公开(公告)号：US12123042B2

公开(公告)日：2024-10-22

申请号：US17899069

申请日：2022-08-30

申请人： EVOLVA SA

发明人： Helene Lunde Robertsen ,  Iben Nordmark Andersen ,  Adam Matthew Takos ,  Swee Chuang Lim Hallwyl ,  Francesca Ambri ,  Manuel Quiros Asensio ,  Michael Dalgaard Mikkelsen ,  Jens Houghton-Larsen ,  Veronique Douchin ,  Jane Dannow Dyekjaer ,  Simon Carlsen ,  Nina Nicoline Rasmussen ,  Esben Halkjaer Hansen

IPC分类号： C12P19/56 ,  A23L27/30 ,  C07H15/256 ,  C12N9/02 ,  C12N9/10 ,  C12N9/88 ,  C12N9/90 ,  C12N15/52

CPC分类号： C12P19/56 ,  A23L27/36 ,  C07H15/256 ,  C12N9/0042 ,  C12N9/0073 ,  C12N9/1085 ,  C12N9/88 ,  C12N9/90 ,  C12N15/52 ,  C12Y106/02004 ,  C12Y114/13078 ,  C12Y114/13079 ,  C12Y205/01029 ,  C12Y402/03019 ,  C12Y505/01013 ,  A23V2002/00 ,  C07K2319/00

摘要： The invention relates to recombinant microorganisms and methods for producing steviol glycosides and steviol glycoside precursors.

公开(公告)号：US20240110215A1

公开(公告)日：2024-04-04

申请号：US18470785

申请日：2023-09-20

申请人： EVOLVA SA

发明人： Ganesh M. Kishore ,  Michael Motion ,  Paula M. Hicks ,  Jorgen Hansen ,  Jens Houghton Larsen ,  Esben Halkjaer Hansen ,  Michael Dalgaard Mikkelsen ,  Sabina Tavares ,  Charlotte Blom

IPC分类号： C12P19/56 ,  A23L2/60 ,  A23L27/30 ,  C07H15/256 ,  C12N9/02 ,  C12N9/04 ,  C12N9/10 ,  C12N9/88 ,  C12N9/90 ,  C12N15/52 ,  C12N15/82 ,  C12P7/42 ,  C12P15/00

CPC分类号： C12P19/56 ,  A23L2/60 ,  A23L27/36 ,  C07H15/256 ,  C12N9/0006 ,  C12N9/0042 ,  C12N9/0073 ,  C12N9/1051 ,  C12N9/1077 ,  C12N9/1085 ,  C12N9/88 ,  C12N9/90 ,  C12N15/52 ,  C12N15/8243 ,  C12N15/8245 ,  C12P7/42 ,  C12P15/00 ,  C12Y101/01088 ,  C12Y106/02004 ,  C12Y114/13078 ,  C12Y114/13079 ,  C12Y204/01126 ,  C12Y205/01029 ,  C12Y402/03019 ,  C12Y505/01012 ,  Y02P20/52

摘要： Recombinant microorganisms, plants, and plant cells are disclosed that have been engineered to express novel recombinant genes encoding steviol biosynthetic enzymes and UDP-glycosyltransferases (UGTs). Such microorganisms, plants, or plant cells can produce steviol or steviol glycosides, e.g., rubusoside or Rebaudioside A, which can be used as natural sweeteners in food products and dietary supplements.

公开(公告)号：US11821015B2

公开(公告)日：2023-11-21

申请号：US17200673

申请日：2021-03-12

申请人： EVOLVA SA

发明人： Veronique Douchin ,  Swee Chuang Lim Hallwyl ,  Kim Olsson

IPC分类号： C12N15/63 ,  C12P19/56 ,  A23L2/60 ,  A23L27/30 ,  G01N30/02

CPC分类号： C12P19/56 ,  A23L2/60 ,  A23L27/36 ,  C12N15/63 ,  G01N30/02 ,  G01N2030/027

摘要： The invention relates to recombinant microorganisms and methods for producing steviol glycosides and steviol glycoside precursors.

公开(公告)号：US20220132841A1

公开(公告)日：2022-05-05

申请号：US17525074

申请日：2021-11-12

申请人： EVOLVA SA

发明人： Jean Davin Amick ,  Bryan N. Julien ,  Kim Thu Le Greenbaum

IPC分类号： A01N35/06

摘要： The invention relates to biting arthropod repellent compositions comprising nootkatone. The application also relates to a method of repelling said biting arthropods by application of the nootkatone composition to a hard or soft surface, to a method of treating an arthropod infestation and to a method of reducing the transmission of a parasite or disease pathogen spread by a biting arthropod using the nootkatone composition.

公开(公告)号：US20220073960A1

公开(公告)日：2022-03-10

申请号：US17373612

申请日：2021-07-12

申请人： EVOLVA SA

发明人： Ganesh M. Kishore ,  Michael Motion ,  Paula M. Hicks ,  Jorgen Hansen ,  Jens Hougton-Larsen ,  Esben Halkjaer Hansen ,  Michael Dalgaard Mikkelsen ,  Sabina Tavares ,  Charlotte Blom, Sr.

