Invention Application
- Patent Title: Carboxilic acid derivatives
- Patent Title (中): 羧酸衍生物
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Application No.: US11870718Application Date: 2007-10-11
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Publication No.: US20080275116A1Publication Date: 2008-11-06
- Inventor: Youichi YAMAGUCHI , Takeshi YANASE , Susumu MUTO , Akiko ITAI
- Applicant: Youichi YAMAGUCHI , Takeshi YANASE , Susumu MUTO , Akiko ITAI
- Applicant Address: JP Tokyo
- Assignee: INSTITUTE OF MEDICINAL MOLECULAR DESIGN, INC.
- Current Assignee: INSTITUTE OF MEDICINAL MOLECULAR DESIGN, INC.
- Current Assignee Address: JP Tokyo
- Priority: JP2006-278528 20061012
- Main IPC: A61K31/235
- IPC: A61K31/235 ; A61K31/195 ; C07C63/04 ; C07C69/78 ; A61K31/192 ; A61P7/04 ; A61P7/02

Abstract:
A compound represented by the following general formula (I) or a salt thereof, or a hydrate thereof or a solvate thereof having an inhibitory action against plasminogen activator inhibitor-1 (PAI-1): wherein R1 represents a C6-10 aryl group; or a substituted C6-10 aryl group, R2 represents a C6-10 aryl group; or a C6-10 aryl group substituted with a group or groups selected from the group consisting of a halogen atom, nitro group, a C1-6 alkyl group, a halogenated C1-6 alkyl group, a C1-6 alkoxy group, a halogenated C1-6 alkoxy group, a phenyl group and carboxy group, X represents —CH2—, —CH2CH2—, —CH═CH— or —N(R3)—C(═O)—, Y represents carboxy group or a bioisostere of carboxy group, R3 represents hydrogen atom, a C1-4 alkyl group or a C7-12 aralkyl group, m represents 0 or 1.
Public/Granted literature
- US08044236B2 Carboxilic acid derivatives Public/Granted day:2011-10-25
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