公开(公告)日：2018-02-06
申请号：US15605816
申请日：2017-05-25
发明人： Samir Kumar Roy , Saravanakumar Iyappan , Saju Varghese , Aparna Devi Addala , Milky Agarwal , Kanumuru Rahul Raju , Banibrata Pandey
CPC分类号： C12N9/90 , C12P19/12 , C12P19/24 , C12Y504/99011
摘要： The present invention is directed towards genetic modification of native gene encoding for sucrose isomerase and isomaltulose synthase to substantially increase the expression level of these enzymes and use of said enzymes in a process to produce rare disaccharides such as isomaltulose and trehalulose. Also disclosed in the present invention is expression constructs comprising the modified genes and a host cells to express the same.
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公开(公告)号：US09883676B2
公开(公告)日：2018-02-06
申请号：US15078670
申请日：2016-03-23
申请人： Bayer CropScience LP
摘要： The present invention relates to a composition comprising a biologically pure culture of a fungicidal Paenibacillus sp. strain comprising a variant fusaricidin synthetase lacking a functional adenylation domain in the third module. The present invention also provides a composition comprising a biologically pure culture of a fungicidal Paenibacillus sp. strain or a cell-free extract thereof comprising at least one Paeniserine and at least one Paeniprolixin. Also provided are isolated compounds and methods of treating a plant to control a plant disease with the disclosed compositions and compounds.
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公开(公告)号：US20180023091A1
公开(公告)日：2018-01-25
申请号：US15547084
申请日：2016-01-29
申请人： MEIOGENIX , INSTITUT CURIE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6)
CPC分类号： C12N15/8213 , C07K2319/09 , C12N9/22 , C12N9/90 , C12N15/102 , C12N15/11 , C12N15/63 , C12N15/65 , C12N15/81 , C12N15/902 , C12N15/905 , C12N2310/20 , C12N2800/22 , C12Y599/01003
摘要： The present invention relates to a fusion protein comprising a Cas9 domain and a Spo11 domain, as well as the use of this protein to induce targeted meiotic recombinations in a eukaryotic cell.
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公开(公告)号：US09828609B2
公开(公告)日：2017-11-28
申请号：US14774769
申请日：2014-03-11
发明人： Raul Cuero Rengifo
CPC分类号： C12N15/8279 , C12N9/0073 , C12N9/90 , C12P5/007 , C12Y114/13129 , C12Y505/01018
摘要： Described herein are devices and methods for enhancing the physiological properties of plants. For example, the devices and methods described herein increase the production of lycopene, which has industrial and economic value. The lycopene produced by the devices and methods does not require the ultra purification that is common in conventional or commercial methods. The devices and methods described herein also enhance the growth rate of plants.
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公开(公告)号：US20170335339A1
公开(公告)日：2017-11-23
申请号：US15656109
申请日：2017-07-21
发明人： Cornelis Maria Petrus VAN DUN , Magdalena Barbara LASTDRAGER , Lena Johanna HUIJBREGTS-DOORDUIN
CPC分类号： C12N15/8261 , A01H5/08 , C07K14/415 , C12N9/90 , C12N15/8287 , C12N15/8294 , C12Y502/01008
摘要： The invention relates to a modified PIN4 gene, the wild type of which is as identified in SEQ ID No. 1, encoding the protein of SEQ ID No. 5, or the wild type of which encodes a protein that has a sequence similarity of at least 80% to SEQ ID No. 5, which modified PIN4 gene encodes a protein that comprises an amino acid change as a result of the modification, and which modified protein is capable of inducing parthenocarpic fruit set when present in a plant. The invention also relates to plants and fruits that carry the gene. Such plants are capable of parthenocarpic fruit set and the fruits do not contain seeds. The invention further relates to use of the gene in breeding and producing plants capable of parthenocarpic fruit set.
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公开(公告)号：US20170321238A1
公开(公告)日：2017-11-09
申请号：US15439660
申请日：2017-02-22
申请人： Evolva SA
发明人： Jens Houghton-Larsen , Paula Hicks , Michael Naesby , Thomas Tange Ostergaard , Jorgen Hansen , Michael Mikkelsen Dalgaard , Esben Halkjaer Hansen , Ernesto Simon , Sabina Tavares
IPC分类号： C12P19/56 , C12N15/82 , C12N15/81 , C12N15/63 , C12N9/06 , C12N9/88 , C12N9/10 , C12N9/02 , C12P19/44 , C12N9/90
CPC分类号： C12P19/56 , C12N9/0032 , C12N9/0071 , C12N9/0073 , C12N9/1051 , C12N9/1085 , C12N9/88 , C12N9/90 , C12N15/63 , C12N15/81 , C12N15/8243 , C12P19/44 , Y02P20/52
摘要： Recombinant microorganisms, plants, and plant cells are disclosed that have been engineered to express recombinant genes encoding UDP-glycosyltransferases (UGTs). Such microorganisms, plants, or plant cells can produce steviol glycosides, e.g., Rebaudioside A and/or Rebaudioside D, which can be used as natural sweeteners in food products and dietary supplements.
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公开(公告)号：US20170296565A1
公开(公告)日：2017-10-19
申请号：US15479761
申请日：2017-04-05
IPC分类号： A61K31/7012 , C12Q1/68 , A01K67/027
CPC分类号： A61K31/7012 , A01K67/0275 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/052 , A01K2217/072 , A01K2227/105 , A01K2267/03 , A01K2267/0306 , A01K2267/0318 , A61D19/04 , C12N9/1205 , C12N9/90 , C12Q1/6883 , C12Q2600/106 , C12Q2600/156 , C12Y207/0106 , C12Y501/03002 , G01N33/5038 , G01N33/573 , G01N2333/91215 , G01N2333/99 , G01N2500/10
摘要： Disclosed herein are methods of treating HIBM in a subject comprising identifying subject in need thereof; and administering to the subject a compound, or a pharmaceutically acceptable salt, ester, amide, glycol, peptidyl, or prodrug thereof, wherein the compound is a compound that is biosynthesized in a wild type individual along a biochemical pathway between glucose and sialic acid, inclusive. Also disclosed herein are vectors comprising a nucleic acid sequence that encodes a polypeptide having at least 80% sequence identity to the sequence set forth in SEQ ID NO:2, recombinant cells comprising these vectors, and recombinant animals comprising the cells. In addition, methods of identifying a compound having therapeutic effect for HIBM are disclosed.
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公开(公告)号：US09757440B2
公开(公告)日：2017-09-12
申请号：US13276577
申请日：2011-10-19
IPC分类号： A61K39/00 , A61K39/002 , C12N1/00 , G01N33/569 , A61K39/015 , C12N1/36 , C12N9/90 , C12N9/00
CPC分类号： A61K39/015 , A61K39/002 , A61K2039/522 , A61K2039/523 , A61K2039/585 , C12N1/36 , C12N9/90 , C12N9/93
摘要： The present invention provides attenuated Toxoplasma gondii mutants for use as vaccines in the prevention or treatment of cancer.
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公开(公告)号：US09752171B2
公开(公告)日：2017-09-05
申请号：US14871483
申请日：2015-09-30
申请人： Codexis, Inc.
CPC分类号： C12P19/24 , C12N9/90 , C12N9/92 , C12N15/81 , C12P7/04 , C12P7/10 , C12P19/02 , C12P2203/00 , C12Y503/01005 , Y02E50/16 , Y02E50/17
摘要： The present invention provides recombinant nucleic acid constructs comprising a xylose isomerase polynucleotide, a recombinant fungal host cell comprising a recombinant xylose isomerase polynucleotide, and related methods.
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