公开(公告)号：US12037596B2

公开(公告)日：2024-07-16

申请号：US17196408

申请日：2021-03-09

Applicant: Regeneron Pharmaceuticals, Inc.

Inventor： Jeffrey D. Lee ,  Alexander O. Mujica ,  Wojtek Auerbach ,  Ka-Man Venus Lai ,  David M. Valenzuela ,  George D. Yancopoulos

IPC: A01K67/0278 ,  A01K67/0276 ,  A61D19/04 ,  C07K14/715 ,  C07K14/775 ,  C12N15/85 ,  C12N15/90

CPC classification number: C12N15/8509 ,  A01K67/0276 ,  A01K67/0278 ,  A61D19/04 ,  C07K14/7155 ,  C07K14/775 ,  C12N15/907 ,  A01K2217/07 ,  A01K2227/105 ,  A01K2267/0362 ,  A01K2267/0381 ,  C12N2015/8527 ,  C12N2800/30 ,  C12N2810/00

Abstract: Compositions and methods are provided for modifying a rat genomic locus of interest using a large targeting vector (LTVEC) comprising various endogenous or exogenous nucleic acid sequences as described herein. Compositions and methods for generating a genetically modified rat comprising one or more targeted genetic modifications in their germline are also provided. Compositions and methods are provided which comprise a genetically modified rat or rat cell comprising a targeted genetic modification in the rat interleukin-2 receptor gamma locus, the rat ApoE locus, the rat Rag2 locus, the rat Rag1 locus and/or the rat Rag2/Rag1 locus. The various methods and compositions provided herein allows for these modified loci to be transmitted through the germline.

公开(公告)号：US11957384B2

公开(公告)日：2024-04-16

申请号：US17510653

申请日：2021-10-26

Applicant: PROGENA INC.

Inventor： Alexander Feskov ,  Irina Feskova ,  Ievgeniia Zhylkova ,  Stanislav Zhilkov

IPC: A61B17/435 ,  A61D19/00 ,  A61D19/04 ,  A61K35/14 ,  C12N5/078 ,  A61K35/12

CPC classification number: A61B17/435 ,  A61D19/00 ,  A61D19/04 ,  A61K35/14 ,  C12N5/0634 ,  A61K2035/124 ,  C12N2501/31

Abstract: A method of in vitro fertilization wherein the embryo is implanted into the uterus of a female patient at least two, and preferably three to twelve months after the eggs are retrieved from the patient in order to reduce the effect of autoimmune rejection of the embryo by the patient's autoimmune system and increase the probability and success of pregnancy and wherein prior to embryo implantation, the endometrium in the uterus is prepared for embryo implantation by introducing peripheral blood mononuclear cells (PBMCs) into the uterus. The procedure is combined with cryopreservation techniques to preserve the oocytes or the IVF-produced embryos of the patient.

公开(公告)号：US20230389961A1

公开(公告)日：2023-12-07

申请号：US18249181

申请日：2021-10-15

Applicant: PREMIUM FERTILITY S.L.

Inventor： Carlos SIMÓN VALLÉS ,  Javier SANTAMARÍA COSTA ,  David JIMÉNEZ MORENO

IPC: A61B17/435 ,  A61B1/303 ,  A61B1/00 ,  A61B90/30 ,  A61D19/04

CPC classification number: A61B17/435 ,  A61B1/303 ,  A61B1/0016 ,  A61B2090/0811 ,  A61B1/00151 ,  A61D19/04 ,  A61B90/30

Abstract: The present invention relates to dispensing instruments and methods for introducing treatment material and fluid-like material with an embryo into a uterus. More specifically, the present invention relates to apparatuses for delivering a fertilized egg or embryo into a maternal uterine endometrium in humans or any other mammalian species and associated computer programs for controlling said apparatuses.

