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    α-Hydroxy-benzeneacetic acid derivatives, and compounds having two 5-membered latone rings fused to central cyclohexa-1,4-diene nucleus based upon the same, and uses of the compounds
    32.
    发明授权
    α-Hydroxy-benzeneacetic acid derivatives, and compounds having two 5-membered latone rings fused to central cyclohexa-1,4-diene nucleus based upon the same, and uses of the compounds 有权
    α-羟基 - 苯乙酸衍生物，以及具有与中心环己1,4-二烯核稠合的两个5元拉伸环的化合物，以及化合物

    公开(公告)号：US07737286B2

    公开(公告)日：2010-06-15

    申请号：US10572233

    申请日：2004-09-17

    Applicant: Man-joon Han ,  Soon-hyun Park ,  Jwung-rhok Kim ,  Urs Lauk

    Inventor： Man-joon Han ,  Soon-hyun Park ,  Jwung-rhok Kim ,  Urs Lauk

    IPC: C07D307/00 ,  D06P1/00

    CPC classification number: C07C51/093 ,  C07C51/29 ,  C07D295/155 ,  C07D295/24 ,  C07D307/12 ,  C07D307/16 ,  C07D309/04 ,  C07D309/06 ,  C07D333/44 ,  C07D493/04 ,  D06P5/00 ,  C07C59/64 ,  C07C59/68

    Abstract: The present invention provides α-hydroxy benzeneacetic acid derivatives of the formula as defined in the specification which is a precursor indispensable for synthesis of compounds having two 5-membered lactone rings fused to central cyclohexa-1,4-diene nucleus, and a process of easily preparing the same. According to the preparation process of the present invention, the α-hydroxy benzeneacetic acid derivative can be readily prepared at high purity and yield without using toxic materials or producing toxic by-products. Some novel compounds, synthesized by using such a α-hydroxy benzeneacetic acid derivative, have excellent fastness properties, dye fixing rate and leveling property to general synthetic fiber materials such as polyester fibers and their blends with other fibers, especially to micro fibers, and also can be used as a coloring agent for plastic resins, color tonors, color filters, etc.

    Abstract translation: 本发明提供了如本说明书中所定义的式的α-羟基苯乙酸衍生物，其是合成具有与中心环己1,4-二烯核心融合的两个5元内酯环的化合物不可或缺的前体， 容易准备相同。 根据本发明的制备方法，α-羟基苯乙酸衍生物可以在不使用有毒物质或产生有毒副产物的情况下以高纯度和高产率容易地制备。 通过使用这种α-羟基苯乙酸衍生物合成的一些新化合物对于一般的合成纤维材料如聚酯纤维及其与其它纤维，特别是微纤维的共混物具有优异的牢度，染色固色率和流平性，以及 可用作塑料树脂，彩色调色剂，滤色片等的着色剂。

    Process
    38.
    发明申请
    Process 失效
    处理

    公开(公告)号：US20080312457A1

    公开(公告)日：2008-12-18

    申请号：US10579854

    申请日：2004-11-25

    Applicant: Hans Jorgen Blixt ,  Bo Lars Gustaf Bosson ,  Roberto Guiseppe Paolo Gatti ,  Simone Zaramella ,  Michael William Senior ,  Kurt Vogtli ,  Andrea Zistler

    Inventor： Hans Jorgen Blixt ,  Bo Lars Gustaf Bosson ,  Roberto Guiseppe Paolo Gatti ,  Simone Zaramella ,  Michael William Senior ,  Kurt Vogtli ,  Andrea Zistler

    IPC: C07D207/04 ,  C07C59/50

    CPC classification number: C07C59/64 ,  C07C51/487

    Abstract: The present invention relates to a new process for the resolution of mandelic acid derivatives from racemic mandelic acid derivative mixtures by salt formation with chiral base cyclic amides; to the resolved mandelic acid cyclic amide salts (see, for example, formula IIa), as well as certain other metal and amine salts of the mandelic acid derivatives, and to the use of the resolved mandelic acid derivatives as intermediates suitable for large-scale manufacturing of, for example, pharmaceutical compounds; Formula IIa, wherein R is selected from CHF2, H, C1-6 Alkyl, CH2F, CHCl2 and CClF2; and wherein n is 0, 1 or 2; R1 is H or C1-6 Alkyl and X is H, halo or C1-6 Alkyl.

