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    Method and apparatus for retaining and presenting at least one microsphere array to solutions and/or to optical imaging systems
    31.
    发明授权
    Method and apparatus for retaining and presenting at least one microsphere array to solutions and/or to optical imaging systems 有权
    用于将至少一个微球阵列保持并呈现给溶液和/或光学成像系统的方法和装置

    公开(公告)号：US06396995B1

    公开(公告)日：2002-05-28

    申请号：US09574962

    申请日：2000-05-19

    Applicant: John R. Stuelpnagel ,  Mark S. Chee ,  Richard J. Pytelewski ,  Todd Alan Dickinson ,  Gan G. Wang

    Inventor： John R. Stuelpnagel ,  Mark S. Chee ,  Richard J. Pytelewski ,  Todd Alan Dickinson ,  Gan G. Wang

    IPC: G02B600

    CPC classification number: G01N35/028 ,  B01J2219/00317 ,  B01J2219/00585 ,  B01J2219/00648 ,  B01J2219/00659 ,  B01J2219/00707 ,  B01L2300/0893 ,  C40B60/14 ,  G01N21/253 ,  G01N21/645 ,  G01N21/6452

    Abstract: A holder for an array of bundles containing multiple fiber optic strands provides a pattern of openings into which one each of each bundle is fit. The openings may (but need not) penetrate the full holder thickness to permit working with bundles from either bundle end. In one embodiment the holder thickness equals the bundle length, and the holder is sized similarly to a microscope slide. An alternative embodiment temporarily retains bundles in a desired registration and subjects the retained bundles to molten material such as wax that is allowed to harden around the bundles and become the holder. A modular holder comprises laminates that each contain parallel grooves sized to receive a bundle. A holder for a single bundle includes cooperating grip-like members, one of which is pivotably attached and biased toward the other member. A common form factor may be used for each holder type to facilitate retaining holders in a common docking station.

    Abstract translation: 用于包含多个光纤线束的束阵列的保持器提供开口的图案，每个束中的每一个都适合于其中。 开口可以（但不需要）穿透整个夹持器的厚度，以允许从任一个束末端束起束。 在一个实施例中，保持器厚度等于束长度，并且保持器的尺寸与显微镜载玻片类似。 一个替代实施例暂时将束保持在期望的配准中，并将保留的束经受允许在束附近硬化并变成保持器的熔融材料例如蜡。 模块化夹持器包括每​​个包含尺寸适于接收束的平行凹槽的层压板。 用于单个束的保持器包括配合的手柄状构件，其中一个可枢转地附接并朝向另一个构件偏置。 每个保持器类型可以使用常见的形状因子，以便于将保持器固定在公共坞站中。

    METHODS AND COMPOSITIONS FOR NUCLEIC ACID ASSEMBLY
    33.
    发明公开
    METHODS AND COMPOSITIONS FOR NUCLEIC ACID ASSEMBLY 审中-公开

    公开(公告)号：US20230332137A1

    公开(公告)日：2023-10-19

    申请号：US18026096

    申请日：2021-09-13

    Applicant: Mark S. CHEE

    Inventor： Mark S. CHEE

    IPC: C12N15/10

    CPC classification number: C12N15/1065

    Abstract: Disclosed in certain aspects herein are methods and compositions for the assembly of genes and even larger nucleic acid molecules, and methods of using assembled nucleic acids, e.g., as synthetic biology tools and/or products.

    Methods of enzymatic discrimination enhancement and surface-bound double-stranded DNA
    35.
    发明授权
    Methods of enzymatic discrimination enhancement and surface-bound double-stranded DNA 有权
    酶鉴别增强方法和表面结合双链DNA

    公开(公告)号：US08236493B2

    公开(公告)日：2012-08-07

    申请号：US12187503

    申请日：2008-08-07

    Applicant: David J. Lockhart ,  Mark S. Chee ,  Martin Digglemann ,  Dirk Vetter

    Inventor： David J. Lockhart ,  Mark S. Chee ,  Martin Digglemann ,  Dirk Vetter

    IPC: C12Q1/68

    CPC classification number: C40B60/12 ,  B01J2219/00427 ,  B01J2219/00529 ,  B01J2219/00596 ,  B01J2219/00608 ,  B01J2219/00659 ,  B01J2219/00722 ,  C12Q1/6837 ,  C12Q1/6869 ,  C12Q2565/507 ,  C12Q2521/501

    Abstract: Methods for discriminating between fully complementary hybrids and those that differ by one or more base pairs and libraries of unimolecular, double-stranded oligonucleotides on a solid support. In one embodiment, the present invention provides methods of using nuclease treatment to improve the quality of hybridization signals on high density oligonucleotide arrays. In another embodiment, the present invention provides methods of using ligation reactions to improve the quality of hybridization signals on high density oligonucleotide arrays. In yet another embodiment, the present invention provides libraries of unimolecular or intermolecular, double-stranded oligonucleotides on a solid support. These libraries are useful in pharmaceutical discovery for the screening of numerous biological samples for specific interactions between the double-stranded oligonucleotides, and peptides, proteins, drugs and RNA. In a related aspect, the present invention provides libraries of conformationally restricted probes on a solid support. The probes are restricted in their movement and flexibility using double-stranded oligonucleotides as scaffolding. The probes are also useful in various screening procedures associated with drug discovery and diagnosis. The present invention further provides methods for the preparation and screening of the above libraries.

    Abstract translation: 用于区分完全互补的杂交体与通过一个或多个碱基对不同的那些的方法和在固体支持物上的单分子双链寡核苷酸的文库。 在一个实施方案中，本发明提供了使用核酸酶处理来提高高密度寡核苷酸阵列上杂交信号质量的方法。 在另一个实施方案中，本发明提供了使用连接反应来提高高密度寡核苷酸阵列上杂交信号质量的方法。 在另一个实施方案中，本发明提供了在固体支持物上的单分子或分子间双链寡核苷酸的文库。 这些文库在药物发现中可用于筛选许多生物样品，用于双链寡核苷酸与肽，蛋白质，药物和RNA之间的特异性相互作用。 在相关方面，本发明提供了在固体支持物上的构象限制探针的文库。 使用双链寡核苷酸作为脚手架，探针的运动和灵活性受到限制。 探针也可用于与药物发现和诊断相关的各种筛选程序。 本发明还提供了制备和筛选上述文库的方法。

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