公开(公告)号：US20230263552A1

公开(公告)日：2023-08-24

申请号：US18014537

申请日：2021-07-06

Applicant: CORNELL UNIVERSITY

Inventor： Amir MOKHTARE ,  Gianpiero D. PALERMO ,  Alireza ABBASPOURRAD

IPC: A61B17/435 ,  C12M3/06 ,  C12M3/00 ,  C12M1/42 ,  C12M1/00

CPC classification number: A61B17/435 ,  C12M23/16 ,  C12M21/06 ,  C12M35/04 ,  C12M29/14 ,  A61D19/04

Abstract: The present invention relates to a microfluidic device for denudation of a cumulus oocyte complex. The device includes a substrate. A first channel having a width of about 200 μm to about 1 mm is located within the substrate. The first channel extends from a first end to a second end of the substrate. The first channel has a one or more ridge elements located along a surface thereof. A first port is located in the substrate and in fluid communication with the first end of the channel. A second port is located in the substrate and in fluid communication with the second end of the channel. Systems and methods of use of the microfluidic device for denudation of a cumulus oocyte complex are also disclosed.

公开(公告)号：US20180193123A1

公开(公告)日：2018-07-12

申请号：US15739357

申请日：2016-06-24

Applicant: Osnir YOSHIMNE WATANABE

Inventor： Osnir YOSHIME WATANABE

IPC: A61D19/04 ,  A61M5/34 ,  A61B17/435

CPC classification number: A61D19/04 ,  A61B17/435 ,  A61M1/008 ,  A61M5/3293 ,  A61M5/34 ,  A61M5/343 ,  A61M5/346

Abstract: The invention refers to a needle for follicular aspiration, comprising a base with a through-hole, inside of which a needle cannula is coupled, the needle cannula having a front aspiration end which protrudes from a front end of the base, and a rear end which freely protrudes from the rear end of the base, the through-hole of the base having a frustro-conical segment tapering from the rear end towards the front end of the base, forming a gap between the inner surface of the base and the outer surface of the needle cannula for coupling a biological sample collecting line.

公开(公告)号：US09949756B2

公开(公告)日：2018-04-24

申请号：US15690096

申请日：2017-08-29

Applicant: Cross Bay Medical, Inc.

Inventor： Steven R. Bacich

IPC: A61B17/43 ,  A61B17/12 ,  A61F2/00 ,  A61M39/24 ,  A61M25/10 ,  A61B17/00 ,  A61B17/34 ,  A61M29/02

CPC classification number: A61B17/43 ,  A61B1/00082 ,  A61B1/303 ,  A61B1/32 ,  A61B17/0218 ,  A61B17/1204 ,  A61B17/12099 ,  A61B17/12136 ,  A61B17/3423 ,  A61B2017/00115 ,  A61B2017/00557 ,  A61B2017/00805 ,  A61B2017/0225 ,  A61B2017/2946 ,  A61B2017/3435 ,  A61B2017/345 ,  A61B2017/4216 ,  A61B2017/4225 ,  A61B2090/037 ,  A61B2090/0807 ,  A61B2090/0809 ,  A61B2090/0811 ,  A61D19/027 ,  A61D19/04 ,  A61F2/0027 ,  A61F6/18 ,  A61F6/22 ,  A61M25/0119 ,  A61M25/10 ,  A61M25/1002 ,  A61M25/1011 ,  A61M25/10181 ,  A61M25/10182 ,  A61M25/1025 ,  A61M25/104 ,  A61M29/02 ,  A61M39/24 ,  A61M2025/0004 ,  A61M2025/0175 ,  A61M2025/1004 ,  A61M2025/1013 ,  A61M2025/1052 ,  A61M2025/1059 ,  A61M2025/1065

Abstract: Everting balloon systems and methods for using the same are disclosed herein. The systems can be configured to access and dilate body lumen and cavities. For example, the systems can be used to dilate the cervix and access the uterine cavity. The systems can also be used to occlude the cervix. The systems can also be used to occlude the urethra.