IPC分类号： C12P19/56 ,  A23L27/30 ,  C12N15/82 ,  C12P15/00 ,  C12N9/10 ,  A23L2/60 ,  C07H15/256 ,  C12N9/04 ,  C12N9/02 ,  C12N9/88 ,  C12N9/90 ,  C12N15/52 ,  C12P7/42

摘要： Recombinant microorganisms, plants, and plant cells are disclosed that have been engineered to express novel recombinant genes encoding steviol biosynthetic enzymes and UDP-glycosyltransferases (UGTs). Such microorganisms, plants, or plant cells can produce steviol or steviol glycosides, e.g., rubusoside or Rebaudioside A, which can be used as natural sweeteners in food products and dietary supplements.

公开(公告)号：US20220017932A1

公开(公告)日：2022-01-20

申请号：US17244089

申请日：2021-04-29

申请人： EVOLVA SA

发明人： Ernesto Simon ,  Iben Nordmark Anderson ,  Michael Dalgaard Mikkelsen ,  Jorgen Hansen ,  Veronique Douchin

IPC分类号： C12P19/56 ,  C12N9/02 ,  C12N9/88 ,  C12N9/90 ,  C07K14/395 ,  C12N9/10 ,  C12P15/00

摘要： Recombinant microorganisms are disclosed that produce steviol glycosides and have altered expression of one or more endogenous transporter or transcription factor genes, or that overexpress one or more heterologous transporters, leading to increased excretion of steviol glycosides of interest.

公开(公告)号：US20200291442A1

公开(公告)日：2020-09-17

申请号：US16754247

申请日：2018-12-05

申请人： EVOLVA SA

发明人： Veronique Douchin ,  Swee Chuang Lim Hallwyl

IPC分类号： C12P19/56 ,  C12N1/18 ,  C12N1/16

摘要： The invention relates to recombinant microorganisms and methods for producing steviol glycosides and steviol glycoside precursors.

公开(公告)号：US10689672B2

公开(公告)日：2020-06-23

申请号：US14438200

申请日：2013-11-05

申请人： Evolva SA ,  University of Copenhagen

发明人： Birger Lindberg Møller ,  Esben Halkjaer Hansen ,  Jørgen Hansen ,  Nethaji Janeshawari Gallage

IPC分类号： C12N9/10 ,  C12P7/24 ,  C12N9/88 ,  C12N15/82 ,  A23L27/24 ,  C12N9/04 ,  C12P7/22 ,  C12P19/46

摘要： The invention relates to methods for producing vanillin and related compounds. The methods involve use of a vanillin synthase capable of catalyzing side chain cleavage of ferulic acid to form vanillin. The invention also relates to host organisms expressing such vanillin synthases useful in the methods.

公开(公告)号：US10662458B2

公开(公告)日：2020-05-26

申请号：US15900557

申请日：2018-02-20

申请人： EVOLVA SA

发明人： Yaoquan Liu ,  Jorgen Hansen ,  Jens Houghton-Larsen ,  Muthuswamy Panchapagesa Murali ,  Sathish Kumar ,  Nina Nicoline Rasmussen

IPC分类号： C12P19/18 ,  C12P33/20 ,  C12N9/10 ,  C12P19/56 ,  C12P33/08 ,  C12N9/02 ,  C12N9/14 ,  C12N9/90 ,  C12P33/00 ,  C12P33/12 ,  C12N15/80

摘要： The invention relates to methods for producing mogrosides with the aid of enzymes. In particular the invention proposes various biosynthetic pathways useful for mogroside production and enzymes useful for mogroside production are provided. Furthermore, the invention provides recombinant hosts useful in performing the methods of the invention.

公开(公告)号：US10435730B2

公开(公告)日：2019-10-08

申请号：US15439660

申请日：2017-02-22

申请人： Evolva SA

发明人： Jens Houghton-Larsen ,  Paula Hicks ,  Michael Naesby ,  Thomas Tange Ostergaard ,  Jorgen Hansen ,  Michael Mikkelsen Dalgaard ,  Esben Hansen Halkjaer ,  Ernesto Simon ,  Sabina De Andrade Periera Tavares

IPC分类号： C12P19/56 ,  C12N9/10 ,  C12N9/02 ,  C12N1/21 ,  C12N9/88 ,  C12N9/06 ,  C12N9/90 ,  C12N15/81 ,  C12N15/82 ,  C12P19/44 ,  C12N15/63

摘要： Recombinant microorganisms, plants, and plant cells are disclosed that have been engineered to express recombinant genes encoding UDP-glycosyltransferases (UGTs). Such microorganisms, plants, or plant cells can produce steviol glycosides, e.g., Rebaudioside A and/or Rebaudioside D, which can be used as natural sweeteners in food products and dietary supplements.