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公开(公告)号：US20100234291A2
公开(公告)日：2010-09-16
申请号：US12519309
申请日：2009-12-22
Applicant: Zuze Wu , Aiping Yu , Chuanling Zhang , Zhongxiong Tang
Inventor： Zuze Wu , Aiping Yu , Chuanling Zhang , Zhongxiong Tang
CPC classification number: C12N15/62 , A61K38/00 , C07K14/46 , C07K14/4711 , C07K14/8128 , C07K14/815 , C07K2319/00 , C12N9/6432 , C12N9/6443 , C12Y304/21006 , C12Y304/21027
Abstract: Provided is an anticoagulant fusion protein comprising oligopeptide recognizable and cleavable by either factor XIa and factor Xa or thrombin and factor Xa. Also provided are the preparation method of the anticoagulant fusion protein and medicinal use thereof.
Abstract translation: 提供了一种抗凝血融合蛋白，其包含由XIa因子和因子Xa或凝血酶和因子Xa可识别和切割的寡肽。 还提供了抗凝血融合蛋白的制备方法及其药物用途。
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2.发明授权Cis-1,2-substituted stilbene derivatives and their use in preparation of drugs for treatment and/or prevention of diabetes 有权顺式1,2-取代的二苯乙烯衍生物及其在制备用于治疗和/或预防糖尿病的药物中的用途公开(公告)号：US08039513B2
公开(公告)日：2011-10-18
申请号：US11658239
申请日：2005-07-20
Applicant: Zhiyun Kang , Zuze Wu , Zhuangrong Sun , Zhongxiong Tang
Inventor： Zhiyun Kang , Zuze Wu , Zhuangrong Sun , Zhongxiong Tang
IPC: A01N33/00 , A01N37/18 , A61K31/13 , A61K31/16 , A61K31/165 , C07C43/02 , C07C233/00 , C07C235/00 , C07C237/00
CPC classification number: C07C235/34 , C07B2200/09 , C07C39/23 , C07C43/23 , C07C59/64 , C07C69/017 , C07C69/54 , C07C235/36 , C07D295/185 , C07D307/14 , C07H15/203
Abstract: The present invention relates to cis-1,2-substituted stilbene derivatives, or their pharmaceutically acceptable salts, glucosides or solvates, a pharmaceutical composition comprising the compound, and use of said compound for preparation of a drug for treatment and/or prevention of diabetes or improvement of diabetic complications.
Abstract translation: 本发明涉及顺式1,2-取代的二苯乙烯衍生物或其药学上可接受的盐，葡糖苷或溶剂化物，包含该化合物的药物组合物和所述化合物用于制备用于治疗和/或预防糖尿病的药物的用途 或改善糖尿病并发症。
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Patent Agency Ranking
3.发明授权Use of stilbene compounds in the manufacture of medicament for the prevention and treatment of diabetes or retrovirus-associated diseases 有权二苯乙烯化合物在制备用于预防和治疗糖尿病或逆转录病毒相关疾病的药物中的用途公开(公告)号：US07384920B2
公开(公告)日：2008-06-10
申请号：US10484821
申请日：2001-07-26
Applicant: Junlin Li , Zuze Wu , Lizhen Yuan , Qiang Li , Zhongxiong Tang
Inventor： Junlin Li , Zuze Wu , Lizhen Yuan , Qiang Li , Zhongxiong Tang
CPC classification number: A61K31/7034 , A61K31/015 , A61K31/05 , A61K31/085
Abstract: This invention relates to a new use of stilbene derivatives or pharmaceutically acceptable salts thereof, especially in the manufacture of medicament for the prevention and treatment of diabetes or retrovirus associated diseases.
Abstract translation: 本发明涉及1,2-二苯乙烯衍生物或其药学上可接受的盐的新用途，特别是在制备用于预防和治疗糖尿病或逆转录病毒相关疾病的药物中。
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4.发明申请Use of stilbene compounds in preparing medicaments for treating or preventing diabetes and diseases associated with retrovirus 有权二苯乙烯化合物在制备用于治疗或预防糖尿病和与逆转录病毒有关的疾病的药物中的应用公开(公告)号：US20050020511A1
公开(公告)日：2005-01-27
申请号：US10484821
申请日：2001-07-26
Applicant: Junlin Li , Zuze Wu , Lizhen Yuan , Qiang Li , Zhongxiong Tang
Inventor： Junlin Li , Zuze Wu , Lizhen Yuan , Qiang Li , Zhongxiong Tang
IPC: A61K31/00 , A61K31/015 , A61K31/05 , A61K31/085 , A61K31/7034 , A61P3/10 , A61P31/12 , A61K31/704
CPC classification number: A61K31/7034 , A61K31/015 , A61K31/05 , A61K31/085
Abstract: This invention relates to a new use of stilbene derivatives or pharmaceutically acceptable salts thereof, especially in the manufacture of medicament for the prevention and treatment of diabetes or retrovirus associated diseases.