公开(公告)号：US20170275692A1

公开(公告)日：2017-09-28

申请号：US15487244

申请日：2017-04-13

Applicant: Inguran, LLC

Inventor： Juan F. Moreno ,  John Dobrinsky ,  David Kendall ,  Claas Heuer

IPC: C12Q1/68 ,  A61D19/04 ,  A01K67/02

CPC classification number: C12Q1/6876 ,  A01K67/02 ,  A01K67/0273 ,  A01K2227/101 ,  A01K2267/02 ,  A61D19/04 ,  C12N5/0605 ,  C12N15/8771 ,  C12Q1/6881 ,  C12Q2600/124 ,  C12Q2600/156

Abstract: The invention encompasses methods for increasing genetic progress in livestock, and for genetic dissemination, including the use of amniocentesis to obtain fetal amniocytes for use in genomic evaluation and cloning.

公开(公告)号：US20170226096A1

公开(公告)日：2017-08-10

申请号：US15497612

申请日：2017-04-26

Applicant: Merck Patent GmbH

Inventor： Henry YU ,  Thomas E. RICHARDSON ,  Pandi BHARATHI ,  Brian H. HEASLEY ,  Matthew G. JENKS ,  Robert J. FOGLESONG

IPC: C07D413/12 ,  A61D19/04 ,  C07D307/68 ,  C07D405/14 ,  A61K31/496 ,  C07D405/12

CPC classification number: C07D413/12 ,  A61B17/435 ,  A61D19/02 ,  A61D19/04 ,  A61K31/496 ,  C07D263/34 ,  C07D307/68 ,  C07D405/12 ,  C07D405/14 ,  C07D407/12 ,  C07D413/14

Abstract: Novel benzamide derivatives of formula (I) wherein W1, W2, R1 to R10 and X have the meaning according to the claims, are positive allosteric modulators of the FSH receptor, and can be employed, inter alia, for the treatment of fertility disorders.

公开(公告)号：US09615903B2

公开(公告)日：2017-04-11

申请号：US12454805

申请日：2009-05-22

Applicant: Michael A. Green ,  Brett Thomas Spear

Inventor： Michael A. Green ,  Brett Thomas Spear

IPC: A61D19/04 ,  A61B17/43 ,  A61B17/435

CPC classification number: A61D19/04 ,  A61B17/43 ,  A61B17/435

Abstract: A device having a catheter and a hub which facilitates the transfer of an embryo containing solution into the uterus of a mammal, for example, a small mammal such as a rat or mouse. The catheter's shape and tip is designed to simplify insertion and minimize injury to the mammal. The hub is designed to further control the insertion of the catheter and to interface with a pipette, for example, that provides the force required for the transfer of an embryo containing solution. As a result, the transfer can occur without requiring surgery.

公开(公告)号：US09592306B2

公开(公告)日：2017-03-14

申请号：US14697243

申请日：2015-04-27

Applicant: THE UAB RESEARCH FOUNDATION

Inventor： Scott Webster Ballinger ,  Danny R. Welch ,  Robert Allen Kesterson ,  Larry W. Johnson

IPC: A61D19/04 ,  A61K49/00 ,  A01K67/027 ,  G01N33/50

CPC classification number: A61K49/0008 ,  A01K67/0271 ,  A01K67/0273 ,  A01K67/0275 ,  A01K2217/00 ,  A01K2227/10 ,  A01K2227/105 ,  A01K2267/0331 ,  A01K2267/0375 ,  A61D19/04 ,  G01N33/5023

Abstract: Provided herein are mitochondrial-nuclear exchanged cells and animals comprising mitochondrial DNA (mtDNA) from one subject and nuclear DNA (nDNA) from a different subject. Methods for producing a mitochondrial-nuclear exchanged animal and animals made by the methods are provided. Also provided are methods of screening for agents useful for treating a disease or disorder using mitochondrial-nuclear exchanged animals or cells, tissues or organs thereof.

Abstract translation: 本文提供了线粒体核交换的细胞和包含来自一个受试者的线粒体DNA（mtDNA）和来自不同受试者的核DNA（nDNA）的动物。 提供了通过该方法制备线粒体 - 核交换动物和动物的方法。 还提供了使用线粒体 - 核交换的动物或其细胞，组织或器官筛选可用于治疗疾病或病症的药剂的方法。