公开(公告)号：US11895992B2

公开(公告)日：2024-02-13

申请号：US16538334

申请日：2019-08-12

申请人： Arturo Solis Herrera

发明人： Arturo Solis Herrera

IPC分类号： A61K49/10 ,  A01K67/00 ,  A01K67/027 ,  A61K31/03 ,  A61K31/05 ,  A61K49/00

CPC分类号： A01K67/027 ,  A61K31/03 ,  A61K31/05 ,  A61K49/0008 ,  A01K2227/10 ,  A01K2267/035

摘要： Methods of producing non-human animal models of corneal ectatic diseases, such as corneal keratoconus, by applying an aromatic compound to the eye of a non-human animal are described. Also described are non-human animal models of corneal ectatic diseases, and methods of using the non-human animal models to screen compounds that modulate corneal ectatic diseases.

公开(公告)号：US20230295088A1

公开(公告)日：2023-09-21

申请号：US18017826

申请日：2021-08-12

申请人： University of Iowa Research Foundation

发明人： Julien A. Sebag ,  Terry C. Yin ,  Robert J. Kerns

IPC分类号： C07D211/04 ,  G01N33/50 ,  A01K67/027 ,  C07C211/45 ,  A61P3/10

CPC分类号： C07D211/04 ,  G01N33/5008 ,  A01K67/0275 ,  C07C211/45 ,  A61P3/10 ,  G01N2333/62 ,  A01K2227/10 ,  A01K2267/0362

摘要： Compositions and methods for insulin sensitization are provided.

公开(公告)号：US20230148563A1

公开(公告)日：2023-05-18

申请号：US18097558

申请日：2023-01-17

申请人： Full Life Wellness, LLC

发明人： William Levy ,  Scott Eller

IPC分类号： A01K5/02

CPC分类号： A01K5/02 ,  A01K2227/10

摘要： A container of pet food and an apparatus for preparing the pet food are disclosed. The apparatus includes a scanner for reading a pet food identifier on the container. The scanner is adapted to read the pet food identifier and provide it to a controller. The controller is adapted to obtain food preparation parameters from an external database and to cause the apparatus to then prepare the pet food according thereto. The containers has an identically-shaped periphery and the apparatus is adapted to receive that periphery such that each container is properly positioned regardless of the container's volume.

公开(公告)号：US20180352792A1

公开(公告)日：2018-12-13

申请号：US16060814

申请日：2016-12-19

申请人： PUBLIC UNIVERSITY CORPORATION YOKOHAMA CITY UNIVERSITY

发明人： Hideki TANIGUCHI ,  Yunzhong NIE ,  Yun-Wen ZHENG ,  Keisuke SEKINE ,  Takanori TAKEBE

IPC分类号： A01K67/027 ,  C12N5/0789 ,  C12N5/071 ,  C12N5/00

CPC分类号： A01K67/0271 ,  A01K67/027 ,  A01K2227/10 ,  A01K2267/025 ,  A01K2267/03 ,  C12N5/0062 ,  C12N5/0647 ,  C12N5/0677 ,  C12Q1/02

摘要： A revised technique for preparing human tissues and organs aiming at application to medical use is provided. With this technique, function per cell is greatly improved and great reduction in production cost is realized.A method of preparing an organ bud, comprising culturing vascular endothelial cells, mesenchymal cells and a tissue or organ cell in vitro in the presence of blood cells. Also provided are an organ bud prepared by the above method and a method of preparing a tissue or an organ using the organ bud. Using the same organ bud, there are provided a method of transplanting an organ bud, a method of regeneration or function recovery of a tissue or an organ, a method of preparing a non-human chimeric animal, and a method of evaluating a drug.

公开(公告)号：US10070632B2

公开(公告)日：2018-09-11

申请号：US15442857

申请日：2017-02-27

申请人： REGENERON PHARMACEUTICALS, INC.

发明人： Lisa Purcell ,  Alexander O. Mujica ,  Yajun Tang

IPC分类号： A01K67/027 ,  C12N5/0735 ,  C12N9/64

CPC分类号： A01K67/0275 ,  A01K67/0278 ,  A01K2207/15 ,  A01K2217/072 ,  A01K2227/10 ,  A01K2227/105 ,  A01K2267/0337 ,  A61K48/00 ,  C07K14/47 ,  C07K2319/00 ,  C12N5/0606 ,  C12N9/6424 ,  C12N15/09 ,  C12N15/63 ,  C12N15/86 ,  C12N2710/10332

摘要： Genetically modified rodents such as mice and rats, and methods and compositions for making and using the same, are provided. The rodents comprise a humanization of at least one endogenous rodent Tmprss gene, such as an endogenous rodent Tmprss2, Tmprss4, or Tmprss11d gene.

