公开(公告)号：US12077765B2

公开(公告)日：2024-09-03

申请号：US16750349

申请日：2020-01-23

申请人： Altria Client Services LLC

发明人： Chengalrayan Kudithipudi ,  Dongmei Xu ,  James A. Strickland ,  Marcos Fernando de Godoy Lusso

IPC分类号： C12N15/82

CPC分类号： C12N15/8243

摘要： The present disclosure provides approaches for reducing nicotine. Also provided are tobacco plants with decreased tobacco-specific nitrosamines (TSNAs). The present disclosure further provides modified tobacco plants with low nicotine and increased antioxidant capacity. Further provided are tobacco plants or material with low nicotine and low TSNAs. Also provided is cured tobacco material of the tobacco plants provided herein and tobacco products comprising this cured tobacco material.

公开(公告)号：US12037593B2

公开(公告)日：2024-07-16

申请号：US17309285

申请日：2019-11-14

申请人： BRITISH AMERICAN TOBACCO (INVESTMENTS) LIMITED

发明人： Sara Ben Khaled ,  Francisco Anastacio De Abreu E Lima

IPC分类号： C12N15/82 ,  C07K14/415 ,  A24B15/10

CPC分类号： C12N15/8243 ,  C07K14/415 ,  C12N15/8218 ,  A24B15/10

摘要： The present invention provides a method for modulating (e.g. decreasing) the alkaloid content of a plant (e.g. a tobacco plant), the method comprising modifying said plant by modulating (e.g. decreasing) the expression of at least one armadillo repeat protein. The present invention also provides for the use of an armadillo repeat protein for modulating the alkaloid content of a plant, as well as tobacco cells, plants, plant propagation materials, harvested leaves, processed tobaccos, or tobacco products obtainable in accordance with the invention.

公开(公告)号：US12037591B2

公开(公告)日：2024-07-16

申请号：US17224659

申请日：2021-04-07

申请人： CORTEVA AGRISCIENCE LLC

发明人： Lakshmi Sastry-Dent ,  Zehui Cao ,  Shreedharan Sriram ,  Steven R. Webb ,  Debra L Camper ,  W. Michael Ainley

IPC分类号： C12N15/82

CPC分类号： C12N15/8213 ,  C12N15/8243 ,  C12N15/8273 ,  C12N15/8274 ,  C12N15/8286

摘要： As disclosed herein, optimal native genomic loci of soybean plants have been identified that represent best sites for targeted insertion of exogenous sequences.

公开(公告)号：US20240229053A1

公开(公告)日：2024-07-11

申请号：US17928516

申请日：2022-05-31

申请人： KT&G CORPORATION

发明人： Hyo Seok SEO ,  Young Gi LEE ,  Jeong Heon LEE ,  Dong Sung JANG ,  Kwang Chul KIM ,  Woong Hyun NA

IPC分类号： C12N15/82 ,  C12N9/10 ,  C12N9/22

CPC分类号： C12N15/8243 ,  C12N9/1077 ,  C12N9/22 ,  C12N15/8205 ,  C12N2310/20 ,  C12Y204/02019

摘要： An aspect provides plant cells with an engineered QPT gene and methods of using the same. When a QPT gene in a plant cell is genetically engineered according to an aspect, biosynthesis of nicotine is effectively inhibited, and nicotine is reduced by about 97% or more, and since alkaloids other than nicotine (nornicotine, anabasine, anatabine) are also reduced by about 68% or more, plant cells with reduced carcinogen TSNAs (NNK, NNN, NAB, and NAT) may be produced.

公开(公告)号：US12018263B2

公开(公告)日：2024-06-25

申请号：US17500196

申请日：2021-10-13

申请人： CORTEVA AGRISCIENCE LLC

发明人： Lakshmi Sastry-Dent ,  Zehui Cao ,  Shreedharan Sriram ,  Steven R. Webb ,  Debra L. Camper

IPC分类号： C12N15/82 ,  A01H5/10

CPC分类号： C12N15/8213 ,  A01H5/10 ,  C12N15/8243 ,  C12N15/8273 ,  C12N15/8274 ,  C12N15/8286

摘要： As disclosed herein, optimal native genomic loci from maize plants have been identified that represent best sites for targeted insertion of exogenous sequences.

公开(公告)号：US20240132929A1

公开(公告)日：2024-04-25

申请号：US18302932

申请日：2023-04-18

申请人： Conagen Inc.

发明人： Guohong Mao ,  Jacob Edward Vick ,  Michael Batten ,  David Byun ,  Yang Luo ,  Yilin Wu ,  Beihua Zhang ,  Xiaodan Yu

IPC分类号： C12P19/56 ,  A21D13/062 ,  A23G4/10 ,  A23L2/60 ,  A23L27/30 ,  C07H1/00 ,  C07H15/24 ,  C07H15/256 ,  C12N9/10 ,  C12N9/42 ,  C12N15/74 ,  C12N15/81 ,  C12N15/82 ,  C12P19/18 ,  C12P19/44

CPC分类号： C12P19/56 ,  A21D13/062 ,  A23G4/10 ,  A23L2/60 ,  A23L27/36 ,  C07H1/00 ,  C07H15/24 ,  C07H15/256 ,  C12N9/1062 ,  C12N9/1081 ,  C12N9/2445 ,  C12N15/74 ,  C12N15/81 ,  C12N15/8243 ,  C12N15/8245 ,  C12P19/18 ,  C12P19/44 ,  A23K20/163 ,  A23V2002/00

摘要： The present invention relates to the production of steviol glycoside rebaudiosides D4, WB1 and WB2 and the production of rebaudioside M from Reb D4.

