公开(公告)号：US12179149B2

公开(公告)日：2024-12-31

申请号：US17622390

申请日：2020-06-25

Applicant: NIHON MEDI-PHYSICS CO., LTD.

Inventor： Yoshio Honda ,  Shinya Yano

IPC: B01D59/50 ,  B01D15/22 ,  B01D15/36 ,  B01D15/42 ,  C25D3/54 ,  G21G1/00 ,  G21G1/06

Abstract: An object of the present invention is to provide a method for purifying efficiently and easily a 226Ra-containing solution obtained when 225Ac is produced from a 226Ra target, a method for producing a 226Ra target by using the purified 226Ra-containing solution obtained by the above purification method, and a method for producing 225Ac including these above methods. The method for purifying a 226Ra-containing solution according to the present invention is characterized by including an adsorption step (R1) of allowing 226Ra ions to adsorb onto a carrier having a function of selectively adsorbing divalent cations by bringing a 226Ra-containing solution (a) into contact with the carrier under an alkaline condition; and an elution step (R2) of eluting the 226Ra ions from the carrier under an acidic condition.

公开(公告)号：US12046385B2

公开(公告)日：2024-07-23

申请号：US17619275

申请日：2020-06-18

Applicant: NIHON MEDI-PHYSICS CO., LTD.

Inventor： Ikuo Kajishiro ,  Shinya Yano ,  Jun Ichinose

IPC: C25D3/54 ,  C25D5/48 ,  G21G1/00 ,  G21G1/06 ,  G21G1/10 ,  G21G1/12 ,  G21G1/04

CPC classification number: G21G1/001 ,  C25D3/54 ,  G21G1/06 ,  G21G1/10 ,  G21G1/12 ,  G21G2001/0089 ,  G21G1/04

Abstract: One embodiment of the present invention relates to a production method of a 226Ra target, a production method of 225Ac, or an electrodeposition solution for producing a 226Ra target, and the production method of a 226Ra target includes an electrodeposition step of electrodepositing a 226Ra-containing substance on a substrate by using an electrodeposition solution that contains 226Ra ions and a pH buffer.

公开(公告)号：US20230310665A1

公开(公告)日：2023-10-05

申请号：US18005129

申请日：2021-07-13

Applicant: NIHON MEDI-PHYSICS CO., LTD.

Inventor： Yoshio HONDA ,  Masashi NATSUSAKO ,  Shunichi ASO

IPC: A61K51/12

CPC classification number: A61K51/121

Abstract: A method for producing 225Ac solution includes steps (I) to (III): a step (I) of passing a solution containing 226Ra and 225Ac through a solid-phase extraction agent (a) that contains a compound represented by formula (A) so as to cause the solid-phase extraction agent (a) to retain 225Ac; a step (II) of passing a liquid containing an eluate, which is obtained by eluting the retained 225Ac from the solid-phase extraction agent (a), through a solid-phase extraction agent (b) that contains a compound represented by formula (B) so as to cause the solid-phase extraction agent (b) to retain 225Ac; and a step (III) of eluting the retained 225Ac from the solid-phase extraction agent (b) to obtain an 225Ac solution.

公开(公告)号：US20230288585A1

公开(公告)日：2023-09-14

申请号：US18040272

申请日：2021-08-11

Applicant: Nihon Medi-Physics Co., Ltd.

Inventor： Takahisa HANADA

IPC: G01T1/36 ,  G01T1/24

CPC classification number: G01T1/36 ,  G01T1/24

Abstract: A radionuclide analysis apparatus includes: a radiation data detection unit that detects energy of alpha-ray emitted from a radionuclide in a sample and another energy emitted from another radionuclide different from the energy of the alpha-ray; a nuclide identification unit that identifies the radionuclide that has emitted the radiation by comparing a measurement spectrum Sa that is an energy spectrum based on the energy of the alpha-ray or another energy detected by the radiation data detection unit with a standard spectrum Ssa; and a distribution acquisition unit that obtains a distribution of a specific nuclide identified by the nuclide identification unit in the sample.

公开(公告)号：US20230112418A1

公开(公告)日：2023-04-13

申请号：US17904792

申请日：2021-03-04

Applicant: NIHON MEDI-PHYSICS CO., LTD. ,  KYOTO UNIVERSITY

Inventor： Yoshifumi MAYA ,  Masahiro ONO ,  Shimpei IIKUNI

IPC: C07D487/04 ,  C07D513/04 ,  C07F5/00 ,  A61K51/04

Abstract: In a compound of the present invention, in a macroscopic view of a chemical structure thereof, a chelating moiety is located at the center of the structure, an atomic group containing an albumin binding moiety binds to one side of the chelating moiety, and an atomic group containing a target molecule binding moiety binds to the other side of the chelating moiety. The chelating moiety is also preferably DOTA or a derivative thereof. The target molecule binding moiety preferably has a structure to bind to a target molecule expressed in a cancer tissue. The present invention also provides a radioactive labeled compound in which the compound is coordinated to a radioactive metal ion.

