公开(公告)号：US20220175896A1

公开(公告)日：2022-06-09

申请号：US17555761

申请日：2021-12-20

申请人： INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) ,  UNIVERSITE PARIS DESCARTES ,  UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6) ,  UNIVERSITE PARIS DIDEROT - PARIS 7

发明人： Roberto MALLONE ,  Slobodan CULINA ,  Nimesh GUPTA ,  Sebastien LACROIX-DESMAZES

IPC分类号： A61K39/00 ,  A61P37/06

摘要： The present invention relates to methods and pharmaceutical compositions of inducing immune tolerance by mucosal vaccination with Fc-coupled antigens. In particular, the present invention relates to a method for inducing tolerance to one antigen of interest in a subject in need thereof, comprising the mucosal administration to the subject of a therapeutically effective amount of a recombinant chimeric construct comprising a FcRn targeting moiety and an antigen-containing moiety.

公开(公告)号：US11110252B2

公开(公告)日：2021-09-07

申请号：US15569962

申请日：2016-04-29

申请人： MMG ,  UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6)

发明人： Thomas Similowski ,  Serge Renaux

IPC分类号： A61M25/02 ,  A61M16/04

摘要： Device (100) for holding in position a probe for placing the inside of a patient's body in communication with the outside, characterized in that it comprises, arranged along a longitudinal axis (X-X′) of the device: at its distal end, a means (110) of supporting the device on the patient's body and that extends radially, comprising an axial opening (114) for the passage of said probe and comprising a first radial opening (111) communicating with the said axial opening, at its proximal end, a means (120) of guiding said probe comprising a second radial opening (121), a means (130) of spacing said bearing means and said guide means apart longitudinally.

公开(公告)号：US20200297749A1

公开(公告)日：2020-09-24

申请号：US16835978

申请日：2020-03-31

申请人： Institut National de la Sante et de la Recherche Medicale (INSERM) ,  Universite Paris Sud ,  Institut Gustave Roussy ,  Institut Pasteur ,  Universite Pierre et Marie Curie (Paris 6) ,  Instituto Nazionale per le Malattie Infettive IRCCS Lazzaro Spallanzani ,  Universite Paris Diderot - Paris 7 ,  Universite Paris Descartes ,  Assistance Publique-Hopitaux de Paris

发明人： Jean-Luc PERFETTINI ,  Audrey PAOLETTI ,  Marie-Lise GOUGEON ,  Guido KROEMER ,  Mauro PIACENTINI

IPC分类号： A61K31/7072 ,  A61K48/00 ,  A61P37/00 ,  A61P31/00 ,  A61P29/00 ,  A61P35/00 ,  A61K31/7034 ,  A61K31/7076 ,  A61K31/7084 ,  A61K38/17

摘要： The present invention relates to methods and pharmaceutical composition for modulation polarization and activation of macrophages. In particular, the present invention relates to methods for modulating macrophage M1/M2 polarization in a subject in need thereof comprising administering to the subject a therapeutically effective amount of P2Y2 receptor agonists or antagonists.

公开(公告)号：US10530230B2

公开(公告)日：2020-01-07

申请号：US14366572

申请日：2012-12-19

申请人： UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6) ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

发明人： Vincent Hayward ,  Amir Berrezag ,  George Dietz

IPC分类号： H02K33/00 ,  H02K15/14 ,  H02K15/06 ,  H02K33/02 ,  H02K33/16

摘要： The invention relates to a miniature linear vibrotactile actuator comprising: a first element 14, 104 of generally cylindrical shape, comprising permanent magnets 15, 105 aligned so that two adjacent sides of two adjacent magnets 15, 105 have identical polarities; a second element 11, 101 defining a cylindrical cavity 12, 102 into which the first element 14, 104 is inserted with play so as to be able to slide therein in a sliding direction X2, the second element 11, 101 comprising coils 13, 103 of conductive wire having strands that extend perpendicularly to the sliding direction X2, in order to form magnetic force generators, and that are placed so as to be able to influence the first element 14, 104 electromagnetically; and means 25, 41, 125 for returning and guiding the first element 14, 104 toward an equilibrium position in the second element 11, 101, in which position a median plane P2 between two adjacent magnets substantially coincides with a median plane P1 of a facing force generator 111.

公开(公告)号：US20190353590A1

公开(公告)日：2019-11-21

申请号：US16461635

申请日：2017-11-17

申请人： Electricite de France ,  Universite Pierre Et Marie Curie (Paris 6)

发明人： Alejandro Ribes Cortes ,  Mohamed Ben Chouikha

IPC分类号： G01N21/55 ,  G01N21/3563 ,  G01N21/27 ,  G01N21/84

摘要： The invention relates to a portable device (1) for estimating at least one parameter characteristic of a polymer material, characterized in that the device comprises at least one infrared source (101), each infrared source (101) being capable of emitting towards the polymer material a spectral line, representing maximum emission energy, selected in one of the wavelengths 10 μm, 9.5 μm, 7.2 μm, 6 μm, 3.5 μm, 2.7 μm or in one of the wave numbers 1000 cm−1, 1050 cm−1, 1350 cm−1, 1700 cm−1, 2900 cm−1, 3700 cm−1, at least one infrared detector (102), capable of receiving infrared radiation (112), which is reflected by the polymer material (M) in response to the spectral line, a unit for determining the parameter characteristic of the polymer material (M) as a function of the energy present in said spectral line in the infrared radiation (112), having been reflected by the polymer material (M) and having been received by the infrared detector (102).