    Abstract translation: 本发明涉及通过与手性碱性环状酰胺形成盐从外消旋扁桃酸衍生物混合物中分离扁桃酸衍生物的新方法。 对于解析的扁桃酸环状酰胺盐（参见例如式IIa）以及扁桃酸衍生物的某些其它金属和胺盐，以及使用分解的扁桃酸衍生物作为适合于大规模的中间体 制造例如药物化合物; 式IIa，其中R选自CHF 2，H，C 1-6烷基，CH 2 F，CHCl 2和CClF 2; 并且其中n为0,1或2; R 1是H或C 1-6烷基，X是H，卤素或C 1-6烷基。

    Carboxilic acid derivatives
    39.
    发明申请
    Carboxilic acid derivatives 失效
    羧酸衍生物

    公开(公告)号：US20080275116A1

    公开(公告)日：2008-11-06

    申请号：US11870718

    申请日：2007-10-11

    Applicant: Youichi YAMAGUCHI ,  Takeshi YANASE ,  Susumu MUTO ,  Akiko ITAI

    Inventor： Youichi YAMAGUCHI ,  Takeshi YANASE ,  Susumu MUTO ,  Akiko ITAI

    IPC: A61K31/235 ,  A61K31/195 ,  C07C63/04 ,  C07C69/78 ,  A61K31/192 ,  A61P7/04 ,  A61P7/02

    CPC classification number: C07C51/00 ,  C07C59/64 ,  C07C65/24 ,  C07C65/28 ,  C07C205/06 ,  C07C205/34 ,  C07C217/86 ,  C07C235/80 ,  C07C255/37

    Abstract: A compound represented by the following general formula (I) or a salt thereof, or a hydrate thereof or a solvate thereof having an inhibitory action against plasminogen activator inhibitor-1 (PAI-1): wherein R1 represents a C6-10 aryl group; or a substituted C6-10 aryl group, R2 represents a C6-10 aryl group; or a C6-10 aryl group substituted with a group or groups selected from the group consisting of a halogen atom, nitro group, a C1-6 alkyl group, a halogenated C1-6 alkyl group, a C1-6 alkoxy group, a halogenated C1-6 alkoxy group, a phenyl group and carboxy group, X represents —CH2—, —CH2CH2—, —CH═CH— or —N(R3)—C(═O)—, Y represents carboxy group or a bioisostere of carboxy group, R3 represents hydrogen atom, a C1-4 alkyl group or a C7-12 aralkyl group, m represents 0 or 1.

    Abstract translation: 具有对纤溶酶原激活物抑制剂-1（PAI-1）具有抑制作用的由以下通式（I）表示的化合物或其盐，或其水合物或其溶剂化物：其中R 1， 表示C 6-10芳基; 或取代的C 6-10芳基，R 2表示C 6〜6-10芳基; 或被选自卤素原子，硝基，C 1-6烷基的基团或基团取代的C 6-10芳基， 卤代C 1-6烷基，C 1-6烷氧基，卤代C 1-6烷氧基，苯基和 羧基，X表示-CH 2 - ， - CH 2 CH 2 - ， - CH-CH-或-N（R' C（-O） - ，Y表示羧基或羧基的生物电子等排物，R 3表示氢原子，C 1-4烷基 >烷基或C 7-12-12芳烷基，m表示0或1。

    Process For the Manufacture of Substituted Propionic Acids
    40.
    发明申请
    Process For the Manufacture of Substituted Propionic Acids 审中-公开
    制备取代丙酸的方法

    公开(公告)号：US20080242876A1

    公开(公告)日：2008-10-02

    申请号：US11813986

    申请日：2006-01-13

    Applicant: Peter McCormack ,  Chen Weiping ,  Mohammed Karim

    Inventor： Peter McCormack ,  Chen Weiping ,  Mohammed Karim

    IPC: C07D333/02 ,  C07C63/04

    CPC classification number: C07C51/36 ,  C07B2200/07 ,  C07C253/30 ,  C07D333/24 ,  C07C59/64 ,  C07C59/68 ,  C07C255/57

    Abstract: The invention concerns a process for the manufacture of substituted propionic acids comprising providing a substrate of formula (I): And subjecting the substrate to enantioselective hydrogenation under enantioselective hydrogenation conditions in the presence of an enantioselective hydrogenation catalyst comprising a catalyst ligand having a metallocene group with a chiral phosphorus or arsenic substituent to provide in enantiomeric excess a product of formula (II): or its enantiomer or if applicable its diastereomer.

    Abstract translation: 本发明涉及一种制备取代的丙酸的方法，其包括提供式（I）的底物：在对映选择性加氢条件下，在对映选择性氢化催化剂存在下使底物进行对映选择性氢化，所述对映选择性氢化催化剂包含具有金属茂基团的催化剂配体， 手性磷或砷取代基以提供对映体过量的式（II）的产物：或其对映体或如果适用，其非对映体。

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