公开(公告)号：US20180235193A1

公开(公告)日：2018-08-23

申请号：US15740654

申请日：2016-07-01

申请人： MINERVA BIOTECHNOLOGIES CORPORATION

发明人： Cynthia Bamdad ,  Benoit Smagghe ,  Mark Carter ,  Andrew Stewart

IPC分类号： A01K67/027 ,  A61K35/545

CPC分类号： A01K67/0276 ,  A01K2227/10 ,  A01K2227/105 ,  A01K2267/025 ,  A61K35/545 ,  C07K16/3092

摘要： The present application discloses a method for generating human tissues in a non-human animal comprising: (i) generating human naïve state stem cells and injecting them into a blastocyst or embryo of a non-human animal such that a chimeric animal is generated; (ii) harvesting human tissues, organs, cells or factors secreted by or made in the human tissues or cells from the chimeric animal; and (iii) transplanting or administering the harvested material into a human resulting in generation of human tissues in a non-human animal.

公开(公告)号：US20180177151A1

公开(公告)日：2018-06-28

申请号：US15738384

申请日：2016-05-31

申请人： LELY PATENT N.V.

发明人： Maria Johanna Aleida VAN HOUTEN ,  Sjors MEIJERS

IPC分类号： A01K5/02 ,  G06F3/0486 ,  G06F3/0482 ,  G06F3/0488

CPC分类号： A01K5/0275 ,  A01K5/00 ,  A01K5/02 ,  A01K5/0266 ,  A01K2227/10 ,  B65G1/1371 ,  B65G2203/041 ,  G06F3/0482 ,  G06F3/0486 ,  G06F3/04883

摘要： An automatic feeding system for preparing at least one feed ration from a plurality of feed types includes a feed kitchen with multiple feed storage places for storing a plurality of feed types, a feed distributing device for receiving feed from the feed kitchen, a feed loading device to load feed from each of the feed storage places into the feed distributing device, and a control system to control the automatic feeding system. The control system includes a graphical user interface with a display screen, including a floor plan with first representations of each of the feed storage places, which representations are formed based on at least the feed storage location data, and second representations of the feed types.

公开(公告)号：US20170265441A1

公开(公告)日：2017-09-21

申请号：US15445532

申请日：2017-02-28

申请人： NIHON MEDI-PHYSICS CO., LTD.

发明人： Shuntaro OKA ,  Masaru KANAGAWA ,  Masahiro ONO ,  Yoshihiro DOI

IPC分类号： A01K67/027 ,  A61K49/00

CPC分类号： A01K67/0271 ,  A01K2207/12 ,  A01K2207/20 ,  A01K2227/10 ,  A01K2227/105 ,  A01K2267/0331 ,  A61K49/0008

摘要： Provided is a method for producing an animal model of osteoblastic bone metastasis. A non-human animal in which an osteoblastic lesion is formed in a wide range has been successfully produced with a probability of 100% by: administering a calcineurin inhibitor to a non-human animal; and injecting a tumor cell into an artery or a vein of the non-human animal, wherein the non-human animal and the tumor cell are in an allogeneic or xenogeneic relation.

公开(公告)号：US20170245482A1

公开(公告)日：2017-08-31

申请号：US15442857

申请日：2017-02-27

申请人： REGENERON PHARMACEUTICALS, INC.

发明人： Lisa Purcell ,  Alexander O. Mujica ,  Yajun Tang

IPC分类号： A01K67/027 ,  C12N5/0735

CPC分类号： A01K67/0275 ,  A01K67/0278 ,  A01K2207/15 ,  A01K2217/072 ,  A01K2227/10 ,  A01K2227/105 ,  A01K2267/0337 ,  A61K48/00 ,  C07K14/47 ,  C07K2319/00 ,  C12N5/0606 ,  C12N9/6424 ,  C12N15/09 ,  C12N15/63 ,  C12N15/86 ,  C12N2710/10332

摘要： Genetically modified rodents such as mice and rats, and methods and compositions for making and using the same, are provided. The rodents comprise a humanization of at least one endogenous rodent Tmprss gene, such as an endogenous rodent Tmprss2, Tmprss4, or Tmprss11d gene.

公开(公告)号：US20170245481A1

公开(公告)日：2017-08-31

申请号：US15424322

申请日：2017-02-03

申请人： REGENERON PHARMACEUTICALS, INC.

发明人： Viktoria Gusarova ,  Andrew J. Murphy ,  Jesper Gromada ,  Dayong Guo

IPC分类号： A01K67/027

CPC分类号： A01K67/0278 ,  A01K2207/15 ,  A01K2217/072 ,  A01K2217/206 ,  A01K2227/10 ,  A01K2227/105 ,  A01K2267/0306 ,  A01K2267/0375 ,  A61K49/0008 ,  A61K2039/505 ,  C07K14/515 ,  C07K16/22

摘要： Non-human animals, and methods and compositions for making and using the same, are provided, wherein said non-human animals comprise a humanization of an Angiopoietin-like protein 8 (ANGPTL8) gene. Said non-human animals may be described, in some embodiments, as having a genetic modification to an endogenous ANGPTL8 locus so that said non-human animals express a human ANGPTL8 polypeptide.