公开(公告)号：US20210100229A1

公开(公告)日：2021-04-08

申请号：US17118241

申请日：2020-12-10

申请人： Regeneron Pharmaceuticals, Inc.

发明人： Kara L. Olson ,  Eric Smith ,  Ka-Man Venus Lai ,  Andrew J. Murphy ,  Gavin Thurston ,  Dayong Guo

IPC分类号： A01K67/027 ,  C07K14/725 ,  G01N33/50

摘要： Non-human animals, expressing humanized CD3 proteins are provided. Non-human animals, e.g., rodents, genetically modified to comprise in their genome humanized CD3 proteins are also provided. Additionally, provided are methods and compositions of making such non-human animals, as well as methods of using said non-human animals.

公开(公告)号：US10932455B2

公开(公告)日：2021-03-02

申请号：US16872226

申请日：2020-05-11

申请人： Regeneron Pharmaceuticals, Inc.

发明人： Kara L. Olson ,  Eric Smith ,  Ka-Man Venus Lai ,  Andrew J. Murphy ,  Gavin Thurston ,  Dayong Guo

IPC分类号： A01K67/00 ,  A01K67/033 ,  A01K67/027 ,  C07K14/725 ,  G01N33/50

摘要： Non-human animals, expressing humanized CD3 proteins are provided. Non-human animals, e.g., rodents, genetically modified to comprise in their genome humanized CD3 proteins are also provided. Additionally, provided are methods and compositions of making such non-human animals, as well as methods of using said non-human animals.

公开(公告)号：US20200275642A1

公开(公告)日：2020-09-03

申请号：US16872226

申请日：2020-05-11

申请人： Regeneron Pharmaceuticals, Inc.

发明人： Kara L. Olson ,  Eric Smith ,  Ka-Man Venus Lai ,  Andrew J. Murphy ,  Gavin Thurston ,  Dayong Guo

IPC分类号： A01K67/027 ,  C07K14/725 ,  G01N33/50

摘要： Non-human animals, expressing humanized CD3 proteins are provided. Non-human animals, e.g., rodents, genetically modified to comprise in their genome humanized CD3 proteins are also provided. Additionally, provided are methods and compositions of making such non-human animals, as well as methods of using said non-human animals.

公开(公告)号：US11937587B2

公开(公告)日：2024-03-26

申请号：US17118241

申请日：2020-12-10

申请人： Regeneron Pharmaceuticals, Inc.

发明人： Kara L. Olson ,  Eric Smith ,  Ka-Man Venus Lai ,  Andrew J. Murphy ,  Gavin Thurston ,  Dayong Guo

IPC分类号： A01K67/027 ,  C07K14/725 ,  C12N5/071 ,  C12N15/85 ,  G01N33/50

CPC分类号： A01K67/0278 ,  A01K67/0276 ,  C07K14/7051 ,  C12N5/0602 ,  C12N15/8509 ,  G01N33/5088 ,  A01K2207/12 ,  A01K2207/15 ,  A01K2217/072 ,  A01K2217/075 ,  A01K2217/15 ,  A01K2227/105 ,  A01K2267/01 ,  A01K2267/03 ,  A01K2267/0337 ,  Y02A50/30

摘要： Non-human animals, expressing humanized CD3 proteins are provided. Non-human animals, e.g., rodents, genetically modified to comprise in their genome humanized CD3 proteins are also provided. Additionally, provided are methods and compositions of making such non-human animals, as well as methods of using said non-human animals.

公开(公告)号：US20240306616A1

公开(公告)日：2024-09-19

申请号：US18442444

申请日：2024-02-15

申请人： Regeneron Pharmaceuticals, Inc.

发明人： Kara L. Olson ,  Eric Smith ,  Ka-Man Venus Lai ,  Andrew J. Murphy ,  Gavin Thurston ,  Dayong Guo

IPC分类号： A01K67/0278 ,  A01K67/0276 ,  C07K14/725 ,  C12N5/071 ,  C12N15/85 ,  G01N33/50

CPC分类号： A01K67/0278 ,  A01K67/0276 ,  C07K14/7051 ,  C12N5/0602 ,  C12N15/8509 ,  G01N33/5088 ,  A01K2207/12 ,  A01K2207/15 ,  A01K2217/072 ,  A01K2217/075 ,  A01K2217/15 ,  A01K2227/105 ,  A01K2267/01 ,  A01K2267/03 ,  A01K2267/0337 ,  Y02A50/30

摘要： Non-human animals, expressing humanized CD3 proteins are provided. Non-human animals, e.g., rodents, genetically modified to comprise in their genome humanized CD3 proteins are also provided. Additionally, provided are methods and compositions of making such non-human animals, as well as methods of using said non-human animals.

公开(公告)号：US10582702B2

公开(公告)日：2020-03-10

申请号：US15424322

申请日：2017-02-03

申请人： REGENERON PHARMACEUTICALS, INC.

发明人： Viktoria Gusarova ,  Andrew J. Murphy ,  Jesper Gromada ,  Dayong Guo

IPC分类号： A01K67/027 ,  A61K49/00 ,  C07K16/22 ,  A61K39/00

摘要： Non-human animals, and methods and compositions for making and using the same, are provided, wherein said non-human animals comprise a humanization of an Angiopoietin-like protein 8 (ANGPTL8) gene. Said non-human animals may be described, in some embodiments, as having a genetic modification to an endogenous ANGPTL8 locus so that said non-human animals express a human ANGPTL8 polypeptide.

公开(公告)号：US20170245481A1

公开(公告)日：2017-08-31

申请号：US15424322

申请日：2017-02-03

申请人： REGENERON PHARMACEUTICALS, INC.

发明人： Viktoria Gusarova ,  Andrew J. Murphy ,  Jesper Gromada ,  Dayong Guo

IPC分类号： A01K67/027

CPC分类号： A01K67/0278 ,  A01K2207/15 ,  A01K2217/072 ,  A01K2217/206 ,  A01K2227/10 ,  A01K2227/105 ,  A01K2267/0306 ,  A01K2267/0375 ,  A61K49/0008 ,  A61K2039/505 ,  C07K14/515 ,  C07K16/22

摘要： Non-human animals, and methods and compositions for making and using the same, are provided, wherein said non-human animals comprise a humanization of an Angiopoietin-like protein 8 (ANGPTL8) gene. Said non-human animals may be described, in some embodiments, as having a genetic modification to an endogenous ANGPTL8 locus so that said non-human animals express a human ANGPTL8 polypeptide.

公开(公告)号：US20170164588A1

公开(公告)日：2017-06-15

申请号：US14949834

申请日：2015-11-23

申请人： Regeneron Pharmaceuticals, Inc.

发明人： Kara L. Olson ,  Eric Smith ,  Ka-Man Venus Lai ,  Andrew J. Murphy ,  Gavin Thurston ,  Dayong Guo

IPC分类号： A01K67/027 ,  C07K14/725

CPC分类号： A01K67/0278 ,  A01K67/0276 ,  A01K2207/12 ,  A01K2207/15 ,  A01K2217/072 ,  A01K2217/075 ,  A01K2217/15 ,  A01K2227/105 ,  A01K2267/01 ,  A01K2267/03 ,  A01K2267/0337 ,  C07K14/7051 ,  G01N33/5088 ,  Y02A50/57

摘要： Non-human animals, expressing humanized CD3 proteins are provided. Non-human animals, e.g., rodents, genetically modified to comprise in their genome humanized CD3 proteins are also provided. Additionally, provided are methods and compositions of making such non-human animals, as well as methods of using said non-human animals.