公开(公告)号：US20240117326A1

公开(公告)日：2024-04-11

申请号：US17767838

申请日：2020-10-09

申请人： Commonwealth Scientific and Industrial Research Organisation

发明人： Ema Jayne JOHNSTON ,  Robert Silas ALLEN ,  Christina Maria GREGG ,  Shoko OKADA ,  Amratha MENON ,  Andrew Charles WARDEN ,  Matthew Craig TAYLOR ,  Craig Christopher WOOD

IPC分类号： C12N9/02 ,  C07K14/415 ,  C12N9/10 ,  C12N9/24 ,  C12N15/62 ,  C12N15/82

CPC分类号： C12N9/0095 ,  C07K14/415 ,  C12N9/1025 ,  C12N9/13 ,  C12N9/2402 ,  C12N15/62 ,  C12N15/8243 ,  C12Y118/06001 ,  C12Y203/03014 ,  C12Y208/01007 ,  C07K2319/07 ,  C07K2319/50

摘要： The present invention relates to methods and means for producing nitrogenase polypeptides in the mitochondria of plant cells.

公开(公告)号：US20240110215A1

公开(公告)日：2024-04-04

申请号：US18470785

申请日：2023-09-20

申请人： EVOLVA SA

发明人： Ganesh M. Kishore ,  Michael Motion ,  Paula M. Hicks ,  Jorgen Hansen ,  Jens Houghton Larsen ,  Esben Halkjaer Hansen ,  Michael Dalgaard Mikkelsen ,  Sabina Tavares ,  Charlotte Blom

IPC分类号： C12P19/56 ,  A23L2/60 ,  A23L27/30 ,  C07H15/256 ,  C12N9/02 ,  C12N9/04 ,  C12N9/10 ,  C12N9/88 ,  C12N9/90 ,  C12N15/52 ,  C12N15/82 ,  C12P7/42 ,  C12P15/00

CPC分类号： C12P19/56 ,  A23L2/60 ,  A23L27/36 ,  C07H15/256 ,  C12N9/0006 ,  C12N9/0042 ,  C12N9/0073 ,  C12N9/1051 ,  C12N9/1077 ,  C12N9/1085 ,  C12N9/88 ,  C12N9/90 ,  C12N15/52 ,  C12N15/8243 ,  C12N15/8245 ,  C12P7/42 ,  C12P15/00 ,  C12Y101/01088 ,  C12Y106/02004 ,  C12Y114/13078 ,  C12Y114/13079 ,  C12Y204/01126 ,  C12Y205/01029 ,  C12Y402/03019 ,  C12Y505/01012 ,  Y02P20/52

摘要： Recombinant microorganisms, plants, and plant cells are disclosed that have been engineered to express novel recombinant genes encoding steviol biosynthetic enzymes and UDP-glycosyltransferases (UGTs). Such microorganisms, plants, or plant cells can produce steviol or steviol glycosides, e.g., rubusoside or Rebaudioside A, which can be used as natural sweeteners in food products and dietary supplements.

公开(公告)号：US20240102034A1

公开(公告)日：2024-03-28

申请号：US17641985

申请日：2021-07-15

申请人： Daniel Kevin FOWLER ,  CANOPY GROWTH COPORATION

发明人： Daniel Kevin FOWLER

IPC分类号： C12N15/82 ,  A01H6/28 ,  C12N9/02 ,  C12N9/22

CPC分类号： C12N15/8243 ,  A01H6/28 ,  C12N9/0004 ,  C12N9/22 ,  C12N15/8213 ,  C12N2310/20 ,  C12Y121/03007

摘要： The present technology generally relates to Cannabis plants having increased cannabigerolic acid (CBGA) and/or cannabigerol (CBG) content. The present technology also generally relates to isolated nucleic acids and isolated amino acids related to same and methods of producing same.

公开(公告)号：US20240067977A1

公开(公告)日：2024-02-29

申请号：US17766786

申请日：2020-10-09

申请人： ALTRIA CLIENT SERVICES LLC

发明人： Chengalrayan KUDITHIPUDI ,  Rajanikanth GOVINDARAJULU ,  Nazmul BHUIYAN ,  Raija PAYYAVULA ,  Yanxin SHEN ,  Dongmei XU

IPC分类号： C12N15/82 ,  C07K14/415 ,  C12N15/113

CPC分类号： C12N15/8243 ,  C07K14/415 ,  C12N15/1137

摘要： The present disclosure provides composition and methods for improving leaf quality of low-alkaloid tobacco plants. Also provided are the identification and genetic engineering of target genes (Leaf Quality Genes) for producing tobacco plants with altered total alkaloid and nicotine levels and commercially acceptable leaf grade, their development via breeding or transgenic approaches, and production of tobacco products from these tobacco plants.