公开(公告)号：US12097090B2

公开(公告)日：2024-09-24

申请号：US15742751

申请日：2016-07-11

申请人： Michael Rathbone

发明人： Michael Rathbone

IPC分类号： A61D7/00 ,  A61K9/00 ,  A61D19/00

CPC分类号： A61D7/00 ,  A61K9/0036 ,  A61D19/00

摘要： There are described delivery devices for insertion into a body cavity of a target mammal, the delivery device comprising a resilient frame adapted to receive one or more moulded impregnated masses. The frame, together with the impregnated mass, are insertable, retainable and withdrawable from the intended body cavity. The impregnated mass or masses are attached to the frame to present substantially all of each face of the masses to exposure to a fluid of the body cavity when retained therein.

公开(公告)号：US20240268863A1

公开(公告)日：2024-08-15

申请号：US18604611

申请日：2024-03-14

申请人： PROGENA INC.

发明人： Alexander FESKOV ,  Irina FESKOVA ,  Ievgeniia ZHYLKOVA ,  Stanislav ZHILKOV

IPC分类号： A61B17/435 ,  A61D19/00 ,  A61D19/04 ,  A61K35/12 ,  A61K35/14 ,  C12N5/078

CPC分类号： A61B17/435 ,  A61D19/00 ,  A61D19/04 ,  A61K35/14 ,  C12N5/0634 ,  A61K2035/124 ,  C12N2501/31

摘要： Disclosed is a method of in vitro fertilization wherein the embryo is implanted into the uterus of a female patient at least two, an preferably three to twelve months after the eggs are retrieved from the patient in order to reduce the effect of autoimmune rejection of the embryo by the patient's autoimmune system and increase the probability and success of pregnancy and wherein prior to embryo implantation, the endometrium in the uterus is prepared for embryo implantation by introducing peripheral blood mononuclear cells (PBMCs) into the uterus. The procedure is combined with cryopreservation techniques to preserve the oocytes or the IVF-produced embryos of the patient.

公开(公告)号：US11974548B2

公开(公告)日：2024-05-07

申请号：US16991522

申请日：2020-08-12

申请人： THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF AGRICULTURE

发明人： Sandra N. Leal

IPC分类号： A61D19/00 ,  A01K29/00 ,  A01K67/033

CPC分类号： A01K29/005 ,  A01K67/033 ,  A61D19/00

摘要： A method for determining the mated status of female fruit flies, focusing on determining the presence of spermatozoa in a sample fly's ventral receptacle (VR). The ventral receptacle is the organ where eggs become fertilized. The VR is the first and last organ in a mated female fly to contain spermatozoa. The VR is thus the most accurate organ for determining whether a female fruit fly has recently mated. The method is a squash method. The fly's ventral receptacle is isolated, and then squeezed so as to cause spermatozoa stored in the ventral receptacle to be released into the lumen of the VR. This permits use of a microscope to determine the presence or absence of spermatozoa in the female fruit fly, and thus the mated status of the female fruit fly.

公开(公告)号：US11883438B2

公开(公告)日：2024-01-30

申请号：US16327817

申请日：2017-08-23

申请人： National University Corporation Nagoya University ,  Gifu University ,  Gifu Prefecture

发明人： Tokunori Yamamoto ,  Satoshi Suzuki ,  Yasuhito Funahashi ,  Yoshihisa Matsukawa ,  Momokazu Gotoh ,  Tomohiro Kitayama ,  Yoichiro Hoshino ,  Tetsuma Murase

IPC分类号： A61K35/50 ,  A61K35/51 ,  A61K35/52 ,  A61P15/08 ,  A61K35/32 ,  A61K35/54 ,  A61K35/28 ,  A61K35/35 ,  A61D19/00 ,  A61D19/02 ,  A61K35/00 ,  C12N5/076 ,  C12N5/0775

CPC分类号： A61K35/50 ,  A61D19/00 ,  A61D19/02 ,  A61K35/00 ,  A61K35/28 ,  A61K35/32 ,  A61K35/35 ,  A61K35/51 ,  A61K35/52 ,  A61K35/54 ,  A61P15/08 ,  C12N5/061 ,  C12N5/0664 ,  C12N5/0665 ,  C12N5/0667 ,  C12N2500/80

摘要： It is an object to provide a technique useful for embryo transfer and development of reproductive medical care. Provided are a sperm activator containing a disrupted product of one or more cells selected from the group consisting of adipose tissue-derived stem cells, dental pulp-derived stem cells, bone marrow-derived stem cells, and umbilical cord blood-derived stem cells as an active ingredient, and an artificial insemination method utilizing the same.

公开(公告)号：US20230165223A1

公开(公告)日：2023-06-01

申请号：US17920353

申请日：2021-04-22

申请人： N.R SOOS TECHNOLOGY LTD.