公开(公告)号：US20190292259A1

公开(公告)日：2019-09-26

申请号：US16301633

申请日：2017-05-24

申请人： INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) ,  MEDIMMUNE, LLC ,  UNIVERSITE PARIS DESCARTES ,  UNIVERSITE PIERRE ET MARIE CURIE(PARIS 6) ,  UNIVERSITE PARIS DIDEROT - PARIS 7 ,  SORBONNE UNIVERSITE

发明人： Diane DAMOTTE ,  Ronald HERBST ,  Jerome BITON ,  Claudie BANTSIMBA MALANDA

IPC分类号： C07K16/28 ,  G01N33/569 ,  G01N33/574

摘要： The disclosure relates to methods and pharmaceutical compositions for the treatment of non-small cell lung cancer (NSCLC) that coexists with chronic obstructive pulmonary disease (COPD). In particular, the disclosure relates to a method of treating non-small cell lung cancer (NSCLC) in a patient suffering from chronic obstructive pulmonary disease (COPD) comprising administering to the patient a therapeutically effective amount of an immune checkpoint inhibitor such as is a multispecific antibody comprising at least one binding site that specifically binds to a PD-1 molecule and at least one binding site that specifically binds to a TIM-3 molecule.

公开(公告)号：US20190228919A1

公开(公告)日：2019-07-25

申请号：US16334275

申请日：2017-09-29

申请人： PARIS SCIENCES ET LETTRES - QUARTIER LATIN ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS ,  UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6) ,  ECOLE SUPÉRIEURE DE PHYSIQUE ET DE CHIME INDUSTRIELLES DE LA VILLE DE PARIS

发明人： Brigitte Leridon ,  Stéphane Hole ,  Rémi Federicci

IPC分类号： H01G11/56 ,  H01G11/30

摘要： The invention relates to a supercapacitor comprising: an electrolyte having a first end and a second end opposite the first end, a first electrode in contact with the first end of the electrolyte, and a second electrode in contact with the second end of the electrolyte. In particular, the electrolyte is made of a solid material that is ion-conductive and electronically insulating.

公开(公告)号：US20190083776A1

公开(公告)日：2019-03-21

申请号：US15527434

申请日：2015-11-19

申请人： Chambre de Commerce et D'Industrie de Region Paris Ile de France (ESIEE Paris) ,  Universite Pierre Et Marie Curie (Paris 6)

发明人： Lionel Rousseau ,  Gaëlle Lissorgues ,  Myline Cottance ,  Serge Picaud ,  Julie Degardin

IPC分类号： A61N1/05 ,  A61N1/36 ,  H01B5/14 ,  H01B13/00

摘要： The invention relates to a process for manufacturing at least one implant for focal electrical stimulation of a nervous structure, said implant being of the type including in a supporting structure a network of cavities at the bottom of which are placed microelectrodes, the cavities being bounded by walls erected and located around the microelectrodes, the supporting structure being produced beforehand by implementing the following steps: deposition and etching, in a planar manner, on an insulating substrate, of electrical contacts, of electrical tracks and of microelectrodes, first tracks electrically connecting the microelectrodes and the electrical contacts, second electrical tracks being electrically connected to a ground.

公开(公告)号：US20190018230A1

公开(公告)日：2019-01-17

申请号：US16028695

申请日：2018-07-06

申请人： Centre National d'Études Spatiales ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6)

发明人： Frédéric BOURCIER ,  Philippe WALTER

IPC分类号： G02B21/00 ,  G02B21/24 ,  G01J3/28 ,  G01N21/64

摘要： The present disclosure concerns a broadband hyperspectral imaging spectrophotometer configured to analyze an object and includes an illumination assembly having a source for emitting a light beam and configured so that the light beam scans line by line the object to be analyzed, a focusing mirror, a first mirror folding, and a planar scanning mirror movable in rotation. The illumination assembly, the focusing mirror, the first folding mirror and the planar mirror are arranged to bring the light beam to the object along a line which will be displaced on the object via the scanning mirror. The imaging spectrophotometer further includes two measuring sensors by a distance between the object and the scanning mirror. The focusing mirror is movable in translation to adapt the imager to the measured distance by the measuring sensors.

公开(公告)号：US10106765B2

公开(公告)日：2018-10-23

申请号：US14905469

申请日：2014-07-15

申请人： Inria Institut National De Recherche En Informatique Et En Automatique ,  Centre National De La Recherche Scientifique (C.N.R.S) ,  Ecole Centrale Paris ,  Universite Pierre Et Marie Curie (Paris 6)

发明人： Olivier Bernard ,  Filipa Lopes ,  Eric Pruvost ,  Antoine Sciandra

IPC分类号： C12M1/00 ,  C12M1/12 ,  C12M1/26 ,  C12M3/00 ,  C12N1/12

摘要： The invention relates to a method for producing microalgae on a support (14) that is movably mounted essentially in an aqueous medium contained in a tank (12), said method comprising a succession of phases in which the microalgae developing on the support (14) are exposed to sunlight and phases in the shade, the light intensity received in the shade being less than 50% of the average light intensity received during the sunlight exposure phases. The total length of the shade phases is more than 50% longer than the total length of the sunlight exposure phases.