- 专利标题： Non-Human Animals Expressing Humanized CD3 Complex
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申请号： US18442444申请日： 2024-02-15
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公开(公告)号： US20240306616A1公开(公告)日： 2024-09-19
- 发明人: Kara L. Olson , Eric Smith , Ka-Man Venus Lai , Andrew J. Murphy , Gavin Thurston , Dayong Guo
- 申请人： Regeneron Pharmaceuticals, Inc.
- 申请人地址： US NY Tarrytown
- 专利权人： Regeneron Pharmaceuticals, Inc.
- 当前专利权人： Regeneron Pharmaceuticals, Inc.
- 当前专利权人地址： US NY Tarrytown
- 分案原申请号： US17118241 2020.12.10
- 主分类号： A01K67/0278
- IPC分类号： A01K67/0278 ; A01K67/0276 ; C07K14/725 ; C12N5/071 ; C12N15/85 ; G01N33/50
摘要：
Non-human animals, expressing humanized CD3 proteins are provided. Non-human animals, e.g., rodents, genetically modified to comprise in their genome humanized CD3 proteins are also provided. Additionally, provided are methods and compositions of making such non-human animals, as well as methods of using said non-human animals.
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