发明人： Gadi Itzhak DEMER

IPC分类号： A01K41/02 ,  A01K41/06 ,  A61D19/00 ,  G10K11/178

CPC分类号： A01K41/023 ,  A01K41/06 ,  A61D19/00 ,  G10K11/178

摘要： Provided herein are egg hatching incubators having a reduced operational noise. In particular, provided are egg hatching incubators configured for affecting or promoting the sex of egg embryos using soundwaves at specific frequencies, wherein the operational noise of the incubator does not interfere with the transmitted soundwaves. Further provided are systems including the incubators and methods of using the same.

公开(公告)号：US10995330B2

公开(公告)日：2021-05-04

申请号：US15115380

申请日：2015-01-28

申请人： LEIBNIZ-INSTITUT FÜR FESTKÖRPER-UND WERKSTOFFFORSCHUNG DRESDEN E.V.

发明人： Oliver G. Schmidt

IPC分类号： A61D19/00 ,  A61B17/425 ,  C12N5/076 ,  C12N11/14 ,  C12N5/071 ,  A61K41/00

摘要： Method for producing mobility in immobile cells in in vivo or in vitro fertilization. The method includes producing mobility in individual immobile cells that are connected to a microstructure. The microstructure is composed at least partially of magnetic materials and a non-reciprocal movement of the microstructure with the immobile cell is executed by a time-varying, three-dimensional external magnetic field.

公开(公告)号：US10806555B2

公开(公告)日：2020-10-20

申请号：US15776482

申请日：2016-09-16

申请人： IMV TECHNOLOGIES

发明人： Eric Schmitt ,  Jean-Charles Gorges ,  Christian Beau ,  Ludovic Lefranc

IPC分类号： B01L3/00 ,  B65B19/34 ,  A61D19/00 ,  A61D19/02

摘要： The invention relates to a storage receptacle (1) with a longitudinal opening (5) through which straws (2) for packing liquid-based substance are passed in a predetermined orientation of the straws, a housing (3) provided for the straws and configured to be inserted slidably in a cover (4) of the receptacle, the latter having an open configuration, in which the housing is partially inserted in the cover and the opening is free for the passage of the straws, and a closure configuration, in which the housing is inserted in the cover and the opening is closed by the cover in order to prohibit the passage of the straws. The housing has a parallelepipedal shape, a first front wall in which the opening is formed, a first bottom wall, two first longitudinal wails extending parallel to the opening, and two first side walls which each have two diagonals of a length less than or equal to the length of the straws.

公开(公告)号：US10668127B2

公开(公告)日：2020-06-02

申请号：US15660647

申请日：2017-07-26

申请人： UNITED-AH II, LLC

发明人： Stephen Kent Webel ,  Mark E. Swanson

IPC分类号： A61K38/09 ,  A61K47/38 ,  A61K47/14 ,  A61K9/06 ,  A61D19/00 ,  A61D7/00 ,  A61D19/02 ,  A61K38/24 ,  A61K9/00

摘要： Methods and compositions for synchronizing the time of insemination in swine are described. More particularly, methods are described for synchronizing the time of insemination by administration of a composition comprising a hormone, wherein the swine is inseminated only one time after administration of the hormone, and wherein there is no heat detection.

公开(公告)号：US10271876B2

公开(公告)日：2019-04-30

申请号：US13655257

申请日：2012-10-18

申请人： MEZADATA MEDICAL IP HOLDING LLC

发明人： Alexander Feskov ,  Irina Feskova ,  Ievgeniia Zhylkova ,  Stanislav Zhilkov

IPC分类号： A61B17/435 ,  A61D19/00 ,  A61D19/04 ,  A61K35/14 ,  C12N5/078 ,  A61K35/12

摘要： A method of in vitro fertilization wherein the embryo is implanted into the uterus of a female patient at least two, and preferably three to twelve months after the eggs are retrieved from the patient in order to reduce the effect of autoimmune rejection of the embryo by the patient's autoimmune system and increase the probability and success of pregnancy and wherein prior to embryo implantation, the endometrium in the uterus is prepared for embryo implantation by introducing peripheral blood mononuclear cells (PBMCs) into the uterus. The procedure is combined with cryopreservation techniques to preserve the oocytes or the IVF-produced embryos of the patient.

公开(公告)号：US20170238504A1

公开(公告)日：2017-08-24

申请号：US15429988

申请日：2017-02-10

申请人： Maria E. Stroud

发明人： Maria E. Stroud

IPC分类号： A01K15/02 ,  A61D19/00

CPC分类号： A01K15/02 ,  A61D19/00 ,  A61D19/021 ,  A61D19/022

摘要： A behavioral training aid comprising: (a) a body; (b) a tract including: (i) a tract locking mechanism that secures the tract to an outer surface of the body; and (ii) a tract insert removably attached to the tract locking mechanism; (c) one or more legs extending from the body; and (d) one or more base supports extending from a distal end of the one or more legs; wherein the tract insert is configured to receive a receptacle so that the receptacle is elongated and forms a depository within the body.