公开(公告)号：US20230094773A1

公开(公告)日：2023-03-30

申请号：US17825430

申请日：2022-05-26

Applicant: NIHON MEDI-PHYSICS CO., LTD. ,  SUMITOMO PHARMA CO., LTD.

Inventor： Norihito Nakata ,  Nobuya Kobashi ,  Yoshinari Shoyama ,  Mitsuhiro Matono ,  Yasushi Ochiai ,  Takayuki Murakami

IPC: A61K51/10 ,  A61K51/04 ,  C07K16/30

Abstract: The RI-labeled anti-MUC5AC humanized antibody of the present invention is a conjugate of a chelating agent chelated with a radionuclide and an antibody (the radionuclide is a metal nuclide that emits α particle or positron, and the antibody is a humanized antibody specifically binding to MUC5AC), and is superior in specificity for MUC5AC and accumulation in tumor. Therefore, it is extremely useful for the treatment and/or diagnosis of diseases in which MUC5AC is overexpressed, particularly cancer.

公开(公告)号：US11551826B2

公开(公告)日：2023-01-10

申请号：US17846398

申请日：2022-06-22

Applicant: NIHON MEDI-PHYSICS CO., LTD.

Inventor： Yoshio Honda ,  Shinya Yano

IPC: G21G1/10 ,  G21G1/00 ,  G21G1/06 ,  G21G1/12

Abstract: A method for producing 225A including: a method (X) for purifying a 226Ra-containing solution, including an adsorption step of allowing a 226Ra ion to adsorb onto a carrier having a function of selectively adsorbing a divalent cation by bringing a 226Ra-containing solution into contact with the carrier under an alkaline condition, and an elution step of eluting the 226Ra ion from the carrier under an acidic condition; a method for producing a 226Ra target, including an electrodeposition liquid preparation step of preparing an electrodeposition liquid by using a purified 226Ra-containing solution obtained by the method (X), and an electrodeposition step of electrodepositing a 226Ra-containing substance on a substrate by using the electrodeposition liquid; and a step of irradiating a 226Ra target produced by the method for producing a 226Ra target with at least one selected from a charged particle, a photon, and a neutron by using an accelerator.

公开(公告)号：US20190255199A1

公开(公告)日：2019-08-22

申请号：US16308014

申请日：2017-06-09

Applicant: Nihon Medi-Physics Co., Ltd.

Inventor： Yoshifumi MAYA

IPC: A61K51/04 ,  A61K9/00

Abstract: The present invention addresses the problem of providing a technique for detecting a lesion of a heart disease in a non-invasive manner. The present invention provides a non-invasive diagnostic imaging agent for a heart disease, which contains a radioactively labeled compound capable of binding to an aldosterone synthase or a salt thereof as an active ingredient.

公开(公告)号：US10258247B2

公开(公告)日：2019-04-16

申请号：US15451686

申请日：2017-03-07

Applicant: Nihon Medi-Physics Co., Ltd.

Inventor： Kazumasa Nishida ,  Kazuo Hamada ,  Kazunori Kobayashi

IPC: A61B5/026 ,  A61B6/00 ,  A61B6/03 ,  A61B5/00 ,  G06T7/00

Abstract: Provided is a highly reliable technique for the evaluation of ischemic conditions. A preferred embodiment is a nuclear medicine measurement protocol in which the administration of a radiopharmaceutical agent and radiation measurement are performed twice at rest and under stress. In the nuclear medicine measurement protocol, radiation collection is performed without radiopharmaceutical agent administration before the second radiopharmaceutical agent administration, and the result is used to correct the nuclear medicine measurement result after the second radiopharmaceutical agent administration.

公开(公告)号：US20180256760A1

公开(公告)日：2018-09-13

申请号：US15977522

申请日：2018-05-11

Applicant: NIHON MEDI-PHYSICS CO., LTD.

Inventor： Osamu ITO ,  Akio HAYASHI ,  Fumie KUROSAKI ,  Masahito TOYAMA ,  Toshiyuki SHINMURA ,  Arinori HARANO

IPC: A61K51/04 ,  C07C67/307 ,  C07C309/65 ,  C07B59/00

CPC classification number: A61K51/0402 ,  A61K51/0406 ,  C07B59/00 ,  C07B2200/05 ,  C07C67/307 ,  C07C309/65 ,  C07C2601/04 ,  Y02P20/55

Abstract: It is intended to provide a novel amino acid organic compound which can be used as a labeling precursor compound for radioactive halogen-labeled amino acid compounds including [18F]FACBC, and which prevents methanol from remaining in the radioactive halogen-labeled amino acid compounds produced therefrom. The novel amino acid organic compound is a compound represented by the following formula: wherein n is an integer of 0 or of 1 to 4; R1 is an ethyl, 1-propyl or isopropyl substituent; X is a halogen substituent or a group represented by —OR2; R2 is a straight-chain or branched-chain haloalkylsulfonic acid substituent with one to 10 carbon atoms, trialkylstannyl substituent with 3 to 12 carbon atoms, fluorosulfonic acid substituent or aromatic sulfonic acid substituent; and R3 is a protective group.