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公开(公告)号：US20180251796A1
公开(公告)日：2018-09-06
申请号：US15755976
申请日：2015-08-28
CPC分类号： C12P5/007 , C12N9/10 , C12N9/90 , C12N15/63 , C12N15/74 , C12P23/00 , C12R1/01 , C12Y103/9903 , C12Y104/99 , C12Y202/01007 , C12Y205/01029 , C12Y205/01032 , C12Y503/03002 , C12Y505/01018
摘要： The present invention concerns a method of producing and enantiomerically pure alpha-ionone. Further, the invention concerns a nucleic acid that comprises a sequence that encodes a lycopene-epsilon-cyclase (EC), a lycopene-epsilon-cyclase (EC), plasmids, which encode components of the alpha-ionone biosynthesis and a microorganism that contains heterologous nucleotide sequences which encode the enzymes geranylgeranyl-diphosphate-synthase, isopentenyl-diphosphate-isomerase (IPI), phytoene desaturase-dehydrogenase (crtI), phytoene synthase (crtB), lycopene-epsilon-cyclase (EC) and carotenoid-cleavage-dioxygenase (CCD1). Further, the invention concerns a method of producing highly pure epsilon-carotene.
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公开(公告)号：US10059974B2
公开(公告)日：2018-08-28
申请号：US14377041
申请日：2013-02-05
发明人： Eleanore T Wurtzel , Rena Quinlan
IPC分类号： C12N9/90 , C12P23/00 , C07C403/24 , C12N9/02 , C12N9/10 , A23L33/135 , A23L33/145
CPC分类号： C12P23/00 , A23L33/135 , A23L33/145 , C07C403/24 , C12N9/001 , C12N9/0073 , C12N9/0083 , C12N9/1085 , C12N9/90 , C12Y103/05006 , C12Y114/13129 , C12Y114/99045 , C12Y205/01029 , C12Y205/01032 , C12Y505/01018 , C12Y505/01019
摘要： Provided herein are recombinant cells (e.g., recombinant bacteria or plant, insect, mammalian, and yeast cells) containing a nucleic acid encoding a CYP97A protein or a nucleic acid encoding a CYP97B protein; a nucleic acid encoding a CYP97C protein; a nucleic acid encoding a geranylgeranyl pyrophosphate synthase protein; a nucleic acid encoding a phytoene synthase protein; a nucleic acid encoding a phytoene desaturase protein; a nucleic acid encoding a lycopene β-cyclase protein; and a nucleic acid encoding a lycopene ε-cyclase protein. Also provided are methods of producing lutein that include culturing these recombinant cells (e.g., recombinant bacteria and yeast cells), and methods of generating these recombinant cells (e.g., recombinant bacteria and yeast cells). Also provided is lutein produced by these methods, and pharmaceutical compositions, food supplements, food products, and cosmetic compositions that contain lutein produced by these methods.
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3.发明申请BIOLOGICAL DEVICES AND METHODS FOR INCREASING THE PRODUCTION OF LYCOPENE FROM PLANTS 有权生物装置和方法，用于增加从植物生产的叶绿素公开(公告)号：US20160017362A1
公开(公告)日：2016-01-21
申请号：US14774769
申请日：2014-03-11
CPC分类号： C12N15/8279 , C12N9/0073 , C12N9/90 , C12P5/007 , C12Y114/13129 , C12Y505/01018
摘要： Described herein are devices and methods for enhancing the physiological properties of plants. For example, the devices and methods described herein increase the production of lycopene, which has industrial and economic value. The lycopene produced by the devices and methods does not require the ultra purification that is common in conventional or commercial methods. The devices and methods described herein also enhance the growth rate of plants.
摘要翻译： 本文描述了用于增强植物生理特性的装置和方法。 例如，本文所述的装置和方法增加了具有工业和经济价值的番茄红素的生产。 由装置和方法生产的番茄红素不需要在常规或商业方法中常见的超纯化。 本文所述的装置和方法还增强了植物的生长速率。
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公开(公告)号：US20190194699A1
公开(公告)日：2019-06-27
申请号：US16230932
申请日：2018-12-21
发明人： Eduardo Esteban Agosin Trumper , Francisco Javier Saitua Perez , Javiera Cecilia Lopez Salinas , Maciej E Domaradzki , Maximiliano Ibaceta Acevedo , Natalia Arenas Frigolett
CPC分类号： C12P7/26 , C12N9/0069 , C12N9/1085 , C12N9/90 , C12N15/52 , C12N15/81 , C12Y113/11071 , C12Y205/01029 , C12Y505/01018
摘要： This invention provides improved biological synthesis of the apocarotenoid α-ionone in Saccharomyces cerevisiae. The final native step involved in the natural apocarotenoid pathway depends on an endogenous farnesyl pyrophosphate synthase (FPPs). From there, heterologous geranylgeranyl pyrophosphate synthase (crtE), phytoene synthase (crtB), phytoene desaturase (crtI), lycopene ε-cyclase (LycE) and a Carotenoid Cleavage Dioxygenase (CCD1) are required to complete the synthesis of α-ionone. Lycopene ε-cyclase from lettuce (Lactuca sativa) or modified cyclase from Arabidopsis thaliana was used to overproduce lycopene which was then cleaved by the carotenoid cleavage dioxygenase from Petunia hybrida (Ph-CCD1).