Abstract translation: 本发明涉及1,2-二苯乙烯衍生物或其药学上可接受的盐的新用途，特别是在制备用于预防和治疗糖尿病或逆转录病毒相关疾病的药物中。
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公开(公告)号：US08101379B2
公开(公告)日：2012-01-24
申请号：US12519309
申请日：2007-12-11
Applicant: Zuze Wu , Aiping Yu , Chuanling Zhang , Zhongxiong Tang
Inventor： Zuze Wu , Aiping Yu , Chuanling Zhang , Zhongxiong Tang
CPC classification number: C12N15/62 , A61K38/00 , C07K14/46 , C07K14/4711 , C07K14/8128 , C07K14/815 , C07K2319/00 , C12N9/6432 , C12N9/6443 , C12Y304/21006 , C12Y304/21027
Abstract: Provided is an anticoagulant fusion protein comprising oligopeptide recognizable and cleavable by either factor XIa and factor Xa or thrombin and factor Xa. Also provided are the preparation method of the anticoagulant fusion protein and medicinal use thereof.
Abstract translation: 提供了一种抗凝血融合蛋白，其包含由XIa因子和因子Xa或凝血酶和因子Xa可识别和切割的寡肽。 还提供了抗凝血融合蛋白的制备方法及其药物用途。
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公开(公告)号：US20100113345A1
公开(公告)日：2010-05-06
申请号：US12519309
申请日：2007-12-11
Applicant: Zuze Wu , Aiping Yu , Chuanling Zhang , Zhongxiong Tang
Inventor： Zuze Wu , Aiping Yu , Chuanling Zhang , Zhongxiong Tang
CPC classification number: C12N15/62 , A61K38/00 , C07K14/46 , C07K14/4711 , C07K14/8128 , C07K14/815 , C07K2319/00 , C12N9/6432 , C12N9/6443 , C12Y304/21006 , C12Y304/21027
Abstract: Provided is an anticoagulant fusion protein comprising oligopeptide recognizable and cleavable by either factor XIa and factor Xa or thrombin and factor Xa. Also provided are the preparation method of the anticoagulant fusion protein and medicinal use thereof.
Abstract translation: 提供了一种抗凝血融合蛋白，其包含由XIa因子和因子Xa或凝血酶和因子Xa可识别和切割的寡肽。 还提供了抗凝血融合蛋白的制备方法及其药物用途。
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7.发明申请Cis-1,2-substituted stilbene derivatives and their use in preparation of drugs for treatment and/or prevention of diabetes 有权顺式1,2-取代的二苯乙烯衍生物及其在制备用于治疗和/或预防糖尿病的药物中的用途公开(公告)号：US20090076114A1
公开(公告)日：2009-03-19
申请号：US11658239
申请日：2005-07-20
Applicant: Zhiyun Kang , Zuze Wu , Zhuangrong Sun , Zhongxiong Tang
Inventor： Zhiyun Kang , Zuze Wu , Zhuangrong Sun , Zhongxiong Tang
IPC: A61K31/085 , C07C43/23 , A61K31/192 , A61K31/341 , A61P3/10 , A61K31/40 , A61K31/165 , C07C59/64
CPC classification number: C07C235/34 , C07B2200/09 , C07C39/23 , C07C43/23 , C07C59/64 , C07C69/017 , C07C69/54 , C07C235/36 , C07D295/185 , C07D307/14 , C07H15/203
Abstract: The present invention relates to cis-1,2-substituted stilbene derivatives, or their pharmaceutically acceptable salts, glucosides or solvates, a pharmaceutical composition comprising the compound, and use of said compound for preparation of a drug for treatment and/or prevention of diabetes or improvement of diabetic complications.
Abstract translation: 本发明涉及顺式1,2-取代的二苯乙烯衍生物或其药学上可接受的盐，葡糖苷或溶剂化物，包含该化合物的药物组合物和所述化合物用于制备用于治疗和/或预防糖尿病的药物的用途 或改善糖尿病并发症。
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