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    Stamp usage to enhance surface layer functionalization and selectivity
    5.
    发明授权
    Stamp usage to enhance surface layer functionalization and selectivity 有权
    印章使用，以增强表面层的功能化和选择性

    公开(公告)号：US08580344B2

    公开(公告)日：2013-11-12

    申请号：US12405218

    申请日：2009-03-16

    Applicant: Nikhil D. Kalyankar ,  Zachary Fresco ,  Chi-I Lang

    Inventor： Nikhil D. Kalyankar ,  Zachary Fresco ,  Chi-I Lang

    IPC: G01N31/00 ,  G01N31/20 ,  G01N31/22 ,  B01L3/00

    CPC classification number: C40B60/08 ,  B01J19/0046 ,  B01J2219/00317 ,  B01J2219/00364 ,  B01J2219/00376 ,  B01J2219/00382 ,  B01J2219/00427 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00659 ,  B01J2219/00702 ,  C40B50/18

    Abstract: This disclosure provides methods, devices and systems for using a stamp to enhance selectivity between surface layers of a substrate, and to facilitate functionalizing selected layers. An array of flat stamps may be used to concurrently stamp multiple regions of a substrate to transfer one or more substances to the topmost layer or layers of the substrate. If desired, the affected regions of the substrate may be isolated from each other through the use of a reactor plate that, when clamped to the substrate's surface, forms reaction wells in the area of stamping. The stamp area can, if desired, be configured for stamping the substrate after the reactor plate has been fitted, with the individual stamps sized and arranged in a manner that permits stamping within each reaction well. If applied in a combinatorial process, a robotic process may be used to transfer multiple combinations of contact substances and processing chemicals to each reaction well to perform many concurrent processes upon a single substrate (e.g., a single coupon). The methods, devices and systems provided facilitate semiconductor design, optimization and qualification, and may be adapted to production manufacturing.

    Abstract translation: 本公开提供了使用印模来增强基底的表面层之间的选择性并促进官能化所选择的层的方法，装置和系统。 可以使用平面阵列阵列来同时印刷衬底的多个区域以将一种或多种物质转移到衬底的最上层或多层。 如果需要，可以通过使用反应器板将基材的受影响区域彼此隔离，当将其夹在基材表面上时，在冲压区域中形成反应孔。 如果需要，邮票区域可以被配置用于在安装反应器板之后冲压衬底，各个邮票的大小和布置方式允许在每个反应井内冲压。 如果应用于组合过程中，机器人过程可用于将接触物质和加工化学品的多种组合转移到每个反应井，以在单个底物（例如，单一试样）上进行许多并行处理。 提供的方法，设备和系统有助于半导体设计，优化和鉴定，并可适用于生产制造。

    APPARATUS, PROCESS AND KIT FOR DETECTING ANALYTES IN A SAMPLE
    8.
    发明申请
    APPARATUS, PROCESS AND KIT FOR DETECTING ANALYTES IN A SAMPLE 审中-公开
    用于检测样品中分析物的装置，工艺和工具包

    公开(公告)号：US20090068757A1

    公开(公告)日：2009-03-12

    申请号：US12279722

    申请日：2007-02-16

    Applicant: Werner Lehmann ,  Uwe Schedler

    Inventor： Werner Lehmann ,  Uwe Schedler

    IPC: G01N21/64 ,  B01J19/00 ,  G01N27/00 ,  G01J3/28 ,  G01N23/04 ,  G01N21/21 ,  B05D1/32 ,  G01N21/00

    CPC classification number: B01J19/0046 ,  B01J2219/00317 ,  B01J2219/00427 ,  B01J2219/00466 ,  B01J2219/005 ,  B01J2219/00576 ,  B01J2219/00648 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/00725

    Abstract: The invention relates to an apparatus (100) for detecting analytes (26) in a sample comprising—a base carrier (10); —a multitude of sensor carriers (18) which are arranged on the base carrier (10) and can be assigned to at least two different sensor carrier populations (181, 182, 183); —the sensor carrier populations (181, 182, 183) being defined at least by different sensor molecules (24) which are assigned to the sensor carrier (18) and each have at least one measurable specificity for an analyte (26) or an analyte group, such that the population (181, 182, 183) of the sensor carriers (18) constitutes a coding which enables the assignment of sensor molecules (24) and/or analyte (26). The apparatus is characterized in that the sensor carriers (18) are present without contact to one another with a predetermined mean distance between one another and with a random statistical distribution on the base carrier (10) with regard to the population (181, 182, 183), as a result of which the detection of only a single entity of a sensor carrier (18) in each case is ensured during the analysis of the sensor molecules and/or of the binding analytes.

    Abstract translation: 本发明涉及一种用于检测样品中的分析物（26）的装置（100），包括： - 基座（10）; - 多个传感器载体（18），其布置在所述基底载体（10）上并且可分配给至少两个不同的传感器载体群（181,182,183）; 传感器载体群体（181,182,183）至少由分配给传感器载体（18）的不同传感器分子（24）限定，并且每个传感器载体群体对分析物（26）或分析物（26）具有至少一个可测量的特异性 使得传感器载体（18）的群体（181,182,183）构成能够分配传感器分子（24）和/或分析物（26）的编码。 该装置的特征在于，传感器载体（18）不存在彼此的接触，彼此之间具有预定的平均距离，并且与基座（10）相对于群体（181,182， 183），其结果是在传感器分子和/或结合分析物的分析期间，确保在每种情况下只检测传感器载体（18）的单个实体。

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