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公开(公告)号：US09828609B2
公开(公告)日：2017-11-28
申请号：US14774769
申请日：2014-03-11
发明人： Raul Cuero Rengifo
CPC分类号： C12N15/8279 , C12N9/0073 , C12N9/90 , C12P5/007 , C12Y114/13129 , C12Y505/01018
摘要： Described herein are devices and methods for enhancing the physiological properties of plants. For example, the devices and methods described herein increase the production of lycopene, which has industrial and economic value. The lycopene produced by the devices and methods does not require the ultra purification that is common in conventional or commercial methods. The devices and methods described herein also enhance the growth rate of plants.
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公开(公告)号：US11920137B2
公开(公告)日：2024-03-05
申请号：US16488504
申请日：2018-02-26
发明人： Congqiang Zhang , Xixian Chen , Heng-Phon Too
CPC分类号： C12N15/52 , C12N9/0069 , C12N9/90 , C12N15/62 , C12N15/70 , C12P5/026 , C12P7/26 , C12P23/00 , C12Y113/11063 , C12Y113/11068 , C12Y505/01018 , C12Y505/01019
摘要： A method for producing a carotenoid or apocarotenoid is disclosed. The method comprises the step of expressing in a host cell an expression module comprising an expression vector having a coding region encoding at least one optimised carotenoid or apocarotenoid generating enzyme, the coding region being operably linked to a promoter. A host cell comprising an expression vector having a coding region encoding at least one optimised carotenoid or apocarotenoid generating enzyme, the coding region being operably linked to a promoter is also provided together with a kit.
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公开(公告)号：US11753614B2
公开(公告)日：2023-09-12
申请号：US17165192
申请日：2021-02-02
发明人： Eon Seon Jin , Jongrae Kim
IPC分类号： A61K36/05 , A61K8/9722 , C12N1/12 , C12N9/90 , C12P23/00 , A23L33/10 , A23L17/60 , A61Q19/08
CPC分类号： C12N1/12 , A23L17/60 , A23L33/10 , A61K8/9722 , A61K36/05 , A61Q19/08 , C12N9/90 , C12P23/00 , C12Y505/01018 , A23V2002/00
摘要： The present invention relates to a novel violaxanthin-overproducing strain of Chlorella vulgaris and a method of producing violaxanthin therefrom. The inventors have developed a strain that produces violaxanthin at a significantly higher level than a wild-type strain by inducing a random chemical mutation in a Chlorella vulgaris strain to, and then as a result of analysis, confirmed that the strain produces violaxanthin up to 0.41% based on dry weight, which reaches the highest level that is possible to be produced in microalgae. Furthermore, as a method of effectively extracting a carotenoid pigment containing violaxanthin from the strain was established, since the strain and the developed pigment extraction method according to the present invention allow effective production and separation of violaxanthin, the strain is expected to increase commercial applications such as cosmetics, health functional foods and feed.
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公开(公告)号：US20180105839A1
公开(公告)日：2018-04-19
申请号：US15694443
申请日：2017-09-01
申请人： ARCH INNOTEK, LLC
发明人： Yechun Wang
CPC分类号： C12P7/02 , C12N9/001 , C12N9/0071 , C12N9/0083 , C12N9/1085 , C12N9/90 , C12P5/007 , C12P23/00 , C12Y103/99 , C12Y114/13129 , C12Y114/99045 , C12Y205/01032 , C12Y505/01018
摘要： The present invention relates to compositions and methods of producing xanthophylls in microorganisms.
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公开(公告)号：US12037630B2
公开(公告)日：2024-07-16
申请号：US17519854
申请日：2021-11-05
发明人： Jeffrey Moseley , Byung-Hee Lee , Chung Soon Im , Jane Kim , Dayoung Kim , Riyaz Bhat
IPC分类号： C12N15/52 , C12N9/02 , C12N9/16 , C12N9/90 , C12P7/6472
CPC分类号： C12P7/6472 , C12N9/0071 , C12N9/0083 , C12N9/16 , C12N9/90 , C12N15/52 , C12Y114/19 , C12Y114/19002 , C12Y301/02014 , C12Y505/01018
摘要： Methods to produce oils with modified profiles of fatty acid, carotenoids and/or terpenoids in microalgal mutants are provided. Microalgal mutants produce the oil containing fatty acids, carotenoids and/or terpenoids of a modified profile with a disruption or ablation of one or more alleles of an endogenous polynucleotide or comprising an exogeneous gene are also provided.
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公开(公告)号：US20240175036A1
公开(公告)日：2024-05-30
申请号：US18384044
申请日：2023-10-26
发明人： Congqiang Zhang , Xixian Chen , Heng-Phon Too
CPC分类号： C12N15/52 , C12N9/0069 , C12N9/90 , C12N15/62 , C12N15/70 , C12P5/026 , C12P7/26 , C12P23/00 , C12Y113/11063 , C12Y113/11068 , C12Y505/01018 , C12Y505/01019
摘要： A method for producing a carotenoid or apocarotenoid is disclosed. The method comprises the step of expressing in a host cell an expression module comprising an expression vector having a coding region encoding at least one optimised carotenoid or apocarotenoid generating enzyme, the coding region being operably linked to a promoter. A host cell comprising an expression vector having a coding region encoding at least one optimised carotenoid or apocarotenoid generating enzyme, the coding region being operably linked to a promoter is also provided together with a kit.
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